scholarly journals Regulatory adaptive status in determining the effectivenessof bisoprololum and sotalolum in patients with hypertensive disease and ventricular arrhythmias

2016 ◽  
Vol 13 (1) ◽  
pp. 15-21
Author(s):  
I Z Shubitidze ◽  
V G Tregubov ◽  
V M Pokrovsky
Keyword(s):  
Combination Therapy ◽  
Ventricular Arrhythmias ◽  
Negative Impact ◽  
Subjective Assessment ◽  
Functional Condition ◽  
Grading System ◽  
Hypertensive Disease ◽  
Drug Regimens ◽  
Minute Walk

Aim. Compare the effectiveness of treatment with bisoprololum or sotalolum in patients with hypertensive disease (HD) and ventricular arrhythmias (VA) taking into account quantitative evaluation of the regulatory adaptive status (RAS).Materials and methods. 48 patients with HD of stages II-III and VA of grade I-IV based on the В.Lown grading system, II-III groups based on J.Bigger grading system took part in the research, they were randomized into two groups for treatment with bisoprololum (6.2±1.7 mg/day) or sotalolum (159.1±47.4 mg/day). As part of combination therapy, patients were administered lisinoprilum (12.8±4.2 mg/day and 13.7±4.5 mg/day), acetylsalicylic acid when required (93.1±19.0 and 95.0±16.2 mg/day), atorvastatinum (15.9±4.6 mg/day and 15.6±4.9 mg/day), respectively. Initially and 6 months after therapy, the following was done: quantitative assessment of RAS (by cardio-respiratory synchronism test), echocardiography, triplex scanning of brachiocephalic arteries, treadmill test, six-minute walk test, all-day monitoring of blood pressure and electrocardiogram, subjective assessment of quality of life.Results. Both drug regimens comparably improved structural and functional condition of the heart, increased exercise tolerance, controlled arterial hypertension, effectively suppressed ventricular arrhythmia, improved the quality of life. At the same time, the use of sotalolum decreased the RAS to a lesser degree than the use of bisoprololum.Conclusion. In patients with HD of stages II-III and VA the use of sotalolum as part of combination therapy may be preferable to bisoprololum due to its less negative impact on the RAS.

scholarly journals Regulatory adaptive status in determining the effectiveness of nebivololum and sotalolum in patients with hypertensive disease and paroxysmal atrial fibrillation

2016 ◽  
Vol 13 (4) ◽  
pp. 30-35
Author(s):  
M A Eremina ◽  
V G Tregubov ◽  
V M Pokrovsky
Keyword(s):  
Quality Of Life ◽  
Combination Therapy ◽  
Positive Impact ◽  
Subjective Assessment ◽  
Functional Condition ◽  
Hypertensive Disease ◽  
Drug Regimens ◽  
Brachiocephalic Arteries ◽  
Minute Walk

Aim: compare the effectiveness of treatment with nebivololum or sotalolum in patients with hypertensive disease (HD) and paroxysmal atral fibrillation (AF) taking into account quantitative evaluation of the regulatory adaptive status (RAS). Materials and methods. 50 patients with HD of stages II-III and paroxysmal AF took part in the research, they were randomized into two groups for treatment with nebivololum (5.6±1.6 mg/day n=25) or sotalolum (157.0±38.3 mg/day, n=25). As part of combination therapy, patients were administered lisinoprilum (14.3±3.7 mg/day and 14.4±3.9 mg/day), when required alsoatorvastatinum (18.8±4.4 mg/day, n=11 and 16.0±5.1 mg/day, n=12), acetylsalicylic acid (91.2±14.1 mg/day, n=11and 92.1±16.8 mg/day, n=11), respectively. Initially and 6 months after therapy, the following was done: quantitative assessment of RAS (by cardio-respiratory synchronism test), echocardiography, triplex scanning of brachiocephalic arteries, treadmill test, six-minute walk test, all-day monitoring of blood pressure and electrocardiogram, subjective assessment of quality of life. Results. Both drug regimens comparably improved structural and functional condition of the heart, controlled arterial hypertension, effectively suppressed paroxysms of AF, improved the quality of life. At the same time, the use of nebivololum increased the RAS and increased exercise tolerance, to a lesser degree than the use of sotalolum. Conclusion. In patients with HD of stages II-III and paroxysmal AF the use of nebivololum as part of combination therapy may be preferable to sotalolum due to its positive impact on the RAS.

