scholarly journals Resveratrol: A Pleiotropic Phytoconstituent

2020 ◽  
Vol 11 (SPL4) ◽  
pp. 1473-1479
Author(s):  
Prashant N. Amale ◽  
Manish P. Deshmukh ◽  
Ashish B. Budhrani ◽  
Shilpa A. Deshpande
Keyword(s):  
Nitric Oxide ◽  
Active Form ◽  
Global Market ◽  
Science Literature ◽  
Glutathione S Transferase ◽  
Reactive Protein ◽  
Anti Cancer ◽  
Web Science ◽  
Hepatoprotective Drug ◽  
Inducible Nitric Oxide

Resveratrol (RSV) is a plant polyphenol or phytolexin phytoconstituents obtained from the grapes, berries, peanut, and wine. RSV is obtained from natural source and regarded as safe, effective, and hepatoprotective drug with no other serious organ toxicities are reported yet. This property of RSV makes it advantageous over the allopathic medicine having symptomatic cure and plethora of adverse effects. It’s a cheap and widely available phytoconstituent approved in the global market in the active form as trans-resveratrol. It has multiple pharmacological actions including, analgesic, anti-inflammatory, anti-anxiety, anti-parkinsonian, anti-alzheimers, antioxidant, antidepressant, anti-cancer, anti-diabetic, anti-atherosclerotic effects. These effects are mediated via modulation of diverse underlying endogenous molecules like reactive oxygen species, nitric oxide, malonaldehyde, neutrophil, sirtulin, cyclo-oxygenase, inducible nitric oxide syntheses, superoxide dismutase, catalase, glutathione s-transferase, alpha-secretase, metalloproteinases, C-reactive protein, dopamine, nor-adrenaline, serotonin, cytokines (interleukins), nuclear factor kappa, signal transducer activator of transcription, brain derived neural nactor, neuropeptide, hypothalamo-pitutary axis, astroglia, mitochondrial dysfunction, glutamate, adrenergic, cholinergic, opioidergic, and purinergic receptors. Researchers are trying to explore its additional health benefits and preparing new analogues for better survival in the field. Present review will help to enlighten the multi-target pleiotropic pharmacological nature of a RSV in relation to the variety of the molecular targets modulation through extensive web science literature survey.

Evidence for Sodium Azide as an Artifact Mediating the Modulation of Inducible Nitric Oxide Synthase by C-Reactive Protein

2005 ◽  
Vol 45 (3) ◽  
pp. 193-196 ◽  
Author(s):  
Nuria Lafuente ◽  
Ver??nica Azcutia ◽  
Nuria Matesanz ◽  
Elena Cercas ◽  
Leocadio Rodr??guez-Ma??as ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Inducible Nitric Oxide Synthase ◽  
Sodium Azide ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Oxide Synthase ◽  
Inducible Nitric Oxide

scholarly journals Aqueous Extract of Carica Papaya Linn Roots Halts Sodium Arsenite-Induced Renal Inflammation through Inhibiting Adenosine Deaminase, 8-Hydroxy-2′-Deoxyguanosine, C-Reactive Protein and Inducible Nitric Oxide Synthase Activity

2017 ◽  
Vol 18 (4) ◽  
pp. 323-330 ◽  
Author(s):  
Oluwafemi Adeleke Ojo ◽  
Adebola Busola Ojo ◽  
Olukemi Adetutu Osukoya ◽  
Basiru Olaitan Ajiboye
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Inducible Nitric Oxide Synthase ◽  
Aqueous Extract ◽  
Carica Papaya ◽  
Inhibitory Effect ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Oxide Synthase ◽  
Inducible Nitric Oxide

