scholarly journals Melicope moluccana Antimalarial Activity of Furoquinoline Alkaloids from the Leaves of Melicope moluccana

2020 ◽  
Vol 5 (2) ◽  
pp. 138-142
Author(s):  
Ryan Ayub Wahjoedi ◽  
Ratih Dewi Saputri ◽  
Tjitjik Srie Tjahjandarie ◽  
Mulyadi Tandjung
Keyword(s):  
Plasmodium Falciparum ◽  
Spectral Data ◽  
Spectroscopic Data ◽  
Chemical Structure ◽  
Antimalarial Activity ◽  
2D Nmr ◽  
Esi Ms ◽  
Ic50 Values

Two furoquinoline alkaloids, leptanoine C (1) and haplopine-3,3´-dimethylallyl ether (2) were isolated from the leaves of Melicope moluccana. The chemical structure of both compounds was determined based on spectroscopic data, including UV, IR, HR-ESI-MS, 1D, and 2D NMR spectral data. The antimalarial activity of compounds 1-2 against Plasmodium falciparum 3D7 showing their IC50 values are 0.18 ppm and 2.28 µg/mL, respectively.

Antiplasmodial Bis-Indole Alkaloids from the Bark of Flindersia pimenteliana

Planta Medica ◽  
2019 ◽  
Vol 86 (01) ◽  
pp. 19-25 ◽  
Author(s):  
Luke P. Robertson ◽  
Leonardo Lucantoni ◽  
Vicky M. Avery ◽  
Anthony R. Carroll
Keyword(s):  
Plasmodium Falciparum ◽  
Spectroscopic Data ◽  
Indole Alkaloids ◽  
2D Nmr ◽  
Antiplasmodial Activity ◽  
Structure Activity Relationships ◽  
Structure Activity ◽  
Ic50 Values ◽  
Significant Attention

AbstractThree new (1–3) and 2 known (4–5) bis-indole alkaloids were identified from the bark of Flindersia pimenteliana (Rutaceae). The structures of 1–3 were elucidated on the basis of their (+)-HRESESIMS and 2D NMR spectroscopic data. Antiplasmodial activity for 1–3 against chloroquine sensitive (3D7) and chloroquine-resistant (Dd2) Plasmodium falciparum is also reported, with IC50 values ranging from 0.96 to 2.41 µg/mL. These results expand our knowledge of the structure-activity relationships of potently antiplasmodial isoborreverine-type alkaloids, the bioactivity of which have recently attracted significant attention in the literature.

scholarly journals SENYAWA STIGMASTEROL (STEROID) DARI KULIT BATANG Chisocheton celebicus koord (MELIACEAE)

2021 ◽  
Vol 14 (1) ◽  
Author(s):  
Dewa Gede Katja
Keyword(s):  
Spectral Data ◽  
Spectroscopic Data ◽  
Chemical Structure ◽  
2D Nmr ◽  
Isolated Compound ◽  
First Time

ABSRTAKStigmasterol (suatu steroid) dengan rumus molekul C29H48O  telah doiisolasi dari kulit batang chisocheton celebicus (Meliacea) menggunakan pelarut n-heksan, kemudian dipisahkan dengan teknik kromatografi dan dihasilkan isolat murni berupa kristal jarum tak berwarna(10,2 mg) dengan titik leleh 169-1710C. Struktur kimia stigmasterol diidentifikasi berdasarkan data-data spektroskopi meliputi IR, NMR-1D, NMR-2D dan masa,serta perbandingan dengan data spektroskopi yang diperoleh dari literatur. Penemuan senyawa stigmasterol dari kulit batang Chisocheton celebicus dilaporkan untuk pertama kalinya dalam penelitian ini.. ABSTRACTStigmasterol C29H48O has been isolated from the bark of Chisocheton celebicus (Meliacee) in n-hexan and separated using several chromatography and it has been pure isolated the crystal calorness compound (10,2 mg). The chemical structure of isolated compound was identified on the basis of spectroscopic data including IR, 1D-NMR, 2D-NMR and mass along with comparison with those spectral data previously reported. The discovery of stigmasterol compound from the bark C. celebicus reported for the first time in this study.

