scholarly journals "Review Article: An Overview of Cellular Signal Transduction Pathway"

2021 ◽  
Vol 38 (2) ◽  
Author(s):  
Soheir E Kotob
Keyword(s):  
Signal Transduction ◽  
Signal Transduction Pathway ◽  
Review Article ◽  
Transduction Pathway ◽  
Cellular Signal Transduction ◽  
Cellular Signal ◽  
Cellular Signal Transduction Pathway

Targeting the JAK/STAT Signaling Pathway for Breast Cancer.

2020 ◽  
Vol 28 ◽  
Author(s):  
Fei Shao ◽  
Xiaonan Pang ◽  
Gyeong Hun Baeg
Keyword(s):  
Breast Cancer ◽  
Signal Transduction ◽  
Signaling Pathway ◽  
Signal Transduction Pathway ◽  
Breast Cancer Treatment ◽  
Review Article ◽  
Transduction Pathway ◽  
Inhibitory Effects ◽  
Stat Proteins ◽  
Stat Signaling

Abstract:: Breast cancer is the most common malignant tumor in women worldwide. Traditional ways of treatment, includ-ing radiotherapy and endocrine therapy, for breast cancer have inevitable side effects. In recent decades, targeted therapies for breast cancer have rapidly advanced and shown a promising future. The JAK/STAT signaling pathway has been shown to play important roles in tumorigenesis, maintenance and metastasis of breast cancer. Hence, many small molecule inhibi-tors of JAK and STAT proteins have been developed. These inhibitors exhibit potent inhibitory effects on breast cancer in both cellular and animal models, and even some of them have already been in clinical trials. This review article discussed the JAK/STAT signal transduction pathway in the pathogenesis of breast cancer, and the potential for the application of JAK/STAT inhibitors in breast cancer treatment.

Delivery of Gefitinib in synergism with Thymoquinone via Transferrin Conjugated Nanoparticle Sensitizes Gefitinib Resistant Non-Small Cell Lung Carcinoma to Control Metastasis and Stemness

2021 ◽  
Author(s):  
Priyanka Upadhyay ◽  
Avijit Ghosh ◽  
Arijita Basu ◽  
P. A. Pranati ◽  
Payal Gupta ◽  
...  
Keyword(s):  
Small Cell Lung Carcinoma ◽  
Growth Factor Receptor ◽  
Signal Transduction Pathway ◽  
Small Cell ◽  
Transduction Pathway ◽  
Small Cell Lung ◽  
Cell Lung Carcinoma ◽  
Cellular Signal ◽  
Cellular Signal Transduction Pathway ◽  
Epidermal Growth

Epidermal growth factor receptor (EGFR) normally over-express in non-small cell lung cancer (NSCLC) and its mutations act as oncogenic drivers in the cellular signal transduction pathway and induce downstream activation...

Receptor component protein (RCP): a member of a multi-protein complex required for G-protein-coupled signal transduction

2002 ◽  
Vol 30 (4) ◽  
pp. 460-464 ◽  
Author(s):  
M. A. Prado ◽  
B. Evans-Bain ◽  
I. M. Dickerson
Keyword(s):  
Signal Transduction ◽  
G Protein ◽  
Signal Transduction Pathway ◽  
Cgrp Receptor ◽  
Receptor Component ◽  
Calcitonin Gene ◽  
Cellular Signal ◽  
Cellular Signal Transduction Pathway ◽  
G Protein Coupled ◽  
Component Protein

The calcitonin-gene-related peptide (CGRP) receptor component protein (RCP) is a 148-amino-acid intracellular protein that is required for G-protein-coupled signal transduction at receptors for the neuropeptide CGRP. RCP works in conjunction with two other proteins to constitute a functional CGRP receptor: calcitonin-receptor-like receptor (CRLR) and receptor-activity-modifying protein 1 (RAMP1).CRLR has the stereotypical seven-transmembrane topology of a G-protein-coupled receptor; it requires RAMP1 for trafficking to the cell surface and for ligand specificity, and requires RCP for coupling to the cellular signal transduction pathway. We have made cell lines that expressed an antisense construct of RCP and determined that CGRP-mediated signal transduction was reduced, while CGRP binding was unaffected. Furthermore, signalling at two other endogenous G-protein-coupled receptors was unaffected, suggesting that RCP was specific for a limited subset of receptors.

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