DYNAMICS OF CLINICAL AND LABORATORY INDICATORS IN THE TREATMENT OF PATIENTS WITH PSORIASIS AND CONCOMITANT ALIMENTARY OBESITY

Psoriasis is one of the most common chronic recurrent systemic autoimmune multifactorial diseases, affected the skin, joints, internal organs and systems of the body. Despite the significant prevalence of psoriasis and a large number of studies devoted this problem there is still no single view on the pathogenesis of this dermatosis. To clear up the pathogenesis of psoriasis, it seems to be reasonable to focus on the common comorbidities or multimorbidities, which may occur in the course of psoriasis, as this issue is still insufficiently studied. Recent reports have proven the evidences of indisputable link between psoriasis and obesity. The scientific literature extensively covers the issues of identical pathogenetic mechanisms of inflammatory processes in psoriasis and obesity. Given the current data on the role of systemic inflammation underlying the development of both psoriasis and obesity, the study of molecular mechanisms of its development and in particularly the role of proinflammatory nuclear transcription factors, thiazolidinediones have been found out as pathogenetically justified medicine of choice for the therapy of these diseases. In this study, we determined the effectiveness of using 30 mg of pioglitazone daily for 6 months in the course of treatment for patients with extensive psoriasis vulgaris of moderate severity, who were also diagnosed as having concomitant grade І-ІІ alimentary obesity that was supported by clinical and immunological findings evidenced of systemic inflammation. Analyzing the results obtained, we have found out the prolonged therapy with pioglitazone leads to a decrease in systemic inflammation and contributes to a milder recurrent course of psoriasis.

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The role of leptin in the pathogenesis of ovarian insufficiency in obesity women

Journal of obstetrics and women s diseases ◽

10.17816/jowd65318-24 ◽

2016 ◽

Vol 65 (3) ◽

pp. 18-24

Author(s):

Ekaterina М Riazantceva

Keyword(s):

Reproductive Age ◽

Blood Levels ◽

Obese Women ◽

Ovarian Dysfunction ◽

Ovarian Insufficiency ◽

Reproductive Age Women ◽

Alimentary Obesity ◽

Immunoenzymatic Assay ◽

Follicular Stimulating Hormone

Actuality. Ovarian insufficiency can be diagnosed in more than 30% of reproductive age women with obesity. The role of leptin in the pathogenesis of ovarian insufficiency in obesity is not well understood and needs to be detalised. The aim of the study: to ivestigate the role of leptin in the pathogenesis of ovarian insufficiency in obesity. Materials and methods. 50 reproductive age females with BMI > 26.5 kg/m2 were studied. 10 healthy reproductive age females were used as control. Blood levels of leptin, gonadotropins, prolactin, sex steroid hormones were measured by immunoenzymatic assay and pelvic echoscopy were performed in all studied patients and co ntrols. Results. 72% of obese women had signs of ovarian insufficiency, such as ovarian enlargement and increased antral follicular count. The level of leptin did not correlate with the presence or absence of ovarian insufficiency in our patient group. The positive correlation between leptin level and BMI, luteinizing hormone (LG) and oestradiol and negative correlation between leptin level and follicular stimulating hormone (FSH) were revealed. Conclusion. The results of our study do not support the hyperleptinemia as the main cause of ovarian dysfunction in alimentary obesity. The most potential reason of ovarian dysfunction in these women could be ovarian or non-ovarian origin hyperoestrogenia leading to premature LG piques, and, thus, disturbing folliculogenesis in ovaria.

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The thiol-disulfide homeostasis and its role in the pathogenesis of the experimental alimentary obesity

Bangladesh Journal of Medical Science ◽

10.3329/bjms.v15i3.26290 ◽

2016 ◽

Vol 15 (3) ◽

pp. 419-423

Author(s):

Mariya Marushchak ◽

Inna Krynytska ◽

Lyudmyla Mazur ◽

Svitlana Yastremska ◽

Nina Begosh

Keyword(s):

Adipose Tissue ◽

Medical Science ◽

Redox System ◽

Control Group ◽

White Rats ◽

The World ◽

Calorie Diet ◽

Alimentary Obesity ◽

High Calorie Diet ◽

High Calorie

Objective: According to WHO, about 30 % of people in the world are overweight that allows to characterize this disease as a new non-infection epidemic of the XXI century. More than 500 million people in the world are overweight and 250 million are obese. There is a clear tendency to increasing of alimentary obesity among people with different age, sex and nationality. The aim of the study is to investigate the thiol-disulfide homeostasis in liver tissue, adipose tissue and erythrocytes in the pathogenesis of experimental alimentary obesity.Materials and methods: 60 males, non-liner, white rats around 3 months of age with alimentary obesity were examined during the study. Experimental obesity was modeled by administering of sodium glutamate to the feed mixture in a ratio of 0.6:100.0 and adding high-calorie diet. The glutathione redox-system activity in erythrocytes, liver and adipose tissue were analyzed by the level of reduced glutathione (GSH), oxidized glutathione (GSSG), glutathione reductase (GR) and glutathione peroxidase (GP) activity.Results and Discussion: The data indicate a decrease in GSH level within 14 days of the experiment in all investigated tissues. The same trend was observed in animals on 28th day of the experiment: GSH index decreased in blood, adipose tissue and liver (P<0.05). The index of GSSG have increased on 28th day of the experiment in all investigated tissues vs control group (P<0.05). The ratio of the reduced and oxidized forms of glutathione contents was much lower vs control group in all the studied tissues within 28 days of the experiment. During additional investigation of the activity of thiol-disulfide system enzymes it was found that reducing the concentration of GSH in rats with alimentary obesity was due to the lack of thiol-disulfide system enzymes activity: GP and GR, which take part in the regeneration of GSH from GSSG.Conclusion: experimental alimentary obesity is characterized by a reduced redox state in blood, adipose and liver tissues, which is determinative in increasing the free radical reactions and accumulation of highly toxic lipoperoxides in the tissue substrates.Bangladesh Journal of Medical Science Vol.15(3) 2016 p.419-423

