scholarly journals The Effect of Alcohol Withdrawal on Bone Turnover in Women with Alcohol Dependence

2021 ◽  
Author(s):  
◽  
Pallavi Wyawahare

<p>Several studies have highlighted the detrimental effects of alcohol dependence upon bone health, but the majority of data relate to male alcoholics. In general, these effects are considered to be either a direct toxic effect on bone or related to confounding lifestyle factors linked to alcohol dependence. Given the rising prevalence of alcohol dependence in young women, data relating to this group are timely. We performed a study to assess bone health in this population and specifically to study change in bone turnover following admission to an alcohol detoxification unit in New Zealand.</p>

2021 ◽  
Author(s):  
◽  
Pallavi Wyawahare

<p>Several studies have highlighted the detrimental effects of alcohol dependence upon bone health, but the majority of data relate to male alcoholics. In general, these effects are considered to be either a direct toxic effect on bone or related to confounding lifestyle factors linked to alcohol dependence. Given the rising prevalence of alcohol dependence in young women, data relating to this group are timely. We performed a study to assess bone health in this population and specifically to study change in bone turnover following admission to an alcohol detoxification unit in New Zealand.</p>


Author(s):  
Emma T Callegari ◽  
Suzanne M Garland ◽  
Alexandra Gorelik ◽  
Cherie Y Chiang ◽  
John D Wark

Background Bone turnover markers (BTMs) may provide insight into bone health in young women, but have been little studied in this demographic. We aimed to explore the association between body composition, hormonal contraception, bone mineral density and biochemical parameters and BTMs in young women. Methods Participants were community-dwelling females aged 16–25 years, living in Victoria, Australia. Carboxy-terminal cross-linking telopeptide of type 1 collagen (CTX) and total procollagen type 1 N-propeptide (P1NP) were analysed on the Roche Elecsys automated analyzer. A total of 305 were evaluated, after excluding participants with medical conditions or medications (except hormonal contraceptives), which may affect bone metabolism. Results Median (Q1, Q3) BTM values were 540 (410, 690) ng/L for CTX and 61.7 (46.2, 83.7) µg/L for P1NP. Serum CTX and P1NP were inversely associated with chronological age ( P < 0.001), transferrin ( P < 0.020) and serum dehydroepiandrosterone sulphate concentration ( P < 0.001). BTM values were up to 22% lower in combined oral contraceptive (COC) pill users ( P < 0.001). Serum CTX was inversely associated with per cent body fat ( P = 0.009) and tibial cortical volumetric bone mineral density (vBMD; P = 0.003). Serum P1NP concentrations were 23  µg/L higher in participants who reported using an osteopath in the previous year ( P = 0.007). Conclusions These data suggest that BTMs are influenced by age, COC use, body composition, iron status and hormonal profiles. Higher CTX values were associated with lower tibial cortical vBMD. Examining BTMs in relation to interventions aimed at improving bone health in young women is warranted.


2021 ◽  
Author(s):  
Katrine Melby ◽  
Olav Spigset ◽  
Rolf Gråwe ◽  
Trond Aamo ◽  
Daniel S Quintana

Alcohol dependence is associated with difficulties in processing emotional stimuli, which can lead to interpersonal problems. The neuropeptide oxytocin has been shown to modulate the processing of emotional stimuli, however, oxytocin treatment has not yet been examined in patients with withdrawal symptoms during alcohol detoxification. The aim of the present study was to investigate the effect of oxytocin on the reading the mind in the eyes test (RMET) during a three-day period of alcohol detoxification at an addiction treatment centre in Norway. We performed a randomized, double-blind, placebo-controlled trial in 39 patients fulfilling criteria for ICD-10 diagnosis of alcohol dependence admitted for alcohol detoxification and withdrawal treatment. Participants were randomized to receive either intranasal oxytocin (24 IU) or placebo, twice daily for three days. The primary outcome was RMET performance on day 2 and day 3 of detoxification and secondary outcome was the differences in RMET scores between day 2 and day 3 of detoxification. Frequentist and Bayesian statistical inference suggested that oxytocin administration during alcohol withdrawal in alcohol-dependent patients did not improve social cognition performance, however alcohol use before detoxification significantly predicted RMET performance on day 2, but not on day 3, of withdrawal.


2021 ◽  
Vol 12 ◽  
Author(s):  
Guoying Wang ◽  
Wolfgang Weber-Fahr ◽  
Ulrich Frischknecht ◽  
Derik Hermann ◽  
Falk Kiefer ◽  
...  

In this report, we present cross-sectional and longitudinal findings from single-voxel MEGA-PRESS MRS of GABA as well as Glu, and Glu + glutamine (Glx) concentrations in the ACC of treatment-seeking alcohol-dependent patients (ADPs) during detoxification (first 2 weeks of abstinence). The focus of this study was to examine whether the amount of benzodiazepine administered to treat withdrawal symptoms was associated with longitudinal changes in Glu, Glx, and GABA. The tNAA levels served as an internal quality reference; in agreement with the vast majority of previous reports, these levels were initially decreased and normalized during the course of abstinence in ADPs. Our results on Glu and Glx support hyperglutamatergic functioning during alcohol withdrawal, by showing higher ACC Glu and Glx levels on the first day of detoxification in ADPs. Withdrawal severity is reflected in cumulative benzodiazepine requirements throughout the withdrawal period. The importance of withdrawal severity for the study of GABA and Glu changes in early abstinence is emphasized by the benzodiazepine-dependent Glu, Glx, and GABA changes observed during the course of abstinence.


