Principal Component Analysis of Intrathecal Chemokine Expression in Multiple Sclerosis and other neurological diseases

2017 ◽  
Author(s):  
Francesca Gilli
Keyword(s):  
Multiple Sclerosis ◽  
Principal Component Analysis ◽  
Neurological Diseases ◽  
Principal Component ◽  
Component Analysis ◽  
Chemokine Expression

scholarly journals The application of principal component analysis to characterize gait and its association with falls in multiple sclerosis

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Andrew S. Monaghan ◽  
Jessie M. Huisinga ◽  
Daniel S. Peterson
Keyword(s):  
Multiple Sclerosis ◽  
Principal Component Analysis ◽  
Dynamic Stability ◽  
Fear Of Falling ◽  
Inertial Sensors ◽  
Principal Component ◽  
Component Analysis ◽  
Functional Mobility ◽  
Timed Up And Go ◽  
Trunk Motion

AbstractPeople with multiple sclerosis (PwMS) demonstrate gait impairments that are related to falls. However, redundancy exists when reporting gait outcomes. This study aimed to develop an MS-specific model of gait and examine differences between fallers and non-fallers. 122 people with relapsing–remitting MS and 45 controls performed 3 timed up-and-go trials wearing inertial sensors. 21 gait parameters were entered into a principal component analysis (PCA). The PCA-derived gait domains were compared between MS fallers (MS-F) and MS non-fallers (MS-NF) and correlated to cognitive, clinical, and quality-of-life outcomes. Six distinct gait domains were identified: pace, rhythm, variability, asymmetry, anterior–posterior dynamic stability, and medial–lateral dynamic stability, explaining 79.15% of gait variance. PwMS exhibited a slower pace, larger variability, and increased medial–lateral trunk motion compared to controls (p < 0.05). The pace and asymmetry domains were significantly worse (i.e., slower and asymmetrical) in MS-F than MS-NF (p < 0.001 and p = 0.03, respectively). Fear of falling, cognitive performance, and functional mobility were associated with a slower gait (p < 0.05). This study identified a six-component, MS-specific gait model, demonstrating that PwMS, particularly fallers, exhibit deficits in pace and asymmetry. Findings may help reduce redundancy when reporting gait outcomes and inform interventions targeting specific gait domains.

Factor Structure of the Values in Action Inventory of Strengths-72 in Individuals With Multiple Sclerosis

2021 ◽  
Vol 35 (2) ◽  
pp. 94-105
Author(s):  
Muna Bhattarai ◽  
Yunzhen Huang ◽  
Yazmin Castruita Rios ◽  
Susan Miller Smedema
Keyword(s):  
Multiple Sclerosis ◽  
Principal Component Analysis ◽  
Factor Structure ◽  
Character Strengths ◽  
Reliability And Validity ◽  
Principal Component ◽  
Internal Consistency Reliability ◽  
Component Analysis ◽  
Rehabilitation Professionals ◽  
Quantitative Descriptive

BackgroundResearch on character strengths in individuals with multiple sclerosis (MS) is lacking. Moreover, measures of character strengths have not been validated in this population, limiting the opportunities for further investigation.ObjectiveTo investigate the factor structure of the Values in Action Inventory of Strengths (VIA)-72 in a sample of individuals with MS.MethodsThis quantitative descriptive study included 624 individuals with MS. The factor structure of the VIA-72 was examined using principal component analysis. The internal consistency reliability and validity were assessed by computing Cronbach's alphas and correlations of the VIA-72 with other psychosocial constructs, respectively.FindingsThe principal component analysis revealed an interpretable four-factor structure of the VIA-72: intellectual and emotional strengths, temperance, transcendence, and interpersonal strengths. The factors significantly correlated with measures of quality of life, resilience, social support, depression, fatigue, and personality traits, indicating good concurrent validity. The four factors did not completely align with Peterson and Seligman's (2004) classification system.ConclusionsThe four-factor structure of the VIA-72 seems to be interpretable, valid, and reliable. Measures like VIA-72 may help rehabilitation professionals learn more about the nature and development of character strengths among persons with MS and suggest ways to cultivate it. Further studies are indicated to confirm the factor structures and psychometric properties of this scale in persons with MS.

