Extreme Leukocytosis in a Man after a Half Marathon Race

2021 ◽  
Vol 6 (1) ◽  
Author(s):  
Ericsson F ◽  
◽  
Jensen NE ◽  
Jensen SE ◽  
◽  
...  
Keyword(s):  
Blood Cell ◽  
Cell Count ◽  
Human Body ◽  
Broad Spectrum ◽  
Bacterial Infections ◽  
Clinical Case ◽  
Common Finding ◽  
Blood Cell Count ◽  
Marathon Race ◽  
Clinical Conditions

Leukocytosis is most often defined as an elevated white blood cell count greater than 11.0 × 109 per L in adults, and is a relatively common finding. Normal adult levels of leucocytes is 4.5 to 11.0 × 109 per L. It is of importance for clinicians to be able to distinguish nonmalignant from malignant conditions, and to differentiate between the most common non-malignant causes of leukocytosis. Extreme leukocytosis can be seen in a broad spectrum of clinical conditions in the human body under stress. It is most commonly found in patients suffering from leukemia or severe bacterial infections, but can also be seen in people after hard exercise [1-7]. The present clinical case describes a young healthy man, suffering from extreme leukocytosis after a syncope during a half marathon.

scholarly journals P.109 Causes of albuminocytologic dissociation and the impact of an age-adjusted reference limit on review of 2,627 CSF samples

2018 ◽  
Vol 45 (s2) ◽  
pp. S45-S45
Author(s):  
JA Brooks ◽  
C McCudden ◽  
A Breiner ◽  
P Bourque
Keyword(s):  
Blood Cell ◽  
Cell Count ◽  
Care Center ◽  
Tertiary Care ◽  
Common Finding ◽  
Blood Cell Count ◽  
Reference Limit ◽  
Number Of Patients ◽  
Upper Reference Limit ◽  
The Impact

Background: We set out to test the discriminative power of an age-adjusted upper reference limit (URL) for CSF total protein (CSF-TP) in identifying pathological causes of albuminocytologic dissociation (ACD). Methods: We reviewed the charts of 2,627 adult patients who underwent a lumbar puncture at a tertiary care center over a 20-year period. Samples with CSF-TP above 45 mg/dL (0.45 g/L) were included. Samples with white blood cell count > 5×109/L, red blood cell count > 50×109/L, and glucose < 2.5 mmol/L (45 mg/dL) were excluded. Patients with CSF-TP elevated above 45 mg/dL were considered to have ‘pseudo’ albuminocytologic dissociation (ACD) or ‘true’ ACD if their CSF-TP was in excess of age-adjusted norms. Results: Among all patients with ACD, a pathological source of CSF-TP elevation was identified in 57% (1490/2627) of cases, 51% of those with ‘pseudo’ ACD, and 75% with ‘true’ ACD (p< 0.001). Use of an age-adjusted upper reference limit favored the detection of polyneuropathy patients (13.5% proportionate increase) and excluded a larger number of patients with isolated headache (10.7% proportionate decrease; p < 0.0001). Conclusions: Elevated CSF-TP is a relatively common finding. Use of age-adjusted upper reference limits for CSF-TP values improve diagnostic specificity and help to avoid over-diagnosis of ACD.

scholarly journals Diagnosis of del(5q) MDS, 14 years after JAK-2 positive PV appearance: complete remission of both diseases with lenalidomide monotherapy

2016 ◽  
Vol 8 ◽  
pp. 2016050
Author(s):  
Antonella Vaccarino ◽  
Irene Dogliotti ◽  
Fabio Marletto ◽  
Andrea Demarchi ◽  
Mario Bazzan
Keyword(s):  
Complete Remission ◽  
Blood Cell ◽  
Myelodysplastic Syndrome ◽  
Cell Count ◽  
Clinical Setting ◽  
Clinical Case ◽  
Low Dose ◽  
Blood Cell Count ◽  
First Case ◽  
One Year

