scholarly journals A Case of Photodynamic Therapy for Advanced Adenocarcinoma of Esophagogastric Junction

2020 ◽  
Vol 4 (6) ◽  
Author(s):  
Wanlu Cai ◽  
Xiaoxiong Hu ◽  
Jianwen Sheng ◽  
Huizhen Fan
Keyword(s):  
Adverse Reaction ◽  
Photodynamic Therapy ◽  
Elderly Patients ◽  
Esophagogastric Junction ◽  
Adverse Reactions ◽  
Clinical Symptoms ◽  
Gastric Fundus ◽  
High Repetition Rate ◽  
Invasive Technique ◽  
Short Term

Photodynamic therapy (PDT) is a new minimally invasive technique for the treatment of tumors. Compared with traditional treatments such as surgery, radiotherapy and chemotherapy, PDT has the advantages of targeted killing of primary and recurrent tumor cells, less damage to surrounding normal tissue, less complications and high repetition rate. The purpose of this study was to investigate the short-term efficacy and adverse reactions of photodynamic therapy in advanced elderly patients with esophageal-gastric junction adenocarcinoma without surgical indications. A patient with advanced adenocarcinoma of esophagus and fundus was treated with photodynamic therapy under gastroscope. Intravenous drip of Cipofen (hematoporphyrin injection 150mg / 0.9% saline 250ml) for 1 hour to keep the patient away from light.48 hours after administration, photodynamic therapy was performed with "Leimai" PDT630-A photodynamic therapy apparatus, 3cm columnar optical fiber, laser treatment wavelength of 630nm, transmission efficiency of 0.70, output power of 1.4W, irradiation at the lower segment of the esophagus and cardia for 150s. The curative effect was evaluated by comparing gastroscopy before and after photodynamic therapy. Before treatment, there were proliferative lesions in the lower part of esophagus and cardia, erosion and necrosis on the surface, stricture of esophageal cavity, huge ulcer near gastric fundus, filthy moss and dam-like hyperplasia and eminence of surrounding mucosa. After treatment, the local mucosa at the entrance of cardia became white and there was no bleeding. Within four days after treatment, the symptoms of nausea and vomiting disappeared; the adverse reaction of retrosternal discomfort began to occur on the second day after operation, and the adverse reaction was not improved after photodynamic therapy. Photodynamic therapy has a significant short-term effect on advanced elderly patients with adenocarcinoma of the esophagogastric junction, which can significantly alleviate the clinical symptoms and relieve the pain of the patients. However, the adverse reactions can not be ignored. Therefore, photodynamic targeting therapy for tumor needs to be further studied. It is believed that with the continuous development of high-performance photosensitizers and new generation lasers, and the continuous progress of endoscopy and image guidance technology, photodynamic therapy will become an important adjuvant or palliative treatment for tumor prevention and treatment.

The effectiveness of analysis of octreotide-depo, a long-acting somatostatin analog, for the treatment of the patients presenting with active phase of acromegalia

2014 ◽  
Vol 60 (3) ◽  
pp. 10-14 ◽  
Author(s):  
A V Dreval ◽  
Yu G Pokramovich ◽  
R S Tishenina
Keyword(s):  
Adverse Reactions ◽  
Clinical Symptoms ◽  
Maximum Dose ◽  
Active Phase ◽  
Somatostatin Analog ◽  
Short Term ◽  
Excessive Sweating ◽  
Maximum Reduction ◽  
Long Acting ◽  
Tissue Oedema

