scholarly journals Case report: Fulminant pneumococcal sepsis in an unvaccinated asplenic patient in Italy

2010 ◽  
Vol 15 (23) ◽  
Author(s):  
M Chironna ◽  
A Sallustio ◽  
A De Robertis ◽  
M Quarto ◽  
C Germinario
Keyword(s):  
Case Report ◽  
Streptococcus Pneumoniae ◽  
Young Adult ◽  
Pneumococcal Vaccine ◽  
Fatal Case ◽  
Pneumococcal Infection ◽  
Post Mortem ◽  
Blood Samples ◽  
Pneumococcal Sepsis ◽  
Asplenic Patient

We report a fatal case of overwhelming pneumococcal infection in an asplenic young adult not vaccinated against Streptococcus pneumoniae (S. pneumoniae). Post-mortem microbiological investigations revealed the presence of S. pneumoniae in blood samples and lungs. Serotyping by molecular methods identified the presence of a 6C serotype not comprised in the current 23-valent pneumococcal vaccine, highlighting that a risk of fatal infections may persist even in vaccinated splenectomised individuals.

scholarly journals Case Report of Necrotizing Fasciitis Associated withStreptococcus pneumoniae

2016 ◽  
Vol 2016 ◽  
pp. 1-4 ◽  
Author(s):  
Lei Jiao ◽  
Zain Chagla ◽  
Reham Mohammedsaeed Kaki ◽  
Gabriela Gohla ◽  
Marek Smieja
Keyword(s):  
Case Report ◽  
Streptococcus Pneumoniae ◽  
Necrotizing Fasciitis ◽  
Neutrophil Infiltration ◽  
Skin Lesions ◽  
Blood Samples ◽  
Surgical Exploration ◽  
Lower Back ◽  
Life Threatening ◽  
The Right

Necrotizing fasciitis, caused byStreptococcus pneumoniae, is an extremely rare and life-threatening bacterial soft tissue infection. We report a case of early necrotizing fasciitis associated withStreptococcus pneumoniaeinfection in a 26-year-old man who was immunocompromised with mixed connective tissue disease. The patient presented with acute, painful, erythematous, and edematous skin lesions of his right lower back, which rapidly progressed to the right knee. The patient underwent surgical exploration, and a diagnosis of necrotizing fasciitis was confirmed by pathological evidence of necrosis of the fascia and neutrophil infiltration in tissue biopsies. Cultures of fascial tissue biopsies and blood samples were positive forStreptococcus pneumoniae. To our knowledge, this is the first report of necrotizing fasciitis resulting fromStreptococcus pneumoniaediagnosed at early phase; the patient recovered well without surgical debridement.

P1430 Quantification of Streptococcus pneumoniae DNA in blood samples from patients with invasive pneumococcal infection

2007 ◽  
Vol 29 ◽  
pp. S398-S399
Author(s):  
R.P.H. Peters ◽  
R.F. de Boer ◽  
T. Schuurman ◽  
M.A. van Agtmael ◽  
M. Kooistra-Smid ◽  
...  
Keyword(s):  
Streptococcus Pneumoniae ◽  
Pneumococcal Infection ◽  
Blood Samples ◽  
Invasive Pneumococcal Infection

scholarly journals A fatal case of pneumococcal sepsis in an asplenic patient in Germany

2002 ◽  
Vol 6 (26) ◽  
Author(s):  
A Krasnici ◽  
W Kiehl
Keyword(s):  
Traffic Accident ◽  
Road Traffic ◽  
Fatal Case ◽  
Food Poisoning ◽  
Food Samples ◽  
Hospital Inpatient ◽  
Toxic Shock ◽  
Pneumococcal Infections ◽  
Pneumococcal Sepsis ◽  
Asplenic Patient

Pneumococcal infections are the most frequent vaccine preventable cause of death in Germany next to influenza. Asplenic patients in particular should be vaccinated to avoid serious illness and even death, as the following case reported in Germany’s surveillance bulletin shows (1). A 37 year old woman who had had a splenectomy after a road traffic accident in 1990, and had recently been treated with mirtazapine as a hospital inpatient for postpartum depression, developed a feverish infection with shivers, dizziness, and vomiting three weeks after being discharged. The patient herself suspected food poisoning but no food samples were available for testing. She deteriorated and developed petechiae, and the next day the emergency doctor admitted her to intensive care. She developed Waterhouse-Friderichsen syndrome with disseminated intravascular coagulation (DIC) and died in the evening of the same day from septic toxic shock. No meningococci or botulinum toxin were found but Streptococcus pneumoniae was isolated from a blood specimen.

scholarly journals Dual infection of rabies virus and Babesia canis in a dog: a case report

2010 ◽  
Vol 55 (No. 6) ◽  
pp. 294-296
Author(s):  
J. Habus ◽  
Z. Stritof ◽  
V. Stevanovic ◽  
K. Martinkovic ◽  
Z. Milas ◽  
...  
Keyword(s):  
Case Report ◽  
Young Adult ◽  
Physical Examination ◽  
Rabies Virus ◽  
Dual Infection ◽  
Babesia Canis ◽  
Post Mortem ◽  
Laboratory Findings ◽  
Leg Weakness

A young adult labrador was presented for evaluation of hind leg weakness, depression, vomiting and severe icterus of skin and mucosa. Physical examination and laboratory findings suggested cerebral babesiosis. Unresponsiveness to treatment and unknown vaccinal status aroused suspicion of rabies which was confirmed post mortem.

