scholarly journals Correlations between acute phase proteins and the body condition score

2017 ◽  
Vol 86 (4) ◽  
pp. 339-344
Author(s):  
Mária Vargová ◽  
Rudolf Hromada ◽  
Katarína Veszelits Laktičová ◽  
Terézia Pošiváková ◽  
Juraj Benculák ◽  
...  
Keyword(s):  
Dairy Cows ◽  
Acute Phase ◽  
Body Condition ◽  
Serum Amyloid A ◽  
Acute Phase Proteins ◽  
Body Condition Score ◽  
The Body ◽  
Serum Amyloid ◽  
Amyloid A ◽  
Condition Score

The objective of this study was to evaluate the dynamics of the body condition score, acute phase proteins (serum amyloid A and haptoglobin) and their relationships in dairy cows of the Slovak Pied Cattle from 3 weeks before parturition to 9 weeks after parturition. Significant differences were found in the means of serum amyloid A (P < 0.01). Haptoglobin concentrations increased from 172.0 ± 0.05 µg/ml to 173.0 ± 0.13 µg/ ml at week 3 and week 1 before the parturition, respectively. The highest value of haptoglobin was recorded in cows 3 week post partum. Cows during the early postparturient period had significantly higher serum amyloid A concentrations compared to cows in the prepartal period (P < 0.01). Significantly higher body condition score values were observed in dry cows (from 4.42 ± 0.20 to 4.25 ± 0.15 points) than in cows after parturition (from 3.90 ± 0.12 to 3.25 ± 0.08 points) (P < 0.001). In the assessment of correlations between the selected acute phase proteins significant positive correlation was found (r = 0.213, P < 0.05). Moreover, negative correlations were found between the body condition score and acute phase proteins. Our results show a strong relationship between the decrease of the body condition score and the increase of acute phase proteins in dairy cows around parturition which indicates the process of a certain form of non-specific inflammation at loss of body fat.

scholarly journals Relationship between pre-partum body condition score changes, acute phase proteins and energy metabolism markers during the peripartum period in dairy cows

2017 ◽  
Vol 16 (2) ◽  
pp. 329-336 ◽  
Author(s):  
Paula Montagner ◽  
Ana Rita Tavares Krause ◽  
Elizabeth Schwegler ◽  
Marina Menoncin Weschenfelder ◽  
Andressa Stein Maffi ◽  
...  
Keyword(s):  
Energy Metabolism ◽  
Dairy Cows ◽  
Acute Phase ◽  
Body Condition ◽  
Acute Phase Proteins ◽  
Body Condition Score ◽  
Condition Score ◽  
Peripartum Period

scholarly journals Determination of selected acute phase proteins during the treatment of limb diseases in dairy cows

2008 ◽  
Vol 53 (No. 4) ◽  
pp. 173-183 ◽  
Author(s):  
P. Jawor ◽  
S. Steiner ◽  
T. Stefaniak ◽  
W. Baumgartner ◽  
A. Rzasa
Keyword(s):  
Treatment Group ◽  
Dairy Cows ◽  
Acute Phase ◽  
Serum Amyloid A ◽  
Acute Phase Proteins ◽  
Acute Phase Protein ◽  
Serum Amyloid ◽  
Blood Samples ◽  
Amyloid A ◽  
Phase Protein

The purpose of this study was to assess the diagnostic value of fibrinogen, haptoglobin, and serum amyloid A determination in the monitoring of the treatment of limb diseases in dairy cows. Fourteen lame cows were examined, while 10 clinically healthy cows constituted the control group. Blood samples from the ill animals were collected on three occasions: (1) upon arrival at the clinic, (2) between the third and sixth day after arriving, and (3) upon return to the owner. Blood samples from the control cows were collected once. Plasma levels of fibrinogen, haptoglobin, serum amyloid A, and total serum protein and its fractions (albumin, &alpha;-, &beta;-, &gamma;-globulins) were measured. Significantly higher fibrinogen, haptoglobin, and serum amyloid A levels were observed in the affected cows upon arrival at the clinic than in the control cows. Based on the changes in fibrinogen, haptoglobin, and serum amyloid A concentrations, the cows were divided into those with a systematic decrease in acute-phase protein levels during treatment (Group I, <I>n</I> = 6) and those which showed an increase in one or more acute-phase proteins despite treatment (Group II, <I>n</I> = 8). A stepwise decrease in the examined acute-phase proteins was observed in the first group and indicated an uncomplicated course of treatment; however, treatment of the second group did not appear to be wholly successful. A majority of the cows under treatment (<I>n</I> = 13) exhibited abnormal levels of the examined acute-phase proteins upon return to the owner. This indicates that these patients did not recover completely. The monitoring of plasma acute-phase protein concentrations can be a valuable complement to the clinical assessment of the treatment course and in the early detection of disease complications.

