Potential Role of Zamzam Water in Some Chronic Diseases in Rats

2017 ◽  
Vol 9 (08) ◽  
Author(s):  
Amal S. Abdel-Azeem ◽  
Adel- Elsayed Mubarak ◽  
YahyaAbd- Elmonem Abd-Elhady ◽  
Asmaa Gaber Mohammed Badawi
Keyword(s):  
Diabetes Mellitus ◽  
Potential Role ◽  
Tap Water ◽  
Hdl Cholesterol ◽  
Protective Role ◽  
Serum Glucose ◽  
Albino Rats ◽  
Liver And Kidney ◽  
Normal Rat

Water from holy zamzam is consumed by many Muslims in the world due to its beneficial role for the health of human beings.Therefore the present study was designed to evaluate the effect of zamzam water in diabetes mellitus, nephrotoxicity and hepatotoxicity in rats as well as to determine the chemical analysis of this water. Fifty six male albino rats weighting (150±5gm) were divided into four main groups and each group was divided into two subgroups a and b, one administered tap water (Tw) and the other subgroup administered zamzam water (zw). The 1st main group was normal rat (-ve control), the 2nd group was diabetic (induced by alloxan 150 mg/kg b.w.), the 3rd was nephrotoxic (induced by gentamicin 100 mg/kg b.w.) and the 4th group was hepatotoxic by carbon tetrachloride (2ml/ kg b.w.). The experiment lasted after four weeks. Zamzam water significantly decreased serum glucose, total lipids, total cholesterol, triglycerides, LDL-cholesterol and elevated HDL- cholesterol. Moreover the liver and kidney markers were also improved in the groups that treated with zamzam water relative to its control taking tap water. Zamzam water has a protective role against hazardous effects of diabetes mellitus, nephrotoxicity and hepatotoxicity in rats.

scholarly journals The protective role of propolis against multi heavy metals-induced oxidative stress-hepato-renal damage in the male of albino rats

2021 ◽  
Author(s):  
Ayman Ahmed Bassiouny El-Amawy ◽  
Samir Attia Mohammed Zaahkouk ◽  
Hesham Gamal Abdel Rasheed ◽  
Bassem Elsayed Elaraby Mohammed
Keyword(s):  
Heavy Metals ◽  
Oral Administration ◽  
Antioxidant Defense System ◽  
Protective Role ◽  
Albino Rats ◽  
Protective Effects ◽  
Toxic Heavy Metals ◽  
Propolis Extract ◽  
Liver And Kidney

Abstract The study was designed to clarify the hepato-renal protective effects of propolis extract against heavy metals-induced toxicity via oral administration to the males of albino rats. Lead (Pb), Nickel (Ni), Cadmium (Cd), and Antimony (Sb) are toxic heavy metals have the ability to produce reactive radicals in the biological systems causing public and animals health hazards through disrupting balances between pro-oxidant and antioxidant defense system, resulting in excessive reactive oxygen species (ROS) production. The most commonly affected organs are liver and kidney. Propolis is a natural product with different shapes and resinous substance collected by honey bees, it attenuates many diseases damage due to its anti-oxidative action and its potentiality to minimize the deleterious effects of free radicals on tissues. The concentrations of Pb, Cd, Ni and Sb as well as the activities of antioxidants endogenous enzymes including; glutathione peroxidase (Gpx), glutathione reductase (GR), catalase (CAT), and superoxide dismutase (SOD) were all determined in the tissues of liver and kidney; while aspartate transaminase (ASAT), alanine transaminase (ALAT), total protein (TP), urea and createnine, were measured in the serum of experimental rats beside histopathologicl examination in the tissues of liver and kidney. The oral administration of propolis provided a significantly therapeutic role against multi-metals-induced hepato-renal toxicity with relative improving to histopathological changes because of its scavenging and chelating properties as concluded from the present investigation.

scholarly journals Protective effects of prebiotic (resistant maltodextrin) and silymarin against toxicity of carbon tetrachloride in liver rat and kidney

2020 ◽  
Vol 8 (1) ◽  
pp. 15
Author(s):  
M. G. A. EL. SAYED ◽  
ENAS. A. H. FARAG ◽  
HEBA. M. Nasr
Keyword(s):  
Carbon Tetrachloride ◽  
Serum Levels ◽  
Protective Role ◽  
Vehicle Group ◽  
Albino Rats ◽  
Protective Effects ◽  
Liver And Kidney ◽  
Resistant Maltodextrin ◽  
Hepatic Injuries

Exposure to carbon tetrachloride induces acute and chronic hepatic injuries as well as renal injuries in rats. Therefore, the current study aimed to evaluate the protective role of prebiotic (digestion resistant maltodextrin) and silymarin against carbon tetrachloride -induced heptorenal toxicity in albino rats. Six groups with ten rats each were used for this purpose; these groups included the control vehicle group that received saline daily for 30 days, prebiotic group (1g/kg, orally) daily for 30 days; silymarin group (200 mg/kg orally) daily for 30 days; carbon tetrachloride group (2.5ml/kg intraperitoneally twice per week for three week; the prebiotic – carbon tetrachloride group; the silymarin – carbon tetrachloride group. The results revealed that carbon tetrachloride significantly increased serum levels of alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, total bilirubin cholesterol, triglyceride, urea and creatinine. In addition, there were substantial increase in lipid peroxidation (malondialdehyde) and level of glucose with significant decreases in albumin, total protein, creatinine kinase, hemoglobin and red blood cells. Carbon tetrachloride also caused histological changes in liver and kidney tissues. However, administration of prebiotic and silymarin alone ameliorated the carbon tetrachloride induced liver and kidney damage with improved hematological, lipid profile and glucose level.  

scholarly journals Gut microbiota influence in type 2 diabetes mellitus (T2DM)

Gut Pathogens ◽  
2021 ◽  
Vol 13 (1) ◽  
Author(s):  
A. L. Cunningham ◽  
J. W. Stephens ◽  
D. A. Harris
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Gut Microbiota ◽  
Potential Role ◽  
Evidence Base ◽  
Human Metabolism ◽  
Altered Glucose

AbstractA strong and expanding evidence base supports the influence of gut microbiota in human metabolism. Altered glucose homeostasis is associated with altered gut microbiota, and is clearly associated with the development of type 2 diabetes mellitus (T2DM) and associated complications. Understanding the causal association between gut microbiota and metabolic risk has the potential role of identifying susceptible individuals to allow early targeted intervention.

The protective role of ferulic acid on sepsis-induced oxidative damage in Wistar albino rats

2014 ◽  
Vol 38 (3) ◽  
pp. 774-782 ◽  
Author(s):  
Merve Bacanlı ◽  
Sevtap Aydın ◽  
Gökçe Taner ◽  
Hatice Gül Göktaş ◽  
Tolga Şahin ◽  
...  
Keyword(s):  
Oxidative Damage ◽  
Ferulic Acid ◽  
Protective Role ◽  
Albino Rats ◽  
Wistar Albino Rats
Sign in / Sign up

Export Citation Format

Share Document