scholarly journals Assessment of disorders of carbohydrate and fat metabolism in children under conditions of oral exposure to organochlorine compounds

2020 ◽  
Vol 99 (11) ◽  
pp. 1263-1270
Author(s):  
Konstantin P. Luzhetskiy ◽  
Vladimir M. Chigvintsev ◽  
Svetlana A. Vekovshinina ◽  
Alexandra Yu. Vandysheva ◽  
Daria A. Eisfeld
Keyword(s):  
Drinking Water ◽  
Carbohydrate Metabolism ◽  
Comparison Group ◽  
Negative Impact ◽  
Critical Assessment ◽  
Organochlorine Compounds ◽  
Oral Exposure ◽  
Hypertensive Disease ◽  
Prevalence Of Obesity

Introduction. The authors performed a hygienic and epidemiological study of the Perm Territory areas with unfavorable sanitary and hygienic indices. Material and methods. The study involved 7,775 children aged from 4 to 14 years (9.2 ± 3.7 years) living in territories using sodium hypochlorite or liquid chlorine (Perm, Krasnokamsky, Nytvensky districts). The comparison group consisted of 425 children (average age 9.3 ± 2.5 years) consuming drinking water that complies with hygienic standards (Sivinsky, Karagai districts). Results. Identified areas with low quality of drinking water supply due to the content of organochlorine compounds (OCS) appeared to have an increased prevalence of obesity, diabetes, ischemic, and hypertensive disease. The authors developed and tested the critical assessment of the risk of formation disorders of fat and carbohydrate metabolism in children consuming drinking water with a high content of organochlorine compounds. Under conditions of oral exposure to OCS (0.43-0.64 mg / l, more than 3 MPC), the index of the risk of impaired fat and carbohydrate metabolism in children (IPI 0.55) was 1.3 times higher than the corresponding levels in the territory of comparison (IPI 0,42). Conclusion. The main markers for the indices of the negative impact of HOS (primarily chloroform) include an increase in the blood level of triglycerides (PS 0.41), LDL (PS 0.25) and a decrease in HDL (PS 0.18), exceeding 1, 2-1.6 times the territory of comparison.

CHRONOBIOLOGICAL AND PSYCHOEMOTIONAL STATUS IN WOMEN WITH CHRONIC RECURRENT BACTERIAL CYSTITIS AND CARBOHYDRATE METABOLISM DISORDER

2020 ◽  
pp. 56-59
Author(s):  
Мария Николаевна Химичева ◽  
Андрей Владимирович Кузьменко ◽  
Владимир Васильевич Кузьменко ◽  
Тимур Асланбекович Гяургиев
Keyword(s):  
Chronic Disease ◽  
Carbohydrate Metabolism ◽  
Negative Impact ◽  
High Risk Group ◽  
Chronic Complications ◽  
Course Of Disease ◽  
Metabolism Disorder ◽  
Common Group ◽  
Tract Infections

Инфекции мочевых путей - наиболее распространённая группа заболеваний в практике врача уролога. Один из представителей является хронический рецидивирующий бактериальный цистит. Данное заболевание встречается во всех возрастных категориях и затрагивает все сферы жизни пациентов. Симптомы, возникающие при обострении хронического бактериального цистита, оказывают негативное влияние на качество жизни, что может приводить к нарушению психоэмоционального состояния больных. Отдельную группу высокого риска в отношении ИНМП составляют пациенты с нарушением углеводного обмена, у которых риск развития различных инфекций выше, чем у людей без подобных нарушений. К факторам, повышающим риск развития ИНМП у больных с нарушением углеводного обмена, относят возраст, компенсацию и наличие хронических осложнений, в первую очередь нефропатии и цистопатии. Человеческий организм функционирует циклически в соответствии с определенными индивидуальными ритмами. Любое хроническое заболевание приводит к рассогласованию процессов, протекающих в различных системах организма, вызывая развитие десинхроноза. Наличие у человека более 1 хронического заболевания утяжеляет течение болезни и приводит к снижению восстановительных способностей организма и сокращению его адаптационного потенциала Urinary tract Infections are the most common group of diseases in the practice of a urologist. One of the representatives is chronic recurrent bacterial cystitis. This disease occurs in all age categories and affects all areas of life of patients. Symptoms that occur with the exacerbation of chronic bacterial cystitis have a negative impact on the quality of life, which can lead to a violation of the psychoemotional state of patients. A separate high-risk group for INMP is patients with impaired carbohydrate metabolism, who have a higher risk of developing various infections than people without such disorders. Factors that increase the risk of developing INMP in patients with impaired carbohydrate metabolism include age, compensation, and the presence of chronic complications, primarily nephropathy and cystopathy. The human body functions cyclically in accordance with certain individual rhythms. Any chronic disease leads to misalignment of the processes occurring in various body systems, causing the development of DS, the Presence of more than 1 chronic disease complicates the course of disease and leads to a decrease in regenerative abilities of the organism and reduce its adaptive capacity

scholarly journals Influence of the quality of drinking water supply sources on the formation of the ecologically-dependent pathology of the population of the Republic of Dagestan

