One adenocarcinoma metastising to another: A rare case of prostate/lung tumour to tumour metastasis

2016 ◽  
Author(s):  
Ricardo Veiga
Keyword(s):  
Rare Case ◽  
Lung Tumour ◽  
Tumour Metastasis

scholarly journals Relationship between pneumonitis induced by immune checkpoint inhibitors and the underlying parenchymal status: a retrospective study

2020 ◽  
Vol 6 (1) ◽  
pp. 00165-2019 ◽  
Author(s):  
Chiara Pozzessere ◽  
Hasna Bouchaab ◽  
Raphael Jumeau ◽  
Igor Letovanec ◽  
Cécile Daccord ◽  
...  
Keyword(s):  
Radiation Field ◽  
Immune Checkpoint ◽  
Immune Checkpoint Inhibitors ◽  
Checkpoint Inhibitors ◽  
Primary Tumour ◽  
Treatment Interruption ◽  
Immunosuppressive Drug ◽  
Lung Tumour ◽  
Radiation Fields ◽  
Tumour Metastasis

In patients with primary or secondary lung tumour treated with immune checkpoint inhibitors, immune-related pneumonitis is a rare adverse event but may evolve to respiratory failure. Prompt management is required and usually consists of treatment interruption and immunosuppressive drug administration. The aim of this study was to evaluate relationships between immune-related pneumonitis and pre-existing parenchymal status, especially tumour location and history of chest radiotherapy.Computed tomography (CT) scans of patients with immune-related pneumonitis were retrospectively reviewed. Pattern, distribution and extent of pneumonitis were assessed in six lung regions. In patients who received radiotherapy, the extent of pneumonitis was evaluated according to the radiation field.Among 253 patients treated with immunotherapy, 15 cases of immune-related pneumonitis were identified. 10 had previous or concomitant chest radiotherapy in addition to immunotherapy. At CT scan, 29 (33%) out of 88 regions encompassed the primary tumour (n=4), a lung metastasis (n=4) and/or radiation fields (n=21). A significantly higher prevalence of parenchymal involvement by immune-related pneumonitis occurred within areas of primary or metastatic malignancy and/or radiation field (97%) as compared to other areas (3%, p=0.009). Lung regions affected by the primary tumour, metastasis or radiotherapy had a higher probability of immune-related pneumonitis than others (OR 10.8, p=0.024). An organising pneumonia (OP) pattern was more frequent after radiotherapy (70% versus 0%, p=0.024), whereas nonspecific interstitial pneumonia features were more commonly seen in radiotherapy-naive patients (100% versus 10%, p=0.002).In patients with primary or secondary lung tumour treated with immune checkpoint inhibitors, immune-related pneumonitis is preferentially located within lung areas involved by tumour and/or radiation fields.

ADAM9 enhances CDCP1 protein expression by suppressing miR-218 for lung tumour metastasis

2016 ◽  
Author(s):  
Kuo-Liang Chiu ◽  
Ting-Ting Kuo ◽  
Qian-Yu Kuok ◽  
Liang-Chuan Lai ◽  
Yuh-Pyng Sher
Keyword(s):  
Protein Expression ◽  
Lung Tumour ◽  
Tumour Metastasis

scholarly journals Dusp3 deletion in mice promotes experimental lung tumour metastasis in a macrophage dependent manner

PLoS ONE ◽  
2017 ◽  
Vol 12 (10) ◽  
pp. e0185786 ◽  
Author(s):  
Maud Vandereyken ◽  
Sophie Jacques ◽  
Eva Van Overmeire ◽  
Mathieu Amand ◽  
Natacha Rocks ◽  
...  
Keyword(s):  
Lung Tumour ◽  
Dependent Manner ◽  
Tumour Metastasis

scholarly journals Carcinoid tumour metastasis to the submandibular gland: a case report

2011 ◽  
Vol 93 (6) ◽  
pp. e67-e68 ◽  
Author(s):  
Aakshay Gulati ◽  
Parkash L Ramchandani ◽  
Emma Victoria King
Keyword(s):  
Case Report ◽  
Submandibular Gland ◽  
Rare Case ◽  
Carcinoid Tumour ◽  
Neck Region ◽  
Distant Metastases ◽  
Head And Neck Region ◽  
Tumour Metastasis ◽  
Pulmonary System ◽  
Slow Growing

Carcinoid tumours are slow growing tumours of neuroendocrine origin that primarily affect the gastrointestinal tract and pulmonary system. They can behave aggressively, with regional and distant metastases, although metastases to the head and neck region are uncommon. We present a rare case of carcinoid metastasis to the submandibular gland, which to the best of our knowledge has not been previously reported in the literature.

scholarly journals Left-Sided Vanishing Lung Tumour: A Rare Case

2018 ◽  
Author(s):  
Karanam Gowrinath ◽  
Chinnangari Vijay Amaranatha Reddy
Keyword(s):  
Rare Case ◽  
Lung Tumour

scholarly journals Laparoscopic Management for Carcinoid Metastasis to the Spleen

HPB Surgery ◽  
2011 ◽  
Vol 2011 ◽  
pp. 1-4 ◽  
Author(s):  
Damian Balmforth ◽  
Christos Skouras ◽  
Fausto Palazzo ◽  
Emmanouil Zacharakis
Keyword(s):  
Chest Pain ◽  
Adjuvant Therapy ◽  
Laparoscopic Splenectomy ◽  
Rare Case ◽  
Carcinoid Tumour ◽  
Pet Scan ◽  
Lung Tumour ◽  
Splenic Metastasis ◽  
Splenic Lesion ◽  
Lung Carcinoid

