scholarly journals Effect of Danshen Polyphenate Combined with Pelectin on Diabetic Pe- ripheral Neuropathy and Its Effects on Serum IGF-1, FFA and MBP

1970 ◽  
Vol 1 (1) ◽  
Author(s):  
Bai Xiaogang
Keyword(s):  
Peripheral Neuropathy ◽  
Conduction Velocity ◽  
Diabetic Peripheral Neuropathy ◽  
Salvia Miltiorrhiza ◽  
Ankle Brachial Index ◽  
Control Group ◽  
Sensory Threshold ◽  
Observation Group ◽  
Before And After ◽  
And Control

Objective: To observe the therapeutic effect of salvia miltiorrhiza phenylephrine combined with puerarin sodium on diabetic peripheral neuropathy (DPN) and the effect of serum insulin-like growth factor 1 (IGF-1), free fatty acid (FFA) and human myelin Protein (MBP). Methods: A total of 116 patients with diabetic peripheral neuropathy were randomly divided into observation group (58 cases) and control group (58 cases). The control group was treated with sodium prostaglandin sodium. The observation group was treated with Danshephenolic acid Treatment, treatment for 8 weeks. The changes of total symptom score system (TSS), vibration sensory threshold (VPT), ankle brachial index (ABI) and peripheral nerve conduction velocity (NCV), serum IGF-1, FFA and MBP were observed before and after treatment. Results: The levels of numbness, tingling, burning, paresthesia and total score were significantly decreased in both groups after treatment, VPT, ABI and NCV were improved (P < 0.05), and the above indexes (P < 0.05). The levels of serum IGF-1 were increased and the levels of FFA and MBP were lower in the two groups. The improvement of the above indexes was better than that of the control group (P < 0.05). Conclusion: Salvia miltiorrhiza polyphenate combined with puerarin sodium can significantly improve the vibration sensory threshold and ankle-brachial index, enhance the nerve conduction velocity and relieve clinical symptoms in patients with diabetic peripheral neuropathy. The mechanism may be related to the regulation of serum IGF-1,FFA, The level of MBP is relevant.

scholarly journals Effect of iRoot BP Plus Pulpotomy for Immediate Repair in Children with Young Permanent Teeth Crown Fracture

2020 ◽  
Vol 4 (2) ◽  
Author(s):  
Jiaying Song
Keyword(s):  
Success Rate ◽  
Clinical Effect ◽  
Permanent Teeth ◽  
Control Group ◽  
Observation Group ◽  
Control Groups ◽  
Before And After ◽  
Random Number Table ◽  
The Difference ◽  
And Control

Objective: To explore the clinical effect of iRoot BP Plus pulpotomy for immediate repair in children with young permanent teeth crown fracture. Methods: From September 2017 to October 2018, 80 children (80 affected teeth) with young permanent teeth crown fracture who treated in the hospital were selected as the research objects. Random number table method was used to divide them into observation and control groups with each group of forty patients (40 affected teeth). The children in the control group were treated with calcium hydroxide resin, while the observation group were treated with iRoot BP Plus for immediate repair. The surgical success rate was compared between the two groups, and the pulp vitality before and after treatment were compared. Results: At 3 months and 6 months after surgery, the success rate of children in the observation group was higher than that in the control group, and the difference was statistically significant (P<0.05). The percentage of children with negative pulp activity in the observation group was higher than that in the control group, and the difference was statistically significant (P<0.05). Conclusion: Immediate repair with iRoot BP Plus pulpotomy in children with young permanent teeth crown fracture has significant clinical effect.

scholarly journals Study on the Regulation of Qinxitong Combined with Methotrexate Tablets on Multiple Inflammatory Indicators and Mechanism Factors in Rheumatoid Arthritis

2021 ◽  
Vol 5 (6) ◽  
pp. 113-117
Author(s):  
Zhaoyang Dong ◽  
Jichao Yin
Keyword(s):  
Rheumatoid Arthritis ◽  
Control Group ◽  
Study Group ◽  
Observation Group ◽  
Regulatory Effect ◽  
Inflammatory Index ◽  
Normal People ◽  
Before And After ◽  
And Control ◽  
Better Than