scholarly journals Dammarane-Type Triterpenoids from The Stembark of Aglaia argentea (Meliaceae)

2018 ◽  
Vol 4 (1) ◽  
pp. 7-13
Author(s):  
Ace Tatang Hidayat ◽  
Kindi Farabi ◽  
Ida Nur Farida ◽  
Kansy Haikal ◽  
Nurlelasari Nurlelasari ◽  
...  
Keyword(s):  
Cytotoxic Activity ◽  
Spectral Data ◽  
Chemical Structure ◽  
2D Nmr ◽  
Leukemia Cells ◽  
Ic50 Values ◽  
First Time ◽  
Murine Leukemia

Two dammarane-type triterpenoids, 20S,24S-epoxy-3α,25-dihydroxydammarane (1) and 3α-acetyl-20S,24S-epoxy-3α,25-dihydroxydammarane (2), have been isolated from the stembark of Aglaia argentea. The chemical structure of compounds (1 and 2) were identified by spectroscopic evidences including UV, IR, 1D-NMR, 2D-NMR and MS as well as by comparing with previously reported spectral data. Those compounds were isolated from this plant for first time. Compounds (1 and 2) showed cytotoxic activity against P-388 murine leukemia cells with IC50 values of 23.96 and 8.14 mM, respectively.DOI:http://dx.doi.org/10.15408/jkv.v4i1.7065

scholarly journals ANTIMALARIAL COMPOUNDS FROM ENDOPHYTIC FUNGI OF BROTOWALI (Tinaspora crispa L)

2011 ◽  
Vol 11 (1) ◽  
pp. 53-58 ◽  
Author(s):  
Elfita Elfita ◽  
Muharni Muharni ◽  
Munawar Munawar ◽  
Leni Legasari ◽  
Darwati Darwati
Keyword(s):  
Plasmodium Falciparum ◽  
Endophytic Fungi ◽  
Spectroscopic Data ◽  
Plant Pathogens ◽  
Antimalarial Activity ◽  
Molecular Structures ◽  
Bioactive Metabolites ◽  
Symbiotic Association ◽  
Ic50 Values ◽  
Pathogenic Effects

The term endophytic refers to a bacteria or a fungi microorganism that colonizes interior organs of plants, but does not have pathogenic effects on its host. In their symbiotic association, the host plant protects and feeds the endophytic, which ";in return"; produces bioactive metabolites to enhance the growth and compotitiveness of the host and to protect it from herbivores and plant pathogens. Plants with ethnobotanical history, for example brotowali (Tinaspora crispa L), are likely candidates to find bioactive compounds. Two alkaloids have been isolated from endophytic fungi of brotowali. The molecular structures of the isolated compounds were determined based on spectroscopic data, including UV, IR, NMR 1D and 2D spectrum. The compounds were determined as: 7- hydroxy-3,4,5-trimethyl-6-on-2,3,4,6-tetrahydroisoquinoline-8-carboxylic acid (1) and 2,5-dihydroxy-1-(hydroxymethyl)pyridin-4-on (2). The compound has antimalarial activity against Plasmodium falciparum 3D7, with IC50 values 0,129 µM and 0,127 µM.

Isolation of New Glycosides from Anemarrhena Asphodeloides Rhizome and Screening of their Anticancer Activity

2019 ◽  
Vol 16 (6) ◽  
pp. 474-477 ◽  
Author(s):  
Pham Van Khang ◽  
Nguyen Thi Hien Lan ◽  
Le Quang Truong ◽  
Mai Thi Minh Chau ◽  
Mai Xuan Truong ◽  
...  
Keyword(s):  
Anticancer Activity ◽  
Spectral Data ◽  
Cell Lines ◽  
Cancer Cell ◽  
Spectroscopic Analysis ◽  
2D Nmr ◽  
Ic50 Values ◽  
Nmr Techniques ◽  
Inhibitory Activities ◽  
Anemarrhena Asphodeloides

