Myocardial Infarction and Three-Vessel Coronary Artery Disease as Presenting Features of Granulomatosis with Polyangiitis: A Case Report with Review of Literature

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Younes A ◽  
◽  
Yalamanchili S ◽  
Ali H ◽  
Onyekwelu C ◽  
...  
Keyword(s):  
Trypanosoma Cruzi ◽  
Chagas Disease ◽  
Systemic Infection ◽  
The United States ◽  
Cardiac Complications ◽  
Gastrointestinal Complications ◽  
Vector Borne ◽  
Artery Disease ◽  
Chronic Chagas Disease ◽  
Vessel Coronary Artery

Chagas disease is a systemic infection due to Trypanosoma cruzi, a parasitic protozoan. Trypanosoma cruzi is endemic in Latin America; however, the prevalence has been increasing in the United States. The infection is mostly vector-borne secondary to triatomine or “kissing” bug bites. However, the infection can also spread via organ transplantation, blood transfusion, or transplacentally resulting in congenital manifestations. Chronic Chagas disease can cause cardiac or gastrointestinal complications that may be irreversible if left untreated. Major cardiac complications include dilated cardiomyopathy, arrhythmias, sudden cardiac death, and thromboembolism.

scholarly journals Current knowledge of Chagas-related heart disease among pediatric cardiologists in the United States

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Sanchi Malhotra ◽  
Imran Masood ◽  
Noberto Giglio ◽  
Jay D. Pruetz ◽  
Pia S. Pannaraj
Keyword(s):  
United States ◽  
Differential Diagnosis ◽  
Heart Disease ◽  
Chagas Disease ◽  
Latin American ◽  
Current Knowledge ◽  
Parasitic Infection ◽  
The United States ◽  
Cardiac Complications ◽  
The U.S

Abstract Background Chagas disease is a pathogenic parasitic infection with approximately 8 million cases worldwide and greater than 300,000 cases in the United States (U.S.). Chagas disease can lead to chronic cardiomyopathy and cardiac complications, with variable cardiac presentations in pediatrics making it difficult to recognize. The purpose of our study is to better understand current knowledge and experience with Chagas related heart disease among pediatric cardiologists in the U.S. Methods We prospectively disseminated a 19-question survey to pediatric cardiologists via 3 pediatric cardiology listservs. The survey included questions about demographics, Chagas disease presentation and experience. Results Of 139 responses, 119 cardiologists treat pediatric patients in the U.S. and were included. Most providers (87%) had not seen a case of Chagas disease in their practice; however, 72% also had never tested for it. The majority of knowledge-based questions about Chagas disease cardiac presentations were answered incorrectly, and 85% of providers expressed discomfort with recognizing cardiac presentations in children. Most respondents selected that they would not include Chagas disease on their differential diagnosis for presentations such as conduction anomalies, myocarditis and/or apical aneurysms, but would be more likely to include it if found in a Latin American immigrant. Of respondents, 87% agreed that they would be likely to attend a Chagas disease-related lecture. Conclusions Pediatric cardiologists in the U.S. have seen very few cases of Chagas disease, albeit most have not sent testing or included it in their differential diagnosis. Most individuals agreed that education on Chagas disease would be worth-while.

scholarly journals Evolution of anti-Trypanosoma cruzi antibody production in patients with chronic Chagas disease: Correlation between antibody titers and development of cardiac disease severity

2017 ◽  
Vol 11 (7) ◽  
pp. e0005796 ◽  
Author(s):  
Ingebourg Georg ◽  
Alejandro Marcel Hasslocher-Moreno ◽  
Sergio Salles Xavier ◽  
Marcelo Teixeira de Holanda ◽  
Eric Henrique Roma ◽  
...  
Keyword(s):  
Trypanosoma Cruzi ◽  
Disease Severity ◽  
Chagas Disease ◽  
Antibody Production ◽  
Cardiac Disease ◽  
Antibody Titers ◽  
Chronic Chagas Disease

scholarly journals Correction: Trypanosoma cruzi-specific IFN-γ-producing cells in chronic Chagas disease associate with a functional IL-7/IL-7R axis

2019 ◽  
Vol 13 (2) ◽  
pp. e0007168 ◽  
Author(s):  
María A. Natale ◽  
Gonzalo Cesar ◽  
Maria G. Alvarez ◽  
Melisa D. Castro Eiro ◽  
Bruno Lococo ◽  
...  
Keyword(s):  
Trypanosoma Cruzi ◽  
Chagas Disease ◽  
Ifn Γ ◽  
Chronic Chagas Disease

Functionally active cardiac antibodies in chronic Chagas' disease are specifically blocked by Trypanosoma cruzi antigens

1998 ◽  
Vol 12 (14) ◽  
pp. 1551-1558 ◽  
Author(s):  
Masako Oya Masuda ◽  
Mariano Levin ◽  
Selma Farias De Oliveira ◽  
Patricia C. Dos Santos Costa ◽  
Pablo Lopez Bergami ◽  
...  
Keyword(s):  
Trypanosoma Cruzi ◽  
Chagas Disease ◽  
Chronic Chagas Disease

Antibody Levels to Trypanosoma Cruzi in Infected Patients with and without Evidence of Chronic Chagas' Disease *

1982 ◽  
Vol 31 (3) ◽  
pp. 452-458 ◽  
Author(s):  
Renato d'A. Gusmāo ◽  
Joffre M. Rezende ◽  
Anis Rassi ◽  
Albert A. Gam ◽  
Franklin A. Neva
Keyword(s):  
Trypanosoma Cruzi ◽  
Chagas Disease ◽  
Antibody Levels ◽  
Chronic Chagas Disease

scholarly journals The indeterminate form of human chronic Chagas' disease: a clinical epidemological review

1989 ◽  
Vol 22 (3) ◽  
pp. 147-156 ◽  
Author(s):  
João Carlos Pinto Dias
Keyword(s):  
Natural History ◽  
Trypanosoma Cruzi ◽  
Chagas Disease ◽  
Clinical Findings ◽  
X Rays ◽  
Classical Concept ◽  
Positive Serology ◽  
Indeterminate Form ◽  
History Of ◽  
Chronic Chagas Disease

Data on the epidemiology and the natural history of the indeterminate form of human chronic Chagas' disease (IFCCD) are discussed, revealing its great importance in endemic areas of Brazil. The work shows that IFCCD presents a gradual and very slow course, causing a benign picture in the studied patients. Evolution patterns, prognostic and anatomopathological features are also discussed. For practical purposes, the classical concept of IFCCD proved to be simple, operational and consistent, It is defined by the absence of symptoms and clinical findings in chronic infected patients with positive serology and/or parasitological examinations for Trypanosoma cruzi coupled with normal electrocardiographic and radiological exams (heart, oesophagus and colon X-Rays). If a patient is submitted to more rigorous and sophisticated tests, these can reveal some alterations, generally small ones and unable to interfere with the prognosis of the infection. It is suggested that research lines specially related to the evolution ary factors and immunological involvement during this phase be adopted.

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