The Symptom and Frequency of the Patients with Multiple Myeloma in Osteoporotic Vertebral Body Fracture in the Elderly: A Case Control Study

In an aging society, osteoporotic vertebral fracture will continue to rise. Multiple myeloma is mostly developed in elderly, so there is also a possibility to increase the number of multiple myeloma.

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The symptom and frequency of the patients with multiple myeloma in osteoporotic vertebral body fracture in the elderly

10.21203/rs.3.rs-29134/v1 ◽

2020 ◽

Author(s):

KENGO HIGUCHI ◽

Shinij Kumamoto ◽

Hidefumi Honke ◽

Masaaki Mawatari

Keyword(s):

Multiple Myeloma ◽

Vertebral Fracture ◽

Bone Lesion ◽

The Elderly ◽

Bone Lesions ◽

Osteoporotic Vertebral Fracture ◽

Old Patients ◽

Body Fracture ◽

The Mean ◽

Bence Jones Proteins

Abstract Background: In an aging society, osteoporotic vertebral fracture will continue to rise. Multiple myeloma is mostly developed in elderly, so there is also a possibility to increase the number of multiple myeloma. Multiple myeloma patients tend to have osteolysis lesion especially in the vertebral, so they are easy to injury vertebral fractures. In the medical care of osteoporotic vertebral fracture, it is not rare that we meet with undiagnosed multiple myeloma, but there are few reports of the symptom and frequency of the patients with multiple myeloma included in osteoporotic vertebral fracture. In multiple myeloma patients, early treatments improve consequence. So early medical examination by orthopaedist is clinically important. The purpose of this study is to investigate the symptom and frequency of the patients with multiple myeloma included in osteoporotic vertebral fracture. Methods: Between April 2016 and March 2017, 145 patients was diagnosed osteoporotic vertebral fracture, among these, the 108 patients was chosen with use of our criteria. Among these 108 patients, we examined blood examinations, Bence Jones proteins in urine, monoclonal protein on serum and numbers of vertebral fracture at the first visit to a doctor. Results: 6.5% (7/108) patients was diagnosed with symptomatic multiple myeloma. The rate between 75 to 84 years old patients was 5.1%, over the 85 years old was 8.2%. In the 7 patients, the mean age was 85, hemoglobin was 7.8g/dL and albumin-globulin ratio was 0.83, that was low value in all 7 patients. Existing vertebral lesion was 6.0 bodies. Conclusions: Multiple bone lesions or early refracture of vertebral is positively suspicious symptom of MM. The measurement of electrophoresis of protein, albumin-globulin ratio is recommended with vertebral lesion in elderly. The MM patients having bone lesion are likely to first visit orthopaedist, so it is necessary to positively considerate this pathophysiology.

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744. Effectiveness of 23-Valent Pneumococcal Polysaccharide Vaccine and Influenza Vaccine Against Pneumococcal Pneumonia Among Elderly Patients Aged 65 Years and Older in the Republic of Korea: A Case–Control Study

Open Forum Infectious Diseases ◽

10.1093/ofid/ofy210.751 ◽

2018 ◽

Vol 5 (suppl_1) ◽

pp. S267-S267

Author(s):

Jong Hun Kim ◽

Byung Chul Chun ◽

Joon Young Song ◽

Hyo Youl Kim ◽

In-Gyu Bae ◽

...

Keyword(s):

