scholarly journals Effect of long-term administration of Deca-Durabolin on reproductive organs of male rats

2017 ◽  
Vol 16 (2) ◽  
pp. 120-125
Author(s):  
Isam Mohammed Jaber Zabiba ◽  
Keyword(s):  
Reproductive Organs ◽  
Male Rats ◽  
Term Administration

Effects of a Long-Term Administration of Aqueous Extract of Prunella vulgaris L. on Survival, Spontaneous Thyroid Carcinoma and Neoplastic C-cell Hyperplasia in Rats

2020 ◽  
Author(s):  
Jia Song ◽  
Min Zhao ◽  
Zhengbao Zhang ◽  
Jianbin Tan ◽  
Bifeng Chen ◽  
...  
Keyword(s):  
Thyroid Carcinoma ◽  
Aqueous Extract ◽  
Metabolic Parameters ◽  
Male Rats ◽  
Preneoplastic Lesion ◽  
Prunella Vulgaris ◽  
Cell Hyperplasia ◽  
C Cell Hyperplasia ◽  
Term Administration

Abstract Background: The continued global rise in thyroid carcinoma calls for alternative prevention and treatment strategies. Prunella vulgaris L. (PV) is a herbaceous plant with a medicinal property in the treatment of thyroid gland dysfunction, but its influence on thyroid carcinoma is unclear so far. This study was designed to investigate the effects of aqueous extract of PV on survival, spontaneous thyroid carcinoma and its preneoplastic lesion in rats.Methods: A total of 552 Wistar rats (half female and half male) were randomly assigned into 4 groups and given one of the following diets for 24 months: chow diet (control), 2.5 (low), 8.25 (middle) and 25 (high) g/kg bw PV diets. After intervention, serum metabolic parameters including indicators of liver and renal function, glucose and lipid profiles were measured. Histological examination was conducted to confirm the types of thyroid carcinoma and its preneoplastic lesion. Results: After intervention, serum aspartate transaminase of male rats in high PV group decreased significantly. No statistical differences among groups in terms of survival, body weight and other metabolic parameters were detected. In the control, low, middle and high PV groups, 14, 14, 15 and 8 rats developed thyroid carcinoma, respectively. Medullary thyroid carcinoma (MTC) emerged as the most common histological type in both sexes. Although PV failed to decrease risk of total thyroid carcinoma or each histological type, the incidence rates of neoplastic C-cell hyperplasia (CCH, a preneoplastic lesion of hereditary MTC) in PV groups were lower than that of control, and the lowest was observed in high PV group, manifesting as 5.25-time decrease in female rats and 5.5-time decrease in male rats.Conclusion: Our results suggested for the first time that, a long-term administration of aqueous extract of PV decreased the incidence of neoplastic CCH without impairing survival and metabolic parameters.

Long-term administration of Greek Royal Jelly decreases GABA concentration in the striatum and hypothalamus of naturally aged Wistar male rats

2018 ◽  
Vol 675 ◽  
pp. 17-22 ◽  
Author(s):  
Justyna Pyrzanowska ◽  
Adriana Wawer ◽  
Ilona Joniec-Maciejak ◽  
Agnieszka Piechal ◽  
Kamilla Blecharz-Klin ◽  
...  
Keyword(s):  
Royal Jelly ◽  
Male Rats ◽  
Gaba Concentration ◽  
Term Administration ◽  
Wistar Male Rats

scholarly journals Chemotherapeutic Potential of Epimedium brevicornum Extract: The cGMP-Specific PDE5 Inhibitor as Anti-Infertility Agent Following Long-Term Administration of Tramadol in Male Rats

Antibiotics ◽  
2020 ◽  
Vol 9 (6) ◽  
pp. 318
Author(s):  
Ahmed S. Abdelaziz ◽  
Mohamed A. Kamel ◽  
Amany I. Ahmed ◽  
Shimaa I. Shalaby ◽  
Salama M. El-darier ◽  
...  
Keyword(s):  
Pde5 Inhibitor ◽  
Chinese Herb ◽  
Chronic Administration ◽  
Male Rats ◽  
Serum Hormones ◽  
Group I ◽  
Apoptotic Marker ◽  
Term Administration

