scholarly journals Detection of Chlamydia Pneumoniae in Lung Tissues Derived from Lung Tumor-Bearing Iraqi Patients

2021 ◽  
pp. 3851-3857
Author(s):  
Zainab M. Lateef ◽  
Alice K. Melconian ◽  
Ehab D. Salman
Keyword(s):  
Chlamydia Pneumoniae ◽  
Lung Tumor ◽  
Lung Tumors ◽  
Rrna Gene ◽  
Upper Respiratory Tract ◽  
Past Infection ◽  
High Prevalence ◽  
Upper Respiratory ◽  
Polymerase Chain ◽  
Tract Infections

Chlamydia pneumoniae is an intracellular gram-negative bacteria associated with lower and upper respiratory tract infections. Several studies, mostly achieved by serological assays, proposed a role for this bacteria in lung cancer risk. Therefore, this study aimed to evaluate the prevalence of Chlamydia pneuomoniae in fresh lung tissues of a sample of Iraqi patients with lung tumors, utilizing polymerase chain reaction (PCR) technique. . Chlamydia pneumoniae DNA was detected in 86.67% of samples. Besides, DNA sequencing of 16S rRNA gene revealed that our isolate is closely related to Chlamydia pneumoniae TW183 strain. It is concluded that Chlamydia pneumoniae  is found in fresh lung tissues of patients, suggesting past infection, reinfection, or persistent form, which may play a role in the development or exacerbation of lung tumors. Our results confirm the high prevalence of this type of bacteria in Iraqi patients.

Treatment of upper respiratory tract infections: the role of doxycycline

2021 ◽  
pp. 29-36
Author(s):  
A. P. Pereverzev ◽  
A. S. Pereverzeva ◽  
G. P. Kovaleva ◽  
O. D. Ostroumova
Keyword(s):  
Respiratory Tract ◽  
Respiratory Tract Infections ◽  
Chlamydia Pneumoniae ◽  
Upper Respiratory Tract Infections ◽  
Temporal Region ◽  
Upper Respiratory Tract ◽  
Nasal Breathing ◽  
Diagnostic Center ◽  
Upper Respiratory ◽  
Tract Infections

Upper respiratory tract infections (URTI) are a large group of infectious diseases (mainly viral and bacterial), affecting the mucous of the nasal cavity, paranasal sinuses, pharynx and larynx. URTI are very common in inpatient and outpatient clinical practice. In this article, we present a clinical case of Patient N., 20 years old, consulted with upper respiratory tract damage caused by Chlamydia pneumoniae. The patient admitted to clinical diagnostic center on 07.07.2021 with complaints of pain in the left maxillary sinus with irradiation to the left temporal region, difficulty in nasal breathing, pain in the pharynx, aggravated by swallowing, and increased body temperature (37,5 °C). The patient was consulted by an interdisciplinary team (ENT doctor and clinical pharmacologist). After carrying out physical, instrumental and laboratory tests the diagnose Chlamydia pneumoniae - associated URTI was established and, the patient was prescribed doxycycline at a dose of 100 mg 2 two times a day on the 1st day following by 100 once a day for the next 6 days with a positive effect. The doxycycline was choisen because of a more favorable safety and efficacy profile compared to fluoroquinolones and some other antibacterial agents. After 7 days of treatment, the patient recovered completely. Among all doxycycline drugs available on the market of the Russian Federation, Doxycycline Express (JSC Pharmstandard-Leksredstva) stands out due to its high quality, bioequivalence to the original drug and comfortable regime of use due to the dosage form (dispersible tablets), that increases the patient’s compliance and allows it to be used by some special categories of patients (elderly and senile patients, patients with dysphagia, etc.

scholarly journals Epidemiology of Haemophilus parasuis isolates from pigs in China using serotyping, antimicrobial susceptibility, biofilm formation and ERIC-PCR genotyping

PeerJ ◽  
2018 ◽  
Vol 6 ◽  
pp. e5040 ◽  
Author(s):  
Yongda Zhao ◽  
Qin Wang ◽  
Jie Li ◽  
Xiaohuan Lin ◽  
Xianhui Huang ◽  
...  
Keyword(s):  
Antimicrobial Susceptibility ◽  
Biofilm Formation ◽  
High Morbidity ◽  
Haemophilus Parasuis ◽  
Upper Respiratory Tract ◽  
High Prevalence ◽  
Upper Respiratory ◽  
Polymerase Chain ◽  
High Degree ◽  
Lineage Diversity

