scholarly journals Deep Belief Network for Predicting the Predisposition to Lung Cancer in TP53 Gene

2020 ◽  
pp. 171-177 ◽  
Author(s):  
Zahraa Naser Shahweli

Lung cancer, similar to other cancer types, results from genetic changes. However, it is considered as more threatening due to the spread of the smoking habit, a major risk factor of the disease. Scientists have been collecting and analyzing the biological data for a long time, in attempts to find methods to predict cancer before it occurs. Analysis of these data requires the use of artificial intelligence algorithms and neural network approaches. In this paper, one of the deep neural networks was used, that is the enhancer Deep Belief Network (DBN), which is constructed from two Restricted Boltzmann Machines (RBM). The visible nodes for the first RBM are 13 nodes and 8 nodes in each hidden layer for the two RBMs. The enhancer DBN was trained by Back Propagation Neural Network (BPNN), where the data sets were divided into 6 folds, each is split into three partitions representing the training, validation, and testing. It is worthy to note that the proposed enhancer DBN predicted lung cancer in an acceptable manner, with an average F-measure value of  0. 96 and an average Matthews Correlation Coefficient (MCC) value of 0. 47 for 6 folds.

2020 ◽  
Vol 23 (8) ◽  
pp. 1562-1572
Author(s):  
Qi Guo ◽  
Lei Feng ◽  
Ruyi Zhang ◽  
Haijun Yin

To solve the problem of poor anti-noise ability faced by traditional pattern recognition methods in damage identification field, a bridge damage identification method based on deep belief network was proposed. Taken the modal curvature difference as the damage index, three restricted Boltzmann machines were constructed for pre-training. Then, the Softmax classifier and neural network were used to identify the damage location and degree under the environmental cases of no noise, weak noise, and strong noise, respectively. Subsequently, the influence of incomplete measurement modal data on the method was studied. Finally, damage identification based on deep belief network was implemented to a continuous beam bridge and compared with that of the back propagation neural network. The results showed that the proposed method could be highly effective not only on damage location but also on degree identification. Compared with back propagation neural network, deep belief network method may possess better identification ability and stronger anti-noise ability. It also demonstrates good identification effect under the condition of incomplete measurement modal data.


Sensors ◽  
2021 ◽  
Vol 21 (24) ◽  
pp. 8498
Author(s):  
Lei Yang ◽  
Chunqing Zhao ◽  
Chao Lu ◽  
Lianzhen Wei ◽  
Jianwei Gong

Accurately predicting driving behavior can help to avoid potential improper maneuvers of human drivers, thus guaranteeing safe driving for intelligent vehicles. In this paper, we propose a novel deep belief network (DBN), called MSR-DBN, by integrating a multi-target sigmoid regression (MSR) layer with DBN to predict the front wheel angle and speed of the ego vehicle. Precisely, the MSR-DBN consists of two sub-networks: one is for the front wheel angle, and the other one is for speed. This MSR-DBN model allows ones to optimize lateral and longitudinal behavior predictions through a systematic testing method. In addition, we consider the historical states of the ego vehicle and surrounding vehicles and the driver’s operations as inputs to predict driving behaviors in a real-world environment. Comparison of the prediction results of MSR-DBN with a general DBN model, back propagation (BP) neural network, support vector regression (SVR), and radical basis function (RBF) neural network, demonstrates that the proposed MSR-DBN outperforms the others in terms of accuracy and robustness.


Author(s):  
Xing Chen ◽  
Tian-Hao Li ◽  
Yan Zhao ◽  
Chun-Chun Wang ◽  
Chi-Chi Zhu

