Insulin-like Growth Factor I and Anthropometric Parameters in a Danish Population

2012 ◽  
Vol 120 (03) ◽  
pp. 171-174 ◽  
Author(s):  
N. Friedrich ◽  
T. Jørgensen ◽  
A. Juul ◽  
C. Spielhagen ◽  
M. Nauck ◽  
...  
Keyword(s):  
Growth Factor ◽  
Causal Relation ◽  
Body Height ◽  
Population Based ◽  
Cross Sectional Study ◽  
Insulin Like Growth Factor ◽  
Anthropometric Parameters ◽  
Anthropometric Measures ◽  
Cross Sectional ◽  
Igf I

AbstractDuring the last decade several studies indicated that low insulin-like growth factor (IGF) I levels are related to higher risk of cardiovascular disease and mortality. Obesity represents one further main cardiovascular risk factor which might also be related to IGF-I. The objective of the present study was to analyse the associations between anthropometric measures and IGF-I levels in a population-based sample.From the Danish cross-sectional Health2006 study 3 328 subjects (1 835 women; 1 493 men) aged 19–72 years were included in the analyses. Serum IGF-I levels were determined by an immunoassay. Body height, weight as well as waist and hip circumferences were measured. Body-mass-index, waist-to-hip ratio and waist-to-height ratio were calculated.Circulating IGF-I levels were inversely associated with all anthropometric markers as evaluated by linear regression adjusting for age, alcohol consumption, smoking and physical activity. Our large cross-sectional study suggests that IGF-I may serve as the link between obesity and mortality although any causal relation cannot be inferred and longitudinal analyses are needed to clarify the causal relation.

scholarly journals Serum Insulin-Like Growth Factor (IGF) Binding Protein-3 and IGF-I Levels during Childhood and Adolescence. A Cross-Sectional Study

1995 ◽  
Vol 38 (2) ◽  
pp. 149-155 ◽  
Author(s):  
M Amalia Andrade Olivié ◽  
Ricardo V García-mayor ◽  
Domingo González Lestón ◽  
Teresa Rodríguez Sousa ◽  
Ana Segura Dominguez ◽  
...  
Keyword(s):  
Growth Factor ◽  
Serum Insulin ◽  
Cross Sectional Study ◽  
Childhood And Adolescence ◽  
Insulin Like Growth Factor ◽  
Sectional Study ◽  
Cross Sectional ◽  
Igf I ◽  
Igf Binding ◽  
Igf Binding Protein

scholarly journals The Relationship Of Insulin‑Like Growth Factor 1 With Bone Mass In Obese Female

2020 ◽  
Vol 9 (2) ◽  
pp. 1041-1046
Author(s):  
Adek Ardiansyah ◽  
Lilik Herawati ◽  
Damayanti Tinduh
Keyword(s):  
Growth Factor ◽  
Bone Mass ◽  
Fasting Blood Glucose ◽  
Cross Sectional Study ◽  
Insulin Like Growth Factor ◽  
Obese Women ◽  
Cross Sectional ◽  
Obese Female ◽  
Relationship Of ◽  
The Relationship

This study aimed to analyze the relationship of insulin-like growth factor 1 with bone mass in obese female. This study used a cross sectional study method using 30 obese women aged 19-23 years, body mass index (BMI) 25-35 kg / m2, normal blood pressure, normal resting heart rate (RHR), normal hemoglobin (Hb). and fasting blood glucose (FBG) <100 mg / dL. Measurement of IGF-1 levels used the Enzym Link Immunosorbent Assay (ELISA) method. Measurement of bone mass using TANITA (Body Composition Analyzer DC3607601 (2) -1604 FA, TANITA Corporation of America, Inc., USA). The data analysis technique used the Pearson product-moment test with Statistical Package for Social Science (SPSS). The results showed that mean levels of IGF-1 (1.17 ± 0.10) ng / mL and bone mass (2.49 ± 0.06) kg (r = 0.712, P ≤ 0.001). Our findings suggest that there was a positive correlation between IGF-1 levels and bone mass

Levels of the small insulin-like growth factor-binding protein are strongly related to those of insulin in prepubertal and pubertal children but only weakly so after puberty