Objective: To study the changes of several inflammatory index mechanism factors in the clinical efficacy of tablet and methotrexate in rheumatoid arthritis. Methods: 20 patients with rheumatoid arthritis were randomly divided into observation (n =10) and control (n =10), then normal people as normal (n=10), all three groups were given methotrexate and the observation group were treated with Qin interest pain tablets. Expression of inflammatory index mechanism factors in each group. Results: After treatment, inflammatory index mechanism factors were detected; a significant decrease of IFN-g, IL-1b, IL-10, IL-37, TNF-a and other factors was found before and after combination treatment (P <0); IL-8 and IL-13 expression (P <0); the CRP, ESR score of the study group was lower than the control group (P <0.05); and the inflammatory index mechanism factors were affected by drug combination. Conclusion: Tablets combined with methotrexate in rheumatoid arthritis patients is better than methotrexate. It obviously changed the expression of the patient’s inflammatory index mechanistic factors, which has a regulatory effect on the inflammatory mechanistic factors.

scholarly journals "Heterozygous Treatment" Method to Improve the Biased Status of the Damp-heat Constitution and Symptom Integral: Randomized Controlled Trial

2018 ◽  
Vol 1 (1) ◽  
pp. 33
Author(s):  
Xianbing Hou ◽  
Haizhang Wang ◽  
Yanzhen Huo ◽  
Hui Zhao
Keyword(s):  
Clinical Symptoms ◽  
Controlled Trial ◽  
Treatment Method ◽  
Control Group ◽  
Observation Group ◽  
Randomized Controlled ◽  
Dark Urine ◽  
Significant Difference ◽  
Before And After ◽  
And Control

Objective: To observe the clinical effect of "heterozygous treatment" intervening the damp-heat constitution. Method: 106 cases with damp-heat constitution were randomly divided into the observation group and control group, 53 cases for each group. Lianpu drink was given to the two groups, and the observation group was treated with scraping, acupuncture, cupping, constitution care and popularization of constitution science for "heterozygous treatment" based on the control group. 70 days later, "constitution classification and determination table of traditional Chinese medicine" was used to determine, and statistics was applied to analyze the change of the symptoms of the two groups before and after the intervention. Results: in the observation group, compared to before the intervention, symptoms like dirty and oily complexion, yellow greasy tongue, bitter taste, dullness and scanty dark urine were significantly improved (P < 0.05), and improvement of the above symptoms was greater than the control group (P < 0.05) .Conclusion: There is no significant difference between the two groups (P > 0.05). Conclusion: the "heterozygous treatment" method can significantly improve the clinical symptoms of people with damp-heat constitution, with a better role in regulating.

scholarly journals Efficacy and Safety of the Injection of the Traditional Chinese Medicine Puerarin for the Treatment of Diabetic Peripheral Neuropathy: A Systematic Review and Meta-Analysis of 53 Randomized Controlled Trials

2018 ◽  
Vol 2018 ◽  
pp. 1-14 ◽  
Author(s):  
Baocheng Xie ◽  
Qinghui Wang ◽  
Chenhui Zhou ◽  
Jiahuan Wu ◽  
Daohua Xu
Keyword(s):  
Peripheral Neuropathy ◽  
Conduction Velocity ◽  
Nerve Conduction ◽  
Diabetic Peripheral Neuropathy ◽  
Nerve Conduction Velocity ◽  
Motor Nerve ◽  
Meta Analysis ◽  
Sensory Nerve ◽  
Control Group ◽  
Efficacy And Safety

Objective. The injection of the traditional Chinese patent medicine puerarin has been widely used in the treatment of various diseases such as angina pectoris or ischemic stroke. We aim to evaluate the efficacy and safety of puerarin injection for the treatment of diabetic peripheral neuropathy (DPN). Methods. A systematic literature search was performed in seven medical databases from their inception until June 2017. 53 studies with RCTs, totaling 3284 patients, were included in this meta-analysis. The included studies were assessed by the Cochrane risk of bias and analyzed by Review Manager 5.3 software. Results. The meta-analysis showed that puerarin injection for the treatment of DPN was significantly better compared with the control group in terms of the total effective rate. The result showed that puerarin injection for the treatment of DPN can significantly increase the probability of sensory nerve conduction velocity (SNCV) and motor nerve conduction velocity (MNCV) of the median and peroneal nerves. Conclusions. This meta-analysis demonstrated that puerarin injection may be more effective and safe for the treatment of DPN. However, further and higher quality RCTs are required to prove its efficacy and provide meaningful evidence for clinical treatment due to the poor methodological quality.

scholarly journals Observation on the Effect of Comfortable Nursing in ICU Patients with Severe Infection

2020 ◽  
Vol 9 (2) ◽  
pp. 36
Author(s):  
Yexin Li
Keyword(s):  
Sleep Quality ◽  
Adverse Reactions ◽  
Severe Infection ◽  
Nursing Intervention ◽  
Control Group ◽  
Observation Group ◽  
Icu Patients ◽  
Before And After ◽  
The Difference ◽  
And Control

