Markers of systemic inflammation and systemic endotoxinemia in patients with acute endogenous psychoses

Актуальность: Современные исследования свидетельствуют о вовлеченности воспаления в патогенез эндогенных психических расстройств. Показано, что активность врождённого иммунитета (высокие показатели лейкоцитарной эластазы (ЛЭ) и а1-протеиназного ингибитора (а1-ПИ)), а также уровень аутоантител к нейроантигенам отражают остроту и тяжесть патологического процесса в мозге. В качестве одного из факторов, инициирующих системное воспаление, рассматривается патогенный формат системной эндотоксинемии (СЭЕ) - эндотоксиновая агрессия (ЭА), - патологический процесс, обусловленный избытком эндотоксина (ЭТ) в кровотоке. Цель: определение взаимосвязи между показателями системного воспаления и СЭЕ у больных с эндогенными психозами, необходимое для оценки роли ЭА в патогенезе изучаемой патологии. Материалы и методы: Обследовано 25 пациентов женского пола в возрасте от 23 до 49 лет (32,6 ± 8,9 лет) с эндогенными психозами (F20, F25 по МКБ-10). Все пациенты находились в остром психотическом состоянии. Психометрическая оценка проведена с помощью шкалы PANSS. Контрольная группа состояла из 25 психически и соматически здоровых женщин соответствующего возраста. В крови пациентов определяли активность воспалительных маркеров ЛЭ и а1-ПИ, а также уровень антител к нейроантигенам S100-B и ОБМ (технология «Нейро-иммуно-тест»), концентрацию эндотоксина (ЭТ) («Микро-ЛАЛ-тест») и активность антиэндотоксинового иммунитета (АЭИ) (технология «СОИС-ИФА»). Данные проанализированы с помощью непараметрических статистических методов (IBM SPSS Statistics 23). Результаты: В сыворотке крови пациентов выявлено статистически значимое повышение активности ЛЭ и а1-ПИ, а в 44% - наличие аутоиммунного компонента к нейроантигенам. У 24% больных на фоне существенного повышения активности маркеров воспаления наблюдалось повышение концентрации ЭТ, сопровождающееся недостаточностью АЭИ (преимущественно к гидрофильной части молекулы ЭТ), что является неблагоприятным фактором, усугубляющим клиническое течение заболевания. У 76% пациентов концентрация ЭТ оставалась в пределах нормативных значений и сопровождалась различным уровнем АЭИ, что, вероятно, может являться следствием ранее перенесённой ЭА. Выявлены корреляции между исследуемыми биологическими показателями, а также их связь с тяжестью клинической симптоматики по PANSS. Выводы: Полученные результаты свидетельствуют о взаимосвязи маркеров системного воспаления и показателей СЭЕ и их вовлеченности в патогенез эндогенных психозов. Background: Recent studies have suggested involvement of inflammation in the pathogenesis of endogenous mental disorders. The activity of innate immunity (increased activities of leukocyte elastase (LE) and a1-proteinase inhibitor (a1-PI)) and the level of autoantibodies to neuroantigens reflect severity of the pathological process in brain. The pathogenic form of systemic endotoxinemia (SE), that is, endotoxin aggression (EA), a pathological process caused by excessive endotoxin (ET) in the bloodstream, is considered as one of the factors initiating systemic inflammation. Objective: to determine the relationship between markers of systemic inflammation and indexes of systemic endotoxinemia in patients with endogenous psychoses to evaluate the role of EA in the pathogenesis of these disorders. Materials and methods: The study included 25 female patients aged 23 to 49 years with endogenous psychoses (F20, F25 according to ICD-10). All patients experienced exacerbation of psychotic symptoms. Psychometric evaluation was performed using the PANSS scale. The control group consisted of 25 healthy women. LE and a1-PI activities and levels of antibodies to S100-B and MBP (Neuro-Immuno-Test technology), endotoxin concentration (ET) (Micro-LAL-test), and antiendotoxin immunity activity (AIA) (SOIS-IFA technology) were measured in the patients’ blood. Results: The patients had significantly increased serum activities of LE and a1-PI. The autoimmune component to neuroantigens was detected in 44% of cases. In 24% of patients with significantly increased activities of inflammatory markers, ET concentrations were increased, and AIA (mainly to the hydrophilic part of the ET molecule) was deficient, which is an unfavorable factor that aggravates the clinical course of disease. In 76% of patients, the ET concentration remained within reference values; however, AIA levels were variable, which likely resulted from a previous EA. The studied biological indexes were shown to be correlated and linked to severity of clinical symptoms as determined with PANSS. Conclusion: The study demonstrated a relationship between systemic inflammatory markers and SE indexes and their involvement in the pathogenesis of endogenous psychoses.

