scholarly journals Extracellular Glycosaminoglycans in Management of Primary Hepatocellular Carcinoma Rather than Alpha Fetoprotein

2016 ◽  
Vol 3 (1) ◽  
Author(s):  
Abdel-Hamid NM ◽  
◽  
Abdel-Fattah SM ◽  
Nazmy MH ◽  
Mahmoud AS ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Hepatocellular Carcinoma ◽  
Extracellular Matrix ◽  
Cancer Progression ◽  
Cost Effective ◽  
Diagnostic Value ◽  
Primary Hepatocellular Carcinoma ◽  
Diagnostic Tools ◽  
Total Sialic Acid ◽  
Design And Methods

Objectives: Extracellular matrix (ECM) is an essential player at various stages of carcinogenesis. Current study aims to evaluate diagnostic value of components of ECM, released to the serum, i.e. total glycosaminoglycans (TGAGs), total sialic acid (TSA) and free glucosamine (FGA) in primary HCC patients solely or confounded by other conditions (i.e. diabetes mellitus (DM), hepatitis C virus (HCV) or bilharziasis (B). Design and Methods: Our study was conducted upon 40 HCC patients: 32 (80%) males, 8 (20%) females, among these samples, patients with ascites, single/or multiple HCC lesions, as shown in demographic Table. Results: Liver and renal indices were significantly disturbed in HCC patients. Significant elevations of AFP, TGAGS and FGA, non-significant increases in TSA in HCC patients compared to normal control. These parameters except AFP showed significant persistent higher levels during cancer progression. AFP showed irrelevant changes to the stages of HCC lesion. HCC patients with HCV, DM or B showed significantly higher levels of AFP than with HCC solely. Both TGAGs and FGA showed the highest diagnostic accuracy over AFP, but TSA showed the lowest value. Conclusion: TGAGs and FGA may be regarded as cost-effective and more accurate diagnostic tools during primary HCC progression, whether solely, or commixed by other diseases.

Diagnostic Value of Serum Ferritin in Primary Hepatocellular Carcinoma

Digestion ◽  
1984 ◽  
Vol 30 (4) ◽  
pp. 236-241 ◽  
Author(s):  
E. Giannoulis ◽  
C. Arvanitakis ◽  
A. Nikopoulos ◽  
I. Doutsos ◽  
A. Tourkantonis
Keyword(s):  
Hepatocellular Carcinoma ◽  
Serum Ferritin ◽  
Diagnostic Value ◽  
Primary Hepatocellular Carcinoma

scholarly journals Diagnostic Value of Adenosine Deaminase and Its Isoforms in Type II Diabetes Mellitus

2016 ◽  
Vol 2016 ◽  
pp. 1-6 ◽  
Author(s):  
Bagher Larijani ◽  
Ramin Heshmat ◽  
Mina Ebrahimi-Rad ◽  
Shohreh Khatami ◽  
Shirin Valadbeigi ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Adenosine Deaminase ◽  
Type Ii Diabetes ◽  
Diagnostic Marker ◽  
Diagnostic Value ◽  
Type Ii Diabetes Mellitus ◽  
Total Serum ◽  
High Hba1c ◽  
Design And Methods

Background and Aims. In the present study, we have investigated the activity of adenosine deaminase (ADA) as a diagnostic marker in type 2 (or II) diabetes mellitus (T2DM). Design and Methods. The deaminase activity of ADA1 and ADA2 was determined in serum from 33 patients with type 2 (or II) diabetes mellitus and 35 healthy controls. We also determined the proportion of glycated hemoglobin (HbA1c). Results. Our results showed significant differences between total serum ADA (tADA) and ADA2 activities in the diabetic groups with HbA1c < 8 (%) and HbA1c ≥ 8 (%) with respect to the values in healthy individuals (p<0.001). ADA2 activity in patients with high HbA1c was found to be much higher than that in patients with low HbA1c (p=0.0001). In addition, total ADA activity showed a significant correlation with HbA1c (r=0.6, p<0.0001). Conclusions. Total serum ADA activity, specially that due to ADA2, could be useful test for the diagnosis of type 2 (or II) diabetes mellitus.

scholarly journals Estimation of serum Alpha feto-protein (AFP), interlukin-6 and Des-?-carboxyprothrombin (DCP) in case of hepatocellular carcinoma

2016 ◽  
Vol 15 (2) ◽  
pp. 230-233 ◽  
Author(s):  
Syed Shahzadul Haque ◽  
Rekha Kumari ◽  
Ali Muzaffar ◽  
Uday Kumar ◽  
Anand Sharan ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Tumor Marker ◽  
Medical Science ◽  
Diagnostic Value ◽  
Incidence Rates ◽  
Intrahepatic Metastasis ◽  
Sub Saharan Africa ◽  
Primary Hepatocellular Carcinoma ◽  
Enzyme Linked Immunosorbent Assay ◽  
Primary Malignancy

