Morphological and functional features of thyroid gland of posterity under in utero and early postnatal exposure to pesticides

2017 ◽  
pp. 33-34
Author(s):  
D. A. Beeva
Keyword(s):  
Thyroid Gland ◽  
In Utero ◽  
Postnatal Exposure ◽  
Functional Features

Morpho-functional features of rabbit's thyroid gland with its autotransplantation in the thigh muscle

2013 ◽  
Author(s):  
Igor V Makarov ◽  
Tatyana A Fedorina ◽  
Larisa T Volova ◽  
Anastasia V Bodrova
Keyword(s):  
Thyroid Gland ◽  
Thigh Muscle ◽  
Functional Features

scholarly journals PBDE-47 and PBDE mixture (DE-71) toxicities and liver transcriptomic changes at PND 22 after in utero/postnatal exposure in the rat

2018 ◽  
Vol 92 (11) ◽  
pp. 3415-3433 ◽  
Author(s):  
J. K. Dunnick ◽  
K. R. Shockley ◽  
A. R. Pandiri ◽  
G. E. Kissling ◽  
K. E. Gerrish ◽  
...  
Keyword(s):  
In Utero ◽  
Postnatal Exposure ◽  
Transcriptomic Changes

scholarly journals Immune-histochemical indicators of the morpho-functional state of the thyroid gland in norm and after prenatal antigenic exposure

2021 ◽  
Vol 26 (2) ◽  
pp. 40-45
Author(s):  
O.V. Fedosieieva
Keyword(s):  
Thyroid Gland ◽  
Functional State ◽  
Individual Development ◽  
Infectious Agents ◽  
Immunohistochemical Expression ◽  
Functional Immaturity ◽  
Functional Features ◽  
Antigenic Exposure ◽  
The Individual ◽  
Newborn Animals

During the individual development and exposure to infectious agents of the organism, the structural components of the thyroid gland can change significantly. In modern research, great importance is attached to the study of mechanisms for maintaining morphological homeostasis of the thyroid gland and ideas about its structural and functional restructuring in response to the body's immune system to various infections. The morpho-functional features of the thyroid gland of newborn animals after prenatal action of thyroid-nonspecific antigen (staphylococcal toxoid) have been experimentally established. In antigen-premiumed rats, the timing of folliculogenesis changes, as well as the size, distribution and immunohistochemical expression of antibodies to thyroglobulin, the functional state of thyrocytes and follicles compared to normal. The detected immuno­histochemical changes indicate signs of morpho-functional immaturity of the organ with hypoactivity elements.

Experimental cryptorchidism enhances testicular susceptibility to dibutyl phthalate or acrylamide in Sprague-Dawley rats

2019 ◽  
Vol 38 (8) ◽  
pp. 899-913 ◽  
Author(s):  
NP de Souza ◽  
AP Ferragut Cardoso ◽  
LMM Gomide ◽  
TRR Lima ◽  
HA Miot ◽  
...  
Keyword(s):  
Germ Cell ◽  
Dibutyl Phthalate ◽  
Reproductive Tract ◽  
In Utero ◽  
Seminiferous Tubules ◽  
Postnatal Exposure ◽  
Sprague Dawley ◽  
Sprague Dawley Rats ◽  
Extended Exposure

Cryptorchidism (CPT), the most common male congenital abnormality, is variably associated with other male reproductive tract problems. We evaluated if cryptorchid rats develop enhanced testicular susceptibility to dibutyl phthalate (DBP) or acrylamide (AA) after extended exposure. Three studies with rats were performed: (1) in utero and postnatal exposure to DBP or AA; (2) establishment of CPT and orchiopexy; and (3) in utero and postnatal exposures to DBP or AA associated with CPT/orchiopexy. Seminiferous tubules were histologically scored according to the severity of lesions: (1) Rats exposed to DBP (score 1.5) or AA (score 1.1) presented mostly preserved spermatogenesis. Some seminiferous tubules showed vacuolated germinative epithelium, germ cell apoptosis, and a Sertoli cell-only (SCO) pattern. (2) CPT (score 3.3) resulted in decreased absolute testes weights, degenerated and SCO tubules, and spermatogenesis arrest that were reversed by orchiopexy (score 1.1). (3) Exposure to DBP or AA with CPT/orchiopexy led to atrophic testes, spermatogenesis arrest, germ cell exfoliation/multinucleation, and SCO tubules (both chemicals score 2.5). Exposure to chemicals such as DBP or AA prevented the recovery of cryptorchid testes by orchiopexy. The possible role of environmental contaminants should be considered when looking for factors that modulate human testicular disorders associated with CPT.

Effects of Polychlorinated Biphenyl/Dioxin Exposure and Feeding Type on Infants' Mental and Psychomotor Development

PEDIATRICS ◽  
1996 ◽  
Vol 97 (5) ◽  
pp. 700-706 ◽  
Author(s):  
Corine Koopman-Esseboom ◽  
Nynke Weisglas-Kuperus ◽  
Maria A. J. de Ridder ◽  
Cornelis G. Van der Paauw ◽  
Louis G. M. Th. Tuinstra ◽  
...  
Keyword(s):  
Infant Development ◽  
Polychlorinated Biphenyl ◽  
In Utero ◽  
Psychomotor Development ◽  
Postnatal Exposure ◽  
Breastfed Infants ◽  
Feeding Type ◽  
Dioxin Exposure ◽  
Duration Of Breastfeeding ◽  
Pcb Exposure

Objective. To evaluate the effects of in utero and lactational exposure to polychlorinated biphenyls (PCBs) and dioxins on the mental and psychomotor development of infants. Design. Prenatal PCB exposure was estimated from the levels in maternal plasma during the last month of pregnancy. Postnatal PCB and dioxin exposure of breastfed infants was calculated from levels in human milk samples and the duration of breastfeeding. Infants were examined at 3, 7, and 18 months of age with the Bayley Scales of Infant Development. Setting. General community. Participants. Voluntary sample of 207 mother-infant pairs. One hundred five infants were breastfed and 102 were bottle-fed. Interventions. None. Results. Higher in utero exposure to PCBs was associated with lower psychomotor scores at 3 months of age: a doubling of the PCB load resulted in a decrease of 3 points. Breastfed infants scored significantly higher on the psychomotor score at 7 months of age, compared with formula-fed infants. However, when corrected for confounders, the psychomotor score of the 66% highest-exposed breastfed infants (>756 pg total PCB-dioxin toxic equivalent) was negatively influenced by this postnatal exposure to PCBs and dioxins, and was comparable to the psychomotor score of the formula-fed infants. Breastfed infants also scored higher on the mental scale at 7 months of age in a dose-dependent way. There was no significant influence of the perinatal PCB and dioxin exposure on the mental outcome at 3 and 7 months of age. At 18 months of age neither the mental nor the psychomotor score was related to perinatal PCB or dioxin exposure, nor to the duration of breastfeeding. Conclusions. Prenatal PCB exposure has a small negative effect on the psychomotor score at 3 months of age. PCB and dioxin exposure through breastfeeding has an adverse effect on the psychomotor outcome at 7 months of age. The mental outcome at 7 months of age is positively influenced by breastfeeding per se; the perinatal exposure to PCBs and dioxins does not influence this outcome. At 18 months of age the development is affected neither by PCB and dioxin exposure nor by feeding type.

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