scholarly journals Regulatory adaptive status in determining the effectiveness of nebivololum and sotalolum in patients with hypertensive disease and paroxysmal supraventricular tachycardia

2017 ◽  
Vol 14 (4) ◽  
pp. 20-26
Author(s):  
N M Nazhalkina ◽  
V G Tregubov ◽  
V M Pokrovsky
Keyword(s):  
Quality Of Life ◽  
Combination Therapy ◽  
Supraventricular Tachycardia ◽  
Positive Impact ◽  
Subjective Assessment ◽  
Functional Condition ◽  
Paroxysmal Supraventricular Tachycardia ◽  
Drug Regimens ◽  
Minute Walk

Objective. Compare the effectiveness of treatment with nebivololum or sotalolum in patients with paroxysmal supraventricular tachycardia (SVT) on a background of essential hypertension (EH) taking into account quantitative evaluation of the regulatory adaptive status (RAS). Materials and methods. 49 patients with paroxysmal SVT against the background of EH of stages II-III took part in the research, they were randomized into two groups for treatment with nebivololum (7.4±1.9 mg/day n=25) or sotalolum (162.5±46.2 mg/day n=24). As part of combination therapy, patients were administered lisinoprilum (14.4±4.4 and 14.3±4.7 mg/day), when required also atorvastatinum (15.9±4.1 mg/day, n=9 and 16.0±4.8 mg/day, n=10), acetylsalicylic acid (93.1±16.2 mg/day, n=14 и 94.1±16.5 mg/day, n=14). Initially and 6 months after therapy, the following was done: quantitative assessment of RAS (by cardio-respiratory synchronism test), echocardiography, triplex scanning of brachiocephalic arteries, treadmill test, six-minute walk test, all-day monitoring of blood pressure and electrocardiogram, subjective assessment of quality of life. Results. Both drug regimens comparably improved structural and functional condition of the heart, controlled arterial hypertension, effectively suppressed paroxysms of SVT, improved the quality of life. At the same time, the use of nebivololum increased the RAS and increased exercise tolerance to a greater degree than the use of sotalolum. Conclusion. In patients with paroxysmal SVT against the background of EH of stages II-III, the use of nebivololum as part of combination therapy may be preferable to sotalolum due to its positive impact on the RAS.

scholarly journals The results of a comparative study effectiveness of therapy with nebivolol and sotalol in patients with ventricular arrhythmias.

2018 ◽  
Vol 95 (11) ◽  
pp. 1050-1056
Author(s):  
V. G. Tregubov ◽  
Iosif Z. Shubitidze ◽  
S. G. Kanorskii ◽  
V. M. Pokrovsky
Keyword(s):  
Quality Of Life ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Essential Hypertension ◽  
Combination Therapy ◽  
Ventricular Arrhythmias ◽  
Positive Impact ◽  
Functional Condition ◽  
Grading System

Aim. Compare the effectiveness of nebivolol and sotalol in patients ventricular arrhythmias (VA) given its impact on the regulatory adaptive status (RAS). Material and methods. 60 patients with VA of grade I-IV based on the В.Lown grading system, I-II groups based on J.T. Bigger grading system against the background of essential hypertension and/or coronary heart disease took part in the research, they were randomized into two groups for treatment with nebivolol (6,5 ± 2,1 mg/day) and sotalol (166,7 ± 49,4 mg/day). As part of combination therapy, patients were administered lisinopril (13,7 ± 4,5 mg/day and 14,0 ± 4,6 mg/day), acetylsalicylic acid when required (92,9 ± 18,2 mg/day and 95,5 ± 15,1 mg/day), atorvastatin (16,5 ± 4,7 mg/day and 15,7 ± 5,1 mg/day) in addition to nebivolol and sotalol, respectively. Initially and 6 months after therapy, the following was done: quantitative assessment of RAS (by cardio-respiratory synchronism test), echocardiography, triplex scanning of common carotid arteries, treadmill test, six-minute walk test, all-day monitoring of blood pressure and electrocardiogram, subjective assessment of quality of life. Results. Both drug regimens comparably improved structural and functional condition of the heart, increased controlled arterial hypertension, effectively suppressed ventricular arrhythmia, improved the quality of life. Nebivolol positively affected the RAS and increased exercise tolerance more. Conclusion. In patients with VA against the background of essential hypertension and/or coronary heart disease as part of combination therapy the use of nebivolol may be preferable to sotalol due to its positive impact on the RAS.