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Elevated activity of superoxide dismutase in male late-life schizophrenia and its correlation with clinical symptoms and cognitive deficits

BMC Psychiatry ◽

10.1186/s12888-021-03604-5 ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Lijuan Huo ◽

Xiaobing Lu ◽

Fengchun Wu ◽

Catherine Chang ◽

Yuping Ning ◽

...

Keyword(s):

Superoxide Dismutase ◽

Cognitive Deficits ◽

Negative Symptoms ◽

Clinical Symptoms ◽

Late Life ◽

Pathological Process ◽

Psychotic Symptoms ◽

Control Group ◽

Sod Activity ◽

Schizophrenia Group

Abstract Background Despite inconsistent findings, accumulative evidence has shown abnormalities of the key antioxidant enzyme, superoxide dismutase (SOD), in patients with schizophrenia. However, few studies explored SOD in late-life schizophrenia (LLS). Our work aimed to investigate changes in SOD activity and the relationship between SOD activity and psychotic symptoms or cognitive deficits in LLS. Methods 32 geriatric male patients with schizophrenia (age ≥ 60) and 28 age-matched male normal controls were recruited in the study. We assessed cognitive functions with the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS), evaluated the severity of clinical symptoms with the Positive and Negative Syndrome Scale (PANSS), and measured the plasma levels of SOD. Results Patients with LLS presented with higher total levels of SOD compared to the controls (81.70 vs. 65.26 U/ml, p < .001). Except for the visuospatial index, the cognitive performance was significantly worse on RBANS total and other domain scores in the schizophrenia group than the control group. In the schizophrenia group, SOD levels were positively correlated with subscores of general psychopathology and negative symptoms and total scores of the PANSS (all p < .05), and inversely associated with performance in immediate memory, language, and RBANS total scores (all p < .05). Conclusions Our findings suggest that patients with LLS display disturbances in the antioxidant system, which may underlie the pathological process of cognitive impairments and negative symptoms in the late stage of schizophrenia. Supplementing with antioxidants could be a potential treatment.

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Probiotic Lactobacillus casei: Effective for Managing Childhood Diarrhea by Altering Gut Microbiota and Attenuating Fecal Inflammatory Markers

Nutrients ◽

10.3390/nu11051150 ◽

2019 ◽

Vol 11 (5) ◽

pp. 1150 ◽

Cited By ~ 10

Author(s):

Hung-Hsiang Lai ◽

Cheng-Hsun Chiu ◽

Man-Shan Kong ◽

Chee-Jen Chang ◽

Chien-Chang Chen

Keyword(s):

