scholarly journals A criticism of the reductionist and holistic vision in the planning of drugs in biological, chemical and physical level

2021 ◽  
Vol 46 (3) ◽  
pp. 17-32
Author(s):  
Daniel Augusto Barra De Oliveira ◽  
Edenilson dos Santos Niculau
Keyword(s):  
Quantum Theory ◽  
Drug Design ◽  
Modern Science ◽  
Biological Molecules ◽  
The Other ◽  
Holistic View ◽  
Physical Level ◽  
Metabolic Action ◽  
Holistic Vision ◽  
Slight Advantage

In this work, two philosophical premises of science applied in the understanding of diseases and in the planning of drugs were studied. The first premise is reductionism. This idea is present in modern science when a problem can be reduced to the sum of its individual parts. Diseases can be understood as the metabolic action of few enzymes. Drugs can be planned through the mimicry of a specific enzymatic substrate. Biological molecules can be explained by the quantum theory applied to atoms and molecules. his idea has been the predominant way in modern science. On the other hand, there is a holistic view of the phenomenon. In this holistic view, the phenomenon must be understood as the whole. Drug design should be thought from a network of proteins, not just from a single enzymatic target. There is in fact a slight advantage in the reductionist method, because this philosophical view simplifies the problem. Today, a holistic view combined with methodological reductionism is used to develop new potential drugs.

X.—Remarks on Coincidence Experiments with Visible Light

1962 ◽  
Vol 66 (2) ◽  
pp. 111-115
Author(s):  
Z. Bay ◽  
P. S. Farago
Keyword(s):  
Quantum Theory ◽  
Visible Light ◽  
The Other ◽  
Coherent Light ◽  
Quadratic Effect ◽  
Linear Effect ◽  
Negative Results ◽  
Light Beams

SynopsisAfter the detection of correlations in two coherent light beams by Hanbury Brown and Twiss, objections were raised by Brannen and Ferguson on the basis of the experiments of Adam, Janossy and Varga and their own experiments in which no correlations were detected. It is pointed out here that the different groups were looking for two entirely different effects, one being quadratic, the other one linear in the number of photons involved; the quadratic effect (discovered by Hanbury Brown and Twiss) is in agreement with quantum theory while the linear effect is not. It was shown by Purcell and by Hanbury Brown and Twiss that the choice of parameters in the experiments which gave negative results was inadequate to show the quadratic effect. It is shown in this paper that their experiments were also inadequate to decide between the existence or nonexistence of the linear effect.

Emergence as a Metaphysical Fact

KronoScope ◽  
2013 ◽  
Vol 13 (1) ◽  
pp. 141-152
Author(s):  
Hervé Barreau
Keyword(s):  
Scientific Explanation ◽  
Laws Of Nature ◽  
Modern Science ◽  
Weak Form ◽  
Anthropic Principle ◽  
The Other ◽  
Teleological Explanation ◽  
Cosmic Evolution ◽  
Modern Cosmology ◽  
The One

Abstract A metaphysical fact is a fact, clearly recognizable in the course of time, for which there is no scientific explanation, that is, no legal explanation or explanation deduced in the manner recommended by modern science. I contend that life’s emergence and human thought’s emergence are metaphysical facts in this sense. These emergences are not to be explained by Darwinian principles which themselves do not seem adequate to explain genetic evolutionism. But modern cosmology has given us leave to reflect on cosmic evolution in a manner which gives sense to overall finality. There is an anthropic principle which has two forms: in the weak form, it can help science discover new legal explanations; in the strong form, it offers a teleological explanation of the laws of nature. As F. Dyson noted, we have two styles of explanation: the one is scientific; the other is metascientific (or metaphysical). We have no reason to reject teleological explanations about ontological questions.

The Gravity Funnels, formed by the longitudinal vortices, according to the new Axioms and Laws

2021 ◽  
Vol 4 (1) ◽  
Keyword(s):  
Gravitational Waves ◽  
Scientific Theory ◽  
Transverse Direction ◽  
Modern Science ◽  
Longitudinal Direction ◽  
Space Time ◽  
The Other ◽  
Longitudinal Vortices ◽  
New Space ◽  
The One

In the age of information, it is no secret that the modern science is in a very difficult position. On the one hand, it has high hopes for solving the problems of modern humanity and very practical tasks. On the other hand, science shows limited potential and difficulty in carrying out the tasks. Beyond scientific theory remain such phenomena as gravity and gravitational waves and other unexplored and very useful phenomena. Obviously, the reason for these limited capabilities of modern science is its limited foundation. The foundation of science is determined by its basic axioms. If we expand the foundation of science, we will be able to build a more comprehensive, perfect and voluminous theory. In two monographs and a series of articles the author offers a system of extended axioms (with two new axioms) and a more extended theory (with eight new laws). To the great surprise of even the author, this new theory turned out to be extensive enough to cover and explain and the gravity. Moreover, the extended axioms and theory directly and naturally outlined the algorithm in the explanation of the so-called Gravity Funnels. According to the new axioms and laws, Gravity Funnels are both for suction (accelerating) and for expansion (decelerating). Expansion Gravity Funnel decelerates along its longitudinal direction as emits the matter in the transverse direction. In this way it consumes energy and generates matter. Suction Gravity Funnel accelerates along its longitudinal direction as sucks the matter in transverse direction. In this way it consumes matter and generates energy. The both of Funnels are situated in a new Space-time. The Space-time of decelerating and accelerating Funnels is packed by longitudinal vortices, in which the Space (S) is constant. It is radically different of the Space-Time where we live now. The Space-time where we live now is packed by cross vortices, where the time (T) is constant. According the new Axioms and Laws the two described Space- times are mutually orthogonal.

