scholarly journals Exploring the Mitigating Effects of Early Somatosensory (Tactile) Stimulation and Acoustic Discrimination Experience in Neonatal Hypoxic-Ischemic Male Rats

2015 ◽  
Author(s):  
Patricia Taubin
Keyword(s):  
Spatial Memory ◽  
Beneficial Effect ◽  
Exploratory Behavior ◽  
Early Life ◽  
Tactile Stimulation ◽  
Auditory Stimulation ◽  
Brain Weight ◽  
Male Rats ◽  
Somatosensory Stimulation ◽  
Acoustic Discrimination

<p>The focus of this study was to determine the effects of early somatosensory (tactile) stimulation and acoustic discrimination experiences in hypoxic-ischemic (HI) male rats on long-term behaviors, learning sensory, and brain weight outcomes. 58 Wistar rats were randomly assigned to one of the three conditions: no stimulation, somatosensory stimulation and auditory stimulation. To observe the effects of the early life stimulation on adult behavioral measures, the following testing was performed: analysis of exploratory behavior, acoustic discrimination, spatial/memory learning, and brain weight. Overall we hypothesized that somatosensory and auditory interventions earlier in life would have beneficial effect on subjects’ performance in all the testing. Results suggested that tactile and auditory stimulation in early life did not have any significant beneficial effects on improving spatial learning, auditory processing or exploratory behavior in HI and sham subjects. However, some beneficial effect was found in the spatial memory task but only for the tactile HI and auditory sham group.</p>

scholarly journals Voluntary Exercise Rescues the Spatial Memory Deficit Associated With Early Life Isoflurane Exposure in Male Rats

2019 ◽  
Vol 129 (5) ◽  
pp. 1365-1373 ◽  
Author(s):  
Gregory A. Chinn ◽  
Jennifer M. Sasaki Russell ◽  
Esther T. Banh ◽  
Saehee C. Lee ◽  
Jeffrey W. Sall
Keyword(s):  
Spatial Memory ◽  
Early Life ◽  
Memory Deficit ◽  
Voluntary Exercise ◽  
Male Rats ◽  
Spatial Memory Deficit

scholarly journals Short-term block of CRH receptor in adults mitigates age-related memory impairments provoked by early-life adversity

2019 ◽  
Author(s):  
Annabel K. Short ◽  
Pamela M. Maras ◽  
Aidan L. Pham ◽  
Autumn S. Ivy ◽  
Tallie Z. Baram
Keyword(s):  
Spatial Memory ◽  
Early Life ◽  
Middle Age ◽  
Memory Function ◽  
Long Term Potentiation ◽  
Male Rats ◽  
Sensitive Period ◽  
Early Life Adversity ◽  
Memory Impairments ◽  
Age Related

AbstractIn humans, early-life adversity (ELA) is associated with impairments in learning and memory that may emerge later in life. In rodent models, ELA directly impacts hippocampal neuron structure and connectivity with progressive deficits in long-term potentiation and spatial memory function. Previous work has demonstrated that augmented release and actions of the stress-activated neuropeptide, CRH, contribute to the deleterious effects of ELA on hippocampal structure and memory-function. Early-life adversity increases CRH production and levels, and blocking CRH receptor type 1 (CRHR1) within the hippocampus immediately following adversity prevented the memory and LTP problems caused by ELA. Here we queried if blocking CRHR1 during adulthood ameliorates the adverse impact of ELA on memory in middle age. Blocking CRHR1 for a week in two month old male rats prevented ELA-induced deficits in object recognition memory that emerge during middle age. The intervention failed to mitigate the reduction of spatial memory at 4 and 8 months, but restored hippocampus-dependent location memory in ELA-experiencing rats during middle age (12 months of age).Notably, neither ELA nor blocking CRHR1 influenced anxiety- or depression-related behaviors These findings suggest a sensitive period during which interventions can fully prevent long-lasting effects of ELA, yet indicate that interventions later in life offer significant benefits.

scholarly journals Paternal Aggression in Early-Life Impairs the Spatial Memory and Passive Avoidance Learning in Adulthood of Male Rats: The Possible Role of DRD2

2021 ◽  
pp. 1-22
Author(s):  
Solmaz Khalifeh Khalifeh ◽  
◽  
Somayeh Tirbakhsh ◽  
Sareh Asadi ◽  
Ehsan Asadi ◽  
...  
Keyword(s):  
Gene Expression ◽  
Spatial Memory ◽  
Passive Avoidance ◽  
Avoidance Learning ◽  
Life Stress ◽  
Early Life ◽  
Passive Avoidance Learning ◽  
Physical Contact ◽  
Male Rats ◽  
Drd2 Gene