Body Weight ◽

Abdominal Pain ◽

Acute Diarrhea ◽

Inflammatory Markers ◽

Lactobacillus Casei ◽

Clinical Symptoms ◽

Control Group ◽

Childhood Diarrhea ◽

Fecal Lactoferrin ◽

Probiotic Lactobacillus

Background: Acute diarrhea is a major cause of childhood morbidity and an economic burden for families. The aim of this study is to explore the effect of probiotics on clinical symptoms, intestinal microbiota, and inflammatory markers during childhood diarrhea. Methods: Children (n = 81) aged six months to six years (mean age 2.31 years) hospitalized for acute diarrhea were randomized to receive probiotics (Lactobacillus casei variety rhamnosus; n = 42) or no probiotics (n = 39) orally twice daily for seven days. Feces samples were also collected to evaluate microbial content using a traditional agar plate and next-generation sequencing. Immunoglobulin A (IgA), lactoferrin, and calprotectin were determined by enzyme-linked immunosorbent assay (ELISA) and compared in different groups. Other clinical symptoms or signs, including fever, vomiting, diarrhea, abdominal pain, bloated abdomen, daily intake, appetite, and body weight were also assessed. Results: Data were collected from 81 individuals across three different time points. Total fecal IgA levels in fecal extracts of the probiotics group were higher than those in the control group, reaching statistical significance (p < 0.05). Concentrations of fecal lactoferrin and calprotectin were significantly downregulated in patients with probiotic Lactobacillus casei variety rhamnosus (Lc) consumption compared to those of the control (p < 0.05). Probiotic Lc administration may be beneficial for gut-microbiota modulation, as shown by the data collected at one week after enrollment. Counts of Bifidobacteria and Lactobacillus species were elevated in stool culture of the probiotic group. Appetite and oral intake, body-weight gain, abdominal pain, bloating, as well as bowel habits (diarrhea) were much better in children receiving probiotics compared with those in the control group. Conclusion: Fecal IgA increased during acute diarrhea under Lc treatment; in contrast, fecal lactoferrin and calprotectin were downregulated during acute diarrhea under Lc treatment. Probiotic Lc may be a useful supplement for application in children during acute diarrhea to reduce clinical severity and intestinal inflammatory reaction.

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Clinical Features of Youth Depression with Attenuated Symptoms of the Schizophrenic Spectrum

Psychiatry ◽

10.30629/2618-6667-2021-19-1-16-25 ◽

2021 ◽

Vol 19 (1) ◽

pp. 16-25

Author(s):

M. A. Omelchenko

Keyword(s):

Mental Health ◽

Depressive Episode ◽

Negative Symptoms ◽

Mental Health Research ◽

Research Centre ◽

Psychotic Symptoms ◽

Control Group ◽

Youth Depression ◽

Icd 10 ◽

Type 3

Objective: establishment of clinical and psychometric features of youth depression with attenuated symptoms of the schizophrenic spectrum (ASSS) for early differential diagnosis and nosological assessment.Patients and methods: clinical and psychometric examination of young 219 inpatients (average age 19.6 ± 2.4 years), first admitted to the clinic “Mental Health Research Centre” from 2011 to 2020 with the first depressive episode with ASSS. Control group of inpatients (52 patients) with “classical” youth depressions without ASSS (average age 19.6 ± 2.4 years). Diagnosis according ICD-10: F32.1, F32.2, F32.28, F32.8.Results: the psychopathological structure of youth depression with ASSS is characterized by the following types: (1) depression with attenuated psychotic symptoms (APS), which were divided into the subtype (1a) depression with APS and (1b) depression with brief limited intermittent psychotic symptoms (BLIPS); (2) depression with attenuated negative symptoms (ANS), comprising two subtypes (2a) with most emotional damage and (2b) with volitional impairment, and type (3) with attenuated symptoms of disorganization (ASD) in the structure of depressive episode. Clinical and reliable psychometric differences have been established between depressions with ASSS and «classical» youth depressions without ASSS. Conclusions: youth depression with ASSS is definitely different from “classical” youth depression without ASSS. Differences have been found in the psychopathological structure of youth depression with ASSS, resulting in a typological differentiation.