<p>Objective: this article aims to explore the effect of comfortable nursing in ICU patients with severe infection. Methods: from January 2018 to January 2019, 44 patients with severe infection were selected as research objects. They were randomly divided into observation group (n=22) and control group (n=22). The control group was given routine nursing, while the observation group was given comfortable nursing on the basis of the control group. Pittsburgh Sleep Quality Index (PSQ1), Self-rating Anxiety Scale (SAS) and the incidence of adverse reactions were observed and compared between the two groups before and after intervention. Results: the PSQI score and SAS score of the patients in the observation group were lower than those in the control group. The incidence of adverse reactions in the observation group was 4.59%, which was significantly lower than that in the control group (27.27%), and the difference between the two groups was statistically significant (P&lt;0.05). Conclusion: comfortable nursing intervention for ICU patients with severe infection can obviously improve their sleep quality and negative emotions, and reduce the incidence of adverse reactions during hospitalization, which has clinical application value.</p>

The Role of Muscle Thickness and Echogenicity in the Diagnosis of Diabetic Peripheral Neuropathy

2021 ◽  
Vol 19 (8) ◽  
pp. 113-118
Author(s):  
Zahid M. Kadhim ◽  
Meqat M. Alkhafaji
Keyword(s):  
Peripheral Neuropathy ◽  
Diabetic Peripheral Neuropathy ◽  
Muscle Thickness ◽  
Biceps Femoris ◽  
Lower Limbs ◽  
Control Group ◽  
Medical City ◽  
And Control ◽  
Muscle Ultrasound

Objectives: This study aims to find the thickness of muscles of lower limbs in patients with diabetic peripheral neuropathy (DPN) along with echogenicity and applying these two findings in the diagnosis of the disease. Methods: This is a case-control study conducted in the clinical neurophysiology unit in Merjan medical city. It includes 73 patients diagnosed to have DPN based on characteristic history and physical examination and documented by nerve conduction study. These patients are matched to 73 control that has matched age and sex to the patient group. Patient and control are examined by high-resolution ultrasound (12 MHz linear probes). We assess muscle thickness and echogenicity of the tibialis anterior, biceps femoris, and abductor halluces brevis. Results: The study showed that there was a statistically significant decrease in muscle thickness and increase in echogenicity in all tested muscles when compared to the control group. Also, we calculated the cut-off value with sensitivity and specificity of muscle thickness in the diagnosis of DPN. Conclusion: Muscle ultrasound is a useful complementary test for the diagnosis of DPN.

Efficacy of Habb-e-Asab in diabetic peripheral neuropathy: a randomized placebo control study

2022 ◽  
Vol 0 (0) ◽  
Author(s):  
Fathima Nafha Nizamdeen ◽  
Mohd Aleemuddin Quamri ◽  
Md Anzar Alam
Keyword(s):  
Peripheral Neuropathy ◽  
Diabetic Peripheral Neuropathy ◽  
Test Group ◽  
Control Group ◽  
Placebo Control ◽  
Placebo Control Study ◽  
Unani Medicine ◽  
And Control ◽  
Control Study

Abstract Objectives Diabetic peripheral neuropathy (DPN) is a common diabetes complication. The prevalence of neuropathy is 55% for type 1 and 66% for type 2 diabetes. In Unani medicine neuropathy is known as Khidr (numbness). It is treated with drugs possessing hypoglycemic and analgesic properties, etc. Habb-e-Asab, a polyherbal Unani formulation used for the treatment of Waja-ul-Asab (neuralgia) is routinely used for its indications in neurological pain in Unani medicine. The aim of this study to investigate the efficacy of Habb-e-Asab in diabetic peripheral neuropathy. Methods Thirty patients with DPN were randomly assigned to test (n=20) and control (n=10) groups in a randomized single-blind placebo control study. For 45 days, the test group was given 250 mg Habb-e-Asab twice a day and the control group 250 mg placebo twice a day. The subjective parameters Pain in feet, burning in feet, and tingling in feet was assessed by the arbitrary scale and VAS fortnightly and objective parameters MNSI, and VPT was assessed in pre–post-treatment. Results The research drug revealed highly statistically significant with p<0.001 on VAS score and MNSI whereas VPT is significant with p<0.01 on few points. But control group exhibits no significant effect in any of the parameters. No adverse effects had been reported in either group. Conclusions Our finding indicated that the Habb-e-Asab for 45 days improved and reduced the severity of DPN in a patient with diabetes (CTRI/2018/02/011725).