scholarly journals Effects of the b-blockers on the functional state of patients with ventricular arrhythmias

2021 ◽  
Vol 18 (1) ◽  
pp. 19-24
Author(s):  
Iosif Z. Shubitidze ◽  
Vitalii G. Tregubov
Keyword(s):  
Quality Of Life ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Essential Hypertension ◽  
Combination Therapy ◽  
Functional State ◽  
Ventricular Arrhythmias ◽  
Grading System ◽  
Positive Effect

Sudden cardiac death and the heaviest arrhythmic events are connected to ventricular arrhythmias (VA). The issue of optimization of drug therapy for VA remains relevant. Given the possible multidirectional effects of antiarrhythmic drugs on the functional state, in order to determine the effectiveness of pharmacotherapy in patients with VA it is advisable to use a stepwise integrated approach. Aim. Compare the effects of bisoprolol, nebivolol and sotalol on the functional state of patients with VA. Materials and methods. 120 patients with VA of grade IIV based on the В. Lown grading system, III groups based on J. Bigger grading system against the background of essential hypertension or its combination with coronary heart disease took part in the research, they were randomized into three groups for treatment with bisoprolol, nebivolol and sotalol. As part of combination therapy, patients were administered lisinopril, and if indicated, acetylsalicylic acid, atorvastatin. Initially and after 24 weeks of therapy the following was done: quantitative assessment of regulatory-adaptive status by cardio-respiratory synchronism test, treadmill test, six-minute walk test, subjective assessment of quality of life, all-day monitoring of blood pressure and electrocardiogram. Results. With comparable hypotensive and antiarrhythmic effects, therapy with nebivolol had a positive effect on the regulatory-adaptive status, had a better effect on exercise tolerance in comparison with bisoprolol and sotalol, more improved the quality of life, in comparison with bisoprolol and sotalol. Conclusion. In patients with VA against the background of essential hypertension or its combination with coronary heart disease as part of combination therapy the use of nebivolol may be preferable to bisoprolol or sotalol due to a more pronounced positive effect on the functional state.

scholarly journals Assessment of the effect of -blockers on the functional state in patients with ventricular arrhythmias: results of a comparative study

2020 ◽  
Vol 11 (2) ◽  
pp. 23-27
Author(s):  
Iosif Z. Shubitidze ◽  
Vitalii G. Tregubov
Keyword(s):  
Quality Of Life ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Essential Hypertension ◽  
Combination Therapy ◽  
Functional State ◽  
Ventricular Arrhythmias ◽  
Subjective Assessment ◽  
Positive Effect

Aim.Compare the effects of bisoprolol, nebivolol and sotalol on the functional state of patients with ventricular arrhythmias (VA). Material and methods.120 patients with VA against the background of essential hypertension or its combination with coronary heart disease took part in the research, they were randomized into three groups for treatment with bisoprolol, nebivolol and sotalol. As part of combination therapy, patients were administered lisinopril, and if indicated, acetylsalicylic acid, atorvastatin. Initially and after 24 weeks of therapy the following was done: echocardiography, treadmill test, six-minute walk test, subjective assessment of quality of life, all-day monitoring of blood pressure and electrocardiogram. Results.With comparable hypotensive and antiarrhythmic effects, therapy with nebivolol increased exercise tolerance to a greater extent, in comparison with bisoprolol and sotalol. Nebivolol and sotalol improved the quality of life, in comparison with bisoprolol. Conclusion.In patients with VA against the background of essential hypertension or its combination with coronary heart disease as part of combination therapy the use of nebivolol may be preferable to bisoprolol or sotalol due to a more pronounced positive effect on the functional state.

scholarly journals DETERMINATION OF THE IMPACT OF BISOPROLOL AND СARVEDILOL ON REGULATORY-ADAPTIVE STATUS OF PATIENTS WITH CHRONIC HEART FAILURE AND PRESERVED LEFT VENTRICULAR FRACTION