Elderly Patients ◽

Elderly Population ◽

Case Control Study ◽

The Elderly ◽

Case Control ◽

Polysaccharide Vaccine ◽

Vaccine Effectiveness ◽

Pneumococcal Polysaccharide Vaccine ◽

The Republic ◽

Control Study

Abstract Background The national immunization program (NIP) of annual influenza vaccination to the elderly population (≥65 years of age) in the Republic of Korea (ROK) has been implemented since 1987. Recently, the 23-valent pneumococcal polysaccharide vaccine (PPV23) through the NIP has been provided to the elderly population in the ROK since May 2013. The aim of this study was to assess PPV23 and influenza vaccine (IV) effectiveness in preventing pneumococcal pneumonia (PP) among elderly patients ≥65 years of age. Methods A case–control study using a hospital-based cohort was conducted. Cases of PP including bacteremic PP and nonbacteremic PP were collected from 14 hospitals in the pneumococcal diseases surveillance program from March 2013 to October 2015. Controls matched by age and sex in the same hospital were selected. Demographic, clinical information, and vaccination histories were collected. Previous immunization was categorized into “vaccinated” if a patient had received vaccines as follows: PPV23 (4 weeks to 5 years) and IV (2 weeks to 6 months) prior to the diagnosis of PP for case patients and prior to the hospital admission for control patients. Adjusted odds ratio (OR) was calculated, controlling for underlying medical conditions. Vaccine effectiveness was defined as (1 – OR) × 100. Results During the study period, a total of 661 cases (104 bacteremic PP cases and 557 nonbacteremic PP cases) and 661 controls were enrolled for analyses. For overall patients ≥65 years of age, there was no significant vaccine effectiveness against PP. For young elderly patients with 65–74 years, IV alone (1.2%, [95% confidence interval (CI) −95.3% to 50.0%]) and PPV23 alone (21.9%, [95% CI −39.0% to 56.1%]) were not effective. However, significant vaccine effectiveness of PPV23 plus IV against PP was noted (54.4%, [95% CI 6.9–77.7%], P = 0.031). For older elderly patients ≥75 years of age, no significant vaccine effectiveness was observed. Conclusion Our study indicates that PPV23 plus IV may be effective in preventing PP among young elderly patients with 65–74 years, suggesting additive benefits of influenza plus PPV23 vaccination. Further studies are required to confirm the persistent additive protective effectiveness. Disclosures All authors: No reported disclosures.

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Neuroleptic drug exposure and treatment of parkinsonism in the elderly: A case-control study

The American Journal of Medicine ◽

10.1016/s0002-9343(99)80104-1 ◽

1995 ◽

Vol 99 (1) ◽

pp. 48-54 ◽

Cited By ~ 38

Author(s):

Jerry Avorn ◽

Rhonda L. Bohn ◽

Helen Mogun ◽

Jerry H. Gurwitz ◽

Mark Monane ◽

...

Keyword(s):

Drug Exposure ◽

Case Control Study ◽

The Elderly ◽

Case Control ◽

Neuroleptic Drug ◽

Control Study

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Altered disc pressure profile after an osteoporotic vertebral fracture is a risk factor for adjacent vertebral body fracture

10.12681/eadd/40028 ◽

2017 ◽

Author(s):

Μιχαήλ Τζερμιαδιανός

Keyword(s):