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Chronic Low-Grade Systemic Inflammation in Children with Asthma and Obesity

Journal of Biomedical and Clinical Research ◽

10.2478/jbcr-2018-0018 ◽

2018 ◽

Vol 11 (2) ◽

pp. 128-134

Author(s):

Niya A. Krasteva ◽

Boiko R. Shentov ◽

Adelaida L. Ruseva ◽

Chaika K. Petrova ◽

Simeon P. Petkov

Keyword(s):

Bronchial Asthma ◽

Systemic Inflammation ◽

Inflammatory Markers ◽

Serum Levels ◽

Control Group ◽

Low Grade ◽

Obese Children ◽

Asthmatic Children ◽

Children With Asthma ◽

Hs Crp

Summary The rising incidence of bronchial asthma and obesity in children raises the question of whether there is a link between them. Chronic low-grade systemic inflammation could be one of the linking mechanisms. We aimed to determine the serum concentrations of high-sensitive C-reactive protein (hs-CRP), interleukin 6 (IL-6) and tumour necrosis factor a (TNF-a) in children with asthma and obesity and to seek a relationship between these inflammatory markers and asthma control. We investigated 88 children aged 6 to 17 years - 25 asthmatic obese children (AsOb), 25 asthmatic non-obese children (AsNOb), 19 obese non-asthmatic children (ObNAs), and 19 non-obese non-asthmatic children as controls. Serum levels of IL-6 and hs-CRP were significantly increased in asthmatic obese and ObNAs compared to AsNOb and the control group. Serum TNF-a concentration was similar in the four studied groups. There were no statistically significant differences in serum levels of these inflammatory markers between controlled and partially controlled/uncontrolled asthmatics (obese and non-obese). Knowing the possible mechanisms of interaction between bronchial asthma and obesity would contribute to a more effective therapeutic approach in these patients.

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Differential diagnosis and therapy of cycloid psychoses: A case report

European Psychiatry ◽

10.1016/j.eurpsy.2017.01.1665 ◽

2017 ◽

Vol 41 (S1) ◽

pp. s843-s843

Author(s):

A.M. Uminska-Albert ◽

G. Eikmeier

Keyword(s):

Differential Diagnosis ◽

Case Report ◽

Clinical Course ◽

Complete Recovery ◽

Psychotic Symptoms ◽

Cycloid Psychosis ◽

Cycloid Psychoses ◽

Endogenous Psychoses ◽

Icd 10 ◽

Competing Interest

Kraepelin already challenged his dichotomy of psychoses, because in clinical practice too many cases were not in line with his pattern. Different terms for these disorders were coined. Leonhard separated cycloid psychoses from other forms of endogenous psychoses. The idealized subtypes (anxiety-beatific, hyperkinetic-akinetic-motility and confusional exited-inhibited) are characterized by a bipolar course with complete recovery. Operationalised criteria were developed by Perris. We report on a 60 year old woman diagnosed as schizophrenic in 1984/1985 and 2006. In August 2015 she was admitted with stupor and mutism and therefore was treated with fluphenazine and lorazepame. Six days later the clinical picture changed, she became confused and very agitated. After change of treatment to benperidole her clinical condition improved within 12 days. After 3 further days she became confused, agitated and euphoric again. The symptoms persisted in spite of a change of treatment to haloperidole. After diagnostic revision therapy was augmented with lithiumcarbonate. Six days later the psychotic symptoms began to improve and were completely remitted after 10 further days. The case report points out that a differential-diagnostic revision of an apparently therapy-resistant schizophrenia should not only be carried out according to ICD 10 criteria but a cycloid psychosis should be taken into account, too. Perris-criteria are contrasted with ICD 10-criteria for schizophrenia and mania with psychotic symptoms. Symptomatology and clinical course in our patient fulfilled exactly the Perris-criteria. We recommend an augmentation trial with lithium in acute phases of cycloid psychoses by all means before ECT.Disclosure of interestThe authors have not supplied their declaration of competing interest.

