Obesity and Gastroesophageal Reflux Disease: A Meta-Analysis Study in Asia and America

2020 ◽  
Author(s):  
Alfiani Vivi Sutanto ◽  
◽  
Hanung Prasetya ◽  
◽  
Keyword(s):  
Gastroesophageal Reflux Disease ◽  
Gastroesophageal Reflux ◽  
Reflux Disease ◽  
Meta Analysis ◽  
Random Effect ◽  
Random Effect Model ◽  
The United States ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Central Java

ABSTRACT Background: Gastroesophageal reflux disease (GERD) is a common disorder with a prevalence of 20% in the United States and less than 5% in Asia. Untreated, GERD can result in a symptomatic burden to the patient, poor health-related quality of life, complications, such as esophageal stricture, Barrett’s esophagus, and esophageal adenocarcinoma, and a high direct and indirect cost to the healthcare system. Various pathophysiological mechanisms have been identified to explain the relationship between obesity and GERD, including a high prevalence of hiatal hernia and increased gastroesophageal pressure gradient. This study aimed to examine the association between obesity and GERD in Asia and America. Subjects and Method: This was meta-analysis and systematic review. The study was conducted by collecting articles from PubMed, Google Scholar, BMC Journals, Science Direct, Mendeley, and clinical key databases. Keywords used “Obesity” OR “HMI” AND “Gastroesophageal reflux disease” OR “GERD” AND “Effect obesity for GERD” AND “aOR”. The inclusion criteria were full text, using cross-sectional study design, and reporting adjusted odds ratio. The study population was adults who experienced GERD. Intervention was obesity. The study outcome was gastroesophageal reflux disease (GERD). The articles were selected using PRISMA flow chart. The quantitative data were analyzed using random effect model run on Revman 5.3. Results: 5 studies were analyzed and reviewed for this study. Current study reported that obesity increased the risk of gastroesophageal reflux disease (GERD) (aOR= 2.04; 95% CI=1.42 to 2.92; p= 0.001). Conclusion: Obesity increases the risk of gastroesophageal reflux disease. Keywords: obesity, gastroesophageal reflux disease Correspondence: Alfiani Vivi Sutanto. Masters Program in Public Health. Universitas Sebelas Maret, Jl. Ir. Sutami 36A, Surakarta 57126, Central Java. Email: [email protected]. Mobile: 085799253568. DOI: https://doi.org/10.26911/the7thicph.05.50

scholarly journals Enfermedad por reflujo gastroesofágico y enfermedades neurológicas en pediatría: complicaciones funcionales y motoras post funduplicatura de Nissen

2020 ◽  
Vol 50 (4) ◽  
Author(s):  
María Alejandra Mortarini ◽  
Daniela Neder ◽  
Ana Rocca
Keyword(s):  
Cerebral Palsy ◽  
Gastroesophageal Reflux Disease ◽  
Gastroesophageal Reflux ◽  
Reflux Disease ◽  
Nissen Fundoplication ◽  
Neurological Impairment ◽  
Cross Sectional Study ◽  
Laparoscopic Technique ◽  
Surgical Time ◽  
Cross Sectional

Motility disorders are frequent in children with cerebral palsy. The prevalence of gastroesophageal reflux disease varies from the 15% to 75% in patients with cerebral palsy. Nissen fundoplication is the most used antireflux technique not without complications in this population. Our objective was to determine the frequency and the characteristics of the long-term functional and motility complications in patients with Nissen fundoplication and cerebral palsy. A descriptive cross-sectional study was performed. Data collection was acquired retrospectively with neurologic compromise between 2012 and 2017 in patients between 0 to 18 years old, with neurological impairment and Nissen fundoplication. 35 patients were included. Median age was 55 months (2-190). Gastroesophageal reflux disease was diagnosed in the 48%, in the 52% of this the diagnosis was clinical. It was performed by laparoscopic technique in the 91.4% of the cases gastrostomy was done in the same surgical time in 86% of the patients because of neurological impairment and risk of aspiration. In 25.7% (n = 9) there were functional and motor complications, Dumping syndrome (5.5%) accommodation disorders (11.4%) and recurrence of reflux (11.4%). Redo Nissen was required in the 8.5% of the patients (n = 3). In 75% of the patients with complications, gastrostomy was performed in the same surgical time. It could not be demonstrated that gastrostomy at the time of antireflux surgery was associated with greater frequency of complications.

scholarly journals Gene Expression Profiling of Inflammatory Cytokines in Esophageal Biopsies of Different Phenotypes of Gastroesophageal Reflux Disease: a cross-sectional study.