Background: Hepatocellular carcinoma (HCC) is one the most common primary malignancy of the liver and represents the third leading cause of cancer-related deaths worldwide. Incidence rates are highest in East Asia and Sub-Saharan Africa. A number of evidence suggests a possible role of interleukin-6 (IL-6), ?-Fetoprotein (AFP) and Des-?-carboxyprothrombin (DCP) in the pathogenesis of hepatocellular carcinoma (HCC). The high DCP may be related to increase tumour behaviour, such as the presence of vascular invasion and intrahepatic metastasis of HCC cells. Patients and methods: We studied IL-6, AFP and DCP in patients with HCC or in healthy controls. AFP was measured by chemiluminescent immunoassay; Serum IL-6 and DCP were measured by enzyme linked immunosorbent assay in 30 patients with primary hepatocellular carcinoma and 30 normal subjects.Results: IL-6, AFP and DCP were found high in the serum of patients initially diagnosed with HCC (18±9.8), (315.99±594.62) and (26.15±5.01) respectively compared with healthy subjects (4.29±2.10), (3.13±1.27) and (4.25±1.22). A significant positive correlation was found between mean levels of IL- 6 & AFP in HCC (P < 0.05), Combination of IL-6, AFP and DCP improved the sensitivity in diagnosing HCC or predicting future HCC development. Conclusions: IL-6, DCP along with AFP could be considered a promising tumor marker for HCC. DCP is a well recognized tumor marker for the screening and diagnosis of HCC. In particular, the diagnostic value of the test is significantly increased when combined with AFP.Bangladesh Journal of Medical Science Vol.15(2) 2016 p.230-233

scholarly journals Extracellular matrix signatures of human mammary carcinoma identify novel metastasis promoters

eLife ◽  
2014 ◽  
Vol 3 ◽  
Author(s):  
Alexandra Naba ◽  
Karl R Clauser ◽  
John M Lamar ◽  
Steven A Carr ◽  
Richard O Hynes
Keyword(s):  
Extracellular Matrix ◽  
Cancer Progression ◽  
Stromal Cells ◽  
Mammary Carcinoma ◽  
Metastatic Potential ◽  
Diagnostic Tools ◽  
Breast Cancer Patients ◽  
Human Mammary Carcinoma ◽  
Primary Tumors ◽  
Novel Biomarkers

The extracellular matrix (ECM) is a major component of tumors and a significant contributor to cancer progression. In this study, we use proteomics to investigate the ECM of human mammary carcinoma xenografts and show that primary tumors of differing metastatic potential differ in ECM composition. Both tumor cells and stromal cells contribute to the tumor matrix and tumors of differing metastatic ability differ in both tumor- and stroma-derived ECM components. We define ECM signatures of poorly and highly metastatic mammary carcinomas and these signatures reveal up-regulation of signaling pathways including TGFβ and VEGF. We further demonstrate that several proteins characteristic of highly metastatic tumors (LTBP3, SNED1, EGLN1, and S100A2) play causal roles in metastasis, albeit at different steps. Finally we show that high expression of LTBP3 and SNED1 correlates with poor outcome for ER−/PR−breast cancer patients. This study thus identifies novel biomarkers that may serve as prognostic and diagnostic tools.

scholarly journals Value of AFP and PIVKA-II in Diagnosis of Primary Hepatocellular Carcinoma and Prediction of Vascular Invasion and Tumor Differentiation

2020 ◽  
Author(s):  
Yuan-quan Si ◽  
Xiu-Qin Wang ◽  
Gang Fan ◽  
Chang-Yin Wang ◽  
Yuan-Wen Zheng ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Roc Curve ◽  
Vascular Invasion ◽  
Serum Levels ◽  
Diagnostic Value ◽  
Primary Hepatocellular Carcinoma ◽  
Tumor Differentiation ◽  
Clinical Value ◽  
The Individual ◽  
Combined Detection

Abstract Background: To explore the value of alpha fetoprotein (AFP) and protein induced by vitamin K absence or antagonist-II (PIVKA-II) in diagnosis of primary hepatocellular carcinoma (HCC) and their relationship with vascular invasion, tumor differentiation and size. Methods: A total of 433 participants were enrolled in this study including 266 cases with HCC, 87 cases with liver cirrhosis and 80 healthy individuals. Then we explored the correlation between AFP, PIVKA-II serum level and several pathological features such as vascular invasion, tumor differentiation and size. The value of these two markers used singly or jointly in diagnosing HCC was evaluated by receiver operating characteristic (ROC) curve. The ROC curve was also plotted to identify AFP, PIVKA-II serum cut-off values that would best distinguish HCC patients with and without vascular invasion.Results: The level of AFP and PIVKA-II in HCC group was significantly higher (Z was 7.428, 11.243 respectively, all P<0.01). When AFP and PIVKA-II were used as the individual tumor marker, the areas under the ROC curve (AUC) of HCC diagnosis were 0.765 (95% CI, 0.713～0.8170) for AFP, 0.901 (95% CI, 0.868～0.935) for PIVKA-II, and 0.917 (95% CI, 0.886～0.948) for AFP and PIVKA-II simultaneously. The serum levels of AFP and PIVKA-II were positively correlated with tumor differentiation and size. High AFP and PIVKA-II expression was significantly associated with the presence of vascular invasion (P was 0.007 and 0.014 respectively). The AFP level >64.4ng/ml or PIVKA-II level >957.61mAU/ml was the best critical value to predict the presence of vascular invasion. Conclusion: Our results validate that AFP and PIVKA-II play a significant role in the diagnosis of HCC. The diagnostic value of AFP and PIVKA-II combined detection or single assay of PIVKA-II is higher than that of separate assay of AFP. Moreover, their concentration has important clinical value in judging tumor size, tumor cell differentiation and vascular invasion.

