Biofilm production: assessment of the clinical impact in 104 Staphyloccus aureus bacteraemia cases

Abstract Background The clinical impact of Escherichia coli biofilm formation is unknown. Methods Adults with E. coli bloodstream infections (BSI) were prospectively enrolled from 2002 to 2015. All E. coli isolates were genotyped using Multilocus sequence typing (MLST) and underwent crystal violet biofilm formation assay quantified by absorbance at 540 nm (OD540) in triplicate. Associations between biofilm formation and patient/bacterial characteristics were characterized by t-tests and ANOVA tests. Results Ninety-eight percent (186) of the 189 isolates formed detectable biofilms. Bacterial sequence type (ST) was associated with biofilm formation (P < 0.001), as ST73 (average OD540 = 0.017) and ST393 (average OD540 = 0.016) had higher average biofilm formation while ST69 (average OD540 = 0.007) and ST405 (average OD540 = 0.002) had lower biofilm formation. E. coli isolates with non-multidrug-resistant (non-MDR) phenotype were associated with increased biofilm formation (MDR: average OD540 = 0.006; average non-MDR: OD540 = 0.01; P = 0.003). BSI isolates arising from pneumonia or urine/pyelonephritis were associated with the highest biofilm production (P = 0.04). No associations were identified between biofilm formation and route of infection, APACHE-II score, mortality, or complications of BSI. Conclusion In this prospective study of E. coli BSI isolates, biofilm formation was associated with ST, non-MDR phenotype, and BSI source. Disclosures All authors: No reported disclosures.

Download Full-text

Clinical impact of Candida spp. biofilm production in a cohort of patients with candidemia

Medical Mycology ◽

10.1093/mmy/myx133 ◽

2017 ◽

Vol 56 (7) ◽

pp. 803-808 ◽

Cited By ~ 5

Author(s):

Priscilla Morais Monfredini ◽

Ana Carolina Remondi Souza ◽

Renan Pelluzzi Cavalheiro ◽

Ricardo Andreotti Siqueira ◽

Arnaldo Lopes Colombo

Keyword(s):

Clinical Impact ◽

Candida Spp ◽

Biofilm Production

Download Full-text

829: PSA-Flare up in Docetaxel Therapy of Hormone-Refractory Prostate cancer (HRPCA): Incidence and Clinical Impact?

The Journal of Urology ◽

10.1016/s0022-5347(18)34998-x ◽

2005 ◽

Vol 173 (4S) ◽

pp. 225-225

Author(s):

Peter Olbert ◽

Andres J. Schrader ◽

Axel Hegele ◽

Zoltan Varga ◽

Axel Heidenreich ◽

...

Keyword(s):

Prostate Cancer ◽

Clinical Impact ◽

Hormone Refractory Prostate Cancer ◽

Hormone Refractory

Download Full-text

966 Clinical impact of adverse events in dual-chamber ICD patients

EP Europace ◽

10.1016/s1099-5129(05)80682-8 ◽

2005 ◽

Vol 7 ◽

pp. 233-233

Keyword(s):

Adverse Events ◽

Clinical Impact ◽

Dual Chamber

Download Full-text

Basic Biology and Clinical Impact of Immunosenescence

10.1016/s1566-3124(00)x0007-7 ◽

2002 ◽

Keyword(s):

Clinical Impact ◽

Basic Biology

Download Full-text

Psychological and Cognitive Aspects of Borderline Intellectual Functioning

European Psychologist ◽

10.1027/1016-9040/a000293 ◽

2017 ◽

Vol 22 (3) ◽

pp. 159-166 ◽

Cited By ~ 2

Author(s):

Bastianina Contena ◽

Stefano Taddei

Keyword(s):

Quality Of Life ◽

Systematic Review ◽

Intellectual Functioning ◽

Clinical Impact ◽

Review Of The Literature ◽

Borderline Intellectual Functioning ◽

General Quality ◽

Meta Analyses ◽

Over Time

Abstract. Borderline Intellectual Functioning (BIF) refers to a global IQ ranging from 71 to 84, and it represents a condition of clinical attention for its association with other disorders and its influence on the outcomes of treatments and, in general, quality of life and adaptation. Furthermore, its definition has changed over time causing a relevant clinical impact. For this reason, a systematic review of the literature on this topic can promote an understanding of what has been studied, and can differentiate what is currently attributable to BIF from that which cannot be associated with this kind of intellectual functioning. Using Preferred Reporting Items for Systematic Review and Meta-Analyses (PRISMA) criteria, we have conducted a review of the literature about BIF. The results suggest that this condition is still associated with mental retardation, and only a few studies have focused specifically on this condition.

Download Full-text