2021 ◽  
Author(s):  
◽  
Emily Kathryn James

<p>This research investigates how young Somali women are navigating through the resettlement process while negotiating their own identities in Wellington, New Zealand. It is important as it addresses two main research gaps: 1) it focuses on research with young Somali women at university and 2) it offers a strength-based analysis. The research also addresses important development concerns about how former refugees can better contribute into their host societies. Employing the use of participatory methods within a feminist qualitative methodology, I created a project that enabled the young women to voice their opinions regarding identity construction, cultural maintenance and their goals for the future.  I conducted approximately 150 hours of ethnographic research at organisations that catered to former refugee needs. I found a young female Somali student who worked as my Cultural Advisor and enhanced my credibility and access within the Somali community. I then conducted a focus group and five individual interviews with young Somali women to hear their narratives about their resettlement experience and their advice on how to improve the process for others. I conducted five interviews with key informants at organisations that provide support services for former refugees. The key informants gave the policy perspective on refugee resettlement as well as advice on how support services and the government can approve the transition for former refugees.  The results of this study revealed that the young women did feel tension at times negotiating their Somali culture and that of their host society but found benefits in both. The importance of the family resettling successfully was vital for the young women especially the wellbeing of their mothers and other female elders. The key informants echoed these sentiments and voiced the necessity for more women-focused support services. The young women also will be facing a second resettlement process through their emigration to Australia as they search for more job opportunities and a better Somali cultural connection.</p>


2021 ◽  
Author(s):  
◽  
Lesley Wright

<p>The sexual behaviour of young emergent adult women in New Zealand has become a target of media attention and commentary. Moralising language is prevalent in the public discourse, describing young women negatively with respect to character and psychology. Research investigating the increase of cultural artefacts such as hooking up or casual sex is often risk-focused, concentrating predominantly on detrimental impacts such as STIs, rape-risks, and depression. Some feminist analyses describe behaviour as postfeminist or as examples of false consciousness. Despite these positions, young New Zealand women are engaging in these and other non-relationship sexual activities in growing numbers, suggesting that current approaches are failing to capture salient explanatory information. Due to the negative impacts of social constraints such as the sexual double standard, traditional femininity and moralising social commentary on young women it is important to present a more holistic image of their behaviour so as to provide a deeper explanatory view which better accounts for young women’s experiences and motivations. In this study I utilise a mixed method research design to access a wide range of participants on a sensitive research topic. A self-selecting sample of 163 young women aged between 18 and 30, recruited from various university campuses around New Zealand, completed an online survey. From this group 18 heterosexually-identifying young women were selected to participate in instant messaging, email and face to face interviews, and an online discussion group. To analyse the material they provided I use a Third Wave feminist theoretical lens in order to give primacy not only to their voices but also their claims to agency and the importance of subjective positionality. I use Sexual Script Theory as a framework to illuminate the impact of cultural dialogues on individuals, and space was conceptualised as a way to illustrate performances and agency. Results suggest that young New Zealand women are strongly affected by risk-focused and moralising dialogues to the effect that they have internalised a risk-focused cultural script that guides their sexual interactions and behaviours within socio-sexual culture in constrained and avoidant ways. Other performed scripts such as ‘good girl’ femininity, traditional masculinity, and the normative performance of heterosex also presented as barriers to subjective sexual experience/development. However, many young women in this study were resistant to some of these scripts, as evidenced in their attempts to occupy traditionally masculine and/or social spaces where non-normative behaviours are (partially) permitted. Their behaviour suggests critical engagement with their socio-sexual environment and some awareness of script elements that dictate acceptable feminine behaviour, and how these constraints can be (at least temporarily) resisted as a means to not only developing sexual subjectivity but also to refashioning modern femininity.</p>


2021 ◽  
Author(s):  
Li Zhou ◽  
Jing Xiong ◽  
Chang-qing Gao ◽  
Jian-jun Bao ◽  
Xin-Fu Zhou

Abstract ObjectiveProlonged excessive ethanol intake impairs learning, memory and also causes brain atrophy. Brain-derived neurotrophic factor (BDNF) plays pivotal roles in the pathology of alcohol dependence. Our previous work found that chronic ethanol exposure altered the metabolism of BDNF, leading to the imbalance of proBDNF and mature BDNF (mBDNF). In this study, we hypothesized that early alcohol withdrawal would reverse the abnormal levels of proBDNF, mBDNF and their receptors.Method30 male alcohol dependence patients were recruited. Peripheral blood was sampled from all the subjects before and one week after alcohol withdrawal. The lymphocyte protein levels of proBDNF, p75NTR, sortilin and TrkB were analyzed by western blots and the serum level of mBDNF and TrkB was assayed by sandwich enzyme-linked immunosorbent assay (ELISA) at two different time points. ResultsThe levels of mBDNF and its receptor (TrkB) increased, oppositely the levels of proBDNF and its receptors (p75NTR and sortilin) decreased one week after alcohol withdrawal. ConclusionsEarly alcohol withdrawal reversed the abnormal levels of proBDNF, mBDNF and their receptors. The shift levels of proBDNF and mBDNF were both taken in the pathology of alcohol withdrawal.


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