2020 ◽  
Author(s):  
Monica Zavala-Solares ◽  
Gabriela Fonseca-Camarillo ◽  
Miguel Valdovinos ◽  
Julio Granados ◽  
Guido Grajales-Figueroa ◽  
...  
Keyword(s):  
Gene Expression ◽  
Gastroesophageal Reflux Disease ◽  
Gastroesophageal Reflux ◽  
Reflux Disease ◽  
Cross Sectional Study ◽  
Control Group ◽  
Esophageal Mucosa ◽  
Cross Sectional ◽  
Tnf Α ◽  
And Control

Abstract Background: Patients clinical endoscopic phenotypes in gastroesophageal reflux disease (GERD) are classified as: Barrett's esophagus (BE), erosive esophagitis (EE) and non-erosive gastroesophageal reflux disease (NERD). NERD are subclassified in Abnormal acid exposure (AAE) and Normal acid exposure (NAE) according to pH monitoring study. The aim of this study was to characterize genes involved in the pathophysiology and immune response of GERD.Methods: This is an observational and cross-sectional study. All patients with BE, EE, AAE, NAE and control group were subjected to a superior endoscopy (with biopsies of esophageal mucosa). The cytokine mRNA relative quantification of target genes was conducted by RT-PCR. Changes in gene expression were assessed of the genes associated with inflammation in each disease phenotype. Statistical analysis of differential gene expression was performed by using Dunn's Multiple Comparison non-parametric test. A p value < 0.05 was considered as significant. Results: A total of 82 patients were included and they were divided into the following groups: Group BE 16 (19.51%), Group EE 23 (28.04%), Group AAE 13 (15.86%), NAE (15.86%) and Control Group 17 (20.73%). When comparing with control group we found: patients with BE showed an increased expression of IL-8 (P<0.005) and higher levels of: IL-10 and MMP-3, MMP-9 as well; patients with EE had higher levels of IL-1B, IL-6 and IL-10 (P<0.005), patients with AAE showed an increased expression of Il-1B, Il-6, IFN-γ and TNF-α (P<0.005). AAE had a higher expression of Il-1B and TNF-α than NAE (P<0.005). Conclusions: This study demonstrates the differential expression of mediators of inflammation in the esophageal mucosa of patients in GERD endoscopic phenotypes. MMP3 could be implicated in damage to esophageal mucosa. IL-1B and TNF-α could be a differential diagnosis between AAE and NAE in the non-erosive phenotype from endoscopic biopsies.

scholarly journals Effect of HIV Infection on Mortality in Patients with Tuberculosis in Asia: A Meta-Analysis

2020 ◽  
Author(s):  
Liza Laela Abida ◽  
◽  
Bhisma Murti ◽  
Hanung Prasetya ◽  
◽  
...  
Keyword(s):  
Hiv Infection ◽  
Meta Analysis ◽  
Random Effect ◽  
Random Effect Model ◽  
Cross Sectional Study ◽  
People Living With Hiv ◽  
Cross Sectional ◽  
Risk Of Mortality ◽  
Hiv Mortality ◽  
Keywords Hiv

ABSTRACT Background: TB/HIV coinfectioned remains the leading cause of mortality among people living with HIV (PLHIV). The purpose of this study was to explore the effect of HIV infection on mortality in patients with tuberculosis in Asia. Subjects and Method: This was meta-analysis and systematic review. The study was conducted by collecting published studies from Google Scholar, PubMed, Springer Link, Hindawi, Clinical Key, and ProQuest databases, from 2010 to 2020. Keywords used “HIV” AND “mortality” OR “HIV Mortality” OR “Tuberculosis Mortality” AND “cross sectional” AND “adjusted odd ratio”. The inclusion criteria were full text, using English or Indonesian language, using cross-sectional study design, and reporting adjusted odds ratio. The articles were selected by PRISMA flow chart. The quantitative data were analyzed using random effect model run on Review Manager 5.3. Results: 5 studies in Asia (Thailand, China, Malaysia, and Oman) were included for this study. Meta analysis study reported that HIV elevated the risk of mortality in patients with tuberculosis (aOR= 3.45; 95% CI= 1.14 to 10.45; p = 0.030). Conclusion: HIV elevates the risk of mortality in patients with tuberculosis. Keywords: HIV, mortality, Tuberculosis Correspondence: Liza Laela Abida. Masters Program in Public Health, Universitas Sebelas Maret. Jl. Ir. Sutami 36A, Surakarta 57126, Central Java. Email: [email protected]. Mobile: 085640115633. DOI: https://doi.org/10.26911/the7thicph.01.52

scholarly journals Effect of Secondary Education on Exclusive Breastfeeding: Meta-Analysis