Negative early-life experiences (e.g., having an aggressive father) can leave long-lasting impacts on the behavior. However, it is not clear if they influence learning and memory. In this study, we investigated the influences that the presence of an aggressive father had on the level of passive avoidance learning and spatial memory. We also studied the changes in the dopamine receptor D2 (DRD2) and peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α) gene expression in the hippocampus. Then, we evaluated if a DRD2 antagonist (Sulpiride, 0.125, 0.25, or 0.5 µg/rat) could modulate these changes. We found that the subjects exposed to early-life stress made by aggressive fathers had impaired passive avoidance learning and spatial memory than those with normal fathers. Treatment with Sulpiride improved passive avoidance learning and spatial memory in rats with aggressive fathers. The rats with aggressive fathers also had higher expression of the DRD2 gene in their hippocampus than those with normal fathers, while the PGC-1α gene expression was not different among groups. Treatment with Sulpiride (0.125, 0.25, or 0.5 µg/rat) reduced the DRD2 gene expression in those with aggressive fathers to the normal level in those with normal fathers. These data suggest that living in a shared place with an aggressive father, even without any physical contact, can detrimentally affect passive avoidance learning and spatial memory which is accompanied by the increased expression of the DRD2 gene. Also, Sulpiride as a dopaminergic antagonist could reverse this process.

scholarly journals Progesterone regulates corticosterone elevation and alterations in spatial memory and exploratory behavior induced by stress in Wistar rats

2010 ◽  
Vol 9 (3) ◽  
pp. 627-640 ◽  
Author(s):  
Yolanda Diaz-Burke ◽  
Carlos Eduardo Valencia-Alfonso ◽  
Claudia Elena González-Sandoval ◽  
Miguel Huerta ◽  
Xóchitl Trujillo ◽  
...  
Keyword(s):  
Spatial Memory ◽  
Exploratory Behavior ◽  
Memory Impairment ◽  
High Performance ◽  
Male Rats ◽  
Protective Effects ◽  
Board Test ◽  
Hole Board ◽  
Hole Board Test ◽  
Induced Changes

The hippocampus is sensitive to high levels of glucocorticoids. During stress response, it suffers biochemical and cellular changes that affect functions such as spatial memory and exploratory behavior. In this study, we analyzed the influence of the neurosteroid progesterone (PROG), on stress-induced changes in urinary corticosterone (CORT) levels, spatial memory and exploratory behavior. Castrated adult male rats were implanted with PROG or vehicle (VEHI), and then exposed to chronic stress by overcrowding or ultrasonic noise for ten days. PROG and CORT levels were assessed in urine using high-performance liquid chromatography (HPLC). Implanted PROG inhibited stress-induced CORT raise, prevented spatial memory impairment in the Morris water maze, and eliminated increased exploratory behavior in the hole-board test. These results suggest protective effects of PROG against the corticosteroids raise and behavioral deficit generated by both stressful situations, possibly mediated by its anxiolytic mechanisms.

scholarly journals Beneficial effect of retigabine on memory in rats receiving ethanol

2020 ◽  
Author(s):  
Ewa Zwierzyńska ◽  
Agata Krupa-Burtnik ◽  
Bogusława Pietrzak
Keyword(s):  
Beneficial Effect ◽  
Fear Conditioning ◽  
Morris Water Maze ◽  
Water Maze ◽  
Experimental Models ◽  
Male Rats ◽  
Ethanol Administration ◽  
Free Access ◽  
Oral Gavage ◽  
The Impact