Epimedium brevicornum Maxim (EbM) is a well-known Chinese herb that has been widely used for the treatment of several diseases. The main purpose of this study is to examine the role of Epimedium brevicornum extract in certain andrological parameters in rats as a natural modulator for adverse viewpoints associated with chronic administration of tramadol (TAM). Fifty rats were categorized into five groups. Untreated rats were known as Group I, whereas rats in Groups II and III were administered 2.43 g/kg/day of E. brevicornum extract and 50 mg/kg/day of TAM for 130 consecutive days, respectively. Both of Groups IV and V were administered TAM for 65 successive days, followed by concomitant use of both drugs for another 65 days, with the E. brevicornum extract at doses of 0.81 and 2.43 g/kg/day, respectively. TAM showed an injurious effect on sperm attributes, serum hormones, tissue malondialdehyde, superoxide dismutase, and nitric oxide. Elevation of the apoptotic marker Bax and a reduction of Bcl2 were recorded. Histopathological abnormalities have been reported in rat testicles. Rats treated with E. brevicornum extract with TAM showed an improvement in all the parameters tested. It could be presumed that E. brevicornum extract plus TAM exhibits a promising effect on the enhancement of male anti-infertility effects.

Storage Levels of Ddt Metabolites in Mouse Tissues following Long Term Exposure to Technical DDT

1971 ◽  
Vol 57 (6) ◽  
pp. 377-396 ◽  
Author(s):  
Lorenzo Tomatis ◽  
Vladimir Turusov ◽  
Benedetto Terracini ◽  
Nicholas Day ◽  
William F. Barthel ◽  
...  
Keyword(s):  
Reproductive Organs ◽  
Whole Body ◽  
Fat Tissue ◽  
Strong Negative Correlation ◽  
Pregnant Females ◽  
Mouse Tissues ◽  
Term Administration ◽  
Liver And Kidney ◽  
Dose Levels

The storage levels of DDT and its metabolites, following the long term administration of technical DDT at the dose levels of 2, 20, 50 and 250 ppm to mice, were evaluated in the fat tissue, liver, kidney, brain and reproductive organs. In addition, storage levels were evaluated in foetuses and newborns of DDT-treated mothers. Apart from op'-DDT, there was a direct relationship between the concentration of each metabolite in each organ and the dose to which the animal was exposed. The highest concentration of DDT and metabolites was found in the fat tissue followed by reproductive organs, liver and kidney together, and lastly brain. The most prevalent metabolite was pp'-DDT, except in the liver, where pp'-DDD showed the highest concentration. Pregnant females had lower concentrations of all metabolites than non-pregnant females. The concentration of residues in samples of total foetal litters was directly related to the concentration of DDT fed to the mother. There was a strong negative correlation between the concentration of pp'-DDT and that of pp'-DDD in the foetuses and the placentas of the same litter. A significant increase in whole body DDT concentration was observed shortly after birth.

Testicular oxytocin: effects of intratesticular oxytocin in the rat

1991 ◽  
Vol 130 (2) ◽  
pp. 231-NP ◽  
Author(s):  
H. D. Nicholson ◽  
S. E. F. Guldenaar ◽  
G. J. Boer ◽  
B. T. Pickering
Keyword(s):  
Leydig Cells ◽  
Light And Electron Microscopy ◽  
Male Rats ◽  
Plasma Testosterone ◽  
Epididymal Sperm ◽  
Long Term Effects ◽  
Sperm Counts ◽  
Term Administration

