The Rate of Increase of Blood Plasma Ascorbic Acid after Ingestion of Ascorbic Acid (Vitamin C)

1942 ◽  
Vol 23 (3) ◽  
pp. 309-319 ◽  
Author(s):  
E. Neige Todhunter ◽  
Ruth C. Robbins ◽  
Jennie A. McIntosh
Keyword(s):  
Ascorbic Acid ◽  
Vitamin C ◽  
Blood Plasma ◽  
Plasma Ascorbic Acid ◽  
Rate Of Increase

scholarly journals Plasma ascorbic acid and the risk of islet autoimmunity and type 1 diabetes: the TEDDY study

Diabetologia ◽  
2019 ◽  
Vol 63 (2) ◽  
pp. 278-286 ◽  
Author(s):  
Markus Mattila ◽  
◽  
Iris Erlund ◽  
Hye-Seung Lee ◽  
Sari Niinistö ◽  
...  
Keyword(s):  
Ascorbic Acid ◽  
Type 1 Diabetes ◽  
Vitamin C ◽  
Data Availability ◽  
Islet Autoimmunity ◽  
Plasma Ascorbic Acid ◽  
Background Population ◽  
Increased Risk ◽  
Nested Case Control

Abstract Aims/hypothesis We studied the association of plasma ascorbic acid with the risk of developing islet autoimmunity and type 1 diabetes and examined whether SNPs in vitamin C transport genes modify these associations. Furthermore, we aimed to determine whether the SNPs themselves are associated with the risk of islet autoimmunity or type 1 diabetes. Methods We used a risk set sampled nested case–control design within an ongoing international multicentre observational study: The Environmental Determinants of Diabetes in the Young (TEDDY). The TEDDY study followed children with increased genetic risk from birth to endpoints of islet autoantibodies (350 cases, 974 controls) and type 1 diabetes (102 cases, 282 controls) in six clinical centres. Control participants were matched for family history of type 1 diabetes, clinical centre and sex. Plasma ascorbic acid concentration was measured at ages 6 and 12 months and then annually up to age 6 years. SNPs in vitamin C transport genes were genotyped using the ImmunoChip custom microarray. Comparisons were adjusted for HLA genotypes and for background population stratification. Results Childhood plasma ascorbic acid (mean ± SD 10.76 ± 3.54 mg/l in controls) was inversely associated with islet autoimmunity risk (adjusted OR 0.96 [95% CI 0.92, 0.99] per +1 mg/l), particularly islet autoimmunity, starting with insulin autoantibodies (OR 0.94 [95% CI 0.88, 0.99]), but not with type 1 diabetes risk (OR 0.93 [95% Cl 0.86, 1.02]). The SLC2A2 rs5400 SNP was associated with increased risk of type 1 diabetes (OR 1.77 [95% CI 1.12, 2.80]), independent of plasma ascorbic acid (OR 0.92 [95% CI 0.84, 1.00]). Conclusions/interpretation Higher plasma ascorbic acid levels may protect against islet autoimmunity in children genetically at risk for type 1 diabetes. Further studies are warranted to confirm these findings. Data availability The datasets generated and analysed during the current study will be made available in the NIDDK Central Repository at https://www.niddkrepository.org/studies/teddy.

Effects of vitamin C supplementation on plasma ascorbic acid and oxalate concentrations and meat quality in swine1

2004 ◽  
Vol 82 (7) ◽  
pp. 2004-2012 ◽  
Author(s):  
S. J. Pion ◽  
E. van Heugten ◽  
M. T. See ◽  
D. K. Larick ◽  
S. Pardue
Keyword(s):  
Ascorbic Acid ◽  
Vitamin C ◽  
Meat Quality ◽  
Plasma Ascorbic Acid ◽  
Vitamin C Supplementation

Maternal Plasma Ascorbic Acid (Vitamin C) and Risk of Gestational Diabetes Mellitus

Epidemiology ◽  
2004 ◽  
Vol 15 (5) ◽  
pp. 597-604 ◽  
Author(s):  
Cuilin Zhang ◽  
Michelle A. Williams ◽  
Tanya K. Sorensen ◽  
Irena B. King ◽  
Mark M. Kestin ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Ascorbic Acid ◽  
Gestational Diabetes ◽  
Vitamin C ◽  
Gestational Diabetes Mellitus ◽  
Maternal Plasma ◽  
Plasma Ascorbic Acid

Blood Plasma Ascorbic Acid Levels on Controlled Intakes of Ascorbic Acid

Science ◽  
1947 ◽  
Vol 106 (2742) ◽  
pp. 67-67
Author(s):  
Mary L. Dodds ◽  
Florence L. MacLeod
Keyword(s):  
Ascorbic Acid ◽  
Blood Plasma ◽  
Plasma Ascorbic Acid

scholarly journals Effects of ascorbic acid on the skeletal response of chicks to vitamin D deficiency