This paper reports the results of the year-long treatment of 46 patients presenting with active phase of acromegalia (39 (85%) women and 7 (15%) men, at the age varying from 22 to 76 years) using the long-acting somatostatin analog octreotide-depo. The treatment was started using a dose of 20 mg with the measurement of GH and IGF-1 levels each 3 months; the dose was titrated as appropriate. The maximum dose of octreotide-depo amounted to 40 mg. The effectiveness of therapy was evaluated from the severity and frequency of the principle symptoms of acromegalia, viz. facial, hand, and leg soft tissue oedema, fatigue, excessive sweating, headache, arthralgia, elevated blood GH and IGF-1 levels. The target GH levels were considered to be below 2.5 ng/ml and those of IGF-1 within the normal age-specific concentration range. The most well-apparent regression of clinical symptoms was observed within the first 3 months after the onset of the treatment, concurrently with the maximum reduction of blood GH and IGF-1 levels. The values reached during the first 3 months remained unaltered up to the end of the study. Simultaneous normalization of the blood GH and IGF-1 levels was documented in 55% of the patients. The clinical symptoms most frequently disappeared in the patients with normal IGF-1 levels. The adverse reactions of octreotide-depo therapy included short-term diarrhea (45.6%), meteorism (25.1%), abdominal pain (26%), nausea (13.4%), constipation (10.8%). These conditions were not serious and did not require the withdrawal of the preparation.

Short-term Effects of i.v. Injected Murine 99M Tc-F(ab’)2 Fragments of an Anti-Melanoma Antibody (HMW-MAA 225.28 S) on Haemato-Immunological Parameters in Patients with Melanoma

1988 ◽  
Vol 3 (2) ◽  
pp. 140-144 ◽  
Author(s):  
G. Castello ◽  
L. Mansi ◽  
E. Leonardi ◽  
S. Lastoria ◽  
G. Melillo
Keyword(s):  
Adverse Reaction ◽  
Malignant Melanoma ◽  
Toxic Effect ◽  
Immune Complexes ◽  
Adverse Reactions ◽  
Low Risk ◽  
Circulating Immune Complexes ◽  
Short Term ◽  
Immunological Parameters ◽  
Advanced Malignant Melanoma

To evaluate alterations induced by injectedmurine radiolabelled F(ab’)2 fragments of the anti HMW-MAA MoAb 225.28S on the principal haemato-immunological parameters, 32 patients with advanced malignant melanoma were studied. No statistically significant change was found after MoAb administration, but monocytes (3h after injection) and granular eosinophils (24 h after) were reduced and circulating immune complexes increased (3 h after). No toxic effect or adverse reaction was observed. Therefore, the controlled administration of purified MoAb fragments for diagnostic purposes seems to involve only a very low risk of immediate adverse reactions

Photodynamic therapy for preinvasive vaginal cancer.

2021 ◽  
Vol 39 (15_suppl) ◽  
pp. 5592-5592
Author(s):  
Viktoria A. Ivanova ◽  
Ekaterina V. Verenikina ◽  
Vera P. Nikitina ◽  
Oksana E. Zhenilo ◽  
Anna Yu. Ardzha
Keyword(s):  
Photodynamic Therapy ◽  
Adverse Reactions ◽  
Clinical Symptoms ◽  
Visual Observation ◽  
Vaginal Cancer ◽  
Complete Regression ◽  
Simultaneous Irradiation ◽  
Atypical Cells ◽  
Stratified Squamous Epithelium

5592 Background: Photodynamic therapy (PDT) is an effective method for the treatment of various cancers resulting in apoptosis, autophagy and ischemic necrosis of irradiated tissues. The purpose of the study was to analyze the efficacy of PDT for pre-invasive vaginal cancer treatment. Methods: PDT results were studied in 20 patients aged 32-65 years with verified pre-invasive vaginal cancer. All patients received PDT with the Latus diode laser and Photolon or Photolan photosensitizers. The effect was evaluated with extended colposcopy. The criteria for efficiency included normalization of the colposcopic picture and the absence of atypical cells. The sizes of the irradiation fields varied from 1.5 to 2 cm, the number of fields - from 1 to 4, the power density - from 0.1 to 0.17 W/cm2, the light dose - from 40 to 100 J/cm2. The duration of a PDT session varied from 10 to 30 min, depending on the number of irradiation fields. The irradiation field necessarily included an area of normal tissue 3-5 mm surrounding the lesion. 4 to 6 sessions were required to restore the normal layer of stratified squamous epithelium. The antitumor efficacy of PDT was evaluated based on the results of visual observation of changes in the area of the treated pathological foci and information on the presence or absence of clinical symptoms of the disease 1 and 3 months after the treatment (WHO criteria). Results: Complete regression was registered in 100% of patients after 3 months. Repeated courses of PDT were required in cases with a wide spread of pathological foci and the impossibility of their simultaneous irradiation. At follow-up after 1 month, 3 of 20 patients (15%) showed local foci of atypical changes in the epithelium managed with repeated PDT courses. In 6 months, stable remission of the disease clinical symptoms in the treated pathological foci was registered. The results of the cytological study performed 3 months after PDT were normal in 100% patients; no negative changes were registered 6 and 12 months after PDT. Conclusions: The results of PDT in the treatment of patients with pre-invasive vaginal cancer demonstrated its high therapeutic efficacy and a minimal number of adverse reactions, which allows recommending PDT in the treatment of pre-invasive vaginal cancer.

