scholarly journals INTRODUCING GAP IN HAIR FOLLICLE ELECTROMAGNETISM AS MECHANISM FOR THE PRESENCE OF BIPOLAR ELECTRICAL CHARGES INHERENT IN THE HUMAN HAIR SHAFT

2021 ◽  
Vol 9 (9) ◽  
pp. 79-87
Author(s):  
Abraham A. Embi
Keyword(s):  
Magnetic Field ◽  
Electrical Property ◽  
Human Hair ◽  
Negative Charge ◽  
Hair Shaft ◽  
Hair Follicles ◽  
Cell Divisions ◽  
Positive Side ◽  
Microscopy Method ◽  
Hair Shafts

The human hair consists of a follicle anchored in the skin and a protruding shaft, it has also been described as a miniorgan, having its own cell divisions, metabolism, and known to undergo aging stages; eventually reaching a point where the old hair sheds and a new hair growing cycle begins from the same follicular tissue. Using sophisticated magnetometers, magnetic field emitted by direct current (DC) in human hair follicles were detected and introduced in 1980. Most recently in 2015, a tabletop optical microscopy method was developed and published in 2016, thus allowing for the detection of hair follicles and shaft magnetic fields. Qualitative images are presented where the bipolar electrical property of the shaft is documented. This finding was inferred since blood tissue carries a negative charge, thus repelled by an equal charge; experiments support a positive (+) field as triggering coagulation. The shaft is repeatedly shown in experiments to express a contralateral positive side triggering. Fibrin formation is also documented by images showing intricate networks indicative of blood coagulation. In conclusion, the genesis of hair shafts bipolarity is shown resulting from a “gap” in the follicle electromagnetic fields inhibiting energy from fully engulfing the shaft.

scholarly journals The local hypothalamic–pituitary–adrenal axis in cultured human dermal papilla cells

2020 ◽  
Vol 21 (1) ◽  
Author(s):  
Eun Young Lee ◽  
You Jin Nam ◽  
Sangjin Kang ◽  
Eun Ju Choi ◽  
Inbo Han ◽  
...  
Keyword(s):  
Hpa Axis ◽  
Hair Loss ◽  
Human Hair ◽  
Stress Hormones ◽  
Dermal Papilla ◽  
Hair Shaft ◽  
Hair Follicles ◽  
Follicle Cells ◽  
Dermal Papilla Cells ◽  
Underlying Mechanisms

Abstract Background Stress is an important cause of skin disease, including hair loss. The hormonal response to stress is due to the HPA axis, which comprises hormones such as corticotropin releasing factor (CRF), adrenocorticotropic hormone (ACTH), and cortisol. Many reports have shown that CRF, a crucial stress hormone, inhibits hair growth and induces hair loss. However, the underlying mechanisms are still unclear. The aim of this study was to examine the effect of CRF on human dermal papilla cells (DPCs) as well as hair follicles and to investigate whether the HPA axis was established in cultured human DPCs. Results CRF inhibited hair shaft elongation and induced early catagen transition in human hair follicles. Hair follicle cells, both human DPCs and human ORSCs, expressed CRF and its receptors and responded to CRF. CRF inhibited the proliferation of human DPCs through cell cycle arrest at G2/M phase and induced the accumulation of reactive oxygen species (ROS). Anagen-related cytokine levels were downregulated in CRF-treated human DPCs. Interestingly, increases in proopiomelanocortin (POMC), ACTH, and cortisol were induced by CRF in human DPCs, and antagonists for the CRF receptor blocked the effects of this hormone. Conclusion The results of this study showed that stress can cause hair loss by acting through stress hormones. Additionally, these results suggested that a fully functional HPA axis exists in human DPCs and that CRF directly affects human DPCs as well as human hair follicles under stress conditions.

scholarly journals The local hypothalamic–pituitary–adrenal axis in cultured human dermal papilla cells

2020 ◽  
Author(s):  
Eun Young Lee ◽  
You Jin Nam ◽  
Sangjin Kang ◽  
Eun Ju Choi ◽  
Inbo Han ◽  
...  
Keyword(s):  
Hpa Axis ◽  
Hair Loss ◽  
Human Hair ◽  
Stress Hormones ◽  
Dermal Papilla ◽  
Hair Shaft ◽  
Hair Follicles ◽  
Follicle Cells ◽  
Dermal Papilla Cells ◽  
Underlying Mechanisms