scholarly journals Interrelationship between Somatic Cell Count and Acute Phase Proteins in Serum and Milk of Dairy Cows

2007 ◽  
Vol 76 (1) ◽  
pp. 51-57 ◽  
Author(s):  
G. Kováč ◽  
M. Popelková ◽  
Ľ. Tkáčiková ◽  
O. Burdová ◽  
O. Ihnát
Keyword(s):  
Dairy Cows ◽  
Somatic Cell ◽  
Cell Count ◽  
Acute Phase ◽  
Somatic Cell Count ◽  
Serum Amyloid A ◽  
Acute Phase Proteins ◽  
Serum Amyloid ◽  
Amyloid A ◽  
Milk Samples

The aim of the present study was to compare the concentrations of two acute phase proteins, haptoglobin (Hp) and serum amyloid A (SAA), in serum and milk of Holstein-Friesian dairy cows grouped according to somatic cell count thresholds (< 100,000 < 400,000 < 400,000 cells/ml) in composite milk samples. The SCC was assessed quantitatively by FOSSOMATIC 90 analyser; serum and milk Hp and SAA concentrations were determined using commercial ELISA kits (Tridelta Development, Ltd., Wicklow, Ireland). We have found a significantly higher Hp and SAA concentrations in the group with SCC > 400,000 cells/ml compared to groups with lower SCC thresholds in composite milk samples. In contrast, significant differences were not demonstrated between the groups in Hp and SAA concentrations determined in serum. The concentrations of Hp in serum and milk were found to be correlated (r = 0.69, P = 0.0003), whereas there was a lower correlation trend in the case of serum versus milk concentrations of SAA (r = 0.43, P = 0.0478). High significant correlations were observed either between milk haptoglobin values and SCC or milk serum amyloid A concentrations and SCC (r = 0.83, r = 0.81, P < 0.0001; respectively). An increase in SCC in cows suffering from mastitis has been accompanied by strong elevation of the milk Hp and SAA, significantly correlated with serum Hp (r = 0.64, P = 0.0014) and poorly correlated with SAA values determined in serum (r = 0.43, P = 0.0478). According to the results obtained in this study we can conclude that measurements of the acute phase proteins, haptoglobin and serum amyloid A predominantly in milk, may be a useful tool in diagnosing mastitis and may be a useful marker of milk quality.

The acute phase response and C-reactive protein

2020 ◽  
pp. 2199-2207
Author(s):  
Mark B. Pepys
Keyword(s):  
Acute Phase ◽  
Acute Phase Response ◽  
Serum Amyloid A ◽  
Acute Phase Proteins ◽  
Phase Response ◽  
Serum Amyloid ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Amyloid A ◽  
Serum Amyloid A Protein

The acute phase response—trauma, tissue necrosis, infection, inflammation, and malignant neoplasia induce a complex series of nonspecific systemic, physiological, and metabolic responses including fever, leucocytosis, catabolism of muscle proteins, greatly increased de novo synthesis and secretion of a number of ‘acute phase’ plasma proteins, and decreased synthesis of albumin, transthyretin, and high- and low-density lipoproteins. The altered plasma protein concentration profile is called the acute phase response. Acute phase proteins—these are mostly synthesized by hepatocytes, in which transcription is controlled by cytokines including interleukin 1, interleukin 6, and tumour necrosis factor. The circulating concentrations of complement proteins and clotting factors increase by up to 50 to 100%; some of the proteinase inhibitors and α‎1-acid glycoprotein can increase three- to fivefold; but C-reactive protein (CRP) and serum amyloid A protein (an apolipoprotein of high-density lipoprotein particles) are unique in that their concentrations can change by more than 1000-fold. C-reactive protein—this consists of five identical, nonglycosylated, noncovalently associated polypeptide subunits. It binds to autologous and extrinsic materials which contain phosphocholine, including bacteria and their products. Ligand-bound CRP activates the classical complement pathway and triggers the inflammatory and opsonizing activities of the complement system, thereby contributing to innate host resistance to pneumococci and probably to recognition and safe ‘scavenging’ of cellular debris. Clinical features—(1) determination of CRP in serum or plasma is the most useful marker of the acute phase response in most inflammatory and tissue damaging conditions. (2) Acute phase proteins may be harmful in some circumstances. Sustained increased production of serum amyloid A protein can lead to the deposition of AA-type, reactive systemic amyloid.

