scholarly journals COMPARISON OF INSULIN LIKE GROWTH FACTOR-1 LEVELS IN CHRONIC MYELOCYTIC LEUKEMIA PATIENTS RECEIVING IMATINIB AND NILOTINIB THERAPY WITH HEALTHY POPULATIONS

2020 ◽  
Vol 7 (12) ◽  
pp. 12-17
Keyword(s):  
Growth Factor ◽  
Philadelphia Chromosome ◽  
Cross Sectional Study ◽  
Lymphocytic Leukemia ◽  
Healthy Population ◽  
Insulin Like Growth Factor ◽  
Chronic Myelocytic Leukemia ◽  
Myeloproliferative Disease ◽  
Cross Sectional ◽  
Myelocytic Leukemia

Introduction. CML is the most common form of chronic leukemia in Indonesia, whereas in Western countries it is more commonly found in the form of chronic lymphocytic leukemia (CLL). Chronic myelocytic leukemia (CML) is a chronic myeloproliferative disease with clonal abnormalities due to genetic changes in stem cell pluripotence. This disease is characterized by proliferation of granulocyte series without differentiation disorders. On the CML, the Philadelphia chromosome (Ph1 chr) is found in a reciprocal translocation 9.22 (t9; 22). Insulin-like Growth Factor-1 is a natural polypeptide in the human body that has similarities with insulin. IGF-1 plays an important role in the growth and development of tissues. As such, several studies have shown an association between IGF-1 and -2 circulation rates. IGF-1 plays an important role in terms of stimulating cell proliferation and inhibition of apoptosis. This affects the regulation of the body's physiological growth as well as pathological growth such as cancer. Until now there has been no research on IGF-1 levels in CML patients with imatinib and nilotinib treatment. Methods. This research is a cross-sectional study, by observing the status of exposure and simultaneous disease in individuals from a single population, in one period. The study was conducted in December 2019 at the Outpatient Clinic of H Adam Malik General Hospital Medan with the approval of the North Sumatera University Research Ethics Commission. Data were analyzed using SPSS where p <0.05 was considered significant. Results. This study showed that there were no differences in IGF-1 levels between CML patients who received imatinib and nilotinib therapy. The mean IGF-1 results were obtained in the imatinib group 107.43±19.70 and nilotinib 107.43±18.09. While the healthy population is 138.60±52.85. Conclusion. No significant differences were found in IGF-1 levels between CML patients receiving imatinib and nilotinib therapy with healthy populations.

scholarly journals The Relationship Of Insulin‑Like Growth Factor 1 With Bone Mass In Obese Female

2020 ◽  
Vol 9 (2) ◽  
pp. 1041-1046
Author(s):  
Adek Ardiansyah ◽  
Lilik Herawati ◽  
Damayanti Tinduh
Keyword(s):  
Growth Factor ◽  
Bone Mass ◽  
Fasting Blood Glucose ◽  
Cross Sectional Study ◽  
Insulin Like Growth Factor ◽  
Obese Women ◽  
Cross Sectional ◽  
Obese Female ◽  
Relationship Of ◽  
The Relationship

This study aimed to analyze the relationship of insulin-like growth factor 1 with bone mass in obese female. This study used a cross sectional study method using 30 obese women aged 19-23 years, body mass index (BMI) 25-35 kg / m2, normal blood pressure, normal resting heart rate (RHR), normal hemoglobin (Hb). and fasting blood glucose (FBG) <100 mg / dL. Measurement of IGF-1 levels used the Enzym Link Immunosorbent Assay (ELISA) method. Measurement of bone mass using TANITA (Body Composition Analyzer DC3607601 (2) -1604 FA, TANITA Corporation of America, Inc., USA). The data analysis technique used the Pearson product-moment test with Statistical Package for Social Science (SPSS). The results showed that mean levels of IGF-1 (1.17 ± 0.10) ng / mL and bone mass (2.49 ± 0.06) kg (r = 0.712, P ≤ 0.001). Our findings suggest that there was a positive correlation between IGF-1 levels and bone mass

Levels of the small insulin-like growth factor-binding protein are strongly related to those of insulin in prepubertal and pubertal children but only weakly so after puberty