Background Haemophilus parasuis is a commensal organism of the upper respiratory tract of healthy pigs and causes high morbidity and mortality in piglets. The aim of this study was to investigate the epidemiology of H. parasuis in China from 2014 to 2017. Methods We characterized 143 H. parasuis isolates by serotyping, antimicrobial susceptibility, biofilm formation and with enterobacterial repetitive intergenic consensus-polymerase chain reaction (ERIC-PCR) assays. Results Serotyping revealed serovar 5 as the most prevalent (26.6%) followed by serovars 4 (22.4%), 7 (9.1 %), 13 (6.3%), 12 (5.6 %), and non-typeable (8.4%). In a panel of 23 antimicrobials, the minimum inhibitory concentration 50% (MIC50) were in the range of 0.25–16 μg/mL and MIC90 were 2–>512 μg/mL. A total of 99 isolates of H. parasuis (69.2%) were able to form biofilms and 59.6% (59/99) performed weak biofilm-forming ability. ERIC-PCR revealed a very heterogeneous pattern with 87 clusters. Discussion These H. parasuis isolates showed a high serovar and genotypic lineage diversity, different abilities to form biofilms and a high degree of genetic diversity. Biofilm formation was related to antimicrobial susceptibility but there were no statistically significant associations between the antimicrobial susceptibility and either the serovars or the ERIC-PCR clusters. This study showed a high prevalence of high-MIC H. parasuis strains and suggests the need for a continuous surveillance of clinical isolates of H. parasuis.

scholarly journals Upper Respiratory Tract Diseases in Athletes in Different Sports Disciplines

2016 ◽  
Vol 53 (1) ◽  
pp. 99-106 ◽  
Author(s):  
Anna Gałązka-Franta ◽  
Edyta Jura-Szołtys ◽  
Wojciech Smółka ◽  
Radosław Gawlik
Keyword(s):  
Respiratory Tract ◽  
Allergic Diseases ◽  
Medical Problem ◽  
Diagnostic Methods ◽  
Respiratory Tract Diseases ◽  
Upper Respiratory Tract ◽  
High Prevalence ◽  
Upper Respiratory ◽  
Tract Disease ◽  
Tract Infections

AbstractUpper respiratory tract diseases in athletes are a very common medical problem. Training conditions in different sports disciplines increase the risk of upper respiratory disease. Epidemiological evidence suggests that heavy acute or chronic exercise is related to an increased incidence of upper respiratory tract infections in athletes. Regular physical exercise at high intensity may lead to transient immunosuppression due to high prevalence of allergic diseases in athletes. Regardless of the cause they can exclude athletes from the training program and significantly impair their performance. In the present work, the most common upper respiratory tract diseases in athletes taking into account the disciplines in which they most often occur were presented. The focus was laid on symptoms, diagnostic methods and pharmacotherapy. Moreover, preventive procedures which can help reduce the occurrence of upper respiratory tract disease in athletes were presented. Management according to anti-doping rules, criteria for return to training and competition as an important issues of athlete’s health were discussed.

scholarly journals Outbreak of pertussis among healthcare workers in a hospital maternity unit

2017 ◽  
Vol 18 (5) ◽  
pp. 253-255
Author(s):  
Christina Petridou ◽  
Hazel Gray ◽  
Michael Heard ◽  
Lorna Sugden ◽  
Karen Davis-Blues ◽  
...  
Keyword(s):  
Respiratory Tract Infections ◽  
District General Hospital ◽  
Control Measures ◽  
Maternity Unit ◽  
Upper Respiratory Tract ◽  
Infection Control Measures ◽  
High Prevalence ◽  
Upper Respiratory ◽  
Tract Infections ◽  
Learning Points

In December 2015, an outbreak of pertussis was detected among staff working in the Maternity Unit of a district general hospital in Hampshire. This occurred in the background of increased pertussis activity in the community. The outbreak occurred over the Christmas holiday period causing staff shortages at a time when the departments were already overstretched. The high prevalence of upper respiratory tract infections at the time were difficult to distinguish from pertussis. This paper describes the outbreak, infection control measures implemented and the learning points.

scholarly journals Influenza A H1N1pdm 2009 Virus in Paraguay: Nucleotide Point Mutations in Hemagglutinin and Neuraminidase Genes are not Associated with Drug Resistance

2014 ◽  
Vol 8 (1) ◽  
pp. 9-13 ◽  
Author(s):  
Emilio E Espínola ◽  
Alberto A Amarilla ◽  
Magaly Martínez ◽  
Víctor H Aquino ◽  
Graciela Russomando
Keyword(s):  
Influenza A ◽  
Influenza Pandemic ◽  
Point Mutations ◽  
Virus Detection ◽  
Upper Respiratory Tract ◽  
Nasal Swabs ◽  
2009 H1n1 ◽  
Upper Respiratory ◽  
Polymerase Chain ◽  
Tract Infections

Influenza virus is associated with upper respiratory tract infections. The fourth influenza pandemic was declared in 2009. The aim of this study was to determine the genetic variability of the 2009 H1N1 pandemic virus circulating in Paraguay. Nasal swabs were collected from 181 patients with flu symptoms managed at the Hospital of the Medical School in Asunción, Paraguay, between August and October 2009. Virus detection was carried out by real-time reverse transcription-polymerase chain reaction, followed by sequencing of the hemagglutinin and neuraminidase genes, and phylogenetic analysis. H1N1pdm09 was detected in 14.9% (27/181) of the suspected cases. Analysis of 13 samples showed that these viruses the clustered in a single genetic group. Neither the mutation related to exacerbation of disease (D239G in hemagglutinin) nor that related to antiviral resistance (H275Y in neuraminidase), both detected in neighboring countries, were found. This genetic analysis of H1N1pdm09 will help to understand the spread of the disease.

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