scholarly journals Diet quality and risk of multiple sclerosis in two cohorts of US women

2018 ◽  
Vol 25 (13) ◽  
pp. 1773-1780 ◽  
Author(s):  
Dalia L Rotstein ◽  
Marianna Cortese ◽  
Teresa T Fung ◽  
Tanuja Chitnis ◽  
Alberto Ascherio ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Principal Component Analysis ◽  
Diet Quality ◽  
Dietary Patterns ◽  
Principal Component ◽  
Component Analysis ◽  
Healthy Eating Index ◽  
Health Study ◽  
Incident Cases ◽  
Dietary Indices

Objective: To determine the association between measures of overall diet quality (dietary indices/patterns) and risk of multiple sclerosis (MS). Methods: Over 185,000 women in the Nurses’ Health Study (NHS) and Nurses’ Health Study II (NHSII) completed semiquantitative food frequency questionnaires every 4 years. There were 480 MS incident cases. Diet quality was assessed using the Alternative Healthy Eating Index-2010 (AHEI-2010), Alternate Mediterranean Diet (aMED) index, and Dietary Approaches to Stop Hypertension (DASH) index. Principal component analysis was used to determine major dietary patterns. We calculated the hazard ratio (HR) of MS with Cox multivariate models adjusted for age, latitude of residence at age 15, body mass index at age 18, supplemental vitamin D intake, and cigarette smoking. Results: None of the dietary indices, AHEI-2010, aMED, or DASH, at baseline was statistically significantly related to the risk of MS. The principal component analysis identified “Western” and “prudent” dietary patterns, neither of which was associated with MS risk (HR, top vs bottom quintile: Western, 0.81 ( p = 0.31) and prudent, 0.96 ( p = 0.94)). When the analysis was repeated using cumulative average dietary pattern scores, the results were unchanged. Conclusion: There was no evidence of an association between overall diet quality and risk of developing MS among women.

A German version of the Intermittent Claudication Questionnaire (ICQ): cultural adaptation and validation

VASA ◽  
2012 ◽  
Vol 41 (5) ◽  
pp. 333-342 ◽  
Author(s):  
Kirchberger ◽  
Finger ◽  
Müller-Bühl
Keyword(s):  
Principal Component Analysis ◽  
Intermittent Claudication ◽  
Completion Time ◽  
Short Form ◽  
Principal Component ◽  
Component Analysis ◽  
German Version ◽  
Average Completion Time ◽  
Sf 36 ◽  
Related Quality

Background: The Intermittent Claudication Questionnaire (ICQ) is a short questionnaire for the assessment of health-related quality of life (HRQOL) in patients with intermittent claudication (IC). The objective of this study was to translate the ICQ into German and to investigate the psychometric properties of the German ICQ version in patients with IC. Patients and methods: The original English version was translated using a forward-backward method. The resulting German version was reviewed by the author of the original version and an experienced clinician. Finally, it was tested for clarity with 5 German patients with IC. A sample of 81 patients were administered the German ICQ. The sample consisted of 58.0 % male patients with a median age of 71 years and a median IC duration of 36 months. Test of feasibility included completeness of questionnaires, completion time, and ratings of clarity, length and relevance. Reliability was assessed through a retest in 13 patients at 14 days, and analysis of Cronbach’s alpha for internal consistency. Construct validity was investigated using principal component analysis. Concurrent validity was assessed by correlating the ICQ scores with the Short Form 36 Health Survey (SF-36) as well as clinical measures. Results: The ICQ was completely filled in by 73 subjects (90.1 %) with an average completion time of 6.3 minutes. Cronbach’s alpha coefficient reached 0.75. Intra-class correlation for test-retest reliability was r = 0.88. Principal component analysis resulted in a 3 factor solution. The first factor explained 51.5 of the total variation and all items had loadings of at least 0.65 on it. The ICQ was significantly associated with the SF-36 and treadmill-walking distances whereas no association was found for resting ABPI. Conclusions: The German version of the ICQ demonstrated good feasibility, satisfactory reliability and good validity. Responsiveness should be investigated in further validation studies.

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