Histopathological Study of The Effect of Cisplatin on The Ovaries of Females' Albino Mice

2014 ◽  
Vol 2 (2) ◽  
pp. 245-255
Author(s):  
Intissar Waheed ◽  
Aveen Mohammed Ameen ◽  
Unce Jasim ◽  
Bakhtyar Ali
Keyword(s):  
Histopathological Study ◽  
Albino Mice

EFFECT OF SILVER NANOPARTICLES SYNTHESIZED USING LEAVES EXTRACT OF OLIVE ON HISTOPATHOLOGICAL AND CYTOGENETIC EFFECTS IN ALBINO MICE

2020 ◽  
Vol 51 (5) ◽  
pp. 1448-1457
Author(s):  
E. H. Al-taee
Keyword(s):  
Chromosomal Aberrations ◽  
Leaf Extract ◽  
Inflammatory Responses ◽  
Experimental Period ◽  
Saline Group ◽  
Histopathological Study ◽  
Olive Leaf ◽  
Ag Nps ◽  
Olive Leaf Extract ◽  
Albino Mice

This study was conducted to examine the possible effects of Ag-NPs synthesized using the olive leaf extract on histopathology and cytogenetic effect in mice. A total of thirty albino mice aged two months were divided into five treatment groups as follows: Group 1: served as control was administrated orally with 0.3 mg/kg bw of normal saline; Group 2 and 3 were administrated orally with varying doses of Ag-NPs synthesized on olive leaf extract (10 and 100 mg/kg bw, respectively) for 30 days; Group 4 and 5 were administrated orally with olive leaf crude extract (300 and 1000 mg/kg bw, respectively) for 30 days. At the end of the experimental period, the detection of possible chromosomal aberrations in blood samples and histopathology (liver, spleen, kidney, uterus, and testes) were carried out. Statistically significant differences (P<0.05) were observed for the chromosomal aberrations in all Ag-NPs groups compared to control and to crude olive leaf extract groups. Histopathological study revealed various alterations in internal organs at high doses of Ag-NPs group including inflammatory reaction, blood congestion, degeneration, fibrosis, mononuclear cell lesion, and necrosis. Slight changes were identified at both doses of crude olive extract treated groups. Based on these results, oral administration of Ag-NPs could cause genotoxic and inflammatory responses in mice and this could be representing a risk to both environment and human health. 

scholarly journals Toxic Effects of Different Doses of Cyclophosphamide on Liver and Kidney Tissue in Swiss Albino Mice: A Histopathological Study

1970 ◽  
Vol 28 (6) ◽  
Author(s):  
Nandini Bhat ◽  
Sneha Guruprasad Kalthur ◽  
Supriya Padmashali ◽  
Vidya Monappa
Keyword(s):  
Kidney Tissue ◽  
Test Group ◽  
The Body ◽  
Cancer Drug ◽  
Histopathological Study ◽  
Duration Of Treatment ◽  
Chemotherapeutic Regimen ◽  
Liver And Kidney ◽  
Albino Mice

BACKGROUND: Cyclophosphamide (CPA) is an anti- cancer drug, used in chemotherapy. This is a toxic drug which targets the cancer cells and also the normal cells of the body. The original compound is inactive in vitro and exercises its biologic action through metabolites, chiefly phosphoramide mustard. The objective is to study the harmful effects of this drug on liver and kidney tissues.METHODS: To study the effect of cyclophosphamide on histology of liver and kidney, 40 adult male mice were taken and divided into two groups: control and test. Those in the test group were injected with the drug at doses of 100, 200, 250 mg/kg body weight. They were then sacrificed on day 7, 28 and 42. The liver and kidney tissue was processed, sectioned and stained with Haematoxylin and Eosin.RESULTS: Pathological changes were seen in the tissue within 7 days in high doses and after 28 days in low doses. As the dosage and the days administered increased, the changes were prominently seen and widespread. Pathology ranging from mild infiltration to necrosis and finally cytolysis were seen in liver and kidney tissue.CONCLUSION: Our study has demonstrated the effect of a progressive increase in dosage of cyclophosphamide in albino mice, and pathological alterations were observed in histology of liver and kidney by sequentially increasing both the dosage and duration of treatment. Subsequently, regular monitoring of liver and kidney function tests in patients undergoing chemotherapeutic regimen with administration of ahepato and nephroprotective agent becomes vital. 

scholarly journals EFFECTS OF LONG TERM ADMINISTRATION OF GENTAMICIN ON CLINICO-PATHOLOGICAL PARAMETERS IN SWISS ALBINO MICE

2012 ◽  
Vol 3 (1) ◽  
pp. 87-91 ◽  
Author(s):  
MAQ Miah ◽  
MA Awal ◽  
MM Rahman ◽  
MS Islam
Keyword(s):  
Clinical Signs ◽  
The Body ◽  
Recommended Dose ◽  
Coagulation Necrosis ◽  
Histopathological Study ◽  
Swiss Albino Mice ◽  
Term Administration ◽  
Albino Mice ◽  
Kg Medium

