scholarly journals Sonographic Features of Chronic Kidney Disease in Agricultural Community in Sri Lanka

2021 ◽  
Vol 4 ◽  
pp. 1
Author(s):  
Muditha S. Bandara ◽  
Buddika Gurunayaka ◽  
Gamage Pemanatha Lakraj ◽  
Aruna Pallewatte ◽  
Sisira Siribaddana ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Sri Lanka ◽  
Kidney Disease ◽  
Shape Index ◽  
Morphological Features ◽  
Unknown Etiology ◽  
Renal Ultrasound ◽  
Kidney Volume ◽  
Agricultural Community ◽  
High Prevalence

Objectives: The aim of this study was to use ultrasound-based kidney morphological features to classify chronic kidney disease (CKD) in an agricultural community in Sri Lanka where there is a high prevalence of CKD with unknown etiology. Materials and Methods: A cohort of CKD patients (n = 50) and healthy subjects (n = 26) underwent B-mode renal ultrasound. CKD patients were further categorized as those clinically diagnosed with diabetes mellitus, hypertension, and other known causes (n = 30) and those of unknown etiology (n = 20). Following kidney morphological features were calculated: Length (LEN), width (WDTH), cortical thickness, volume (VOL), and shape index. Results: CKD kidneys of both groups were significantly smaller than the healthy kidneys (P < 0.001). Based on a random forest procedure, the top three influential features that distinguished CKD kidneys from healthy kidneys were: VOL normalized to waist circumference (CKD = 0.6 ± 0.2 cm2, healthy = 0.9 ± 0.2 cm2), VOL normalized to body surface area (CKD = 36 ± 9 cm3/m2, healthy = 52 ± 13 cm3/m2), and WDTH (CKD = 3.6 ± 0.5 cm, healthy = 4.3 ± 0.6 cm). Patients with CKD of unknown etiology had higher kidney LEN and VOL normalized to height (HGHT) (LEN/HGHT = 0.58 ± 0.05 cm/m, VOL/HGHT = 0.40 ± 0.09 cm3/m, P < 0.05) compared to those of the known etiology group (LEN/HGHT = 0.51 ± 0.09 cm/m, VOL/HGHT = 0.30 ± 0.10 cm3/m). Conclusion: The study shows that ultrasound-based kidney volume can distinguish healthy versus diseased kidneys as well as CKD of known versus unknown etiology. Normalizing for height is required when comparing diseased groups.

scholarly journals Identification of Social and Occupational Risk Factors Associated with CKDu (Chronic Kidney Disease of Unknown Etiology) Patients Living in an Agricultural Community in Kebithigollewa, Sri Lanka

2021 ◽  
Vol 7 (4) ◽  
Author(s):  
Lowe C ◽  
Kumarasinghe N
Keyword(s):  
Risk Factors ◽  
Chronic Kidney Disease ◽  
Sri Lanka ◽  
Kidney Disease ◽  
Occupational Risk ◽  
Unknown Etiology ◽  
Occupational Risk Factors ◽  
Factors Associated ◽  
Agricultural Community ◽  
The Social

Aim: To identify the social and occupational risk factors associated with CKDu (Chronic Kidney Disease of unknown etiology) patients living in an agricultural community in Kebithigollewa, Sri Lanka.

scholarly journals GENETIC KIDNEY DISEASES AS AN UNDERECOGNIZED CAUSE OF CHRONIC KIDNEY DISEASE: THE KEY ROLE OF INTERNATIONAL REGISTRY REPORTS

2021 ◽  
Author(s):  
Roser Torra ◽  
Mónica Furlano ◽  
Alberto Ortiz ◽  
Elisabet Ars
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Kidney Diseases ◽  
Unknown Etiology ◽  
Correct Treatment ◽  
Monogenic Diseases ◽  
High Prevalence ◽  
Incorrect Diagnosis ◽  
Kidney Replacement Therapy

Abstract Inherited kidney diseases (IKDs) are among the leading causes of early-onset chronic kidney disease (CKD) and are responsible for at least 10–15% of cases of kidney replacement therapy (KRT) in adults. Pediatric nephrologists are very aware of the high prevalence of IKDs among their patients, but this is not the case for adult nephrologists. Recent publications have demonstrated that monogenic diseases account for a significant percentage of adult cases of CKD. A substantial number of these patients have received a non-specific/incorrect diagnosis or a diagnosis of CKD of unknown etiology, which precludes correct treatment, follow-up and genetic counseling. There are a number of reasons why genetic kidney diseases are difficult to diagnose in adulthood: a) adult nephrologists, in general, are not knowledgeable about IKDs, b) existence of atypical phenotypes, c) genetic testing is not universally available, d) family history is not always available or may be negative, e) lack of knowledge of various genotype–phenotype relationships, f) conflicting interpretation of the pathogenicity of many sequence variants.