Risk Factor ◽

Vertebral Fracture ◽

Vertebral Body ◽

Pressure Profile ◽

Osteoporotic Vertebral Fracture ◽

Adjacent Vertebral Body ◽

Vertebral Body Fracture ◽

Body Fracture

Η κύφωση από ένα οστεοπορωτικό σπονδυλικό κάταγμα θεωρείται παράγοντας κίνδυνου για νέα κατάγματα, ιδιαίτερα στους παρακείμενους σπονδύλους. Όμως, ο ρόλος της παραμόρφωσης της τελικής πλάκας δεν έχει εκτιμηθεί. Η παρούσα μελέτη ελέγχει την υπόθεση ότι η αλλαγή στις μηχανικές ιδιότητες του μεσοσπονδύλιου δίσκου μετά από κάταγμα της τελικής του πλάκας, ακόμη και επί απουσίας κύφωσης, αλλάζει την μεταφορά φορτίων και προδιαθέτει σε παρακείμενα σπονδυλικά κάταγμα. Χρησιμοποιήθηκαν οκτώ ανθρώπινα θωρακοσφυϊκά παρασκευάσματα, αποτελούμενα από πέντε σπονδύλους. Για την επιλεκτική θραύση της μίας τελικής πλάκας του μεσαίου σπονδύλου δημιουργήθηκε κενό στο σπογγώδες οστό κάτω από την τυχαία επιλεγμένη πλάκα και το παρασκεύασμα συμπιέστηκε σε θέση κάμψης. Στη συνέχεια εφαρμόστηκε ροπή έκτασης υπό συμπιεστικό φορτίο 150 Ν, η οποία αποκατέστησε το ύψους του πρόσθιου τοιχώματος και την κυφωτική παραμόρφωση του σπονδυλικού σώματος, ενώ η τελική πλάκα παρέμεινε σημαντικά παραμορφωμένη. Το σπονδυλικό σώμα πληρώθηκε στην αναταγμένη θέση με πολυμεθακρυλικό τσιμέντο μετά τον προσεκτικό καθαρισμό του από τις οστικές δοκίδες ώστε να διασφαλιστεί η ομοιόμορφη κατανομή του τσιμέντου κάτω από τις τελικές πλάκες. Κάθε παρασκεύασμα ελέγχθηκε σε κάμψη και έκταση (ροπή ±6 Nm) υπό φορτίο 400 Ν, ενώ γινόταν καταγραφή της πίεση στους δίσκους άνω και κάτω του μεσαίου σπονδύλου και της τάσης (strain) στο πρόσθιο τοίχωμα των παρακείμενων σπονδύλων. Η πίεση των δίσκων στα άθικτα παρασκευάσματα αυξήθηκε κατά την κάμψη κατά 26 ± 14%. Μετά την ενίσχυση με τσιμέντο η πίεση των δίσκων κατά την κάμψη αυξήθηκε κατά 15 ± 11% στους δίσκους με άθικτη τελική πλάκα, ενώ μειώθηκε κατά 19,0 ± 26,8% στους δίσκους με παραμορφωμένη τελική πλάκα. Κατά την κάμψη, η συμπιεστική φόρτιση στο πρόσθιο τοίχωμα του σπονδύλου που βρισκόταν δίπλα από την παραμορφωμένη πλάκα αυξήθηκε κατά 94,2 ± 22,8% σε σχέση με τα άθικτα παρασκευάσματα (p<0,05), ενώ δεν άλλαξε σημαντικά στο σπόνδυλο δίπλα στην μη παραμορφωμένη πλάκα (18,2 ± 7,1%, p>0,05). Επακόλουθη κάμψη με συμπίεση προκάλεσε παρακείμενα κατάγματα δίπλα από την παραμορφωμένη πλάκα σε έξι παρασκευάσματα και μη παρακείμενο κάταγμα σε ένα, ενώ σε άλλο ένα παρασκεύασμα δεν παρατηρήθηκε νέο κάταγμα.Στους δίσκους με ακέραιες τελικές πλάκες η πίεση του πυρήνα αυξάνεται κατά την κάμψη αποτρέποντας την υπερβολική συγκέντρωση φορτίου στο πρόσθιο τοίχωμα. Ο αυξημένος χώρος που διατίθεται στον πυρήνα μετά από ένα οστεοπορωτικό κάταγμα επηρεάζει την ικανότητά του να κατανέμει το φορτίο και αναγκάζει τον ινώδη δακτύλιο να μεταφέρει περισσότερο φορτίο κατά την κάμψη, με αποτέλεσμα την υπέρμετρη καταπόνηση του πρόσθιου τμήματος του παρακείμενου σπονδύλου που προδιαθέτει σε κάταγμα ακόμη και μετά από διόρθωση της κύφωσης. Η παρούσα μελέτη υποδεικνύει ότι η διόρθωση της παραμόρφωσης της τελικής πλάκας μπορεί να έχει ρόλο στη μείωση του κινδύνου παρακείμενων καταγμάτων.

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Correction: Spectrum of Cerebrovascular Disease in Patients with Multiple Myeloma Undergoing Chemotherapy—Results of a Case Control Study

PLoS ONE ◽

10.1371/journal.pone.0175218 ◽

2017 ◽

Vol 12 (3) ◽

pp. e0175218

Author(s):

Archana Hinduja ◽

Kaustubh Limaye ◽

Rahul Ravilla ◽

Appalanaidu Sasapu ◽

Xenofon Papanikolaou ◽

...

Keyword(s):

Multiple Myeloma ◽

Cerebrovascular Disease ◽

Case Control Study ◽

Case Control ◽

Control Study

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Risk of Multiple Myeloma following Medication Use and Medical Conditions: A Case-Control Study in Connecticut Women

Cancer Epidemiology Biomarkers & Prevention ◽

10.1158/1055-9965.epi-06-0097 ◽

2006 ◽

Vol 15 (12) ◽

pp. 2342-2347 ◽

Cited By ~ 44

Author(s):

Ola Landgren ◽

Yawei Zhang ◽

Sheila Hoar Zahm ◽

Peter Inskip ◽

Tongzhang Zheng ◽

...