Abstract Background Retigabine belongs to the novel generation of antiepileptic drugs but its complex mechanism of action causes that the drug might be effective in other diseases, for instance, alcohol dependence. It is known that ethanol abuse impaired the function of brain structures associated with memory and learning such as the hippocampus. In our previous study, retigabine reduced hippocampal changes induced by ethanol in the EEG rhythms in rabbits. This study is focused on the impact of retigabine on memory processes in male rats receiving alcohol. Methods Memory was evaluated in various experimental models: Morris water maze, Contextual, and Cued Fear Conditioning tests. Retigabine was administered for 3 weeks directly to the stomach via oral gavage at a dose of 10 mg/kg. Rats received also 20% ethanol (5 g/kg/day in two doses) via oral gavage for 3 weeks and had free access to 5% ethanol in the afternoon and at night. Morris water maze was performed after 1 and 3 weeks of ethanol administration and after 1 week from the discontinuation of ethanol administration. Contextual and Cued Fear Conditioning tests were carried out after 24 h and 72 h of alcohol discontinuation. Results The drug significantly decreased ethanol-induced memory disturbances during alcohol administration as well as slightly improved learning processes after the discontinuation of ethanol administration. Conclusions This beneficial effect of retigabine-ethanol interaction on memory may be a relevant element of the drug’s impact on the development of addiction.

Caloric restriction following early-life high fat-diet feeding represses skeletal muscle TNF in male rats

2021 ◽  
Vol 91 ◽  
pp. 108598
Author(s):  
Diego Hernández-Saavedra ◽  
Laura Moody ◽  
Xinyu Tang ◽  
Zachary J. Goldberg ◽  
Alex P. Wang ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Caloric Restriction ◽  
High Fat Diet ◽  
Early Life ◽  
Male Rats ◽  
High Fat

Early life disruption to the ghrelin system with over-eating is resolved in adulthood in male rats

2017 ◽  
Vol 113 ◽  
pp. 21-30 ◽  
Author(s):  
Luba Sominsky ◽  
Ilvana Ziko ◽  
Thai-Xinh Nguyen ◽  
Zane B. Andrews ◽  
Sarah J. Spencer
Keyword(s):  
Early Life ◽  
Male Rats

Influence of pre-exposure to morphine on cannabinoid-induced impairment of spatial memory in male rats

2013 ◽  
Vol 256 ◽  
pp. 157-164 ◽  
Author(s):  
Maryam Farahmandfar ◽  
Mehdi Kadivar ◽  
Nasser Naghdi ◽  
Samira Choopani ◽  
Mohammad-Reza Zarrindast
Keyword(s):  
Spatial Memory ◽  
Male Rats

Environmental and tactile stimulation modulates the neonatal handling effect on adult rat spatial memory

2009 ◽  
Vol 27 (8) ◽  
pp. 747-755 ◽  
Author(s):  
Nikolaos P. Daskalakis ◽  
Maria Kaperoni ◽  
Christos Koros ◽  
E. Ronald Kloet ◽  
Efthimia Kitraki
Keyword(s):  
Spatial Memory ◽  
Tactile Stimulation ◽  
Neonatal Handling ◽  
Adult Rat

Early postnatal overnutrition impairs VO2max gains with moderate exercise and increase post-exercise muscle damage in adult male rats

2021 ◽  
pp. 1-5
Author(s):  
Douglas Lopes Almeida ◽  
Gabriel Sergio Fabricio ◽  
Laize Peron Tófolo ◽  
Tatiane Aparecida Ribeiro ◽  
Camila Cristina Ianoni Matiusso ◽  
...  
Keyword(s):  
Early Life ◽  
Male Rats ◽  
Moderate Intensity ◽  
Moderate Exercise ◽  
Moderate Intensity Exercise ◽  
Post Exercise ◽  
Reduced Body ◽  
Male Wistar Rats ◽  
The Impact ◽  
Adaptation To Exercise

Abstract Exercise counteracts obesity effects, but information on how early-life obesity may affect long-term adaptation to exercise is lacking. This study investigates the impact of early-life postnatal overfeeding (PO) on animals’ adaptation to exercise. Only male Wistar rats were used. On postnatal day (PN) 30, rats from control (NL-9 pups) or PO (SL-3 pups) litters were separated into four groups: NL-sedentary (NL-Se), NL-exercised (NL-Ex), SL-sedentary (SL-Se), and SL-exercised (SL-Ex). Exercised groups performed moderate-intensity exercise, running on a treadmill, from PN30 to PN90. Further experiments were carried out between PN90 and PN92. PO promoted obesity in SL versus NL rats (P < 0.05). Exercise reduced body weight (P < 0.001), body fat (P < 0.01), and improved glucose homeostasis in SL-Ex versus SL-Se. SL-Ex presented lower VO2max (P < 0.01) and higher post-exercise LDH (P < 0.05) compared to NL-Ex rats. Although moderate exercise counteracted obesity in SL rats, early-life overnutrition restricts fitness gains in adulthood, indicating that early obesity may impair animals’ adaptation to exercise.

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