Significance of Mg-hardness and fluoride in drinking water on chronic kidney disease of unknown etiology in Monaragala, Sri Lanka

2021 ◽  
pp. 111779
Author(s):  
D.N.D. Liyanage ◽  
Saranga Diyabalanage ◽  
S.P. Dunuweera ◽  
Sanath Rajapakse ◽  
R.M.G. Rajapakse ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Drinking Water ◽  
Sri Lanka ◽  
Kidney Disease ◽  
Unknown Etiology

Anthropometric changes in chronic kidney disease of unknown etiology (CKDU) patients: a single-center longitudinal study in Sri Lanka

2021 ◽  
Vol 46 ◽  
pp. S692
Author(s):  
H.M. Abeywickrama ◽  
Y. Koyama ◽  
S. Wimalasiri ◽  
M. Uchiyama ◽  
U. Shimizu ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Longitudinal Study ◽  
Sri Lanka ◽  
Kidney Disease ◽  
Unknown Etiology ◽  
Single Center

Health-related Quality of Life among Patients with Chronic Kidney Disease of Unknown Etiology (CKDu) of an agricultural Community in Kebithigollawa, Sri Lanka

2021 ◽  
Author(s):  
Nishantha Kumarasinghe
Keyword(s):  
Quality Of Life ◽  
Chronic Kidney Disease ◽  
Sri Lanka ◽  
Kidney Disease ◽  
Unknown Etiology ◽  
Health Related Quality ◽  
Early Assessment ◽  
Related Quality ◽  
Health Related

Background: The significant increase in the burden of chronic kidney disease of unknown etiology (CKDu) of Sri Lanka has led to evaluate the factors related to physical, social and mental aspects of health-related quality of life (HRQOL) in CKDu patients. Methods: The quality of life of 84 CKDu patients (stages 1-5) were assessed by means of the Kidney Disease Quality of Life Short-Form survey (KDQOL™-36) Version 1.3 along with biomarkers and patient demographics. The estimated glomerular filtration rate (eGFR) was calculated using the Modification of Diet in Renal Disease (MDRD) formula. Results: KDQOL™-36 scores impaired substantially across all stages of CKDu and comparatively lower scores were present in later stages of the disease than the initial stages. The mental composite summary (MCS) scores were more impaired when compared to physical composite summary (PCS) scores during the early stage of the disease. Poor KDQOL™-36 scores were present in males than in females with a significant difference in MCS and social support scales. Biochemical parameters showed a significant correlation with the majority of KDQOL™-36 dimensions while urine albumin to creatinine ratio did not. Conclusion: CKDu patients in any stage of the disease despite their age and gender have a significant physical and mental health burden. Thereby, early assessment of health-related quality of life will help to identify high-risk patients, and modifying these factors may provide a better active and healthy lifestyle.

scholarly journals Upregulation of Oxidative Stress Related Genes in a Chronic Kidney Disease Attributed to Specific Geographical Locations of Sri Lanka

2016 ◽  
Vol 2016 ◽  
pp. 1-9 ◽  
Author(s):  
Saravanabavan Sayanthooran ◽  
Dhammika N. Magana-Arachchi ◽  
Lishanthe Gunerathne ◽  
Tilak D. J. Abeysekera ◽  
Suneth S. Sooriyapathirana
Keyword(s):  
Oxidative Stress ◽  
Chronic Kidney Disease ◽  
Sri Lanka ◽  
Kidney Disease ◽  
Quantitative Polymerase Chain Reaction ◽  
Fibroblast Growth Factor 23 ◽  
Study Groups ◽  
Unknown Etiology ◽  
Pyrin Domain ◽  
Expression Of Genes

Objective.To infer the influence of internal and external oxidative stress in chronic kidney disease patients of unknown etiology (CKDu) in Sri Lanka, by analyzing expression of genes related directly or indirectly to oxidative stress: glutamate-cysteine ligase catalytic subunit (GCLC), glutathione S-transferase mu 1 (GSTM1), glucose-6-phosphate dehydrogenase (G6PD), fibroblast growth factor-23 (FGF23), and NLR family pyrin domain containing 3 (NLRP3).Methods.Reverse transcription quantitative polymerase chain reaction (RT-qPCR) was carried out for the selected populations: CKDu patients (n=43), chronic kidney disease patients (CKD;n=14), healthy individuals from a CKDu endemic area (GHI;n=9), and nonendemic area (KHI;n=16). Fold changes were quantified relative to KHI.Results.GCLC had greater than threefold upregulation in all three study groups, with a maximum of 7.27-fold upregulation in GHI (p=0.000). GSTM1 was not expressed in 25.6% of CKDu and 42.9% of CKD patients, but CKDu patients expressing GSTM1 showed upregulation of 2.60-fold (p<0.05). Upregulation of FGF23 and NLRP3 genes in CKD and CKDu was observed (p<0.01), with greater fold changes in CKD.Conclusion.Results suggest higher influence of external sources of oxidative stress in CKDu, possibly owing to environmental conditions.

Structural violence and chronic kidney disease of unknown etiology in Sri Lanka

2017 ◽  
Vol 178 ◽  
pp. 184-195 ◽  
Author(s):  
M.W. Amarasiri de Silva ◽  
Steven M. Albert ◽  
J.M.K.B. Jayasekara
Keyword(s):  
Chronic Kidney Disease ◽  
Sri Lanka ◽  
Kidney Disease ◽  
Structural Violence ◽  
Unknown Etiology
Sign in / Sign up

Export Citation Format

Share Document