1968 ◽  
Vol 22 (1) ◽  
pp. 77-82 ◽  
Author(s):  
P. A. Thornton
Keyword(s):  
Vitamin D ◽  
Ascorbic Acid ◽  
Vitamin C ◽  
Vitamin D Deficiency ◽  
Bone Tissue ◽  
Compact Bone ◽  
Significant Degree ◽  
Plasma Ascorbic Acid ◽  
Bone Ash ◽  
Plate Width

1. The skeletal response of vitamin D-deficient chicks to dietary ascorbic acid was tested.2. The epiphyseal cartilaginous plate width, which was increased by the vitamin D deficiency, was further increased when ascorbic acid was added and the effect appeared sooner.3. Absence of vitamin D was associated with a reduction in the relative amount of cancellous to compact bone ash in the tibia. Dietary ascorbic acid intensified this effect to a significant degree.4. Plasma ascorbic acid levels in rachitic chicks were approximately 25% less than in controls. This observation may explain the skeletal response to added vitamin C and suggests that avian bone tissue has a particularly high requirement for this vitamin.

scholarly journals Study of oxidative stress biomarkers in obese children

2018 ◽  
Vol 6 (10) ◽  
pp. 3335
Author(s):  
Avni Kanji Fariya ◽  
Bina F. Dias
Keyword(s):  
Oxidative Stress ◽  
Lipid Peroxidation ◽  
Ascorbic Acid ◽  
Childhood Obesity ◽  
Vitamin C ◽  
Low Grade ◽  
Obese Children ◽  
Oxidative Stress Biomarkers ◽  
Plasma Ascorbic Acid ◽  
Increased Risk

Background: The objective is to study the oxidative stress in obese and non-obese children by assessing the biomarkers of lipid peroxidation and antioxidant status, Malondialdehyde (MDA) and Ascorbic acid (vitamin C) respectively. Childhood obesity is a growing global epidemic that requires attention due to the burden placed on the healthcare system for children and adults. Consumption of fatty foods and a high sugar, fat diet, and no exercise qualify as the main reasons for obesity among children and adults. Childhood obesity is connected with an increased risk of various diseases such as diabetes, cardiovascular, stroke, certain types of cancer later in life, social problems and depression among youths. Obesity is also characterized by chronic low grade inflammation with permanently increased oxidative stress (OS). Over-expression of oxidative stress damages cellular structures together with under-production of anti-oxidant mechanisms, leading to the development of obesity-related complications.Methods: The study involved 25 obese children for Vitamin C, 20 obese children for Malondialdehyde (MDA) and 18 non obese children for both Vitamin C and MDA in the age group of 5-14 years, without any complications. This study was conducted at L.T.M.M College. Plasma Ascorbic Acid was estimated colorimetrically by using 2,6- dicholrophenol indophenol dye and similarly Malondialdehyde was estimated colorimetrically by MDA-TBA colored complex.Results: The study showed significantly higher values of MDA and lower level of Vitamin C in obese children as compared with non-obese children.Conclusions: The levels of lipid peroxidation marker Malondialdehyde (MDA) is higher and level of antioxidant marker Ascorbic Acid (Vitamin C) is lower in obese children as compared with non-obese children. Thereby increasing oxidative stress and hence the oxidative damage to cells.

Ascorbic Acid Content of Blood Plasma, Erythrocytes, Leukocytes and Liver in Camels (Camelus dromedarius) without or with Parasite Infections

2002 ◽  
Vol 72 (6) ◽  
pp. 369-371 ◽  
Author(s):  
Mohamed ◽  
Beynen
Keyword(s):  
Ascorbic Acid ◽  
Vitamin C ◽  
Blood Plasma ◽  
Red Blood Cells ◽  
Whole Blood ◽  
Acid Content ◽  
Blood Cells ◽  
White Blood Cells ◽  
Ascorbic Acid Content ◽  
Parasite Infections

Healthy camels (Camelus dromedaris) and those naturally infected with trypanosomiasis, sarcoptic mange, and helminthiasis were compared as to ascorbic acid (vitamin C) contents of red blood cells, white blood cells, whole blood, plasma, and liver. The camels were kept under natural grazing conditions in Sudan. Reduced levels of vitamin C were found in camels with parasite infections, especially in animals with trypanosomiasis. It is suggested that the low vitamin C status in infected camels is caused by increased utilization and/or decreased synthesis of vitamin C.

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