The effects of long-term intramuscular injection of gentamicin (Gentin® inj., Opsonin, Bangladesh Ltd.) were studied clinicopathologically on twenty 60 day-old Swiss Albino mice of either sex for 42 days during January to March 2002. All the mice were grouped into four, each consisting of one male and four female mice, of which one group (group A) served as control without giving any treatment while groups B, C and D received recommended (50 mg / kg), medium (75 mg / kg) and double the recommended (100 mg / kg) doses of gentamicin intramuscularly daily for 42 days. All the treated mice produced mild to severe clinical signs, i.e., roughness of the body coat, dullness, depression, anorexia and weakness. At recommended and medium doses the offspring were apparently normal but at double the recommended dose, 10% offspring were died and others were weak and emaciated. No significant gross change was found in lungs, spleen and heart of all the treated groups but the kidney was found soft, flabby and enlarged and the heart was found darker, congested with necrotic foci on the surface. Histopathological changes showed chronic interstitial nephritis in groups B and C following recommended (50 mg / kg) and medium (75 mg / kg) doses while severe glomerulonephritis was observed following double the recommended dose (100 mg / kg) of gentamicin. In liver, histopathological study showed coagulation necrosis following recommended dose, whereas, karyorrhoexis and tissue regeneration were found following medium and double the recommended doses. In lungs, haemorrhage and thickening of interstitial tissues were observed following double the recommended dose of gentamicin in mice. Thus long term administration of higher dose of gentamicin is detrimental to the vital organs.

A Computerized Coding System for Processing Basic Histopathological Changes – Application to Vascular Pathology

1986 ◽  
Vol 25 (03) ◽  
pp. 139-142 ◽  
Author(s):  
A. Mauriello ◽  
Y. Sambuy ◽  
E. Bonanno ◽  
A. Orlandi ◽  
G. Palmieri ◽  
...  
Keyword(s):  
Vascular Wall ◽  
Final Diagnosis ◽  
Vascular Pathology ◽  
Histopathological Study ◽  
Coding System ◽  
Histopathological Changes ◽  
Histological Changes ◽  
Pathological Conditions ◽  
Computer Based ◽  
Sufficient Space

SummaryAmong the numerous existing computer-based systems for processing pathological data, none contains sufficient space for encoding data on the basic cytological or histological changes of a certain organ or tissue, upon which the final diagnosis is based.An “analytical record” was constructed listing all the basic changes that can be encountered in the various pathological conditions of the vascular wall. The data collected on the “analytical record” were coded by means of an alphanumeric code and stored in an Apple II 48 K minicomputer.The advantages of this system include the computerization of the data by non-specialized personnel and the possibility to’ quantitatively analyze the histocytopathological parameters used for diagnosis in vascular pathology. This coding system may easily be adapted, with minor modifications, to the histopathological study of other organs and tissues.

Evaluation of Breast Lumps by Ultrasound and Correlation with Histological Findings

2020 ◽  
Vol 23 (1) ◽  
pp. 10-12
Author(s):  
Nelema Jahan ◽  
Md. Mamunur Rahman ◽  
Mohammad Shahidul Alam ◽  
Md Saiful Islam
Keyword(s):  
Histopathological Examination ◽  
Breast Diseases ◽  
Histopathological Study ◽  
Common Symptom ◽  
Breast Lump ◽  
Histopathological Findings ◽  
Malignant Breast ◽  
Breast Lumps ◽  
One Year ◽  
A Prospective Study

Background: A breast lump is the most common symptom associated with both benign and malignant breast diseases. Therefore, a distinction of benign from malignant lump is of importance for proper management. Though a definitive diagnosis is possible with imaging for all the lesions, histopathological study is proven essential for confirming the diagnosis. Objective: The objective of this study was to evaluate the role of USG and histopathological findings of different breast lump in diagnosis and their comparison. Methods: A prospective study was conducted over a period of one year from January 2017 to December 2017. A total of 116 patients were included in this study. All breast lumps underwent surgery and the ultrasound findings of these lumps were compared with the histopathological findings. Data were collected from these patients by a preformed questionnaire and finally the data were analyzed. Results: Out of 116 patients only 21 cases were reported as malignant in ultrasound report but histopathology revealed 31 malignant patients. On histopathological examination 10 benign cases turned out to be malignant. Conclusion: The present study was undertaken to evaluate in diagnosing breast mass lesions individually by ultrasound and compared with histopathology for definitive management of a patient. Journal of Surgical Sciences (2019) Vol. 23 (1) : 10-12

A histopathological study on human cysticercosis

1978 ◽  
Vol 16 (2) ◽  
pp. 123 ◽  
Author(s):  
Hyun Sook Chi ◽  
Je Geun Chi
Keyword(s):  
Histopathological Study
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