2020 ◽  
Author(s):  
Ferda Fibi Tyas Nurkholifa ◽  
◽  
Eti Poncorini Pamungkasari ◽  
Hanung Prasetya ◽  
◽  
...  
Keyword(s):  
Secondary Education ◽  
Exclusive Breastfeeding ◽  
Meta Analysis ◽  
Random Effect ◽  
Random Effect Model ◽  
South Australia ◽  
Inclusion Criteria ◽  
Or Education ◽  
Cross Sectional ◽  
Central Java

ABSTRACT Background: Many studies reported the importance of exclusive breastfeeding for infants. However, there are many obstacles faced by lactating mothers to provide exclusive breastfeeding for their children. This study aimed to investigate the effect of secondary education on exclusive breastfeeding using a meta-analysis. Subjects and Method: Meta-analysis and systematic review were conducted by collecting articles from PubMed, Science Direct, and Google Scholar databases. Keywords used exclusive breastfeeding” AND “secondary education” OR “education for breastfeeding” AND “cross sectional” AND “adjusted odd ratio”. The study population was postpartum mothers. Intervention was secondary education with comparison primary education. The study outcome was exclusive breastfeeding. The inclusion criteria were full text, using English or Indonesian language, and reporting adjusted odds ratio. The articles were selected by PRISMA flow chart. The quantitative data were analyzed using random effect model run on Revman 5.3. Results: 7 studies from Peru, China, Nigeria, Korea, Ireland, Sub-Sahara, and South Australia were met the inclusion criteria. There was high heterogeneity between groups (I2= 94%; p<0.001). This study reported that secondary education reduced exclusive breastfeeding, but it was statistically non-significant (aOR= 0.86; 95% CI= 0.60 to 1.24; p= 0.430). Conclusion: Secondary education reduced exclusive breastfeeding, but it was statistically non-significant. Keywords: exclusive breastfeeding, secondary education, postpartum Correspondence: Ferda Fibi Tyas Nurkholifa. Masters Program in Public Health, Universitas Sebelas Maret. Jl. Ir. Sutami 36A, Surakarta 57126, Central Java. Email: [email protected]. Mobile: +6285655778863. DOI: https://doi.org/10.26911/the7thicph.03.131

scholarly journals Associations among Bruxism, Gastroesophageal Reflux Disease, and Tooth Wear

2018 ◽  
Vol 7 (11) ◽  
pp. 417 ◽  
Author(s):  
Yuanyuan Li ◽  
Fan Yu ◽  
Lina Niu ◽  
Wei Hu ◽  
Yong Long ◽  
...  
Keyword(s):  
Gastroesophageal Reflux Disease ◽  
Gastroesophageal Reflux ◽  
Reflux Disease ◽  
Matched Control ◽  
Tooth Wear ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Time Periods ◽  
The Relationship ◽  
Control Study

The relationship between bruxism and tooth wear is contentious in the literature. The pathophysiological processes of tooth wear may be complicated by the relationship between bruxism and gastroesophageal reflux disease (GERD). The objective of this study was to evaluate the associations among bruxism, GERD, and tooth wear. Two complementary studies were performed: a case-control study to verify the linkage between GERD and bruxism and a cross-sectional study on the same cohort to establish the connection between GERD and tooth wear in bruxism patients. A cohort of 363 consecutive bruxism patients and 363 matched control participants were recruited. Gastroesophageal reflux disease was diagnosed in accordance with the Montreal criteria. Tooth wear was scored based on the index recommended by Smith and Knight. Logistic regression analyses were performed. After adjustment, GERD was identified as a risk factor of bruxism. Bruxism with reflux symptoms for extensive time-periods was associated with severe tooth wear for the whole dentition (odds ratio, 4.70, 95% confidence interval, 2.04–10.83). Increased odds ratios for severe tooth wear were also found in all tooth locations and palatal/lingual and occlusal/incisal surfaces of bruxism patients with GERD for extensive time-periods. In conclusion, strong associations were identified among bruxism, GERD, and tooth wear.

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