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Emotional Deficits in Remitted Bipolar and Schizoaffective Patients

European Psychiatry ◽

10.1016/j.eurpsy.2017.01.2173 ◽

2017 ◽

Vol 41 (S1) ◽

pp. S209-S209

Author(s):

R.S. Romosan ◽

A.M. Romosan ◽

L.M. Ienciu ◽

L. Dehelean ◽

A.C. Bredicean

Keyword(s):

Emotion Recognition ◽

Schizoaffective Disorder ◽

Clinical Symptoms ◽

Control Group ◽

Icd 10 ◽

Healthy Control ◽

Competing Interest ◽

Emotional Deficits ◽

Bipolar Patients ◽

The Mind

IntroductionBoth bipolar and schizoaffective patients have deficient social skills persisting even during the remission of the clinical symptoms. These deficits may represent impediments for the social reintegration and recovery of these patients.ObjectivesThe purpose of the study was to assess and compare emotion recognition abilities of schizoaffective and bipolar patients during remission.MethodsThe study was conducted between 2014 and 2016 on remitted outpatients, diagnosed with either bipolar disorder (n = 38) or schizoaffective disorder (n = 32), according to ICD 10 criteria, and a healthy control group (n = 65). In order to evaluate patients’ ability of understanding the emotional expressions of other people, we used the revised version of the “Reading the Mind in the Eyes” test (“Eyes test”).ResultsThe patient group consisted of 41 (58.6%) women and 29 (41.4%) men, with a mean age of 43.57 years (SD = 10.56). The control group was comprised of 25 males (38.5%) and 40 females (61.5%), with a mean age of 42.03 years (SD = 11.07). We found statistically significant differences (P = 0.003) between the patient groups and the control group regarding emotion recognition abilities (poorer emotion recognition skills than the control group in both bipolar and schizoaffective patients). Patients with schizoaffective disorder gave significantly more incorrect answers in the “Eyes test” than bipolar patients (P = 0.015). Although not statistically significant, women had better emotion recognition abilities than men, both in the patient sample and the control group.ConclusionsSchizoaffective patients have more severe emotional deficits than bipolar patients during euthymic periods.Disclosure of interestThe authors have not supplied their declaration of competing interest.

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Effects of nicotine abstinence on clinical symptoms. Study at 3 and 6-months follow-up of outpatients with schizophrenia

European Psychiatry ◽

10.1016/j.eurpsy.2016.01.669 ◽

2016 ◽

Vol 33 (S1) ◽

pp. s261-s262

Author(s):

P.A. Sáiz Martinez ◽

S. Al-Halabí ◽

S. Fernández-Artamendi ◽

L. García-Álvarez ◽

E. Díaz-Mesa ◽

...

Keyword(s):

Heart Rate ◽

Tobacco Use ◽

Rating Scale ◽

Clinical Symptoms ◽

Psychotic Symptoms ◽

Control Group ◽

Open Label ◽

Anthropometric Measures ◽

Nicotine Abstinence

IntroductionTobacco use has been associated with more excitement and agitation symptoms, greater severity of global psychopathology as measured by the Clinical General Impression (CGI) Scale, and psychotic symptoms in patients with schizophrenia.AimTo assess the effects of nicotine abstinence versus nicotine maintenance on the clinical symptoms of a sample of outpatients smokers diagnosed with schizophrenia.MethodsSample: 81 outpatients with schizophrenia [72.8% males; mean age (SD) = 43.35 (8.82)] currently smoking tobacco [no. of cigarettes (SD) = 27.96 (12.29)]. Desing: non-randomized, open-label, 6-month follow-up and multi-center study conducted at 3 sites in Spain (Oviedo, Santiago de Compostela and Orense). Instruments: Positive and Negative Syndrome Scale (PANSS), Clinical Global Impression for Schizophrenia (CGI-SCH), Hamilton Depression Rating Scale (HDRS). Antropometric measures: Body mass index (BMI) and waist circumference. Vital sings: heart rate. Procedure: Patients were assigned to 2 conditions:– control group = patients continuing their tobacco use;– experimental group = patients participated in vareniclina or nicotine patches treatment for smoking cessation.Patients were evaluated at baseline (all patients smoking) and after 3 and 6 months.ResultsNo significant differences (P>.05) were found between groups at baseline evaluation. Likewise, there were no significant differences between smokers and non-smokers after treatment (3 and 6 months follow-up) in their clinical symptomatology (according to PANSS, HDRS and CGI-SCH), anthropometric measures and heart rate.ConclusionsNo significant differences were found in the clinical symptoms after a period of nicotine abstinence. Therefore, clinicians should motivate and help their patients to quit smoking (CIBERSAM - FIS PI11/01891).Disclosure of interestThe authors have not supplied their declaration of competing interest.