ABSTRACT The long-term effects of oxytocin administration on the testis were studied using intratesticular implants. Adult male rats had an Accurel device containing 20 μg oxytocin (releasing approximately 200 ng/day) implanted into the parenchyma of each testis; control animals received empty devices. The animals were killed at weekly intervals for 4 weeks. Some animals were perfused and the testes processed for light and electron microscopy. Blood was collected from the remaining animals for the measurement of testosterone, dihydrotestosterone, LH, FSH and oxytocin; epididymal sperm counts were measured and the testes were extracted and radioimmunoassayed for testosterone, dihydrotestosterone and oxytocin. Long-term administration of oxytocin resulted in a significant reduction in testicular and plasma testosterone levels throughout the 4-week period examined and, after 14 days of treatment, lipid droplets were seen in the Leydig cells of treated but not control animals. Concentrations of dihydrotestosterone in the plasma and testes of the oxytocin-treated animals, however, were significantly elevated after 7 and 14 days and at no time fell below control values. Plasma FSH levels were also lower in the oxytocin-treated animals. Intratesticular oxytocin treatment did not affect LH or oxytocin concentrations in the plasma, epididymal sperm counts or the number of Leydig cells in the testis. Empty Accurel devices had no effect on testicular morphology. This study provides the first evidence that oxytocin in vivo can modify steroidogenesis in the testis. Journal of Endocrinology (1991) 130, 231–238

Long-term administration of Greek Royal Jelly improves spatial memory and influences the concentration of brain neurotransmitters in naturally aged Wistar male rats

2014 ◽  
Vol 155 (1) ◽  
pp. 343-351 ◽  
Author(s):  
Justyna Pyrzanowska ◽  
Agnieszka Piechal ◽  
Kamilla Blecharz-Klin ◽  
Ilona Joniec-Maciejak ◽  
Konstantia Graikou ◽  
...  
Keyword(s):  
Spatial Memory ◽  
Royal Jelly ◽  
Male Rats ◽  
Brain Neurotransmitters ◽  
Term Administration ◽  
Wistar Male Rats

Long-term administration of Aspalathus linearis infusion affects spatial memory of adult Sprague-Dawley male rats as well as increases their striatal dopamine content

2019 ◽  
Vol 238 ◽  
pp. 111881 ◽  
Author(s):  
Justyna Pyrzanowska ◽  
Izabela Fecka ◽  
Dagmara Mirowska-Guzel ◽  
Ilona Joniec-Maciejak ◽  
Kamilla Blecharz-Klin ◽  
...  
Keyword(s):  
Spatial Memory ◽  
Striatal Dopamine ◽  
Male Rats ◽  
Sprague Dawley ◽  
Aspalathus Linearis ◽  
Dopamine Content ◽  
Term Administration

scholarly journals Assessment of sperm production and reproductive organs of Wistar rats to long-term exposure of Caesalpinia ferrea

2010 ◽  
Vol 82 (4) ◽  
pp. 907-914 ◽  
Author(s):  
Leda M.F. Lucinda ◽  
Camila B. Rocha ◽  
Maycon M. Reboredo ◽  
Vinícius C. Faria ◽  
Rita C.S. Sá
Keyword(s):  
Reproductive System ◽  
Wistar Rats ◽  
Wistar Rat ◽  
Reproductive Organs ◽  
The Body ◽  
Male Rats ◽  
Sperm Production ◽  
Male Wistar Rats ◽  
The Right

Caesalpinia ferrea Mart (Leguminosae) is a medicinal plant used to treat diabetes, among other therapeutic properties, but which is also reported to have hepatotoxic effects. Although it contains substances such as flavonoids and coumarin, which are known to have antifertility activity, no studies have apparently been conducted to evaluate the potential adverse side effects of this plant on the function of the reproductive system after a chronic treatment. Therefore, this investigation was carried out to evaluate the effect and safety of the long-term exposure to C. ferrea on male Wistar rats' vital organs, reproductive system and sperm production. Adult and immature male rats were treated with an aqueous extract of C. ferrea at a dose level of 300 mg/kg of body weight, administered during one or two spermatogenic cycles of this species. The reproductive and vital organs were analyzed, and sperm was collected from the epididymal secretion of the right epididymis cauda. The long-term administration of C. ferrea did not significantly alter the body, vital and reproductive organs weights. Gamete production was not affected either. The chronic assessment of C. ferrea suggests that this plant does not affect the normal functioning of the Wistar rat reproductive system.

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