2021 ◽  
Vol 15 (4) ◽  
pp. 168-176
Author(s):  
M. G. Daudova ◽  
R. B. Bagomedova ◽  
K. K. Bekshokov ◽  
M. M. Medzhidova ◽  
S. M. Nakhibashev ◽  
...  
Keyword(s):  
Water Quality ◽  
Drinking Water ◽  
Water Supply ◽  
Negative Impact ◽  
Kidney Diseases ◽  
Ecological Condition ◽  
Drinking Water Quality ◽  
Chemical Contamination ◽  
The Republic

Aim. Study of the influence of drinking water quality on the ecologically-dependent morbidity of the population of the Republic of Dagestan.Material and Methods. Methods of current and retrospective analysis of regional health indicators and methods of mathematical-statistical and medical-geographical analysis were used. Statistical processing of the results was carried out using the STATISTICA and Excel software packages. When carrying out laboratory studies on the quality of drinking water, we used a Lumex atomic absorption spectrometer "MGA-915MD".Results. Numerous hygiene studies indicate the direct impact of unsatisfactory drinking water quality on the health of a population. The relationship between sanitary and chemical indicators and the incidence rate for a number of nosological forms has been proven. It is generally accepted that human health is influenced by lifestyle factors (working, living and relaxation conditions), heredity and the ecological condition of the area of residence, including the quality of drinking water. Although it is not possible to differentiate the share of the negative effect caused by the consumption of poor quality drinking water but the incidence of certain nosological forms (cancer of the esophagus, gastrointestinal tract and kidney diseases) in the those regions of the Republic of Dagestan under consideration correlates with the characteristics of drinking water.Conclusion. The problem of pollution of water supply sources for the population in the dynamics of the long-term remains a priority concern. The quality and safety of drinking water are decreasing, which cannot but have a negative impact on public health. Correlation linkages between indicators of drinking water quality and oncological morbidity of the population were also established in indicators below the maximum permissible concentrations, which corresponds to a typical logistic model of causal relationships and serves as evidence of the high dependence of health disorders on chemical contamination of water supply sources. 

scholarly journals SCIENTIFIC AND METHODOLOGICAL ASPECTS AND PRACTICAL EXPERIENCE FOR THE FORMATION OF THE EVIDENTIAL BASE OF HAZARD TO HEALTH IN THE POPULATION IN THE ZONE OF INFLUENCE OF WASTE FROM THE PAST ECONOMIC ACTIVITY

2019 ◽  
Vol 96 (11) ◽  
pp. 1038-1044 ◽  
Author(s):  
N. V. Zaitseva ◽  
Irina V. May ◽  
S. V. Klein ◽  
S. S. Khankharev ◽  
A. A. Boloshinova
Keyword(s):  
Heavy Metals ◽  
Drinking Water ◽  
Negative Impact ◽  
Health Hazard ◽  
Harmful Effect ◽  
Morbidity Rate ◽  
Atmospheric Air ◽  
The Past ◽  
Zone Of Influence

There are described an algorithm and methods for collecting the evidential base for causing hazard to the health of the population of Zakamensk (the Republic of Buryatia) in the zone of influence of the waste of the past activities of the Dzhidinsky tungsten-molybdenum combine. The source of danger is lying sands, containing a complex of toxic heavy metals - lead, cadmium, manganese, nickel, chromium, etc. The algorithm for the formation of the evidential base included: a general analysis of the sanitary and hygienic situation; assessment in the dynamics of the quality of atmospheric air, drinking water, soil, food; assessment of the risk to the health of the population; epidemiological studies; in-depth clinical surveys of a representative group of city residents (280 people). In the blood of the examinees, heavy metals were identified as biological markers of the exposure. There was evaluated a complex of the response (effect) adequate to effects of laboratory markers. By methods of mathematical statistics there was established the presence of reliable relationships in the system “source of hazard - the quality of the environment - exposure to risk factors - health status.” The hazard to the health of a citizen, due to the negative impact of the factor, was considered to be proven if it was possible to build a continuous step-by-step logical chain of relationships between the source of the harmful effect, the quality of the habitat and the establishment of the fact of the disease. The quality of the habitat of the population of Zakamensk was shown to give rise in unacceptable risks to the health of residents. The main influencing factor is the pollution of atmospheric air, local food products and drinking water from public and private wells. Risks are realized in terms of a level of the primary morbidity rate of the population of the respiratory diseases, endocrine system, digestive organs that is relatively high compared to the matched area. The relationship between health hazard and environmental factors has been fully proved in 14% of the surveyed persons. At the same time, the territory was shown not be characterized as a zone of “ecological disaster” or “an emergency environmental situation”.