scholarly journals Clinical Effect of Integrated Traditional Chinese and Western Medicine on Diabetic Peripheral Neuropathy

2021 ◽  
Vol 5 (6) ◽  
pp. 122-124
Author(s):  
Hao Peng ◽  
Yuhong Duan
Keyword(s):  
Peripheral Neuropathy ◽  
Chinese Medicine ◽  
Treatment Effect ◽  
Western Medicine ◽  
Diabetic Peripheral Neuropathy ◽  
Clinical Effect ◽  
Nerve Repair ◽  
Effective Rate ◽  
Control Group ◽  
Observation Group

Objective: Patients with diabetic peripheral neuropathy were treated with integrated traditional Chinese and western medicine, and the final results were observed. Methods: 70 patients with such symptoms were randomly divided into two groups. The number of people is the same, and the treatment methods are different. The control group uses western medicine, while the observation group uses traditional Chinese medicine to evaluate the treatment effect. Results: After treatment, the effective rate of the observation group was (P < 0.05), indicating that the treatment effect was significantly better. Conclusion: Patients with clinical diabetic peripheral neuropathy treated with routine nutrition and nerve repair, and with Chinese medicine, the effect is more satisfactory, and the effect is positive, so as to promote the optimization of their health.

Effects of Time and Perceptual Orientation on Actors' and Observers' Attributions

1984 ◽  
Vol 58 (1) ◽  
pp. 23-30
Author(s):  
Donald S. Martin ◽  
Ming-Shiunn Huang
Keyword(s):  
Video Recording ◽  
Control Group ◽  
Control Groups ◽  
Video Recordings ◽  
Before And After ◽  
Perceptual Orientation ◽  
Initial Difference ◽  
Variety Show ◽  
And Control ◽  
Unrelated Variety

The actor/observer effect was examined by Storms in a 1973 study which manipulated perceptual orientation using video recordings. Storms' study was complex and some of his results equivocal. The present study attempted to recreate the perceptual reorientation effect using a simplified experimental design and an initial difference between actors and observers which was the reverse of the original effect. Female undergraduates performed a motor co-ordination task as actors while watched by observers. Each person made attributions for the actor's behaviour before and after watching a video recording of the performance. For a control group the video recording was of an unrelated variety show excerpt. Actors' initial attributions were less situational than observers'. Both actors and observers became more situational after the video replay but this effect occurred in both experimental and control groups. It was suggested the passage of time between first and second recording of attributions could account for the findings and care should be taken when interpreting Storms' (1973) study and others which did not adequately control for temporal effects.

Melatonin Improves Erythropoietin Hyporesponsiveness via Suppression of Inflammation

2019 ◽  
Vol 14 (3) ◽  
pp. 203-208
Author(s):  
Evan Noori Hameed ◽  
Haydar F. Hadi AL Tukmagi ◽  
Hayder Ch Assad Allami
Keyword(s):  
Iron Status ◽  
Transferrin Saturation ◽  
Control Group ◽  
Base Line ◽  
Inadequate Response ◽  
Inflammatory Parameters ◽  
Tnf Α ◽  
Before And After ◽  
And Control ◽  
Controlled Clinical Study

Background: Inadequate response to Erythropoietin Stimulating Agents (ESA) despite using relatively larger doses regimen represents a potential risk factor of Cardiovascular (CV) related mortality in addition to health-care economic problems in anemic patients with Chronic Kidney Disease (CKD). Erythropoietin (EPO) hyporesponsiveness related to inflammation has been increased progressively. Melatonin is well known as a potent anti-inflammatory agent. Therefore, the current study was designed to evaluate whether melatonin could improve anemic patients response to EPO. Methods: This single controlled clinical study was carried out in 41 CKD patients with hemoglobin (Hb) levels less than 11g/dl divided randomly in a 1:1 ratio into 2 groups; treatment group who received 5mg melatonin plus their regular treatments and control group who received their regular treatments only. Hematological and iron status parameters include Hb level, serum iron (S. iron), Transferrin Saturation Ratio (TSAT) and serum ferritin (S. ferritin) in addition to inflammatory parameters that include tissue necrotic factor alfa (TNF-α), interleukin-1beta (IL-1β) and interleukin-6 (IL-6) determined before and after 12 weeks of treatment. Results: Melatonin remarkably increases the Hb level with a significant increase in S. iron and TSAT compared to baseline. The elevation of S. iron and TSAT was significantly higher in the melatonin group. Additionally, all inflammatory markers estimated were reduced significantly by melatonin compared to base line and control group. Conclusion: The results of the current study showed that melatonin has an advantageous effect on improving EPO response in anemic patients with CKD.

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