In this report, two new steroidal glycosides were isolated and determined from n-butanol fraction of A.asphodeloides. The structures were confirmed in comparison with the spectral data of known compounds by using different spectroscopic analysis approaches including 1D & 2D-NMR techniques and HRMS. The anti-proliferation screening against cancer cell lines A549 and HeLa indicated that compound 1 exhibited good inhibitory activities with IC50 values of 0.79 and 0.55 µg/mL, respectively.

scholarly journals New Antimalarial and Antimicrobial Tryptamine Derivatives from the Marine Sponge Fascaplysinopsis reticulata

Marine Drugs ◽  
2019 ◽  
Vol 17 (3) ◽  
pp. 167 ◽  
Author(s):  
Pierre-Eric Campos ◽  
Emmanuel Pichon ◽  
Céline Moriou ◽  
Patricia Clerc ◽  
Rozenn Trépos ◽  
...  
Keyword(s):  
Plasmodium Falciparum ◽  
Minimum Inhibitory Concentration ◽  
Marine Sponge ◽  
Nmr Spectra ◽  
Inhibitory Concentration ◽  
Chemical Study ◽  
2D Nmr ◽  
Antimicrobial Activities ◽  
2D Nmr Spectra ◽  
Ic50 Values

Chemical study of the CH2Cl2-MeOH (1:1) extract of the sponge Fascaplysinopsis reticulata collected in Mayotte highlighted three new tryptophan derived alkaloids, 6,6′-bis-(debromo)-gelliusine F (1), 6-bromo-8,1′-dihydro-isoplysin A (2) and 5,6-dibromo-8,1′-dihydro-isoplysin A (3), along with the synthetically known 8-oxo-tryptamine (4) and the three known molecules from the same family, tryptamine (5), (E)-6-bromo-2′-demethyl-3′-N-methylaplysinopsin (6) and (Z)-6-bromo-2′-demethyl-3′-N-methylaplysinopsin (7). Their structures were elucidated by 1D and 2D NMR spectra and HRESIMS data. All compounds were evaluated for their antimicrobial and their antiplasmodial activities. Regarding antimicrobial activities, the best compounds are (2) and (3), with minimum inhibitory concentration (MIC) of 0.01 and 1 µg/mL, respectively, towards Vibrio natrigens, and (5), with MIC values of 1 µg/mL towards Vibrio carchariae. In addition the known 8-oxo-tryptamine (4) and the mixture of the (E)-6-bromo-2′-demethyl-3′-N-methylaplysinopsin (6) and (Z)-6-bromo-2′-demethyl-3′-N-methylaplysinopsin (7) showed moderate antiplasmodial activity against Plasmodium falciparum with IC50 values of 8.8 and 8.0 µg/mL, respectively.

scholarly journals New Antiplasmodial Diterpenes from Gutierrezia Sarothrae

2016 ◽  
Vol 11 (6) ◽  
pp. 1934578X1601100
Author(s):  
Qingxi Su ◽  
Seema Dalal ◽  
Michael Goetz ◽  
Maria B. Cassera ◽  
David G. L Kingston
Keyword(s):  
Mass Spectrometry ◽  
Plasmodium Falciparum ◽  
Spectroscopic Data ◽  
2D Nmr ◽  
Antiplasmodial Activity ◽  
Drug Resistant ◽  
Meoh Extract ◽  
Bioassay Guided Fractionation ◽  
Gutierrezia Sarothrae ◽  
Related Compounds

Bioassay guided fractionation of the MeOH extract of the plant Gutierrezia sarothrae (Asteraceae) using an assay for antiplasmodial activity against the drug-resistant Dd2 strain of Plasmodium falciparum led to the isolation of the two new diterpenes 3α-angeloyloxy-15-hydroxylabda-7,13-dien-16,15-olid-18-oic acid (1) and 3α-angeloyloxy-15-methoxylabda-7,13-dien-16,15-olid-18-oic acid (2). The structures of 1 and 2 were elucidated by interpretation of ID and 2D NMR spectroscopic data, mass spectrometry, and comparison with the data of related compounds reported in the literature. Compound 1 exhibited moderate antiplasmodial activity with an IC50 values of 10.4 ± 4.3 μM.