1989 ◽  
Vol 121 (2) ◽  
pp. 383-387 ◽  
Author(s):  
J. M. P. Holly ◽  
C. P. Smith ◽  
D. B. Dunger ◽  
J. A. Edge ◽  
R. A. Biddlecombe ◽  
...  
Keyword(s):  
Growth Factor ◽  
Binding Protein ◽  
Pubertal Development ◽  
Circadian Variation ◽  
Cross Sectional Study ◽  
Insulin Like Growth Factor ◽  
Sectional Study ◽  
Normal Children ◽  
Cross Sectional ◽  
The Relationship

ABSTRACT We have looked at the relationship between fasting levels of insulin and a small insulin-like growth factor (IGF)-binding protein (IBP-1) in a cross-sectional study of 116 normal subjects aged 5–48 years. The relationship between IBP-1 and insulin was also examined within individual normal children in over-night profiles of IBP-1 and insulin obtained from two children at each stage of puberty (Tanner stages 1–5). In the cross-sectional study high levels of IBP-1 were found in early childhood and these fell throughout puberty as fasting levels of insulin rose. Multiple regression analysis revealed that both these changes were predominantly due to pubertal development rather than to age. After the age of 16 IBP-1 levels remained low despite fasting insulin levels returning to prepubertal levels. A strong negative correlation was obtained between IBP-1 and insulin in children of 5–16 years (r = −0·63; n = 60; P <0·001), no such relationship being found after the age of 16. In the second study, IBP-1 underwent a marked circadian variation in all cases and an inverse correlation with insulin, measured at the same time, was obtained at pubertal stages 1 to 4, but not at stage 5 (pooled data stages 1–4, r = −0·69; n = 53; P <0·001). We have demonstrated that a potential inhibitor of IGF-activity is inversely related to insulin throughout the period of active GH-related growth and that this relationship weakens after puberty. Journal of Endocrinology (1989) 121, 383–387

scholarly journals The Effect of Oral Glucose on Serum Free Insulin-Like Growth Factor-I and -II in Healthy Adults*

1997 ◽  
Vol 82 (9) ◽  
pp. 3124-3127 ◽  
Author(s):  
Jan Frystyk ◽  
Thorbjørn Grøfte ◽  
Christian Skjærbæk ◽  
Hans Ørskov
Keyword(s):  
Growth Factor ◽  
Healthy Subjects ◽  
Time Course ◽  
Oral Glucose ◽  
Insulin Like Growth Factor ◽  
Serum Samples ◽  
Cross Sectional ◽  
Igf System ◽  
Igf I ◽  
The Impact

Abstract Insulin-like growth factor (IGF) binding protein-I (IGFBP-1) has been suggested to regulate the availability of free IGF and the glucose lowering activity of the IGF-system in relation to fuel supply. Our recent observations of significant inverse correlations between free IGF-I and IGFBP-1 in cross-sectionally collected fasting serum samples support a possible physiological association between the peptides. To further study the impact of IGFBP-1 on free IGF levels and the possible participation of the IGF-system in glucose homeostasis, we studied the time course of changes in IGFBP-1 and free IGFs in 13 healthy subjects undergoing an oral glucose tolerance test (OGTT). Serum was collected every 30 min for 330 min. Glucose, insulin, and GH followed the expected patterns and had regained baseline levels at 270 min. Total IGF-I and free and total IGF-II remained unaltered. IGFBP-1 decreased significantly by 37–52% (P &lt; 0.05) from 150 to 210 min, whereafter the concentration gradually increased by 75% to a level that tended to be above baseline (P = 0.052). Free IGF-I decreased by 29–38% (P &lt; 0.05) at the end of the study (270–330 min). IGFBP-1 was inversely correlated to free IGF-I at baseline (r = −0.57; P &lt; 0.05), as well as during the OGTT (r = 0.66; P &lt; 0.0001). In contrast, free IGF-II was not correlated to IGFBP-1. Insulin, but not free IGF-I, correlated significantly with serum glucose (P &lt; 0.05). These results extend our previous findings of an inverse correlation between free IGF-I and IGFBP-1 in cross-sectional studies to include longitudinal observations, and thus further substantiates the hypothesis that IGFBP-1 is an important determinant of free IGF-I in vivo. Significant changes in free IGF-I were observed only in the late postprandial phase, when glucose and insulin were fully normalized, demonstrating that free IGFs probably do not participate in glucoregulation to any significant degree during an oral glucose load in healthy subjects.

scholarly journals Assessment of Anthropometric Indices for Optimal Cut-Offs for Obesity Screening in a South African Adolescent Population