This is the report of the clinical case of a patient who presents the association of a JAK-2 positive chronic myeloproliferative neoplasia to a subsequent 5q- myelodysplastic syndrome, developed after about 14 years from the first diagnosis. Patient’s symptoms had rapidly worsened, and she became transfusion-dependent. Therapy with low-dose Lenalidomide quickly reduced the splenomegaly, and completely brought white cells counts, haemoglobin and platelets back to normal.  After more than one year from start, blood cell count is still normal. As far as we know this is the first case of an effective treatment with Lenalidomide reported in this clinical setting.

scholarly journals Diagnosis of del(5q) MDS, 14 years after JAK-2 positive PV appearance: complete remission of both diseases with lenalidomide monotherapy

2016 ◽  
Vol 8 ◽  
pp. e2016050 ◽  
Author(s):  
Antonella Vaccarino ◽  
Irene Dogliotti ◽  
Fabio Marletto ◽  
Andrea Demarchi ◽  
Mario Bazzan
Keyword(s):  
Complete Remission ◽  
Blood Cell ◽  
Myelodysplastic Syndrome ◽  
Cell Count ◽  
Clinical Setting ◽  
Clinical Case ◽  
Low Dose ◽  
Blood Cell Count ◽  
First Case ◽  
One Year

This is the report of the clinical case of a patient who presents the association of a JAK-2 positive chronic myeloproliferative neoplasia to a subsequent 5q- myelodysplastic syndrome, developed after about 14 years from the first diagnosis. Patient’s symptoms had rapidly worsened, and she became transfusion-dependent. Therapy with low-dose Lenalidomide quickly reduced the splenomegaly, and completely brought white cells counts, haemoglobin and platelets back to normal.  After more than one year from start, blood cell count is still normal. As far as we know this is the first case of an effective treatment with Lenalidomide reported in this clinical setting.

Pneumoperitoneum Post-Fluoroscopic Percutaneous Gastrojejunostomy Insertion: Computed Tomography and Clinical Evaluation

2012 ◽  
Vol 63 (3_suppl) ◽  
pp. S33-S36
Author(s):  
Grant Stoneham ◽  
Brent Burbridge ◽  
Jaime Pinilla ◽  
Andrea Gourgaris ◽  
Valerie Astrope ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Blood Cell ◽  
Cell Count ◽  
Clinical Evaluation ◽  
Clinical Signs ◽  
Signs And Symptoms ◽  
Tube Placement ◽  
Common Finding ◽  
Blood Cell Count ◽  
Tube Insertion

Introduction To assess the incidence and clinical significance of pneumoperitoneum after radiologic percutaneous gastrojejunostomy (PGJ) tube insertion. Methods Sixteen subjects were prospectively assessed after imaging-guided PGJ tube insertion to discern the incidence of pneumoperitoneum related to specific clinical signs and symptoms. Computed tomography of the abdomen and the pelvis was performed immediately after PGJ insertion. A clinical evaluation, including history, general and abdominal physical examination, temperature, complete blood cell count, abdominal pain, and abdominal tension, was performed on days 1 and 3, and at the discretion of the nutritional support team on day 7 after PGJ insertion. Results Fifteen of the 16 subjects demonstrated imaging findings of pneumoperitoneum after the PGJ-tube insertion. Only a small amount of pneumoperitoneum was demonstrated in 10 of the subjects, whereas a large volume of gas was detected in 2 of the subjects. The only altered clinical findings encountered were increased white blood cell count and fever. These abnormal clinical data were most frequently seen immediately after feeding-tube placement. Discussion Pneumoperitoneum was a common finding after PGJ-tube placement in our study population. There were no statistically significant abnormal clinical parameters, in the presence or absence of pneumoperitoneum, for any of the subjects after PGJ-tube insertion. Conservative management of pneumoperitoneum after PGJ is warranted.

White blood cell count and eosinopenia as valuable tools for the diagnosis of bacterial infections in the ED

2019 ◽  
Vol 38 (8) ◽  
pp. 1523-1532 ◽  
Author(s):  
Charles-Eric Lavoignet ◽  
◽  
Pierrick Le Borgne ◽  
Sylvie Chabrier ◽  
Joffrey Bidoire ◽  
...  
Keyword(s):  
Blood Cell ◽  
Cell Count ◽  
White Blood Cell Count ◽  
White Blood Cell ◽  
Bacterial Infections ◽  
Blood Cell Count
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