scholarly journals Correlation of Pentosidine with Kidney Diseases in Iraqi Patients with Diabetic Nephropathy

2021 ◽  
pp. 3436-3442
Author(s):  
Ghada Salam Hamid ◽  
Ali A. Allawi ◽  
Kadhim K. Ghudhaib
Keyword(s):  
Diabetic Nephropathy ◽  
Kidney Diseases ◽  
Kidney Injury ◽  
Strong Positive Correlation ◽  
Creatinine Ratio ◽  
Albumin Creatinine Ratio ◽  
Elisa Kit ◽  
End Stage ◽  
Apparently Healthy

Diabetic nephropathy (DN) is a principle cause of microangiopathy and the main reason for kidney disease at the end stage in patients with type 2 diabetes mellitus (T2DM). This work aimed to study the relation of pentosidine with kidney injury in the case of diabetic nephropathy. This study included 75 patients suffering from T2DM and 75 apparently healthy subjects. The patients group was divided into three groups ((normoalbumin, microalbuminuria, and macroalbuminuria; 25 patients for each) on the basis of albumin-creatinine ratio (ACR) . The level of serum pentosidine was determined using an ELISA kit. The level of pentosidine was found to be significantly higher in DN patients than in the healthy group. Also, the results revealed a strong positive correlation of pentosidine with each of creatinine and blood urea levels, while a negative correlation was recorded with eGFR. It can be concluded that pentosidine may be associated with disease progression and it may be employed as one of the most efficient markers for the prediction of renal function.

scholarly journals Effect of Glycosylated Hemoglobin with Microalbuminuria and Albumin Creatinine Ratio in Type 2 Diabetes

2021 ◽  
Vol 15 (7) ◽  
pp. 1974-1977
Author(s):  
Vitasari Indriani ◽  
Wahyu Siswandari ◽  
Andreas . ◽  
Tri Lestari
Keyword(s):  
Type 2 Diabetes ◽  
Diabetic Nephropathy ◽  
Glycated Hemoglobin ◽  
Glycosylated Hemoglobin ◽  
Glycated Albumin ◽  
Diabetes Duration ◽  
Creatinine Ratio ◽  
Albumin Creatinine Ratio ◽  
Detailed Medical History

Background: Diabetes mellitus has strong correlation with end stage renal disease (ESRD) and responsible for 30-40% of all ESRD cases.This study is focused on assessing the diabetic nephropathy status in patients with type 2 diabetes. Glycated hemoglobin levels over therapeutic targets (>7%) had two times the risk of complications for diabetic nephropathy, ISN recommends the use of microalbuminuria and urinary albumin creatinine ratio (UACR) for early detection of diabetic nephropathy and for monitoring therapy. Objective: This study was conducted to prove the correlation between Glycated Albumin with microalbuminuria and UACR in type 2 diabetes. Methods: Cross sectional study was done in70diabetic type 2 patients who attended PROLANIS program in Primary Health Care from May to November 2018.Detailed medical history including the diabetes duration and relevant clinical examination like FBS, PPBS, HbA1c, urinary creatinineand urinary microalbumin were recorded in each patient.Significance is assessed at 5% level of significance. Results: This study obtained the mean age of the study population was 51.89 ± 6.78 years with female preponderance (51.1%).Mean FBS, PPBS, HbA1c, duration of diabetes, blood pressure, microalbuminuria and urinary creatinine were182.51 ± 74.63 mg/dL, 186.25±26.72 mg/dL, 8.8 ± 1.83%, 9.37±5.96 years, 138.44±14, 13/84.44±19.25 mmHg,30.32±3.2 mg/day and 1.33±0.64 mg/dl respectively.Microalbuminuria (r=0.91, p≤0.05) and UACR (r=0.67, p≤0.05) were positively associated with glycated hemoglobin. Conclusion: It can be concluded that microalbuminuria level and ACR increase in line with the worsening of glycosylated hemoglobin and diabetes duration. Keywords: Albumin Creatinine Ratio; Diabetes; HbA1c; Microalbuminuria

scholarly journals The study of dyslipidemia and its correlation with nephropathy in diabetes mellitus type 2 patients

