<P>Background: Type 2 diabetes (T2DM) is a risk factor for Alzheimer’s disease and mild cognitive
impairment. The etiology of cognitive impairment in people with T2DM is uncertain but, chronic
hyperglycemia, cerebral micro vascular disease, severe hypoglycemia, and increased prevalence of
macro vascular disease are implicated.
</P><P>
Objectives: To determine the serum levels of soluble vascular adhesion molecule (sVCAM-1) and
highly sensitive C-reactive protein (hs-CRP) in elderly type 2 diabetics with mild cognitive impairment
(MCI).
Methods:
Our study was conducted on 90 elderly subjects (aged 60 years old or more). They were divided
into Group І, 30 patients with T2DM and mild cognitive impairment, group ІІ, 30 patients with
T2DM without cognitive impairment and group III, 30 healthy subjects as a control group. They were
subjected to history taking, full clinical examination, anthropometric measurement, the Addenbrooke’s
Cognitive Examination III (ACE---III 2012), Fasting plasma glucose, 2 hours plasma glucose, HbA1c,
lipid profile, protein/creatinine ratio, serum sVCAM-1 and hs-CRP.
Results:
Serum levels of sVCAM-1 in diabetic elderly patients with MCI were significantly higher
(946.7 ± 162.01 ng/ml) than diabetic elderly patients without cognitive impairment (479.06 ± 65.27
ng/ml) and control (263.7 ± 72.05 ng/ml) with (P=0.002). Serum levels of Hs-CRP in diabetic elderly
patients with MCI were significantly higher than as diabetic elderly patients without cognitive impairment
and control with (P=0.005).
Conclusion:
Elderly diabetic patients with mild cognitive impairment have higher levels of soluble adhesion
molecules and markers of low-grade systemic inflammation than other groups.</P>
Correlations Between the Microstructural Changes of the Medial Temporal Cortex and Mild Cognitive Impairment in Patients With Cerebral Small Vascular Disease (cSVD): A Diffusion Kurtosis Imaging Study