A New Flavanone from Spatholobus Suberectus Dunn

2018 ◽  
Vol 42 (10) ◽  
pp. 529-530 ◽  
Author(s):  
Ruo-Xi Liu ◽  
Yi-Lian Xu ◽  
Lie-Feng Ma ◽  
You-Min Ying ◽  
Zha-Jun Zhan
Keyword(s):  
Spectroscopic Data ◽  
2D Nmr ◽  
Esi Ms ◽  
Spatholobus Suberectus ◽  
Ethanol Extracts

A new flavanone, namely 2-(S)-6,7,3’,5′-tetrahydroxyflavanone, was separated from the ethanol extracts of the dried vine stems of Spatholobus suberectus dunn, together with three known ones, 2-(S)-7,3’,5′-trihydroxyflavanone, liquiritigenin and butin. The structure of the new flavanone was identified by detailed analyses of the spectroscopic data, especially 1D and 2D NMR, and HR-ESI-MS.

Potential Antimalarials. XVI. 4'-Chloro-3-[7″-chloro(and trifluoromethyl)quinolin-4″-yl]amino-5-(substituted amino)methylbiphenyl-4-ols and 4'-Bromo(and 3'-trifluoromethyl)-3-(substituted amino)methyl-5-(7″-trifluoromethylquinolin-4″-yl)aminobiphenyl-2-ols

1992 ◽  
Vol 45 (11) ◽  
pp. 1845 ◽  
Author(s):  
GB Barlin ◽  
FL Tian ◽  
B Kotecka ◽  
KH Rieckmann
Keyword(s):  
Plasmodium Falciparum ◽  
Antimalarial Activity ◽  
Mannich Bases ◽  
In Vitro Tests ◽  
Ic50 Values

Twenty-four mono-Mannich bases of the general formulae 4'-chloro-3-[7″-chloro(and trifluoro-methyl)quinolin-4'-yl]amino-5-(substituted amino)methylbiphenyl-4-ols and 4'-bromo(and 3'- trifluoromethyl-3(substituted amino)methyl-5(7″-trifluoromethylquinolin-4″-yl) aminobiphenyl-2-ols have been prepared by condensation of the 4-chloro heterocycle with 5-amino-3-(N-substituted amino)methyl-4'-chlorobiphenyl-4-ols or 5-amino-3-(N-substituted amino)methyl- 4'-bromo(or 3'-trifluoromethyl)biphenyl-2-ols. The antimalarial activity of these products in in vitro tests against Plasmodium falciparum reveals many with IC50 values of 50-100 nM ( chloroquine 20-40 nM ). The biphenyl-2-ols were more active than comparable biphenyl-4-ols.

scholarly journals Antiplasmodial Quinones from the Rhizomes of Kniphofia Foliosa

2013 ◽  
Vol 8 (9) ◽  
pp. 1934578X1300800 ◽  
Author(s):  
Martha Induli ◽  
Meron Gebru ◽  
Negera Abdissa ◽  
Hosea Akala ◽  
Ingrid Wekesa ◽  
...  
Keyword(s):  
Plasmodium Falciparum ◽  
Methyl Ether ◽  
Spectroscopic Data ◽  
Antimalarial Activity ◽  
In Vivo Assay

Extracts of the rhizomes of Kniphofia foliosa exhibited antiplasmodial activities against the chloroquine-sensitive (D6) and chloroquine-resistant (W2) strains of Plasmodium falciparum with IC50 values of 3–5 μg/mL. A phenyloxanthrone, named 10-acetonylknipholone cyclooxanthrone (1) and an anthraquinone-anthrone dimer, chryslandicin 10-methyl ether (2), were isolated from the rhizomes, along with known quinones, including the rare phenylanthraquinone dimers, joziknipholones A and B. The structures of these compounds were determined based on spectroscopic data. This is the second report on the occurrence of the dimeric phenylanthraquinones in nature. In an in vitro antiplasmodial assay of the isolated compounds, activity was observed for phenylanthraquinones, anthraquinone-anthrone dimers and dimeric phenylanthraquinones, with joziknipholone A being the most active. The new compound, 10-acetonylknipholone cyclooxanthrone, also showed anti-plasmodial activity. In an in vivo assay, knipholone anthrone displayed marginal antimalarial activity.

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