In Silico Structure Analysis of Type 2 Diabetes Associated Toll Like Receptor-4 (Tlr4)

2018 ◽  
Vol 15 (7) ◽  
pp. 130-137
Author(s):  
Neeraj Kharor ◽  
Poonam Bansal ◽  
Raman Kumar ◽  
Jasbir Singh
Keyword(s):  
Type 2 Diabetes ◽  
Structure Analysis ◽  
In Silico ◽  
Toll Like Receptor ◽  
Toll Like Receptor 4

Association of Toll-Like Receptor 4 Polymorphisms with Type 2 Diabetes Mellitus

Inflammation ◽  
2012 ◽  
Vol 36 (1) ◽  
pp. 251-257 ◽  
Author(s):  
Zhao-Shun Jiang ◽  
Su-Xia Wang ◽  
Hong-Xia Jia ◽  
Jing Wang ◽  
Yuan-Tao Liu
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Toll Like Receptor ◽  
Toll Like Receptor 4

scholarly journals Association between Toll-Like Receptor 4 and Occurrence of Type 2 Diabetes Mellitus Susceptible to Pulmonary Tuberculosis in Northeast China

2016 ◽  
Vol 2016 ◽  
pp. 1-6 ◽  
Author(s):  
Yuze Li ◽  
Dianzhong Li ◽  
Jinfeng Zhang ◽  
Shurui Liu ◽  
Haijun Chen ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Pulmonary Tuberculosis ◽  
Gene Polymorphism ◽  
Future Research ◽  
Control Group ◽  
Toll Like Receptor ◽  
Toll Like Receptor 4

The purpose of this study is to explore why type 2 diabetes mellitus (T2DM) patients are susceptible to pulmonary tuberculosis through detection of serum Toll-like receptor 4 (TLR4), an important immune-related receptor, especially in terms of content and TLR4gene polymorphism. Patients with T2DM complicated by pulmonary tuberculosis (T2DMTB) were selected as the case group and T2DM patients without tuberculosis were selected as the control group. Forty patients in each group were randomly selected and their serum TLR4levels were detected and compared. Determination of six sites of TLR4gene polymorphism was carried out in 238 T2DMTB patients and 310 patients with T2DM, and results showed that the serum TLR4content of the T2DMTB group was significantly lower than that of the T2DM group (p<0.05). The six sites of TLR4gene polymorphism did not show significant associations with T2DMTB risk. No statistically significant differences in genotype distributions were observed between T2DMTB patients and patients with T2DM when studied using the recessive and dominant genetic models. How two diseases with contradictory nutritional statuses can occur in the same person is difficult to explain from environmental factors perspective alone. Future research should study the causes of T2DMTB from the perspective of genetics.

scholarly journals Association between Asp299Gly and Thr399Ile Polymorphisms in Toll-Like Receptor 4 Gene and Type 2 Diabetes Mellitus: Case-Control Study and Meta- Analysis

2018 ◽  
Vol 09 (07) ◽  
Author(s):  
Taís Silveira Assmann ◽  
Natalia Emerim Lemos ◽  
Letícia de Almeida Brondani ◽  
Rodrigo Carlessi ◽  
Carmen Maldonado Bernal ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Case Control Study ◽  
Meta Analysis ◽  
Case Control ◽  
Toll Like Receptor ◽  
Toll Like Receptor 4 ◽  
Control Study

scholarly journals Expression of toll-like receptor 4 and its connection with type 2 diabetes mellitus

2018 ◽  
Vol 64 (13) ◽  
pp. 15 ◽  
Author(s):  
Inass Mohamed Taha ◽  
Azza M Abdu Allah ◽  
Eman Masoud Abd El Gayed
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Toll Like Receptor ◽  
Toll Like Receptor 4
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