Abstract Background: Stress is an important cause of skin disease, including hair loss. The hormonal response to stress is due to the HPA axis, which comprises hormones such as corticotropin releasing factor (CRF) , adrenocorticotropic hormone (ACTH) , and cortisol. Many reports have shown that CRF, a crucial stress hormone, inhibits hair growth and induces hair loss. However, the underlying mechanisms are still unclear. The aim of this study was to examine the effect of CRF on human dermal papilla cells (DPCs) as well as hair follicles and to investigate whether the HPA axis was established in cultured human DPCs.Results: CRF inhibited hair shaft elongation and induced early catagen transition in human hair follicles. Hair follicle cells, both human DPCs and human ORSCs, expressed CRF and its receptors and responded to CRF. CRF inhibited the proliferation of human DPCs through cell cycle arrest at G2/M phase and induced the accumulation of reactive oxygen species (ROS) . Anagen-related cytokine levels were downregulated in CRF-treated human DPCs. Interestingly, increases in proopiomelanocortin (POMC) , ACTH, and cortisol were induced by CRF in human DPCs, and antagonists for the CRF receptor blocked the effects of this hormone. Conclusion: The results of this study showed that stress can cause hair loss by acting through stress hormones. Additionally, these results suggested that a fully functional HPA axis exists in human DPCs and that CRF directly affects human DPCs as well as human hair follicles under stress conditions.

scholarly journals THE SHEPHERDS HOOK PHENOMENON PATTERN OF HAIR ROOTS A DEMONSTRATION OF COMPARATIVE BIOLECTROMAGNETISM BETWEEN HUMAN HAIRS AND MOUSE WHISKERS BY MEANS OF THE PHOTOELECTRIC EFFECT

2018 ◽  
Vol 6 (7) ◽  
pp. 317-326
Author(s):  
Abraham A.
Keyword(s):  
Human Hair ◽  
Photoelectric Effect ◽  
Hair Shaft ◽  
Hair Follicles ◽  
Iron Particles ◽  
Magnetic Attraction ◽  
Microscopy Technique ◽  
Hair Roots ◽  
Blue Stain ◽  
Fine Iron

In this manuscript, the phenomena herein reported have been observed in some of prior publications by this author. This manuscript is a compilation of cross-species similarities on the biomagnetic fields (BMFs) emitted by the human hair and mouse vibrissa follicles. The introduction of a novel optical microscopy technique designed to detect BMFs in plant and animal tissue has allowed researchers to publish interesting and unique findings. They range from hair follicles BMFs penetrating glass barriers to the biomagnetic effect on crystals accretion of fronted hair follicles. Both rodents (whiskers) and human (hair follicles) show similarities regarding spontaneous BMFs expressed as light rays with one sided greater BMF activity. The technique used as a base the iron staining property of Prussian Blue Stain (PBS) mixed with very fine iron particles 2000 nm in diameter (for magnetic attraction). For this manuscript, previously published images were re-reviewed and addressed as such in the manuscript. Both PBS mixed with the diamagnetic Potassium Ferrocyanide and PBS mixed with the paramagnetic Potassium Ferricyanide were alternatively chosen in those experiments. During evaporation, the hair shaft and follicle, due to their intrinsic diamagnetism, repels the crystals of diamagnetic PBS and attracts the paramagnetic ones. Experiments are presented consistently demonstrating a unique pattern observed of BMFs skewed towards or along one side of the human hair shaft and follicle of humans and rodent vibrissa whiskers. This is attributed to “The Photoelectric Effect” discovered in 1887 by the German physicist Heinrich Rudolf Hertz.

scholarly journals DEMONSTRATION OF THE HUMAN HAIR FOLLICLE MAGNETORECEPTION OF BIOMAGNETISM RADIATED BY THE CONCAVE PART OF THE HUMAN HAND

2020 ◽  
Vol 8 (5) ◽  
pp. 348-354
Author(s):  
Abraham A. Embi
Keyword(s):  
Optical Microscopy ◽  
Hair Follicle ◽  
Human Hair ◽  
Quantum Interference ◽  
Hair Follicles ◽  
The Body ◽  
Human Hand ◽  
Human Hair Follicle ◽  
Concave Part ◽  
Microscopy Method

Biological material has been documented to produce an external magnetic field that radiates out. There have been several papers documenting the magnetic fields produced by steady currents in the body. The most notable was published in 1980 by Cohen et al. where the human hair follicle was used as sentinel and biophysically evaluated via sophisticated equipment such as a double planar Superconducting Quantum Interference Devices (SQUID). Most recently, in 2019 Cohen’s work was duplicated by Khan,S by also using double-planar gladiometers. Of interest to this manuscript is that since the introduction of anovel optical microscopy method in 2016 by Scherlag BJ et al is that numerous papers have been introduced in the literature now identifying intrinsic biomagnetic properties of the follicle such as penetration through glass barriers. In this manuscript, a concept of biomagnetic fields by the concave part of the human hand transferring energy to hair follicles is introduced, this was accomplished by using a novel optical microscopy method, in other words, the hair follicle is not limited to radiate out biomagnetism; but also, to receive externally radiated biomagnetic fields from a body part. This magneto receptive property is herein introduced.

scholarly journals The local hypothalamic–pituitary–adrenal axis in cultured human dermal papilla cells

2020 ◽  
Author(s):  
Eun Young Lee ◽  
You Jin Nam ◽  
Sangjin Kang ◽  
Eun Ju Choi ◽  
Inbo Han ◽  
...  
Keyword(s):  
Hpa Axis ◽  
Hair Loss ◽  
Human Hair ◽  
Stress Hormones ◽  
Dermal Papilla ◽  
Hair Shaft ◽  
Hair Follicles ◽  
Follicle Cells ◽  
Dermal Papilla Cells ◽  
Underlying Mechanisms