scholarly journals Interrelationship of Neurogenic Obesity and Chronic Neuropathic Pain in Persons With Spinal Cord Injury

2021 ◽  
Vol 27 (1) ◽  
pp. 75-83
Author(s):  
Elizabeth R. Felix ◽  
David R. Gater
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Neuropathic Pain ◽  
Negative Impact ◽  
Chronic Neuropathic Pain ◽  
Excess Adiposity ◽  
Cord Injury ◽  
Significant Negative Impact ◽  
Prevalence Of Obesity

The prevalence of obesity and of neuropathic pain are both estimated at above 50% in the population of people with chronic spinal cord injury (SCI). These secondary consequences of SCI have significant negative impact on physical functioning, activities of daily living, and quality of life. Investigations of relationships between weight or body composition and chronic neuropathic pain in people with SCI are lacking, but investigations in non-SCI cohorts suggest an association between obesity and the presence and severity of neuropathic pain conditions. In the present article, we present a review of the literature linking obesity and neuropathic pain and summarize findings suggesting that metabolic syndrome and chronic, systemic inflammation due to excess adiposity increase the risk for neuropathic pain after an SCI.

scholarly journals Regulatory adaptive status in determining the effectivenessof bisoprololum and sotalolum in patients with hypertensive disease and ventricular arrhythmias

2016 ◽  
Vol 13 (1) ◽  
pp. 15-21
Author(s):  
I Z Shubitidze ◽  
V G Tregubov ◽  
V M Pokrovsky
Keyword(s):  
Combination Therapy ◽  
Ventricular Arrhythmias ◽  
Negative Impact ◽  
Subjective Assessment ◽  
Functional Condition ◽  
Grading System ◽  
Hypertensive Disease ◽  
Drug Regimens ◽  
Minute Walk

Aim. Compare the effectiveness of treatment with bisoprololum or sotalolum in patients with hypertensive disease (HD) and ventricular arrhythmias (VA) taking into account quantitative evaluation of the regulatory adaptive status (RAS).Materials and methods. 48 patients with HD of stages II-III and VA of grade I-IV based on the В.Lown grading system, II-III groups based on J.Bigger grading system took part in the research, they were randomized into two groups for treatment with bisoprololum (6.2±1.7 mg/day) or sotalolum (159.1±47.4 mg/day). As part of combination therapy, patients were administered lisinoprilum (12.8±4.2 mg/day and 13.7±4.5 mg/day), acetylsalicylic acid when required (93.1±19.0 and 95.0±16.2 mg/day), atorvastatinum (15.9±4.6 mg/day and 15.6±4.9 mg/day), respectively. Initially and 6 months after therapy, the following was done: quantitative assessment of RAS (by cardio-respiratory synchronism test), echocardiography, triplex scanning of brachiocephalic arteries, treadmill test, six-minute walk test, all-day monitoring of blood pressure and electrocardiogram, subjective assessment of quality of life.Results. Both drug regimens comparably improved structural and functional condition of the heart, increased exercise tolerance, controlled arterial hypertension, effectively suppressed ventricular arrhythmia, improved the quality of life. At the same time, the use of sotalolum decreased the RAS to a lesser degree than the use of bisoprololum.Conclusion. In patients with HD of stages II-III and VA the use of sotalolum as part of combination therapy may be preferable to bisoprololum due to its less negative impact on the RAS.

scholarly journals Evaluation of effectiveness of complex treatment of chronic generalized periodontitis using original splinting design

2021 ◽  
Vol 38 (6) ◽  
pp. 83-93
Author(s):  
N. B. Astashina ◽  
E. P. Rogozhnikova ◽  
A. S. Arutyunov ◽  
N. N. Malginov ◽  
S. V. Kazakov
Keyword(s):  
Quality Of Life ◽  
Comparison Group ◽  
Negative Impact ◽  
Young Patients ◽  
Pathological Process ◽  
Main Group ◽  
Complex Treatment ◽  
Periodontal Tissues