1989 ◽  
Vol 121 (2) ◽  
pp. 383-387 ◽  
Author(s):  
J. M. P. Holly ◽  
C. P. Smith ◽  
D. B. Dunger ◽  
J. A. Edge ◽  
R. A. Biddlecombe ◽  
...  
Keyword(s):  
Growth Factor ◽  
Binding Protein ◽  
Pubertal Development ◽  
Circadian Variation ◽  
Cross Sectional Study ◽  
Insulin Like Growth Factor ◽  
Sectional Study ◽  
Normal Children ◽  
Cross Sectional ◽  
The Relationship

ABSTRACT We have looked at the relationship between fasting levels of insulin and a small insulin-like growth factor (IGF)-binding protein (IBP-1) in a cross-sectional study of 116 normal subjects aged 5–48 years. The relationship between IBP-1 and insulin was also examined within individual normal children in over-night profiles of IBP-1 and insulin obtained from two children at each stage of puberty (Tanner stages 1–5). In the cross-sectional study high levels of IBP-1 were found in early childhood and these fell throughout puberty as fasting levels of insulin rose. Multiple regression analysis revealed that both these changes were predominantly due to pubertal development rather than to age. After the age of 16 IBP-1 levels remained low despite fasting insulin levels returning to prepubertal levels. A strong negative correlation was obtained between IBP-1 and insulin in children of 5–16 years (r = −0·63; n = 60; P <0·001), no such relationship being found after the age of 16. In the second study, IBP-1 underwent a marked circadian variation in all cases and an inverse correlation with insulin, measured at the same time, was obtained at pubertal stages 1 to 4, but not at stage 5 (pooled data stages 1–4, r = −0·69; n = 53; P <0·001). We have demonstrated that a potential inhibitor of IGF-activity is inversely related to insulin throughout the period of active GH-related growth and that this relationship weakens after puberty. Journal of Endocrinology (1989) 121, 383–387

Somatomedins in Adolescence: A Cross-Sectional Study of the Effect of Puberty on Plasma Insulin-Like Growth Factor I and II Levels*

1983 ◽  
Vol 57 (2) ◽  
pp. 268-271 ◽  
Author(s):  
ALICE M. LUNA ◽  
DARRELL M. WILSON ◽  
CHARLES J. WIBBELSMAN ◽  
RICHARD C. BROWN ◽  
RAYMOND J. NAGASHIMA ◽  
...  
Keyword(s):  
Growth Factor ◽  
Plasma Insulin ◽  
Cross Sectional Study ◽  
Insulin Like Growth Factor ◽  
Sectional Study ◽  
Cross Sectional ◽  
Factor I ◽  
Growth Factor I

Age, Sex, and Smoking Are Predictors of Circulating Insulin-Like Growth Factor 1 and Insulin-Like Growth Factor–Binding Protein 3

1999 ◽  
Vol 17 (3) ◽  
pp. 813-813 ◽  
Author(s):  
Virginia G. Kaklamani ◽  
Athena Linos ◽  
Evangelia Kaklamani ◽  
Ioanna Markaki ◽  
Christos Mantzoros
Keyword(s):  
Growth Factor ◽  
Binding Protein ◽  
Serum Levels ◽  
Cross Sectional Study ◽  
Insulin Like Growth Factor ◽  
Sectional Study ◽  
Cross Sectional ◽  
Negatively Associated ◽  
Coffee Drinking ◽  
History Of

PURPOSE: Insulin-like growth factor (IGF-1) and its major binding protein (IGF-BP3) have recently been implicated in the pathogenesis of several malignancies. However, anthropometric and lifestyle predictors of these hormones have not been elucidated. Here we report the results of a cross-sectional study. SUBJECTS AND METHODS: This cross-sectional study examines the relationship of a series of epidemiologic parameters (age, sex, height, body mass index, smoking, alcohol consumption, and coffee drinking) with IGF-1 and IGF-BP3 in a sample of 130 healthy adults. RESULTS: We observed that serum levels of IGF-1 are higher, whereas levels of IGF-BP3 are lower, in men than in women. In addition, serum levels of IGF-1 are independently and negatively associated with age and positively associated with pack-year history of smoking. Finally, serum levels of IGF-BP3 are independently and negatively associated with the number of cigarettes smoked per day or pack-year history of smoking. CONCLUSION: Age, sex, and smoking are independent predictors of IGF-1 and/or IGF-BP3. The influence of these epidemiologic variables on the pathogenesis of disease states associated with IGF-1 and IGF-BP3 warrants further exploration.