scholarly journals Acute phase response in the primiparous dairy cows after repeated percutaneous liver biopsy during the transition period

2016 ◽  
Vol 19 (2) ◽  
pp. 393-399 ◽  
Author(s):  
P. Jawor ◽  
A. Brzozowska ◽  
K. Słoniewski ◽  
Z.M. Kowalski ◽  
T. Stefaniak
Keyword(s):  
Body Temperature ◽  
Liver Biopsy ◽  
Dairy Cows ◽  
Acute Phase ◽  
Acute Phase Response ◽  
Serum Amyloid A ◽  
Transition Period ◽  
Phase Response ◽  
Serum Amyloid ◽  
Amyloid A

Abstract The aim of this study was to evaluate the acute phase response of dairy cows to repeated liver biopsy in order to estimate the safety of this procedure during the transition period. Liver biopsies (up to 1000 mg of liver tissue) were conducted twice a day, 7 days before expected parturition and 3 days after calving. The number of needle insertions for each biopsy was recorded and was dependent on the amount of obtained tissue. Blood samples were taken on day 7 before expected parturition, then on days 3, 4, 7 and 14 after calving. Body temperature was measured daily in all 30 cows from day 3 until day 14 after calving. The concentrations of haptoglobin, serum amyloid A, fibrinogen and interleukin-6 were determined in serum and plasma. In 16.7% of cows, the rectal body temperature rose by ≥ 0.5°C on the day after liver biopsy. Although the concentrations of haptoglobin, serum amyloid A and fibrinogen increased significantly after calving (p<0.01), there was no influence of the number of biopsies on the acute phase reaction and repeated biopsy during the transition period had no effect on body temperature. Therefore, the procedure may be regarded as safe for cows during the transition period.

scholarly journals Two major ruminant acute phase proteins, haptoglobin and serum amyloid A, as serum biomarkers during active sheep scab infestation

2013 ◽  
Vol 44 (1) ◽  
pp. 103 ◽  
Author(s):  
Beth Wells ◽  
Giles T Innocent ◽  
Peter D Eckersall ◽  
Eilidh McCulloch ◽  
Alasdair J Nisbet ◽  
...  
Keyword(s):  
Acute Phase ◽  
Serum Amyloid A ◽  
Acute Phase Proteins ◽  
Serum Biomarkers ◽  
Serum Amyloid ◽  
Sheep Scab ◽  
Amyloid A

Haptoglobin and serum amyloid A in milk and serum during acute and chronic experimentally induced Staphylococcus aureus mastitis

2003 ◽  
Vol 70 (4) ◽  
pp. 379-386 ◽  
Author(s):  
Ulrika Grönlund ◽  
Cecilia Hultén ◽  
Peter D. Eckersall ◽  
Caroline Hogarth ◽  
Karin Persson Waller
Keyword(s):  
Staphylococcus Aureus ◽  
Acute Phase ◽  
Serum Amyloid A ◽  
Acute Phase Proteins ◽  
Chronic Phase ◽  
Subclinical Mastitis ◽  
Serum Amyloid ◽  
Amyloid A ◽  
Healthy Control ◽  
Experimentally Induced

Local and systemic changes in the acute phase proteins, haptoglobin and serum amyloid A (SAA), were studied in six dairy cows during the acute and chronic phases of experimentally induced Staphylococcus aureus mastitis. Haptoglobin and SAA were measured in serum, and in milk from infected and healthy control udder quarters within each cow. Concentrations of haptoglobin and SAA increased rapidly in both serum and milk during the acute phase of mastitis and followed a similar pattern. Significantly raised milk concentrations of SAA were also found during chronic subclinical mastitis. Serum concentrations of SAA also tended to be higher during the chronic phase than pre-infection. Increases in milk haptoglobin and SAA were specific for the infected udder quarters. In conclusion, measurement of SAA in milk samples could be a useful tool in diagnosing mastitis.

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