Relevance. The relevance of the study is dictated by the high prevalence of periodontal disease among young people and by the need to search for new approaches to periodontitis treatment in order to increase the effectiveness of treatment at early stages of pathological process. Objective. To evaluate the effectiveness of complex treatment of chronic generalized periodontitis (CGP) of mild severity using a removable splinting construction made according to the author's technique. Materials and methods. At the orthopedic stage of the complex treatment of mild CGP, splinting constructions were used for 47 young patients: in the main group (n = 16) the authors treatment and preventive splint, in the first comparison group (n = 15) a removable metal splint, in the second comparison group (n = 16) a fixed adhesive fiber splint. Periodontal hemodynamics was assessed using ultrasound Doppler analysis 1, 6 and 12 months after the therapeutic measures and tooth immobilization. To identify the possible negative impact of the treatment on the quality of life (QOL) in patients with splint constructions, we used the OHIP-14-Ru questionnaire; the follow-up period was 1.3, 6, and 12 months. Results. Dental immobilization contributed to the improvement of blood flow in the periodontal tissues in the short and long term follow-up, so after 12 months: Vam in the main group increased by 39,8 % and amounted to 0,397 0,004 cm / s, in patients of the comparison groups Vam was 0,329 0,006 cm / s and 0,335 0,003 cm / s, respectively, that is 15,4 % and 18,4 % higher compared with the figures before treatment. The quality of life index for patients using splinting constructions made according to the author's technique, by the OHIP-14-Ru questionnaire was assessed as good 1 year after (3.46 0.59). Conclusions. The use of the proposed original orthopedic design in a complex plan for mild periodontitis treatment helps to improve regional blood circulation and stabilize the pathological process.

scholarly journals Analysis of the impact of organochlorine compounds contained in the water network of the domestic water supply on the health of population in cities of the Perm Krai

2019 ◽  
Vol 95 (1) ◽  
pp. 14-17
Author(s):  
A. S. Sboev ◽  
Christina V. Romanenko
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Drinking Water ◽  
Digestive System ◽  
Endocrine System ◽  
Organochlorine Compounds ◽  
Excretory System ◽  
Oral Exposure ◽  
The Impact ◽  
Perm Region

The article presents the analysis of the impact of drinking water organochlorine compounds on the population health (Perm region). Results of the carcinogenic and non-carcinogenic health risk assessment for population of the city of Perm and the Perm region under the chronic oral exposure of organochlorine compounds in drinking water are presented. Real concentrations of organochlorine compounds in drinking water were determined to be potent of emerging an unacceptable risk of diseases of the digestive system, endocrine system, hormone system, excretory system, central nervous system and the blood system. According to the results of epidemiological studies there was established the statistically significant relation between the consumption of water containing organochlorine compounds and the development of diseases of the digestive system, endocrine system, central nervous system, and excretory system.

scholarly journals DETERMINATION OF NECESSARY CONDITIONS FOR EFFICIENT PURIFICATION OF DRINKING WATER WITH HIGH CHLOROFORM CONTENT BY PLASMA TREATMENT IN AEROSOL

2021 ◽  
Vol 5 (33) ◽  
pp. 71-76
Author(s):  
Yu. Zabulonov ◽  
◽  
D. Charny ◽  
L. Odukalec ◽  
D. Yaroshchuk ◽  
...  
Keyword(s):  
Drinking Water ◽  
Water Purification ◽  
Negative Impact ◽  
Anthropogenic Factors ◽  
Anthropogenic Pressure ◽  
Regulatory Quality ◽  
Quality Of Water ◽  
Water State ◽  
Treatment Technologies

Sustainable development of any country is possible only if the stable supply of its population with drinking water in accordance with their needs, quantity and regulatory quality. This issue is extremely relevant for Ukraine as a low-water state, especially with the further negative impact of climatic and anthropogenic factors on the quality of source water. This is especially true of surface water sources in general and the Dnieper cascade of reservoirs in particular. The regulation of the Dnieper River, global warming and the increase in anthropogenic pressure in the form of a significant (at times) increase in polyphosphates and nitrogen compounds in the effluents entering the Dnieper River provokes catastrophic cyanide growth for four to five months a year. Outdated water treatment technologies are unable to combat this factor and use the only possible technological method for them to combat high organic matter of any genesis – increase the dose of chlorine and coagulants. This usually does not improve the quality of water purification, but leads to the sustainable formation of organochlorine compounds in the process of water purification and transportation. Chloroform is a constant marker of trihalogen methanes and its concentration is determined by water supply laboratories. Accordingly, we investigated the possibilities of oxidation of chloroform by means of complex oxides formed by corona discharge in a water-air medium in the mixing chamber of the ejector. The influence of medium pH on the process of chloroform destruction was studied. It has been experimentally established that even a weakly acidic environment does not allow the efficient oxidation of chloroform and leads to its recombination and even increases its concentration. At the same time, in an alkaline environment, the oxidation process is intense and with lower energy consumption.