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Stress Response to Physical Exercise in Rats with Alimentary Obesity

Bulletin of Experimental Biology and Medicine ◽

10.1007/s10517-018-4037-6 ◽

2018 ◽

Vol 164 (5) ◽

pp. 587-590

Author(s):

N. A. Pal’chikova ◽

O. I. Kuzminova ◽

V. G. Selyatitskaya

Keyword(s):

Stress Response ◽

Physical Exercise ◽

Alimentary Obesity

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The conception of the probable role of the biological active chromium in the emergence of insulin resistance and alimentary obesity

International Professional Journal Medicine ◽

10.31082/1728-452x-2021-223-1-34-38 ◽

2021 ◽

Vol 1 (223) ◽

pp. 34-38

Author(s):

Bolat Abishev ◽

Keyword(s):

Insulin Resistance ◽

Structural Organization ◽

Redox State ◽

Metabolic Response ◽

Essential Element ◽

Insulin Receptors ◽

Trivalent Chromium ◽

Manual Search ◽

Alimentary Obesity ◽

Search And Selection

The conception of probable alimentary chromium role in connection with metabolic reasons emergence of insulin resistance in the alimentary obesity and type 2 diabetes is represented. The violation of insulin receptors structural organization and conformation with these pathological conditions in connection with redox states of chromium is supposed. Based on information from general chemistry and chromium metabolism, higher biological activity of hexavalent chromium when compared to the activity of trivalent chromium is assumed in insulin-resistant conditions. Aim. To analyze the literature data on the a supposed participation of chromium in food and chromium nutraceuticals in connection with insulin resistance at the metabolic level. Material and methods. The analysis of the literature was carried out by the method of manual search and selection of the most important and significant for the analyzed issue monographs and articles up to 60 years in depth. The search criteria were works directly related to the association of food chromium with the insulin-dependent metabolic response of cells and the activity of insulin receptors. No works published over the past 10 years that introduce principled novelty and are of principled importance for the present problem have not been identified. Results and discussion. The concept of the supposed participation of chromium as an essential element in connection with the metabolic reasons for the formation of insulin resistance and the structural organization of insulin receptors depending on the redox state of chromium is presented. Keywords: hexavalent and trivalent chromium, insulin resistance, redox state, insulin receptor, alimentary obesity, diabetes.

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The prevalence of subclinical hypercorticism among the patients presenting with type 2 diabetes mellitus and alimentary obesity

Problems of Endocrinology ◽

10.14341/probl20146019-17 ◽

2014 ◽

Vol 60 (1) ◽

pp. 9-17

Author(s):

A V Dreval ◽

I V Komerdus ◽

A V Murzina ◽

O A Nechaeva ◽

R S Tishenina ◽

...

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Adrenal Glands ◽

Clinical Manifestations ◽

Cortisol Secretion ◽

Pathological Changes ◽

Imaging Studies ◽

Alimentary Obesity

Subclinical hypercorticism is characterized by increased cortisol secretion in the absence of the specific clinical manifestations of the disease. The prevalence of subclinical hypercorticism has been estimated at 8 cases per 10,000 population even though the frequency of subclinical hypercorticism may be higher among certain groups of the patients. We observed 111 patients presenting with type 2 diabetes mellitus and 40 ones with alimentary obesity. As a result, subclinical hypercorticism was diagnosed in 4 (10%) patients with obesity and in 12 (12%) ones with diabetes mellitus. In two of these cases, the diagnosis was later changed to clinically manifested hypercorticism. The imaging studies revealed pathological changes in pituitary and adrenal glands in six of the 16 patients presenting with subclinical hypercorticism. An algorithm for the examination of the patients with type 2 diabetes mellitus and alimentary obesity for the purpose of diagnostics of subclinical hypercorticism is proposed.

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Thyrocyte morphology and function in alimentary obesity: An ontogenetic approach

Bulletin of Experimental Biology and Medicine ◽

10.1007/bf00827224 ◽

1982 ◽

Vol 94 (4) ◽

pp. 1441-1445

Author(s):

V. G. Baranov ◽

O. K. Khmel'nitskii ◽

G. S. Kreichman

Keyword(s):

Alimentary Obesity ◽

And Function

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