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Chronic Rhinosinusitis with Nasal Polyps: Age and Disease Severity Differences in the Levels of Inflammatory Markers

Medicina ◽

10.3390/medicina57030282 ◽

2021 ◽

Vol 57 (3) ◽

pp. 282

Author(s):

Justinas Vaitkus ◽

Astra Vitkauskienė ◽

Regimantas Simuntis ◽

Žygimantas Vaitkus ◽

Nora Šiupšinskienė ◽

...

Keyword(s):

Chronic Rhinosinusitis ◽

Inflammatory Markers ◽

Nasal Polyps ◽

Clinical Symptoms ◽

Age Groups ◽

Magnetic Bead ◽

Control Group ◽

Control Subjects ◽

Nasal Tissue ◽

And Control

Background and objectives: The aim of our study was to analyze the concentrations of inflammatory markers in the nasal tissue of patients with chronic rhinosinusitis with nasal polyps (CRSwNPs) and controls of different age groups, as well as to find associations between age, inflammation development, and NPs. Materials and methods: Patients were divided into two groups—patients with CRSwNPs and control subjects who had nasal surgery for another reason beside CRS. Our analysis was performed across three different age groups (18–30 years, 31–50 years, and 51 years and more). Tissue biopsies from the sinus cavity for all study participants were taken and frozen at −80 °C, until use. The concentrations of IL-1β, IL-2, IL-4, IL-5, IL-6, IL-7, IL-10, IL-13, IL-21, and IL-22, were quantified using a magnetic bead-based multiplex assay. Results: In the group aged 18–30 years, the levels of inflammatory markers IL-1, IL-2, IL-5, and IL-22 were significantly higher in patients with CRSwNPs than the control subjects. Among patients aged 31–50 years, significantly higher concentrations of IL-2, IL-4, IL-5, and IL-22 were recorded in patients with CRSwNPs, as compared to the control subjects. In the oldest group (aged 51 years and more), patients with CRSwNPs had significantly higher concentrations of IL-2, IL-4, and IL-22, as compared to the control group. In the CRSwNP group, only the concentration of IL-21 was significantly higher among patients aged 31–50 years, as compared with those aged 51 years and older (p = 0.013). Conclusions: IL-2 and IL-22 levels were significantly higher in patients with CRSwNP than the control, across all age groups. Only the concentration of IL-21 was higher among patients with CRSwNP in the middle age group, as compared to the oldest group. IL-2, IL-4, and IL-22 levels correlated with the severity of CRSwNPs. Elevated concentrations of IL-2, IL-4, and IL-22 were determined in patients’ groups with higher sinonasal outcome test (SNOT-22) scores, pointing to more severe clinical symptoms.

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Efficacof Cinnamon Extract (Cinnamomum burmannii) as Supplementation in Lir-psychotic-induced Rats through Oxidative Stress Regulation in Neuronal Cells

Open Access Macedonian Journal of Medical Sciences ◽

10.3889/oamjms.2021.5977 ◽

2021 ◽

Vol 9 (A) ◽

pp. 177-182

Author(s):

Rachmat Hidayat ◽

Patricia Wulandari ◽

Carla Raymondalexas Marchira ◽

Budi Pratiti

Keyword(s):