scholarly journals Peculiarities of Quality of Life in Patients with Pemphigus Vulgaris according to the Results of the Analysis of the SF-36V2 Questionnaires and Dermatological Index of Quality of Life in the Background of Glucocorticosteroid Therapy

2021 ◽  
Vol 6 (6) ◽  
pp. 123-133
Author(s):  
V. A. Litvinov ◽  
Keyword(s):  
Quality Of Life ◽  
Comparison Group ◽  
Negative Impact ◽  
Pemphigus Vulgaris ◽  
Clinical Problem ◽  
Subjective Health ◽  
Main Group ◽  
Control Group ◽  
Index Of Quality

The purpose of the study was to carry out a comparative assessment of the parameters of the quality of life in patients with pemphigus vulgaris according to the results of the analysis of the SF-36V2 questionnaires and the dermatological index of the quality of life against the background of glucocorticosteroid therapy. Materials and methods. The results of the study are based on the data of a comprehensive study and further follow-up of 47 patients with pemphigus vulgaris (of which 30 are the main group and 17 are the comparison group) who were hospitalized at the Zaporizhzhya Regional Skin and Venereal Clinical Dispensary, Zaporizhzhia. At the time of observation, the majority of patients were aged 61-70 years old. As a control group, 20 apparently healthy people were examined, randomized by age and sex. Results and discussion. Pemphigus vulgaris is a severe systemic dermatosis, which, according to the literature, accounts for about 1% in the structure of dermatological pathology, the main pathomorphological sign of which is acantholysis. Although the share of pemphigus vulgaris in the structure of dermatological pathology is 0.6 per 100 thousand people per year, the severity of the disease and its outcome determine the relevance of further study of the pathogenesis of dermatosis and the search for new effective therapies. The etiology of true pemphigus still remains unclear. The obtained results of questioning the patients with the SF-36V2 questionnaires and the dermatological index of quality of life indicate a significant negative impact of pemphigus vulgaris on the key parameters of the quality of life of patients in the main group and in the comparison group before treatment – the ability to perform their daily duties, work or study, have personal relationships, and also on the desire to be treated and adhere to all the rules of the therapy. Patients with pemphigus vulgaris in the group of monotherapy with glucocorticosteroids had statistically worse indicators of the quality of life after treatment than patients with additional use of Armadin, which was characterized by a low level of physical activity, an increase in the role of physical and psychoemotional problems in everyday life, general discomfort and subjective health. Conclusion. Evaluation of the quality of life of patients allowed for a more qualified study of the health disorders of patients with pemphigus vulgaris, to see the essence of the clinical problem, to select the most optimal treatment regimen for each patient, and also to assess the expected results in terms of parameters that are on the verge of a scientific approach and evidence-based medicine on the one hand, and also the subjective point of view of patients with pemphigus vulgaris on the other hand

scholarly journals Disorders of lipid and carbohydrate metabolism in children consuming drinking water of a non-normative quality

2019 ◽  
Vol 95 (1) ◽  
pp. 66-70 ◽  
Author(s):  
Konstantin P. Luzhetsky ◽  
O. A. Maklakova ◽  
L. N. Palagina
Keyword(s):  
Drinking Water ◽  
Carbon Tetrachloride ◽  
Carbohydrate Metabolism ◽  
Antioxidant Defense ◽  
Comparison Group ◽  
Resource Depletion ◽  
Overweight Children ◽  
Negative Effects ◽  
Blood Concentrations ◽  
Radical Oxidation

Clinical and laboratory investigation of violations of lipid and carbohydrate metabolism in children consuming drinking water of non-normative quality on content of organochlorine compounds. Children with elevated blood concentrations of chloroform and carbon tetrachloride, endocrine pathology are diagnosed 2.1 times more likely, the relative risk of developing obesity (E66.0) and excess supply (E67.8) is by 2.7 times higher than in the comparison group. There was found a causal relationship between the development of overweight children with a high content of chloroform in blood. Negative effects of organochlorines (chloroform, carbon tetrachloride) manifested by dysfunction of the hypothalamic-adrenal and pituitary-thyroid system, the activation offree radical oxidation and the accumulation ofperoxidation products, overvoltage and resource depletion of antioxidant defense, and violation of neurotransmitter processes was found to be followed by dysregulation offat and carbohydrate exchange. There were identified markers of disorders of lipid and carbohydrate metabolism in the conditions of exposure to chloroform and carbon tetrachloride.

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