Abstract Background: Stress is an important cause of skin disease, including hair loss. The hormonal response to stress is due to the HPA axis, which comprises hormones such as corticotropin releasing factor (CRF) , adrenocorticotropic hormone (ACTH) , and cortisol. Many reports have shown that CRF, a crucial stress hormone, inhibits hair growth and induces hair loss. However, the underlying mechanisms are still unclear. The aim of this study was to examine the effect of CRF on human dermal papilla cells (DPCs) as well as hair follicles and to investigate whether the HPA axis was established in cultured human DPCs. Results: CRF inhibited hair shaft elongation and induced early catagen transition in human hair follicles. Hair follicle cells, both human DPCs and human ORSCs, expressed CRF and its receptors and responded to CRF. CRF inhibited the proliferation of human DPCs through cell cycle arrest at G2/M phase and induced the accumulation of reactive oxygen species (ROS) . Anagen-related cytokine levels were downregulated in CRF-treated human DPCs. Interestingly, increases in proopiomelanocortin (POMC) , ACTH, and cortisol were induced by CRF in human DPCs, and antagonists for the CRF receptor blocked the effects of this hormone. Conclusion: The results of this study showed that stress can cause hair loss by acting through stress hormones. Additionally, these results suggested that a fully functional HPA axis exists in human DPCs and that CRF directly affects human DPCs as well as human hair follicles under stress conditions.

Human hair growth in vitro

1990 ◽  
Vol 97 (3) ◽  
pp. 463-471
Author(s):  
M.P. Philpott ◽  
M.R. Green ◽  
T. Kealey
Keyword(s):  
Hair Follicle ◽  
Human Hair ◽  
Subcutaneous Fat ◽  
Hair Shaft ◽  
Hair Follicles ◽  
Anagen Hair ◽  
Scalpel Blade ◽  
Thymidine Autoradiography

We report for the first time the successful maintenance and growth of human hair follicles in vitro. Human anagen hair follicles were isolated by microdissection from human scalp skin. Isolation of the hair follicles was achieved by cutting the follicle at the dermo-subcutaneous fat interface using a scalpel blade. Intact hair follicles were then removed from the fat using watchmakers' forceps. Isolated hair follicles maintained free-floating in supplemented Williams E medium in individual wells of 24-well multiwell plates showed a significant increase in length over 4 days. The increase in length was seen to be attributed to the production of a keratinised hair shaft, and was not associated with the loss of hair follicle morphology. [methyl-3H]thymidine autoradiography confirmed that in vitro the in vivo pattern of DNA synthesis was maintained; furthermore, [35S]methionine labelling of keratins showed that their patterns of synthesis did not change with maintenance. The importance of this model to hair follicle biology is further demonstrated by the observations that TGF-beta 1 has a negative growth-regulatory effect on hair follicles in vitro and that EGF mimics the in vivo depilatory effects that have been reported in sheep and mice.

Erythropoietin promotes hair shaft growth in cultured human hair follicles and modulates hair growth in mice

2010 ◽  
Vol 59 (2) ◽  
pp. 86-90 ◽  
Author(s):  
Bo Mi Kang ◽  
Seung Hyun Shin ◽  
Mi Hee Kwack ◽  
HyeRim Shin ◽  
Ji Won Oh ◽  
...  
Keyword(s):  
Human Hair ◽  
Hair Growth ◽  
Hair Shaft ◽  
Hair Follicles

scholarly journals Plucked Human Hair Shafts and Biomolecular Medical Research

2013 ◽  
Vol 2013 ◽  
pp. 1-7 ◽  
Author(s):  
Kevin Schembri ◽  
Christian Scerri ◽  
Duncan Ayers
Keyword(s):  
Hair Follicle ◽  
Human Hair ◽  
Molecular Model ◽  
Three Dimensional ◽  
Diagnostic Procedures ◽  
Hair Shaft ◽  
Hair Follicles ◽  
Do No Harm ◽  
The Individual ◽  
Near Future

The hair follicle is a skin integument at the boundary between an organism and its immediate environment. The biological role of the human hair follicle has lost some of its ancestral importance. However, an indepth investigation of this miniorgan reveals hidden complexity with huge research potential. An essential consideration when dealing with human research is the awareness of potential harm and thus the absolute need not to harm—a rule aptly qualified by the Latin term “primum non nocere” (first do no harm). The plucked hair shaft offers such advantages. The use of stem cells found in hair follicles cells is gaining momentum in the field of regenerative medicine. Furthermore, current diagnostic and clinical applications of plucked hair follicles include their use as autologous and/or three-dimensional epidermal equivalents, together with their utilization as surrogate tissue in pharmacokinetic and pharmacodynamics studies. Consequently, the use of noninvasive diagnostic procedures on hair follicle shafts, posing as a surrogate molecular model for internal organs in the individual patient for a spectrum of human disease conditions, can possibly become a reality in the near future.

Sign in / Sign up

Export Citation Format

Share Document