Myths, Myths, Everywhere

2021 ◽  
pp. 135-158
Author(s):  
David Hutchings
Keyword(s):  
Modern Science ◽  
Science And Religion ◽  
The Other ◽  
Galileo Galilei ◽  
Giordano Bruno ◽  
John William Draper ◽  
The Church ◽  
True Science

This chapter debunks a series of myths about science and religion. These include the idea that Giordano Bruno and then Galileo Galilei were martyrs of modern science; that Copernicanism was unilaterally opposed by the Church; that Christianity sets faith against evidence; that reason has played no part in Christian thinking over its history; that true science is only ever cold, detached, and rational; that thinkers must pick a side in the war between “science” and “religion.” Modern examples of all of these myths are given, ranging from academic works to bestselling novels. Each is studied in turn, and then revealed to be false. As with the other chapters, John William Draper and Andrew Dickson White are shown to be largely responsible for popularizing them in the first place.

scholarly journals Perspective: The promises of a holistic view of proteins—impact on antibody engineering and drug discovery

2019 ◽  
Vol 39 (1) ◽  
Author(s):  
Ser-Xian Phua ◽  
Kwok-Fong Chan ◽  
Chinh Tran-To Su ◽  
Jun-Jie Poh ◽  
Samuel Ken-En Gan
Keyword(s):  
Drug Discovery ◽  
Drug Design ◽  
Antibody Engineering ◽  
Rational Drug Design ◽  
Biomedical Science ◽  
Great Promise ◽  
Holistic View ◽  
Rational Drug ◽  
Big Picture ◽  
Reductionist Approach

AbstractThe reductionist approach is prevalent in biomedical science. However, increasing evidence now shows that biological systems cannot be simply considered as the sum of its parts. With experimental, technological, and computational advances, we can now do more than view parts in isolation, thus we propose that an increasing holistic view (where a protein is investigated as much as a whole as possible) is now timely. To further advocate this, we review and discuss several studies and applications involving allostery, where distant protein regions can cross-talk to influence functionality. Therefore, we believe that an increasing big picture approach holds great promise, particularly in the areas of antibody engineering and drug discovery in rational drug design.

scholarly journals Investigating nature within different discursive and ideological contexts: case studies of Chinese and Indian coal capitals

BJHS Themes ◽  
2016 ◽  
Vol 1 ◽  
pp. 199-220 ◽  
Author(s):  
PIN-HSIEN WU
Keyword(s):  
Comparative Analysis ◽  
Case Studies ◽  
Environmental Performance ◽  
Knowledge Construction ◽  
Modern Science ◽  
The Other ◽  
The Public ◽  
Indian Coal ◽  
Environmental Campaigns ◽  
Critical Literature

AbstractGiven that purely scientific accounts of ‘environmental performance’ and ‘development’ cannot fully explain the environment and its interactions with people, this paper investigates how nature has been historically and sociopolitically defined in different societies. The analyses and observations presented in this paper are based on a critical literature review and on case studies of two ‘coal capitals’, one in Guizhou in China and the other in Jharkhand in India. The study examines the historical representations of environmental campaigns (particularly from the 1950s to the 1990s) in the two countries, and discusses how historical, sociopolitical and ideological factors have affected conceptualizations of nature and how they are reflected nowadays in people's narratives concerning the environment. The paper concludes that the Chinese pattern of development, as well as of knowledge construction, reflects a greater intention of homogenizing the public with the language of development deployed by the centralized power; meanwhile, the Indian pattern allows a greater space for the representation of conflicts, including people's struggles against the state. The comparative analysis enriches our understanding of people's responses to official perceptions of the environment endorsed by modern science and governance.

Two Teaching Styles, Problem Solving, and Guided Discovery in Motor Performance and Learning

1979 ◽  
Vol 48 (3_suppl) ◽  
pp. 1243-1248
Author(s):  
S. E. Moxley ◽  
F. P. Covey
Keyword(s):  
Problem Solving ◽  
Learning Strategies ◽  
Relative Effectiveness ◽  
Teaching Styles ◽  
Motor Task ◽  
The Other ◽  
Guided Discovery ◽  
Practice Condition ◽  
Practice Trials ◽  
Slight Advantage

Three groups of 25 matched subjects (aged 10 to 12 yr.) took part in this study. In the practice condition one group performed the solution of the Tinkertoy Motorcycle Model in a problem-solving manner, while the other two groups performed in a guided manner. One guided group performed the same number of trials as the problem-solving group, while the other group had the same total time performing each trial as the problem-solving group. Their relative effectiveness was compared on the six initial practice trials and on six trials after a period of no practice. The problem-solving group received no direct assistance. The guided groups saw two demonstrations of the assembling procedure along with verbal feedback as to the selection and placement of pieces on the figure. The guided groups performed the task significantly faster than the problem-solving group on all practice trials. When measured for retention there were no significant differences among groups. The two guided groups however did maintain a slight advantage over the problem-solving group. It was concluded the practice of the perceptual motor task was facilitated by a guided discovery, while retention was not significantly different. The results are discussed in relation to learning strategies and type of task.