Case Report—Aspergillus Empyema Necessitans Post Double-lung Transplant

2016 ◽  
Vol 01 (01) ◽  
pp. 19
Author(s):  
Gannon J Yu ◽  
Harvey R Rabin ◽  
Michael D Parkins ◽  
◽  
◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Staphylococcus Aureus ◽  
Mycobacterium Tuberculosis ◽  
Case Report ◽  
Streptococcus Pneumoniae ◽  
Lung Transplant ◽  
Soft Tissues ◽  
Fatal Case ◽  
Pleural Space ◽  
Parapneumonic Effusion

Empyema necessitans (also called empyema necessitatis) is a sequelae of empyema/parapneumonic effusion where infection progresses beyond the pleural space into the soft tissues of the chest wall. Typical pathogens includeMycobacterium tuberculosis,Streptococcus pneumoniae, andStaphylococcus aureus. Fungal empyema necessitans is uncommon, with the majority of cases secondary to Candida species. We report a rare and fatal case of empyema necessitans presenting in a patient with cystic fibrosis more than 10 years following double-lung transplant.

scholarly journals Fusion Proteins Containing Family 1 and Family 2 PspA Fragments Elicit Protection against Streptococcus pneumoniae That Correlates with Antibody-Mediated Enhancement of Complement Deposition

2007 ◽  
Vol 75 (12) ◽  
pp. 5930-5938 ◽  
Author(s):  
M. Darrieux ◽  
E. N. Miyaji ◽  
D. M. Ferreira ◽  
L. M. Lopes ◽  
A. P. Y. Lopes ◽  
...  
Keyword(s):  
Streptococcus Pneumoniae ◽  
Animal Models ◽  
Pneumococcal Vaccine ◽  
Fusion Proteins ◽  
Vaccine Candidate ◽  
Pneumococcal Infection ◽  
Structural Diversity ◽  
Immunization Strategy ◽  
Single Transcript ◽  
Complement Deposition

ABSTRACT PspA is an important pneumococcal vaccine candidate that is capable of inducing protection in different animal models. Because of its structural diversity, a PspA-based vaccine should contain at least one fragment from each of the two major families (1 and 2) in order to elicit broader protection. In the present work, we have tested the potential of PspA hybrids containing fused portions of family 1 and 2 (PspA1ABC-4B and PspA1ABC-3AB) PspA fragments to induce protection against pneumococci bearing distinct PspA fragments. Sera from mice immunized with these hybrid PspA fragments were able to increase C3 deposition on pneumococci bearing PspA fragments from both families, in contrast with sera made against the PspA family 1 (PspA1ABC) and PspA family 2 (PspA3ABC) fragments, which were effective only within the same family. Although PspA hybrids were able to extend protection against pneumococcal infection with strains bearing diverse PspA fragments, the immunity elicited by family 2 was clade dependent, suggesting that PspA fragments from family 2 clades 3 and 4 should both be included in a comprehensive PspA vaccine. These results indicate that PspA fusion proteins constitute an efficient immunization strategy for future PspA-based antipneumococcal vaccines since they are able to extend protection provided by a protein derived from a single transcript.

FERROUS SULFATE POISONING

PEDIATRICS ◽  
1952 ◽  
Vol 10 (6) ◽  
pp. 677-680
Author(s):  
LEROY K. BRANCH
Keyword(s):  
Body Weight ◽  
Case Report ◽  
Ferrous Sulfate ◽  
Fatal Case ◽  
Post Mortem ◽  
Potential Danger ◽  
Peripheral Vascular ◽  
Autopsy Findings ◽  
Iron Poisoning ◽  
Venous Thromboses

A fatal case of ferrous sulfate poisoning in a 29 month old boy, with autopsy findings, is recorded. He died approximately 4½ hours after ingestion of about seventy-five 0.3 gm. ferrous sulfate tablets (1.87 gm./kg. body weight). Signs of severe gastrointestinal irritation were followed by cyanosis and peripheral vascular collapse. Hemorrhagic gastroenteritis with mucosal slough and submucosal venous thromboses were demonstrated post mortem. Prevention and measures for correction of shock were emphasized in discussion of treatment. This case report should re-emphasize the potential danger of iron poisoning.

Species composition of community–acquired pneumonia pathogens in children in assosiation with decreed pneumococcal conjugated vaccine immunisations

2021 ◽  
pp. 9-15
Author(s):  
Viktor Ivanovich Sergevnin ◽  
Kirill Vyacheslavovich Ovchinnikov ◽  
Elena Zhernoldovna Kuzovnikova ◽  
Nadezhda Vyacheslavovna Elmemetova
Keyword(s):  
Streptococcus Pneumoniae ◽  
Species Composition ◽  
Mycoplasma Pneumoniae ◽  
Pneumococcal Vaccine ◽  
Molecular Genetic ◽  
Pneumococcal Infection ◽  
Community Acquired Pneumonia ◽  
Species Structure ◽  
Genetic Studies

Based on the results of selective molecular genetic studies, the species structure of the community-acquired pneumonia pathogens in children of Perm was studied in association with the decreed vaccination against pneumococcal infection in 2014–2019. It has been established that in recent years, against a background of an increase in the volume of decreed immunisations with the conjugated pneumococcal vaccine Prevenar 13, there is a decrease in the frequency of extraction in patients with Streptococcus pneumoniae and, on the contrary, an increase in the frequency of Mycoplasma pneumoniae extraction.

Is cardiac defibrillation contraindicated in patients with deep brain stimulation? A post-mortem case report

2005 ◽  
Vol 32 (S 4) ◽  
Author(s):  
M Kronenbürger ◽  
K Nolte ◽  
A Grave ◽  
C Fromm ◽  
V Sturm ◽  
...  
Keyword(s):  
Case Report ◽  
Deep Brain Stimulation ◽  
Brain Stimulation ◽  
Post Mortem ◽  
Deep Brain
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