2020 ◽  
pp. 86-92
Author(s):  
V. G. Tregubov ◽  
P. V. Khilkevich ◽  
I. Z. Shubitidze ◽  
V. M. Pokrovsky
Keyword(s):  
Quality Of Life ◽  
Heart Failure ◽  
Chronic Heart Failure ◽  
Combination Therapy ◽  
Positive Impact ◽  
Subjective Assessment ◽  
Left Ventricular ◽  
The Impact

Objective. To determine the effect of bisoprolol or carvedilol therapy on the regulatory-adaptive status (RAS) of patients with chronic heart failure (CHF) and preserved ejection fraction (pEF) of the left ventricle (LV) the background of hypertensive disease (HD).Material and methods. The study involved 68 patients with CHF and pEF of the LV, who were randomized into two groups for treatment with bisoprolol (7,3±2,4 mg/day, n=34) and carvedilol (28,4±12,3 mg/day, n=34). As part of the combination therapy, quinapril was prescribed (13,5±2,5 mg/ day, n=34 and 12,6±2,9 mg/day, n=34), and if indicated – atorvastatin (16,3±5,0 mg/day, n=11 and 15,5±5,2 mg/day, n=11) and acetylsalicylic acid in the intestinal soluble shell (93,8±17,7 mg/day, n=8 and 94,4±15,8 mg/day, n=8), respectively. Initially and after 6 months of therapy were carried out: quantitative assessment of RAS (by means of a sample of cardiac-respiratory synchronism), treadmill test, six-minute walking test, subjective assessment of quality of life, determination of the level of N-terminal fragment of brain natriuretic peptide, echocardioscopy, daily monitoring of blood pressure.Results. Both regimens of combined drug therapy had comparable cardioprotective, hypotensive and neuromodulating effects, equally increased exercise tolerance. In comparison with bisoprolol, carvedilol differed positive impact on RAS, improved quality of life more.Conclusion. In patients with CHF and pEF LV in combination therapy, the use of carvedilol, in comparison with bisoprolol, may be preferable due to the positive effect on the RAS.

scholarly journals Assessment of disorders of carbohydrate and fat metabolism in children under conditions of oral exposure to organochlorine compounds

2020 ◽  
Vol 99 (11) ◽  
pp. 1263-1270
Author(s):  
Konstantin P. Luzhetskiy ◽  
Vladimir M. Chigvintsev ◽  
Svetlana A. Vekovshinina ◽  
Alexandra Yu. Vandysheva ◽  
Daria A. Eisfeld
Keyword(s):  
Drinking Water ◽  
Carbohydrate Metabolism ◽  
Comparison Group ◽  
Negative Impact ◽  
Critical Assessment ◽  
Organochlorine Compounds ◽  
Oral Exposure ◽  
Hypertensive Disease ◽  
Prevalence Of Obesity

Introduction. The authors performed a hygienic and epidemiological study of the Perm Territory areas with unfavorable sanitary and hygienic indices. Material and methods. The study involved 7,775 children aged from 4 to 14 years (9.2 ± 3.7 years) living in territories using sodium hypochlorite or liquid chlorine (Perm, Krasnokamsky, Nytvensky districts). The comparison group consisted of 425 children (average age 9.3 ± 2.5 years) consuming drinking water that complies with hygienic standards (Sivinsky, Karagai districts). Results. Identified areas with low quality of drinking water supply due to the content of organochlorine compounds (OCS) appeared to have an increased prevalence of obesity, diabetes, ischemic, and hypertensive disease. The authors developed and tested the critical assessment of the risk of formation disorders of fat and carbohydrate metabolism in children consuming drinking water with a high content of organochlorine compounds. Under conditions of oral exposure to OCS (0.43-0.64 mg / l, more than 3 MPC), the index of the risk of impaired fat and carbohydrate metabolism in children (IPI 0.55) was 1.3 times higher than the corresponding levels in the territory of comparison (IPI 0,42). Conclusion. The main markers for the indices of the negative impact of HOS (primarily chloroform) include an increase in the blood level of triglycerides (PS 0.41), LDL (PS 0.25) and a decrease in HDL (PS 0.18), exceeding 1, 2-1.6 times the territory of comparison.

scholarly journals The role of regulatory adaptive status in determining the effectiveness of bisoprololum and sotalolum in patients with hypertensive disease and paroxysmal atrial fibrillation

