Background A significant number of patients with mild traumatic brain injury (mTBI) would experience cognitive deficit. Purpose To investigate the brain structural changes in sub-acute mTBI by diffusion kurtosis imaging (DKI) and volumetric analysis, and to assess the relationship between brain structural changes and cognitive functions. Material and Methods A total of 23 patients with sub-acute mTBI and 24 control participants were recruited. All the participants underwent examinations of neuropsychological tests, DKI, and magnetic resonance imaging (MRI)-based morphological scans. Images were investigated using whole brain-based analysis and further regions of interest-based analysis for subcortical nuclei. The neuropsychological tests were compared between the mTBI and the control group. Correlation analysis was performed to examine the relationship between gray matter (GM) volume, DKI parameters, and cognitive functions. Results Compared with control participants, mTBI patients performed worse in the domains of verbal memory, attention and executive function ( P < 0.05). No regional GM volume differences were observed between the mTBI and control groups ( P > 0.05). Using DKI, patients with mTBI showed lower mean kurtosis (MK) in widespread white matter (WM) regions and several subcortical nuclei ( P < 0.05), and higher mean diffusivity (MD) in the right pallidum ( P < 0.05). Lower MK value of multiple WM regions and several subcortical nuclei correlated with cognitive impairment ( P < 0.05). Conclusion DKI was sensitive in detecting brain microstructural changes in patients with sub-acute mTBI showing lower MK value in widespread WM regions and several subcortical nuclei, which were statistically associated with cognitive deficits.
Differentiating between Alzheimer’s disease, amnestic mild cognitive impairment, and normal aging via diffusion kurtosis imaging