Translanguaging and linguistic landscapes

2015 ◽  
Vol 1 (1-2) ◽  
pp. 54-74 ◽  
Author(s):  
Durk Gorter ◽  
Jasone Cenoz
Keyword(s):  
The Other ◽  
Holistic View ◽  
Linguistic Resources ◽  
School Settings ◽  
Other Hand ◽  
San Sebastian ◽  
The One ◽  
The Individual ◽  
Neighborhood Level

In this article we discuss the concept of translanguaging in relation to a holistic view of linguistic landscapes that goes beyond the analysis of individual signs. On the one hand, we look at instances of multilingual signage as a combination of linguistic resources. On the other hand, at the neighborhood level the individual signs combine, alternate and mix to shape linguistic landscapes as a whole. We expand our “Focus on Multilingualism” approach from school settings to the multilingual cityscape. One bookshop and its surrounding neighborhoods in Donostia-San Sebastián illustrate how readers navigate between languages and go across linguistic borders. Through translanguaging we foreground the co-occurrence of different linguistic forms, signs and modalities. At the level of neighborhood emerges the space in which translanguaging goes outside the scope of single signs and separate languages. We conclude that translanguaging is an approach to linguistic landscapes that takes the study of multilingualism forward.

Towards a self-consistent thermodynamic magmatic model for conduit transport processes

2020 ◽  
Author(s):  
Jost von der Lieth ◽  
Matthias Hort
Keyword(s):  
Numerical Study ◽  
Numerical Models ◽  
Fluid Dynamic ◽  
Dynamic Modelling ◽  
Explosive Volcanism ◽  
Transport Processes ◽  
The Other ◽  
Full Potential ◽  
Holistic View ◽  
Self Consistent

<p>The geodynamical side of explosive volcanic eruption modelling on the one hand, as well as the petrological one on the other, have reached a high degree of sophistication and maturity independently from each other over the years. Unfortunately, adherents of one discipline often only utilize the other’s tools in a simplified and makeshift way, obscuring the full potential of their synergies. Over the past decade efforts have been made to re-integrate both approaches to the issue into a more holistic view on the sub-surface processes leading to and concurrent with explosive volcanism.<br>One of the difficulties encountered in that effort are conceptual and technical incompatibilities between thermo- and fluid-dynamic modelling toolboxes. While the tools perform well individually, they are often not suitable to work in combination in highly complex numerical models, due to interface problems impeding performance.<br>For an ongoing numerical study on transport processes within a volcanic conduit, it has been deemed necessary to re-implement an established thermodynamic model based on Holland and Powell (2011, and follow-ups) in order to a) attain the required computing performance and b) to gain sufficient petrological insight (starting from a geophysical point of view) to be able to make apt use of the tool then at hand.<br>The path to the intermediate goal of deriving the thermodynamic and transport properties (e.g. density, viscosity, heat capacity and conductivity) in a <em>self-consistent and stable</em> manner suitable for further use in a numerical fluid-dynamics model is illustrated here. The focus is on problems encountered with the petrological modelling, and on the subsequent derivation of the above properties, that are not directly available from the former results. The methods presented are general and applicable to various settings regarding volcanic chemistry and transport processes, however, they will be demonstrated on low-viscosity open-conduit systems typical for strombolian activity.</p>

Russian and Chinese Communicative Tradition in the Language of Legal Documents: Lexical Aspect

10.12737/5743 ◽  
2014 ◽  
Vol 3 (5) ◽  
pp. 28-33
Author(s):  
Никифорова ◽  
Kh. Nikiforova ◽  
Маслов ◽  
A. Maslov ◽  
Просвиркина ◽  
...  
Keyword(s):  
Modern Science ◽  
Business Communication ◽  
The Other ◽  
Business Culture ◽  
Cultural Meaning ◽  
New Words ◽  
Lexical Aspect ◽  
Legal Documents ◽  
Chinese Business ◽  
The One

This article focuses on communicative language tradition in the language of legal documents. Authors dwell on the analysis of the «verbal communication » term and its understanding in modern science. As evidence, the analysis of this definition in various Russian and Chinese dictionaries is given. In addition, the article mentions the fact that the modern business communication (both Russian and Chinese), on the one hand, is under the influence of western business culture, and on the other hand, preserves communicative traditions of business letter. The authors note that the Chinese communicative tradition is more stable, which is observed in the lexical legislative «word creation». This phenomenon is due to the special way of «borrowing» of new words in Chinese. In addition, the article draws attention to the particular cultural meaning of lexical units of Chinese business documents.

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