scholarly journals Randomized trial of total fundoplication and fundal mobilization with or without division of short gastric vessels: a short-term clinical evaluation

2007 ◽  
Vol 22 (6) ◽  
pp. 422-429 ◽  
Author(s):  
José Francisco de Mattos Farah ◽  
José Carlos Del Grande ◽  
Alberto Goldenberg ◽  
Júlio César Martinez ◽  
Renato Arione Lupinacci ◽  
...  
Keyword(s):  
Clinical Symptoms ◽  
Operating Time ◽  
Gastric Fundus ◽  
First Year ◽  
Short Term ◽  
Total Fundoplication ◽  
Group A ◽  
Group B ◽  
Short Gastric Vessels

PURPOSE: Evaluate short results after fundoplication procedure, concerning the division of short gastric vessels. METHODS: A prospective randomization of 90 patients with indication for hiatoplasty and total fundoplication with fundus mobilization was performed. They were divided into two groups: no SGV division (group A, n= 46) and with SGV division (Group B, n=44), although in both groups the gastric fundus was mobilized to perform a floppy valve. Early outcome with clinical follow up (1 year) was observed. RESULTS: Both groups were similar regarding preoperative parameters and severity of gastroesophageal reflux disease (GERD). No difference in morbidity was observed during hospital stay. Nevertheless, the median operating time was 80,2 minutes in group A and 94,1 minutes (p=0,021) in Group B. Transitory dysphagia during the first year was significantly lower in group B (46,6% versus 23,2%, p=0,012). However, in 12 months clinical outcome was similar in both groups (clinical symptoms of GERD, persistent dysphagia and reoperations). CONCLUSION: There was no improvement in routine division of SGV in total fundoplication procedure when the gastric fundus was mobilized.

Influence of Sex on the Short-term Outcome of Elderly Patients With a First Acute Myocardial Infarction

Circulation ◽  
1995 ◽  
Vol 92 (5) ◽  
pp. 1133-1140 ◽  
Author(s):  
Héctor Bueno ◽  
M. Teresa Vidán ◽  
Aureliano Almazán ◽  
José L. López-Sendón ◽  
Juan L. Delcán
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Elderly Patients ◽  
Short Term ◽  
Term Outcome ◽  
Short Term Outcome

scholarly journals Endoscopically controlled surgery with open hemilaminectomy for the treatment of intradural extramedullary tumors: an operative technique and short-term outcomes of 20 consecutive cases

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Xiaorong Yan ◽  
Huiqing Wang ◽  
Cai Li ◽  
Yuanxiang Lin ◽  
Lin Lin ◽  
...  
Keyword(s):  
Surgical Technique ◽  
Spinal Deformity ◽  
Tumor Recurrence ◽  
Clinical Symptoms ◽  
Short Term ◽  
Before And After ◽  
Intradural Extramedullary ◽  
Controlled Surgery

Abstract Background To present a surgical technique for the treatment of intradural extramedullary (IDEM) tumors by using endoscopically controlled surgery with open hemilaminectomy technique. Methods In this study, 20 patients with 22 IDEM tumors were enrolled. An endoscopically controlled surgery with open hemilaminectomy was employed to remove the tumors. Data related to clinical symptoms and medical images before and after surgery were collected for perioperative evaluation and follow-up analysis. Results All the tumors in 20 patients were well removed. The clinical symptoms were significantly reduced in all the patients as well. The short-term follow-up data showed that there was no tumor recurrence or spinal deformity. Conclusion The endoscopically controlled surgery with open hemilaminectomy technique provided favorable exposure and satisfactory resection to the IDEM tumors. It may be an effective surgical method for treating IDEM tumors. Larger samples and longer follow-up data are needed to verify its long-term effectiveness.