scholarly journals Association between Insulin-Like Growth Factor-1 and Uric Acid in Chinese Children and Adolescents with Idiopathic Short Stature: A Cross-Sectional Study

2018 ◽  
Vol 2018 ◽  
pp. 1-6 ◽  
Author(s):  
Panpan Wang ◽  
Baolan Ji ◽  
Qian Shao ◽  
Mei Zhang ◽  
Bo Ban
Keyword(s):  
Uric Acid ◽  
Growth Factor ◽  
Children And Adolescents ◽  
Short Stature ◽  
Cross Sectional Study ◽  
Chinese Children ◽  
Insulin Like Growth Factor ◽  
Sectional Study ◽  
Cross Sectional ◽  
Chinese Children And Adolescents

Objective. The aim of this study was to examine the relationship between insulin-like growth factor-1 (IGF-1) and serum uric acid (UA) in Chinese children and adolescents with idiopathic short stature (ISS).Methods. A cross-sectional study of 91 Chinese children and adolescents with ISS was performed. Anthropometric measurements and biochemical parameters were tested. The standard deviation score of IGF-1 (IGF-1 SDS) was calculated.Results. A univariate analysis displayed a significant positive correlation between IGF-1 SDS and UA (P=0.004). In multivariate piecewise linear regression, the levels of IGF-1 SDS increased with the elevation of UA when UA was between 168 μmol/L and 301 μmol/L (β0.010, 95% CI 0.004–0.017;P=0.002). The levels of IGF-1 SDS decreased with the elevation of UA when UA was either less than 168 μmol/L (β  −0.055, 95% CI −0.081–−0.028;P<0.001) or more than 301 μmol/L (β  −0.005, 95% CI −0.013–0.002;P=0.174).Conclusions. This study demonstrated a nonlinear relationship between IGF-1 and UA levels in Chinese children and adolescents with ISS. This finding suggests that either high or low levels of UA may have an adverse effect on IGF-1, whereas appropriate UA levels have a beneficial effect.

Insulin-like Growth Factor I and Anthropometric Parameters in a Danish Population

2012 ◽  
Vol 120 (03) ◽  
pp. 171-174 ◽  
Author(s):  
N. Friedrich ◽  
T. Jørgensen ◽  
A. Juul ◽  
C. Spielhagen ◽  
M. Nauck ◽  
...  
Keyword(s):  
Growth Factor ◽  
Causal Relation ◽  
Body Height ◽  
Population Based ◽  
Cross Sectional Study ◽  
Insulin Like Growth Factor ◽  
Anthropometric Parameters ◽  
Anthropometric Measures ◽  
Cross Sectional ◽  
Igf I

AbstractDuring the last decade several studies indicated that low insulin-like growth factor (IGF) I levels are related to higher risk of cardiovascular disease and mortality. Obesity represents one further main cardiovascular risk factor which might also be related to IGF-I. The objective of the present study was to analyse the associations between anthropometric measures and IGF-I levels in a population-based sample.From the Danish cross-sectional Health2006 study 3 328 subjects (1 835 women; 1 493 men) aged 19–72 years were included in the analyses. Serum IGF-I levels were determined by an immunoassay. Body height, weight as well as waist and hip circumferences were measured. Body-mass-index, waist-to-hip ratio and waist-to-height ratio were calculated.Circulating IGF-I levels were inversely associated with all anthropometric markers as evaluated by linear regression adjusting for age, alcohol consumption, smoking and physical activity. Our large cross-sectional study suggests that IGF-I may serve as the link between obesity and mortality although any causal relation cannot be inferred and longitudinal analyses are needed to clarify the causal relation.

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