scholarly journals Value of AFP and PIVKA-II in diagnosis of primary hepatocellular carcinoma and prediction of vascular invasion and tumor differentiation

2019 ◽  
Author(s):  
Yuan-Quan Si(Former Corresponding Author) ◽  
Xiu-qin Wang ◽  
Gang fan ◽  
chang-yin wang ◽  
yuan-wen zheng ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Roc Curve ◽  
Vascular Invasion ◽  
Serum Levels ◽  
Diagnostic Value ◽  
Primary Hepatocellular Carcinoma ◽  
Tumor Differentiation ◽  
Clinical Value ◽  
The Individual ◽  
Combined Detection

Abstract Background: To explore the value of alpha fetoprotein (AFP) and protein induced by vitamin K absence or antagonist-II (PIVKA-II) in diagnosis of primary hepatocellular carcinoma (HCC) and their relationship with vascular invasion, tumor differentiation and size. Methods: A total of 433 participants were enrolled in this study including 266 cases with HCC, 87 cases with liver cirrhosis and 80 healthy individuals. Then we explored the correlation between AFP, PIVKA-II serum level and several pathological features such as vascular invasion, tumor differentiation and size. The value of these two markers used singly or jointly in diagnosing HCC was evaluated by receiver operating characteristic (ROC) curve. The ROC curve was also plotted to identify AFP, PIVKA-II serum cut-off values that would best distinguish HCC patients with and without vascular invasion. Results: The level of AFP and PIVKA-II in HCC group was significantly higher (Z was 7.428, 11.243 respectively, all P<0.01). When AFP and PIVKA-II were used as the individual tumor marker, the areas under the ROC curve (AUC) of HCC diagnosis were 0.765 (95% CI, 0.713～0.8170) for AFP, 0.901 (95% CI, 0.868～0.935) for PIVKA-II, and 0.917 (95% CI, 0.886～0.948) for AFP and PIVKA-II simultaneously. The serum levels of AFP and PIVKA-II were positively correlated with tumor differentiation and size. High AFP and PIVKA-II expression was significantly associated with the presence of vascular invasion (P was 0.007 and 0.014 respectively). The AFP level >64.4ng/ml or PIVKA-II level >957.61mAU/ml was the best critical value to predict the presence of vascular invasion. Conclusion: The diagnostic value of AFP and PIVKA-II combined detection or single assay of PIVKA-II is higher than that of separate assay of AFP. And the proper concentration has important clinical value for judging tumor size, tumor cell differentiation and vascular invasion. Above results validate that AFP and PIVKA-II play a significant role in the diagnosis of HCC.

Matrix metalloproteinases as biomarkers of disease: updates and new insights

2015 ◽  
Vol 53 (3) ◽  
Author(s):  
Emanuela Galliera ◽  
Lorenza Tacchini ◽  
Massimiliano M. Corsi Romanelli
Keyword(s):  
Extracellular Matrix ◽  
Cardiovascular Diseases ◽  
Matrix Metalloproteinases ◽  
Cancer Progression ◽  
Neurodegenerative Disorders ◽  
Clinical Management ◽  
Diagnostic Tools ◽  
Clinical Use ◽  
Diagnostic Panel

AbstractMatrix metalloproteinases (MMPs) play a pivotal role in remodeling the extracellular matrix (ECM) and are therefore of interest for new diagnostic tools for the clinical management of diseases involving ECM disruption. This setting ranges from the classical areas of MMP studies, such as vascular disease, cancer progression or bone disorders, to new emerging fields of application, such as neurodegenerative disease or sepsis. Increasing the knowledge about the role of MMPs in the pathogenesis of diseases where a clear diagnostic panel is still lacking could provide new insight and improve the identification and the clinical treatment of these human diseases. This review focuses on the latest descriptions of the clinical use of MMP as biomarkers in the diagnosis, prognosis and monitoring of different diseases, such as diabetes, cardiovascular diseases, cancer and metastasis, neurodegenerative disorders and sepsis.

scholarly journals Diagnostic value of imaging examinations in patients with primary hepatocellular carcinoma

2018 ◽  
Vol 6 (9) ◽  
pp. 242-248 ◽  
Author(s):  
Xing-Hui Li ◽  
Qi Liang ◽  
Tian-Wu Chen ◽  
Jian Wang ◽  
Xiao-Ming Zhang
Keyword(s):  
Hepatocellular Carcinoma ◽  
Diagnostic Value ◽  
Primary Hepatocellular Carcinoma
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