The role of zinc, copper, plasma glutathione peroxidase enzyme, and vitamins in the development of allergic diseases in early childhood: The Polish mother and child cohort study

Abstract. Myxoedematous endemic cretinism is prevalent in African goitre endemies. It has been related to a thyroid 'exhaustion' atrophy occurring near birth. It is proposed that this might result from the low resistance of a fragile tissue to enhanced H2O2 generation under intense thyroid stimulation by thyrotropin. In support of this hypothesis, low selenium and glutathione peroxidase serum levels have been found in the African endemic area of the Idjwi Island (Kivu, Zaire). Serum selenium and plasma glutathione peroxidase were lower in the area of high endemicity of goitre and cretinism (Northern part of the Island). However, only the former difference is statistically significant. These data thus suggest a role of oligoelements and oxygen toxicity in the pathogenesis of endemic cretinism.

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The Plasma Glutathione Peroxidase Enzyme in Hemodialyzed Subjects

ASAIO Journal ◽

10.1097/00002480-199440040-00011 ◽

1994 ◽

Vol 40 (4) ◽

pp. 968-971 ◽

Cited By ~ 6

Author(s):

Renzo Schiavon ◽

Stefano Biasioli ◽

Emanuela De Fanti ◽

Luigi Petrosino ◽

Lucia Cavallini ◽

...

Keyword(s):

Glutathione Peroxidase ◽

Plasma Glutathione Peroxidase ◽

Peroxidase Enzyme ◽

Plasma Glutathione

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Sulforaphane Attenuates Gentamicin-Induced Nephrotoxicity: Role of Mitochondrial Protection

Evidence-based Complementary and Alternative Medicine ◽

10.1155/2013/135314 ◽

2013 ◽

Vol 2013 ◽

pp. 1-17 ◽

Cited By ~ 21

Author(s):

Mario Negrette-Guzmán ◽

Sara Huerta-Yepez ◽

Omar Noel Medina-Campos ◽

Zyanya Lucía Zatarain-Barrón ◽

Rogelio Hernández-Pando ◽

...

Keyword(s):

Glutathione Peroxidase ◽

Protective Effect ◽

Nitrosative Stress ◽

Kidney Injury ◽

Caspase 9 ◽

Plasma Glutathione Peroxidase ◽

Plasma Glutathione ◽

Cytoprotective Enzymes ◽

Death And Loss

Sulforaphane (SFN), an isothiocyanate naturally occurring in Cruciferae, induces cytoprotection in several tissues. Its protective effect has been associated with its ability to induce cytoprotective enzymes through an Nrf2-dependent pathway. Gentamicin (GM) is a widely used antibiotic; nephrotoxicity is the main side effect of this compound. In this study, it was investigated if SFN is able to induce protection against GM-induced nephropathy both in renal epithelial LLC-PK1 cells in culture and in rats. SFN prevented GM-induced death and loss of mitochondrial membrane potential in LLC-PK1 cells. In addition, it attenuated GM-induced renal injury (proteinuria, increases in serum creatinine, in blood urea nitrogen, and in urinary excretion on N-acetyl-β-D-glucosaminidase, and decrease in creatinine clearance and in plasma glutathione peroxidase activity) and necrosis and apoptosis in rats. The apoptotic death was associated with enhanced active caspase-9. Caspase-8 was unchanged in all the studied groups. In addition, SFN was able to prevent GM-induced protein nitration and decrease in the activity of antioxidant enzymes catalase and glutathione peroxidase in renal cortex. In conclusion, the protective effect of SFN against GM-induced acute kidney injury could be associated with the preservation in mitochondrial function that would prevent the intrinsic apoptosis and nitrosative stress.

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