2017 ◽  
Vol 4 (5) ◽  
pp. 1231
Author(s):  
Rakesh K. Sisodia ◽  
Archana Gupta ◽  
Neelima Singh
Keyword(s):  
Diabetic Nephropathy ◽  
P Value ◽  
Diabetic Patients ◽  
Creatinine Ratio ◽  
Type 2 Diabetic Patients ◽  
Albumin Creatinine Ratio ◽  
Urine Albumin ◽  
Lipid Abnormalities ◽  
Type 2 Diabetic

Background: Diabetic nephropathy is one of the most severe diabetic microangiopathies. The aim of this study was to evaluate the lipid abnormalities associated with different stages of proteinuria in type 2 diabetic patients.Methods: In this study 100 type 2 diabetic patients were subjected to detailed history, clinical examination, Serum lipid profile, urine albumin creatinine ratio and routine biochemical investigations.Results: Out of 100 patients were included in study, 41 patients were normoabluminuric, 37 patients were microalbuminuric and 22 patients were overt proteinuric. Most common dyslipidemia found in study is increased triglyceride (43%) followed by increased LDL (28). On comparing normoalbuminuric to overt proteinuric, a positive correlation found in increased triglyceride (P value < 0.001) and increases LDL (P value <0.001).Conclusions: Concluded that raised Triglyceride and LDL are associated with Diabetic Nephropathy.

scholarly journals The Pattern of Plasma Gas-6 elevation among Type II Diabetes Mellitus Patients in Relation to Microalbuminuria using Urinary Albumin Creatinine Ratio

2020 ◽  
pp. 332-339
Author(s):  
AE Emedoh ◽  
Chukwudi Okani ◽  
FM Abbiyesuku
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Diabetic Nephropathy ◽  
Experimental Studies ◽  
Urinary Albumin ◽  
Creatinine Ratio ◽  
College Hospital ◽  
Albumin Creatinine Ratio

Due to the global increase in diabetes, diabetic nephropathy is becoming a significant issue. Diagnosis and treatment in the early stages of nephropathy may avert this considerable complication, and new biomarkers other than microalbuminuria are required to detect diabetic nephropathy earlier in type 2 diabetes mellitus. Moreover, the pathogenesis of complications associated with diabetes as indicated in recent experimental studies showed that growth arrest-specific-6 protein (Gas-6) might have a role. We therefore, embarked on this study to determine the pattern of plasma Gas-6 elevation among type 2 diabetes mellitus patients and to describe any relationship with microalbuminuria using urinary albumin creatinine ratio. This research was a descriptive; a hospital-based cross-sectional study conducted at the Endocrinology Clinic, University College Hospital, Ibadan, Oyo State, Nigeria. We recruited 71 type-2 diabetic participants, and 71 apparently-healthy participants who served as the control. The study showed that the concentrations of Gas-6 protein and UACR in the diabetic participants were all significantly higher than in the healthy control participants (p ˂ 0.001). There was also a positive correlation between Gas-6 protein and UACR value which was statistically significant (rho = 0.41, p = ˂0.001). The sensitivity and specificity of Gas-6 was 75.0% and 19.1% respectively, with a PPV and NPV of 0.68 and 0.25 respectively. In conclusion, Plasma Gas-6protein correlated with microalbuminuria. However, Gas-6 protein alone may be of limited diagnostic value in diabetic nephropathy.

scholarly journals Association between obesity and urinary albumin-creatinine ratio in the middle-aged and elderly population of Southern and Northern China: a cross-sectional study

