C-Kit, CD34 & Alpha-SMA immunohistochemical features in classic Kaposi sarcoma and Kaposiform hemangioendothelioma

2016 ◽  
Author(s):  
Eiman Adel Hasby Saad
Keyword(s):  
Kaposi Sarcoma ◽  
Kaposiform Hemangioendothelioma ◽  
Classic Kaposi Sarcoma

scholarly journals Kaposiform Hemangioendothelioma: clinicopathological characteristics of 8 cases of a rare vascular tumor and review of literature

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Qurratulain Chundriger ◽  
Muhammad Usman Tariq ◽  
Jamshid Abdul-Ghafar ◽  
Arsalan Ahmed ◽  
Nasir Ud Din
Keyword(s):  
Pediatric Population ◽  
Adult Population ◽  
Correct Diagnosis ◽  
Kaposi Sarcoma ◽  
Minor Component ◽  
Vascular Tumor ◽  
Giant Cells ◽  
Clinicopathological Characteristics ◽  
Multinucleated Giant Cells ◽  
Kaposiform Hemangioendothelioma

Abstract Background Kaposiform Hemangioendothelioma (KHE) is a rare vascular tumor of intermediate malignant potential which shows locally aggressive growth but only rarely metastasizes. It is mostly considered to be a tumor of pediatric population but its occurrence in the adults is not uncommon as once considered. Histologically, KHE can mimic other soft tissue neoplasms of different behaviors (e.g. Kaposi Sarcoma, hemangioma) and establishing the correct diagnosis is important for appropriate treatment. Herein, we describe the clinicopathological features of 8 cases of KHE which will be helpful in making their diagnosis. Methods We reviewed pathology reports, microscopy glass slides and obtained follow up information about 8 cases of KHE which were diagnosed at our institution from January 2008 till June 2020. Immunohistochemical stain for HHV8 was also performed. Results Age ranged from 7 months to 25 years. Seven patients were less than 20 years of age and one patient was 25 years old. Equal gender distribution was observed. Extremities were the most common sites of involvement, followed by head and neck, pancreas and ischiorectal region. 2 cases were resection specimen and all others were incisional biopsies. The largest tumor size was 5.5 cm in one of the resections. The incisional/fragmented tissues were all less than 5 cm in aggregate. Most cases showed predominance of nodular growth and a minor component of spindle cell population along with lymphangiomatosis like vascular channels, with evidence of microthrombi in 2 cases. Few multinucleated giant cells were observed in 2 cases. None of the cases exhibited significant nuclear atypia or mitotic activity. One of the cases arising in dermis showed underlying bone involvement. HHV8 was negative in 7/7 cases. Conclusions KHE can also involve adult population and it should always be considered in the differential diagnoses of a vascular lesion. Presence of multinucleated giant cells is a rare finding. Knowledge about histological features and potential mimics is helpful in avoiding misdiagnosis.

scholarly journals Risk of Classic Kaposi Sarcoma with Residential Exposure to Volcanic and Related Soils in Sicily

2009 ◽  
Vol 19 (8) ◽  
pp. 597-601 ◽  
Author(s):  
Colleen Pelser ◽  
Carmelo Dazzi ◽  
Barry I. Graubard ◽  
Carmela Lauria ◽  
Francesco Vitale ◽  
...  
Keyword(s):  
Kaposi Sarcoma ◽  
Residential Exposure ◽  
Classic Kaposi Sarcoma

Disseminated classic Kaposi sarcoma in a seven-year-old girl

2021 ◽  
Vol 31 (2) ◽  
pp. 269-270
Author(s):  
Thilo Gambichler ◽  
Victoria Brown ◽  
Alicia Siebold ◽  
Markus Stücker ◽  
Maria Bakirtzi
Keyword(s):  
Kaposi Sarcoma ◽  
Classic Kaposi Sarcoma

Familial Classic Kaposi Sarcoma in Two Siblings: Case Report and Literature Review

2013 ◽  
Vol 17 (5) ◽  
pp. 356-361 ◽  
Author(s):  
Mohammad Almohideb ◽  
A. Kevin Waiters ◽  
William Gerstein
Keyword(s):  
Laboratory Data ◽  
Kaposi Sarcoma ◽  
Immune Deficiency Syndrome ◽  
Deficiency Syndrome ◽  
Eastern European ◽  
Familial Cases ◽  
Vascular Proliferation ◽  
Classic Kaposi Sarcoma ◽  
Acquired Immune Deficiency

Background: Kaposi sarcoma (KS) is a cutaneous endothelial vascular proliferation with four subtypes: iatrogenic, acquired immune deficiency syndrome (AIDS) related, African, and classic. Familial cases of KS are rare, with 72 cases reported to date, and all were described with the classic variant. The occurrence of classic KS in the Jewish population is well documented, and most of the familial classic KS cases were also reported in Jewish families. Objective: We briefly present the history, biopsies, laboratory data, diagnosis, and treatment of localized lower limb classic KS in two siblings of Jewish Eastern European ethnic descent with their response to different therapy modalities. One of our cases had the second longest reported period of follow-up for familial classic KS of 40 years.

scholarly journals Candidate Predisposition Variants in Kaposi Sarcoma as Detected by Whole-Genome Sequencing

2019 ◽  
Vol 6 (10) ◽  
Author(s):  
Sanni J Rinne ◽  
Lauri J Sipilä ◽  
Päivi Sulo ◽  
Emmanuelle Jouanguy ◽  
Vivien Béziat ◽  
...  
Keyword(s):  
Whole Genome Sequencing ◽  
Genome Sequencing ◽  
Kaposi Sarcoma ◽  
The Other ◽  
Whole Genome ◽  
Genome Wide ◽  
Starting Point ◽  
Familial Clustering ◽  
Iranian Family ◽  
Classic Kaposi Sarcoma

Abstract Familial clustering of classic Kaposi sarcoma (CKS) is rare with, approximately 100 families reported to date. We studied 2 consanguineous families, 1 Iranian and 1 Israeli, with multiple cases of adult CKS and without overt underlying immunodeficiency. We performed genome-wide linkage analysis and whole-genome sequencing to discover the putative genetic cause for predisposition. A 9-kb homozygous intronic deletion in RP11-259O2.1 in the Iranian family and 2 homozygous variants, 1 in SCUBE2 and the other in CDHR5, in the Israeli family were identified as possible candidates. The presented variants provide a robust starting point for validation in independent samples.

scholarly journals Isolated classic Kaposi Sarcoma in an old female patient

2014 ◽  
Vol 4 (2) ◽  
Author(s):  
Nursel Dilek ◽  
Aziz Ramazan Dilek ◽  
Yunus Saral ◽  
Recep Bedir
Keyword(s):  
Female Patient ◽  
Kaposi Sarcoma ◽  
Classic Kaposi Sarcoma
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