Oxidative Stress ◽

Psychotic Disorder ◽

Clinical Symptoms ◽

Neuronal Cells ◽

Natural Antioxidants ◽

Psychotic Symptoms ◽

Control Group ◽

Cinnamon Extract ◽

Central Java ◽

Testing Center

BACKGROUND: Cinnamon is a plant that is often found in Indonesia and is rich in secondary metabolites such as flavonoids, phenols, tannins, and alkaloids. Flavonoids and phenols are very potential as natural antioxidants to suppress various oxidant activities, including oxidant activity that occurs in the hippocampus, which is the underlying psychotic disorder. AIM: This study was aimed to explore the potential of cinnamon extract (CE) on psychotic symptoms. METHODS: Cinnamon simplicia was obtained from the Research and Testing Center for Traditional Medicine, Tawangmangu, Central Java, Indonesia. The extraction of cinnamon was carried out using the maceration method. The animals were subjected to lir-psychotic induction by intraperitoneal injection with ketamine (30 mg/kg BW) for 5 days. The rats were grouped into six groups; each group contained five animals; normal control group, a lir-psychotic group without treatment, lir-psychotic group with haloperidol, lir-psychotic with CE (25 mg/kg BW, 50 mg/kg BW, and 100 mg/kg BW). Oxidative stress in experimental animals was measured by evaluating malondialdehyde (MDA) expression in the brain tissue using immunohistochemical tests. RESULTS: There were differences in clinical symptoms of psychotic disorder in the animal model between before intervention with CE supplementation and after the intervention. The higher the CE dose administered, the better the improvement in psychotic symptoms seen in the psychotic-induced rats. CE supplementation could reduce MDA expression in the hippocampus. This suggests that there was an optimal significance of cinnamon supplementation in reducing oxidative stress from the hippocampus. CONCLUSION: CE was effective in improving psychotic symptoms in lir-psychotic rats through regulation of oxidative stress in neuronal cells.

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Interrelation of clinical-anamnestic, medical-biological and neurocognitive characteristics of maladaptation in remission as a component of pathopersonological transformations in patients with schizoaffective disorder

Ukrains'kyi Visnyk Psykhonevrolohii ◽

10.36927/20790325-v28-is1-2020-15 ◽

2020 ◽

pp. 68-74

Author(s):

Mykola Khomitskyi

Keyword(s):

Schizoaffective Disorder ◽

Pathological Process ◽

Psychotic Symptoms ◽

Neurocognitive Deficits ◽

Psychoactive Substances ◽

Psychopharmacological Treatment ◽

Icd 10 ◽

Rehabilitation Measures ◽

Neurological Pathology

The aim of the study was to study the interrelation between clinical, medical, biological and neurocognitive characteristics of maladaptation (as a component of pathopersonological transformations) in patients with schizoaffective disorder in remission. On the basis of the Regional Clinical Psychiatric Hospital (Zaporizhzhia, Ukraine) 102 persons with the established diagnosis of “schizoaffective disorder” were examined. Diagnosis was per formed according to the International ICD-10. The mandatory criteria for inclusion in the study were the presence of a condition of clinical remission with reduction of psychotic symptoms and the absence of severe somatic and neurological pathology, abuse of psychoactive substances. The main methods of the study were clinical psychopathological, psychodiagnostical, clinical-anamnestic and clinical-cathamnestic as well as medi cal and statistical analysis. The study established the presence and regularities of conjugation of clinical, medical, biological, and neurocognitive characteristics of maladaptation (as a component of pathopersonological transformations) in patients with schizoaffective disorder in remission. The structure of neurocognitive deficits in schizoaffective disorder in remission is related to the clinical type of the disease, the sex, the duration of the pathological process, and the characteristics of psychopharmacological treatment. The established regularities emphasize the importance of neurocognitive disorders in the structure of pathopersonological transformations and can be used in the formation of the system of diagnostic and treatment and rehabilitation measures to improve the quality of differential diagnosis and to carry out preventive and therapeutic rehabilitation measures to reduce the level of social maladaptation of patients with schizoaffective disorder. Keywords: schizoaffective disorder, clinic, neurocognition, social maladaptation, pathopersonalogical transformations

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