We report a rare case of a laparoscopic splenectomy performed for a carcinoid metastasis. The patient represented with pleuritic left-sided chest pain from pleural deposits 9 years following resection of a primary lung carcinoid tumour. They were found to have a 4.7 cm splenic lesion on CT with a probable left acetabular metastasis demonstrated on Gallium PET scan. The patient underwent laparoscopic splenectomy for debulking treatment of the splenic lesion that was confirmed to be a splenic metastasis of the resected carcinoid lung tumour. Following an uncomplicated recovery, the patient was discharged on the second postoperative day. On discharge, she received adjuvant therapy with Lutetium 177 DOTATATE. This is the first report of a carcinoid splenic metastasis successfully treated with laparoscopic splenectomy.

scholarly journals Recombinant single-cycle influenza virus as a new tool to augment antitumour immunity with immune checkpoint inhibitors

2021 ◽  
Author(s):  
Matheswaran Kandasamy
Keyword(s):  
Influenza Virus ◽  
T Cell ◽  
Cell Response ◽  
Checkpoint Inhibitors ◽  
Cd8 T Cell ◽  
T Cell Response ◽  
Lung Tumour ◽  
Antigen Delivery ◽  
Tumour Metastasis ◽  
Flu Virus

Virus-based tumour vaccines offer many advantages compared to other antigen delivering systems. They generate concerted innate and adaptive immune response, and robust CD8+T cell responses. We engineered a non-replicating pseudotyped influenza virus (S-FLU) to deliver the well-known cancer testis antigen, NY-ESO-1 (S-NY-ESO-1 FLU). Intranasal or intramuscular immunization of NY-ESO-1 S-FLU virus in mice elicited a strong NY-ESO-1 specific CD8+T cell response in lungs and spleen that resulted in the regression of NY-ESO-1 expressing lung tumour and subcutaneous tumour respectively. Combined administration with anti PD-1 antibody, NY-ESO-1 S-FLU virus augmented the tumour protection by reducing the tumour metastasis. We propose that the antigen delivery through S-FLU is highly efficient in inducing antigen specific CD8+T cell response and protection against tumour development in combination with PD-1 blockade.

scholarly journals SIPA1 Is a Modulator of HGF/MET Induced Tumour Metastasis via the Regulation of Tight Junction-Based Cell to Cell Barrier Function

Cancers ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 1747
Author(s):  
Chang Liu ◽  
Wen G. Jiang ◽  
Lijian Zhang ◽  
Rachel Hargest ◽  
Tracey A. Martin
Keyword(s):  
Lung Cancer ◽  
Tight Junction ◽  
Barrier Function ◽  
Tyrosine Kinases ◽  
Cancer Metastasis ◽  
Cell Function ◽  
Quantitative Polymerase Chain Reaction ◽  
Lung Tumour ◽  
Tumour Metastasis

Background: Lung cancer is the leading cause of cancer death. SIPA1 is a mitogen induced GTPase activating protein (GAP) and may hamper cell cycle progression. SIPA1 has been shown to be involved in MET signaling and may contribute to tight junction (TJ) function and cancer metastasis. Methods: Human lung tumour cohorts were analyzed. In vitro cell function assays were performed after knock down of SIPA1 in lung cancer cells with/without treatment. Quantitative polymerase chain reaction (qPCR) and western blotting were performed to analyze expression of HGF (hepatocyte growth factor), MET, and their downstream markers. Immunohistochemistry (IHC) and immunofluorescence (IFC) staining were performed. Results: Higher expression of SIPA1 in lung tumours was associated with a poorer prognosis. Knockdown of SIPA1 decreased invasiveness and proliferation of in vitro cell lines, and the SIPA1 knockdown cells demonstrated leaky barriers. Knockdown of SIPA1 decreased tight junction-based barrier function by downregulating MET at the protein but not the transcript level, through silencing of Grb2, SOCS, and PKCμ (Protein kinase Cµ), reducing the internalization and recycling of MET. Elevated levels of SIPA1 protein are correlated with receptor tyrosine kinases (RTKs), especially HGF/MET and TJs. The regulation of HGF on barrier function and invasion required the presence of SIPA1. Conclusions: SIPA1 plays an essential role in lung tumourigenesis and metastasis. SIPA1 may be a diagnostic and prognostic predictive biomarker. SIPA1 may also be a potential therapeutic target for non-small cell lung cancer (NSCLC) patients with aberrant MET expression and drug resistance.

Identification of Pulmonary Deposits from a Sandpaper Worker: A Study by Electron Microscopy and X-Ray Microanalysis

1982 ◽  
Vol 40 ◽  
pp. 52-53
Author(s):  
S. K. Peng ◽  
M.A. Egy ◽  
J. K. Singh ◽  
M.B. Bishop
Keyword(s):  
Electron Microscopy ◽  
Environmental Pollution ◽  
Rare Case ◽  
Interstitial Fibrosis ◽  
X Ray ◽  
Documented Case ◽  
Etiologic Agents ◽  
Pulmonary Interstitial Fibrosis ◽  
Gold Miners ◽  
Pulmonary Changes

Electron microscopy and energy dispersive x-ray microanalysis (EDXA) are found to be very useful tools for identification of etiologic agents in pneumoconiosis or interstitial pulmonary disorders. Pulmonary interstitial fibrosis and granulomatosis are frequently associated with occupational and environmental pollution. Numerous reports of pneumoconiosis in various occupations such as coal and gold miners are presented in the literature. However, there is no known documented case of pulmonary changes in workers in the sandpaper industry. This study reports a rare case of pulmonary granulomatosis containing deposits from abrasives of sandpaper diagnosed by using EDXA.

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