Efficacy of an Oxycodone-Propofol Combination versus a Fentanyl-Propofol Combination in Conscious Sedation during Therapeutic Endoscopic Retrograde Cholangiopancreatography in Elderly Patients

Gerontology ◽  
2020 ◽  
pp. 1-8
Author(s):  
Peipei Guo ◽  
Huisheng Wu ◽  
Lan Liu ◽  
Qiu Zhao ◽  
Zhao Jin
Keyword(s):  
Adverse Events ◽  
Elderly Patients ◽  
Endoscopic Retrograde Cholangiopancreatography ◽  
Postoperative Nausea ◽  
Recovery Time ◽  
Adverse Reactions ◽  
Conscious Sedation ◽  
Endoscopic Retrograde ◽  
Patients Satisfaction ◽  
Low Incidence

<b><i>Background:</i></b> With a rapidly aging population, the need for endoscopic retrograde cholangiopancreatography (ERCP) is increasing. The commonly used sedation anesthesia in ERCP is a combination of propofol and fentanyl, even though fentanyl may cause some adverse reactions such as respiratory depression. <b><i>Objectives:</i></b> This study aimed to evaluate the efficacy of oxycodone combined with propofol versus fentanyl combined with propofol for sedation anesthesia during ERCP. <b><i>Methods:</i></b> A total of 193 patients aged from 65 to 80 years undergoing ERCP were enrolled and randomized into two groups: an “oxycodone combined with propofol” group (group OP, <i>n</i> = 97) and a “fentanyl combined with propofol” group (group FP, <i>n</i> = 96). The rate of perioperative adverse events as well as the recovery time, patients’ satisfaction, and endoscopists’ satisfaction were noted. <b><i>Results:</i></b> There was no difference in the frequency of hypotension or bradycardia between the two groups, but there were more episodes of desaturation (SpO<sub>2</sub> &#x3c;90% for &#x3e;10 s in 8.3%), postoperative nausea (7.3%), and vomiting (5.2%) in group FP than in group OP. Patients’ satisfaction in group FP was lower than that in group OP. The recovery time was longer in group FP than in group OP. <b><i>Conclusions:</i></b> Oxycodone combined with propofol was effective in ERCP, with a low incidence of perioperative adverse events.

Effects of Atovaquone on the Ultrastructural Morphology of Pneumocystis Carinii

1997 ◽  
Vol 3 (S2) ◽  
pp. 81-82
Author(s):  
M.P. Goheen ◽  
M.S. Bartlett ◽  
M.M. Shaw ◽  
S.R. Meshnick ◽  
J.W. Smith
Keyword(s):  
Adverse Reactions ◽  
Pneumocystis Carinii ◽  
Spinner Flask ◽  
Short Term ◽  
Human Embryonic Lung ◽  
Transmission Electron ◽  
Significant Incidence ◽  
Wide Range ◽  
Acquired Immunodeficiency ◽  
Immunodeficiency Syndrome

Pneumocystis carinii pneumonia (PCP) occurs at some time in most patients with acquired immunodeficiency syndrome (AIDS). Trimethoprim/sulfamethoxazole or pentamidine isothionate are the traditional modes of therapy for treatment and prophylaxis of PCP. Unfortunately these drugs are associated with a significant incidence of adverse side effects particularly in patients with AIDS. Toxicity and a growing concern that P. carinii strains are becoming resistant to these compounds is providing the impetus for the search for additional drugs to combat P. carinii. Atovaquone, developed as an antimalarial agent, has activity against a wide range of other organisms, including Toxoplasma sp. and P. carinii, with a lower incidence of adverse reactions during clinical trials. Atovaquone inhibits mitochondrial respiration in P. falciparum and P. carinii. In this study transmission electron microscopy (TEM) was used to observe the effects of atovaquone on P. carinii organisms in short term spinner flask culture.Spinner flask cultures of human embryonic lung cells were inoculated with P. carinii from infected rat lung.

Sign in / Sign up

Export Citation Format

Share Document