AbstractObjectives: Inflammation plays a crucial role in many of the metabolic abnormalities. The prototypic marker of inflammation is C-reactive protein (CRP), Nitric Oxide (NO), inducible nitric oxide synthase (iNOS) and their inhibition is considered a promising strategy to combat inflammation. Here, we report the anti-inflammatory mechanism of Carica papaya root aqueous extract in sodium arsenic-induced renal dysfunction.Methodology: Thirty-five rats were used for the experiments. Griess assay was used to evaluate the inhibitory effect of Carica papaya roots aqueous extract on the overproduction of nitric oxide (NO). ELISA was used to determine the level of pro-inflammatory markers including c-reactive protein (CRP). ELISA was used to analyze 8-OHdG. The inhibitory effect on the enzymatic activity of inducible nitric oxide synthase (iNOS), adenosine deaminase (ADA), malondialdehyde (MDA) was tested by enzyme activity assay kits.Results:Carica papaya roots aqueous extract suppressed sodium arsenite-stimulated NO production and proinflammatory secretion, such as CRP. Carica papaya roots aqueous extract significantly (p < 0.05) decrease the activities of iNOS, 8-OHdG, ADA and MDA.Conclusion: These results indicated that potent inhibition on CRP, NO, iNOS, ADA, 8-OHdG might constitute the anti-inflammatory mechanism of Carica papaya roots aqueous extract.

scholarly journals Flutamide protects against trauma-hemorrhage-induced liver injury via attenuation of the inflammatory response, oxidative stress, and apopotosis

2008 ◽  
Vol 105 (2) ◽  
pp. 595-602 ◽  
Author(s):  
Wen-Hong Kan ◽  
Chi-Hsun Hsieh ◽  
Martin G. Schwacha ◽  
Mashkoor A. Choudhry ◽  
Raghavan Raju ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Nitric Oxide ◽  
Lipid Peroxidation ◽  
Liver Injury ◽  
Inducible Nitric Oxide Synthase ◽  
Hypoxia Inducible Factor ◽  
Myeloperoxidase Activity ◽  
Glutathione S Transferase ◽  
Oxide Synthase ◽  
Inducible Nitric Oxide

Although studies have shown that administration of testosterone receptor antagonist, flutamide, following trauma-hemorrhage, improves hepatic, cardiovascular, and immune functions, the precise cellular/molecular mechanisms responsible for producing these salutary effects remain largely unknown. To study this, male C3H/HeN mice were subjected to a midline laparotomy and hemorrhagic shock (35 ± 5 mmHg for ∼90 min), followed by resuscitation with Ringer lactate. Flutamide (25 mg/kg) or vehicle was administered subcutaneously at the onset of resuscitation, and animals were killed 2 h thereafter. Hepatic injury was assessed by plasma α-glutathione S-transferase concentration, liver myeloperoxidase activity, and nitrotyrosine formation. Hepatic malondialdehyde and 4-hydroxyalkenals (lipid peroxidation indicators), cellular DNA fragmentation, and the expression of inducible nitric oxide synthase and hypoxia-inducible factor-1α were also evaluated. Cytokines (TNF-α, IL-6) and chemokines (keratinocyte-derived chemokine and monocyte chemoattractant protein-1) levels were determined by cytometric bead array. The results indicate that flutamide administration after trauma-hemorrhage reduced liver injury, which was associated with decreased levels of α-glutathione S-transferase, myeloperoxidase activity, nitrotyrosine formation, lipid peroxidation, and cytokines/chemokines (systemic, liver tissue, and intracellular cytokines/chemokines). Cellular apoptosis, hepatocyte hypoxia-inducible factor-1α, and inducible nitric oxide synthase expression were also decreased under such conditions. Thus administration of flutamide following trauma-hemorrhage protects against liver injury via reduced inflammation, cellular oxidative stress, and apoptosis.

289: Roles of Inducible Nitric Oxide Synthase in Voiding Function and Bladder Pain During Experimental Cystitis

2006 ◽  
Vol 175 (4S) ◽  
pp. 96-96
Author(s):  
Masayoshi Nomura ◽  
Hisae Nishii ◽  
Masato Tsutsui ◽  
Naohiro Fujimoto ◽  
Tetsuro Matsumoto
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Inducible Nitric Oxide Synthase ◽  
Voiding Function ◽  
Bladder Pain ◽  
Oxide Synthase ◽  
Inducible Nitric Oxide
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