Abstract MicroRNA (miRNA) plays an important role in the occurrence, development, diagnosis and treatment of diseases. More and more researchers begin to pay attention to the relationship between miRNA and disease. Compared with traditional biological experiments, computational method of integrating heterogeneous biological data to predict potential associations can effectively save time and cost. Considering the limitations of the previous computational models, we developed the model of deep-belief network for miRNA-disease association prediction (DBNMDA). We constructed feature vectors to pre-train restricted Boltzmann machines for all miRNA-disease pairs and applied positive samples and the same number of selected negative samples to fine-tune DBN to obtain the final predicted scores. Compared with the previous supervised models that only use pairs with known label for training, DBNMDA innovatively utilizes the information of all miRNA-disease pairs during the pre-training process. This step could reduce the impact of too few known associations on prediction accuracy to some extent. DBNMDA achieves the AUC of 0.9104 based on global leave-one-out cross validation (LOOCV), the AUC of 0.8232 based on local LOOCV and the average AUC of 0.9048 ± 0.0026 based on 5-fold cross validation. These AUCs are better than other previous models. In addition, three different types of case studies for three diseases were implemented to demonstrate the accuracy of DBNMDA. As a result, 84% (breast neoplasms), 100% (lung neoplasms) and 88% (esophageal neoplasms) of the top 50 predicted miRNAs were verified by recent literature. Therefore, we could conclude that DBNMDA is an effective method to predict potential miRNA-disease associations.


2021 ◽  
Vol 12 (4) ◽  
pp. 265
Author(s):  
Dexin Gao ◽  
Yi Wang ◽  
Xiaoyu Zheng ◽  
Qing Yang

If an accident occurs during charging of an electric vehicle (EV), it will cause serious damage to the car, the person and the charging facility. Therefore, this paper proposes a fault warning method for an EV charging process based on an adaptive deep belief network (ADBN). The method uses Nesterov-accelerated adaptive moment estimation (NAdam) to optimize the training process of a deep belief network (DBN), and uses the historical data of EV charging to construct the ADBN of the normal charging process of an EV model. The real-time data of EV charging is obtained and input into the constructed ADBN model to predict the output, calculate the Pearson coefficient between the predicted output and the actual measured value, and judge whether there is a fault according to the size of the Pearson coefficient to realize the fault warning of the EV charging process. The experimental results show that the method is not only able to accurately warn of a fault in the EV charging process, but also has higher warning accuracy compared with the back propagation neural network (BPNN) and conventional DBN methods.


2020 ◽  
Vol 62 (9) ◽  
pp. 3753-3781
Author(s):  
Manomita Chakraborty ◽  
Saroj Kumar Biswas ◽  
Biswajit Purkayastha

Sensors ◽  
2021 ◽  
Vol 21 (4) ◽  
pp. 1318
Author(s):  
Jizhong Huang ◽  
Yepeng Guan

A non-destructive identification method was developed here based on dropout deep belief network in multi-spectral data of ancient ceramic. A fractional differential algorithm was proposed to enhance the spectral details by making use of the difference between the first and second-order differential pre-process spectral data. An unsupervised multi-layer restricted Boltzmann machine (RBM) was employed to extract some high-level features during pre-training. Some weight and bias values trained by RBM were used to initialize a back propagation (BP) neural network. The RBM deep belief network was fine-tuned by the BP neural network to promote the initiative performance of network training, which helped to overcome local optimal limitation of the network due to the random initializing weight parameter. The dropout strategy has been put forward into the RBM network to solve the over-fitting of small sample spectral data. The experimental results show that the proposed method has excellent recognition performance of the ceramics by comparisons with some other ones.


2020 ◽  
Vol 39 (6) ◽  
pp. 8823-8830
Author(s):  
Jiafeng Li ◽  
Hui Hu ◽  
Xiang Li ◽  
Qian Jin ◽  
Tianhao Huang

Under the influence of COVID-19, the economic benefits of shale gas development are greatly affected. With the large-scale development and utilization of shale gas in China, it is increasingly important to assess the economic impact of shale gas development. Therefore, this paper proposes a method for predicting the production of shale gas reservoirs, and uses back propagation (BP) neural network to nonlinearly fit reservoir reconstruction data to obtain shale gas well production forecasting models. Experiments show that compared with the traditional BP neural network, the proposed method can effectively improve the accuracy and stability of the prediction. There is a nonlinear correlation between reservoir reconstruction data and gas well production, which does not apply to traditional linear prediction methods


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