2017 ◽  
Vol 95 (9) ◽  
pp. 810-816
Author(s):  
V. G. Tregubov ◽  
Marina A. Eremina ◽  
S. G. Kanorsky ◽  
V. M. Pokrovsky
Keyword(s):  
Quality Of Life ◽  
Atrial Fibrillation ◽  
Quantitative Assessment ◽  
Negative Impact ◽  
Beta Blockers ◽  
Combined Therapy ◽  
Functional Condition ◽  
The Body ◽  
Stage Ii

A rise in mortality from cardiovascular causes, systemic thromboembolism, and congestive heart failure, in the frequency of hospitalization and deterioration of the quality of life is associated with atrial fibrillation (AF). Essential hypertension (EH) and ischemic heart disease (IHD) are the most common causes of AF. To prevent recurrence of AF in patients with hypertension or IHD, beta-blockers (BAB) can be used. Taking into account the possible effect of multidirectional BAB on the functional state of the body, it is advisable to apply the quantitative assessment of the regulatory-adaptive status (RAS), in order to determine the effectiveness of therapy. Aim. To compare the effectiveness of treatment with bisoprololum or sotalolum in patients with paroxysmal AF associated with EH and/or IHD taking into account the quantitative evaluation of the regulatory adaptive status (RAS). Material and methods. 60 patients with paroxysmal AF , stage II-III EH and/or IHD took part in the study; they were randomized into two groups for the treatment with bisoprololum (6,7±1,6 mg/day n=30) or sotalolum (156,0±35,2 mg/day n=30). As part of combined therapy, the patients were administered lisinoprilum (12,9±3,8 mg/day and 13,3±4,0 mg/day) and, if required, atorvastatin (16,6±4,1 mg/day, n=12 and 16,3±4,9 mg/day, n=13) and acetylsalicylic acid (90,8±16,8 mg/day, n=13 и 91,7±14,4 mg/day, n=12), respectively. Initially and 6 months after therapy, the following was done: quantitative assessment of RAS (by cardio-respiratory synchronism test), echocardiography, triplex scanning of brachiocephalic arteries, treadmill test, six-minute walk test, all-day monitoring of blood pressure and electrocardiogram, subjective assessment of the quality of life. Results. Both drug regimens comparably improved structural and functional condition of the heart, increased exercise tolerance, controlled arterial hypertension, reduced symptoms of IHD, effectively suppressed paroxysms of AF, improved the quality of life. At the same time, sotalolum decreased the RAS to a lesser degree than bisoprololum. Conclusion. In patients with paroxysmal AF associated with stage II-III HD and/or IHD, the use of sotalolum as part of combined therapy may be preferable to bisoprololum due to its lower negative impact on the RAS.

scholarly journals A Proposal of Physical Performance Tests Adapted as Home Workout Options during the COVID-19 Pandemic

2020 ◽  
Vol 10 (14) ◽  
pp. 4755 ◽  
Author(s):  
Danúbia da Cunha de Sá-Caputo ◽  
Redha Taiar ◽  
Adérito Seixas ◽  
Borja Sanudo ◽  
Anelise Sonza ◽  
...  
Keyword(s):  
Negative Impact ◽  
Sedentary Behaviors ◽  
Timed Up And Go ◽  
Balance Test ◽  
Home Based ◽  
Physical Tests ◽  
The Individual ◽  
Clinical Conditions ◽  
Minute Walk

Social isolation and physical distancing measures, such as quarantine, local confinement, lockdown and isolation, aim to slow the spread of the coronavirus disease (COVID-19). This condition is necessary; however, sedentary behaviors are stimulated. The aim of this manuscript is to propose simple home-based exercises that everyone, considering their individual limitations, could perform. Moreover, individuals might monitor their performance daily. Feasible and useful home-based exercise strategies, to counter-balance the negative impact of the sedentary lifestyle during confinement, will stimulate the population to perform some exercises wherever possible. For this, home-based exercises were proposed based on physical tests, such as a stair climb test, balance test, single-leg-stance-test, gait speed, five-chair stand, free walking, free run, six-minute walk test, timed up and go, sit-and-reach, fingertip-to-floor test, and free physical exercises. It is important to consider that when the individual is performing the test, physical exercise is also being done. In conclusion, several exercises that consider the clinical conditions of the individuals and can reduce their sedentary behavior, considering COVID-19 confinement, are suggested to improve the population’s quality of life.

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