BMJ Open ◽  
2021 ◽  
Vol 11 (1) ◽  
pp. e040214
Author(s):  
Shan Qin ◽  
Anping Wang ◽  
Shi Gu ◽  
Weiqing Wang ◽  
Zhengnan Gao ◽  
...  
Keyword(s):  
Kidney Diseases ◽  
Northern China ◽  
Cross Sectional Study ◽  
Urinary Albumin ◽  
Creatinine Ratio ◽  
Sectional Study ◽  
The South ◽  
Northern Population ◽  
Cross Sectional ◽  
Albumin Creatinine Ratio

ObjectiveThe relationship between obesity and albuminuria has not been clarified. This study aimed to investigate the correlation between obesity and the urinary albumin-creatinine ratio (UACR) in Southern and Northern China.DesignA descriptive, cross-sectional study.SettingEight regional centres in REACTION (China’s Risk Evaluation of cAncers in Chinese diabeTic Individuals, a lONgitudinal study), including Dalian, Lanzhou, Zhengzhou, Guangzhou, Guangxi, Luzhou, Shanghai and Wuhan.ParticipantsA total of 41 085 patients who were not diagnosed with chronic kidney disease (CKD) and had good compliance were selected according to the inclusion criteria. Patients who were diagnosed with CKD, who had other kidney diseases that could lead to increased urinary protein excretion, who were using angiotensin-converting-enzyme inhibitors or angiotensin II receptor blockers and whose important data were missing were excluded.ResultsParticipants with both, central and peripheral obesity, had a higher risk of elevated UACR, even after adjusting for multiple factors (OR: 1.14, 95% CI: 1.07 to 1.12, p<0.001), and the risk of high UACR in the South was more prominent than that in the North (OR South: 1.22, 95% CI: 1.11 to 1.34; OR North: 1.13, 95% CI: 1.04 to 1.22, p<0.001). The risk was also elevated in the male population, hypertensive individuals, glycosylated haemoglobin (HbA1c)≥6.5% and age ≥60 years in the South. Besides the above groups, diabetes was also a risk factor for the Northern population.ConclusionsIn China, people with both central and peripheral obesity are prone to a high UACR, and the southern population has a higher risk than northern population. Factors such as male sex, hypertension, HbA1c≥6.5% and an age ≥60 years are also risk factors for CKD.

scholarly journals Identification of Novel Biomarker for Early Detection of Diabetic Nephropathy

Biomedicines ◽  
2021 ◽  
Vol 9 (5) ◽  
pp. 457
Author(s):  
Kyeong-Seok Kim ◽  
Jin-Sol Lee ◽  
Jae-Hyeon Park ◽  
Eun-Young Lee ◽  
Jong-Seok Moon ◽  
...  
Keyword(s):  
Diabetic Nephropathy ◽  
Early Stage ◽  
Kidney Injury ◽  
Diabetic Patients ◽  
High Morbidity ◽  
Neutrophil Gelatinase Associated Lipocalin ◽  
Zucker Diabetic Fatty Rats ◽  
Kidney Injury Molecule 1 ◽  
Stage Renal Disease ◽  
End Stage

Diabetic nephropathy (DN) is one of the most common complications of diabetes mellitus. After development of DN, patients will progress to end-stage renal disease, which is associated with high morbidity and mortality. Here, we developed early-stage diagnostic biomarkers to detect DN as a strategy for DN intervention. For the DN model, Zucker diabetic fatty rats were used for DN phenotyping. The results revealed that DN rats showed significantly increased blood glucose, blood urea nitrogen (BUN), and serum creatinine levels, accompanied by severe kidney injury, fibrosis and microstructural changes. In addition, DN rats showed significantly increased urinary excretion of kidney injury molecule-1 (KIM-1) and neutrophil gelatinase-associated lipocalin (NGAL). Transcriptome analysis revealed that new DN biomarkers, such as complementary component 4b (C4b), complementary factor D (CFD), C-X-C motif chemokine receptor 6 (CXCR6), and leukemia inhibitory factor (LIF) were identified. Furthermore, they were found in the urine of patients with DN. Since these biomarkers were detected in the urine and kidney of DN rats and urine of diabetic patients, the selected markers could be used as early diagnosis biomarkers for chronic diabetic nephropathy.

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