Keyword(s):

Multiple Myeloma ◽

Case Control Study ◽

Medication Use ◽

Case Control ◽

Medical Conditions ◽

Control Study

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A Case-Control Study on Risk Factors affected Peripherals Neuropathic complication in Elderly with Type 2 Diabetes Mellitus

Research Journal of Pharmacy and Technology ◽

10.52711/0974-360x.2021.00700 ◽

2021 ◽

pp. 4040-4046

Author(s):

Made Krisna Adi Jaya ◽

Dewa Ayu Swastini ◽

Baiq Leny Nopitasari ◽

Putu Rika Veryanti

Keyword(s):

Diabetes Mellitus ◽

Risk Factors ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Case Control Study ◽

The Elderly ◽

Case Control ◽

Smoking History ◽

Control Study

Background: Diabetic Peripheral Neuropathy (DPN) is a microvascular complication that commonly occurs in people with diabetes mellitus. Geriatrics with type 2 diabetes mellitus is one of the populations most vulnerable to this complication. An epidemiological study states that geriatrics has a 32% greater risk of developing this complication compared to other age groups. There have not been many studies conducted to evaluate the risk factors that influence this DPN complication, so it needs to be done an individual evaluation for the elderly population. Objective: This study aims to explore the risk factors that influence the incidence of DPN in elderly patients with type 2 diabetes mellitus. Methods: A case-control study design was carried out on 70 geriatrics with type 2 diabetes mellitus. The outcome determined was the incidence of DPN to track the cause of DPN exposure retrospectively. Influential risk factors are determined by the Odds Ratio (OR) with a 95% confidence interval (CI). All statistical analyzes were two-tailed, and p-values <0.05 were considered as statistically significant. Results: Seven factors influence the incidence of DPN in the elderly consisting of smoking history (OR=13.1), uncontrolled lipid profile (OR=5.1), non-neuroprotector users (OR=5.6), uncontrolled blood glucose (OR=42.7), history of heart disease (OR=9.0), uncontrolled blood pressure (OR=4.3), and BMI above normal (OR=5.1). Conclusion: Strong recommendation for medical personnel to focus attention on seven significant risk factors affected complications of DPN to reduce its progression or prevent upcoming complications.

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Malnutrition Concerning Geriatric Depression and Associated Risk Factors: A Community-based Case-control Study in Rural Elderly of Bangladesh

10.21203/rs.3.rs-127639/v1 ◽

2020 ◽

Author(s):

Md Ziaul Islam ◽

Tasnim Disu ◽

Shatmin Farjana ◽

Mohammad Rahman

Keyword(s):

Risk Factors ◽

Case Control Study ◽

The Elderly ◽

Case Control ◽

Rural Elderly ◽

Geriatric Depression ◽

Elderly Individuals ◽

Significant Difference ◽

Associated Risk Factors ◽

Control Study

Abstract Background: Malnutrition and depression are highly prevalent in the elderly and can lead to disparaging outcomes. Analytical studies on malnutrition concerning geriatric depression (GD) are very scarce in Bangladesh, although the size of the elderly population is increasing fast in the country. The current study aimed to assess the association between malnutrition and depression and associated risk factors in the rural elderly.Methods: A case-control study was conducted in 600 elderly residents (aged ≥60 years) of three rural communities of Bangladesh from January to October 2019. Three hundred depressed elderly people were enrolled as cases and 300 non-depressed elderly individuals were included as community controls by matching the age and living area of the cases. We used a semi-structured questionnaire based on the Geriatric Depression Scale-15 and the Bangla version of Mini-Nutritional Assessment-Short Form to collect data through face-to-face interviews. Measures included baseline and personal characteristics, malnutrition, GD, and associated risk factors. A binary logistic regression model was fitted to identify variables associated with the risk of GD.Results: The study found no significant difference in gender (male Vs. female) between cases (44.0% Vs. 56.0%) and controls (46.0% Vs. 54.0%). The study revealed that malnutrition was significantly (p<0.01) higher in cases (56.0%) than in controls (18.0%). The malnourished elderly had around three times AOR=3.155; 95% CI: 1.53-6.49, p=0.002) more (risk of having depression than the controls. The unemployed elderly (AOR=4.964; 95% CI: 2.361-10.440; p=0.0001) and the elderly of the lower and middle class (AOR=3.654; 95% CI: 2.266-7.767; p=0.001) were more likely to experience depression. The elderly having a poor diet were more likely to experience depression (AOR=3.384; 95% CI: 1.764-6.703; p=0.0001). The single elderly (AOR=2.368; 95% CI: 1.762-6.524; p=0.001) and the elderly tobacco users (AOR=2.332; 95% CI: 1.663-5.623; p=0.003) were more likely to experience depression.Conclusions: A significant association between malnutrition and depression is evident in the rural elderly individuals of Bangladesh. It will be a prolific initiative if policymakers merge malnutrition and the risk factors associated with geriatric depression in the provision of universal health care for better health and well-being of the rural elderly populations.

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