Biology ◽  
2021 ◽  
Vol 10 (11) ◽  
pp. 1118
Author(s):  
Godwill Azeh Engwa ◽  
Karin Schmid-Zalaudek ◽  
Chungag Anye ◽  
Boitumelo P. Letswalo ◽  
Paul Chungag Anye ◽  
...  
Keyword(s):  
South African ◽  
Roc Analysis ◽  
Cross Sectional Study ◽  
Screening Tools ◽  
Sub Saharan Africa ◽  
Anthropometric Parameters ◽  
Anthropometric Indices ◽  
Anthropometric Measures ◽  
Cross Sectional ◽  
Adolescent Population

The assessment of obesity in sub-Saharan Africa relies on cut-offs established from western populations. This study assessed anthropometric indices to determine optimal cut-off values for obesity screening in the South African adolescent population. A cross-sectional study involving 1144 (796 females and 348 males) adolescents aged 11–17 years from the Eastern Cape Province of South African was conducted. Anthropometric parameters were measured. Receiver operating characteristic (ROC) analysis was performed to assess the sensitivity and specificity of obesity screening tools and establish cut-offs. The optimal cut-offs for obesity in the cohort using waist-to-height ratio (WHtR) as reference were: neck circumference (NC) = 30.6 cm, mid-upper arm circumference (MUAC) = 25.9 cm, waist circumference (WC) = 75.1 cm, hip circumference (HC) = 92.15 cm and body mass index percentile (pBMI) = p85.2th. The new pBMI cut-off value at p85.2th improved the sensitivity of the test by approximately 30% compared to the CDC recommended BMI percentile (pBMIr) of p95.0th. When pBMI was used as reference, the optimal cut-offs in the cohort were: WHtR = 0.481, NC = 30.95 cm, MUAC = 27.95 cm, WC = 76.1 cm and HC = 95.75 cm. The WHtR optimal cut-off of 0.481 was close to the recommended cut-off value of 0.5. The predicted prevalence of obesity obtained using cut-offs from ROC analysis was higher than those from recommended references. All cut-off values for the various anthropometric measures generally increased with age for all percentile ranges. This study reveals a lower pBMI cut-off value, different from the CDC recommended cut-off, for screening obesity in a South African adolescent population. The study has established that the optimal pBMI cut-off for obesity screening may be ethnic-specific.

scholarly journals COMPARISON OF INSULIN LIKE GROWTH FACTOR-1 LEVELS IN CHRONIC MYELOCYTIC LEUKEMIA PATIENTS RECEIVING IMATINIB AND NILOTINIB THERAPY WITH HEALTHY POPULATIONS

2020 ◽  
Vol 7 (12) ◽  
pp. 12-17
Keyword(s):  
Growth Factor ◽  
Philadelphia Chromosome ◽  
Cross Sectional Study ◽  
Lymphocytic Leukemia ◽  
Healthy Population ◽  
Insulin Like Growth Factor ◽  
Chronic Myelocytic Leukemia ◽  
Myeloproliferative Disease ◽  
Cross Sectional ◽  
Myelocytic Leukemia

Introduction. CML is the most common form of chronic leukemia in Indonesia, whereas in Western countries it is more commonly found in the form of chronic lymphocytic leukemia (CLL). Chronic myelocytic leukemia (CML) is a chronic myeloproliferative disease with clonal abnormalities due to genetic changes in stem cell pluripotence. This disease is characterized by proliferation of granulocyte series without differentiation disorders. On the CML, the Philadelphia chromosome (Ph1 chr) is found in a reciprocal translocation 9.22 (t9; 22). Insulin-like Growth Factor-1 is a natural polypeptide in the human body that has similarities with insulin. IGF-1 plays an important role in the growth and development of tissues. As such, several studies have shown an association between IGF-1 and -2 circulation rates. IGF-1 plays an important role in terms of stimulating cell proliferation and inhibition of apoptosis. This affects the regulation of the body's physiological growth as well as pathological growth such as cancer. Until now there has been no research on IGF-1 levels in CML patients with imatinib and nilotinib treatment. Methods. This research is a cross-sectional study, by observing the status of exposure and simultaneous disease in individuals from a single population, in one period. The study was conducted in December 2019 at the Outpatient Clinic of H Adam Malik General Hospital Medan with the approval of the North Sumatera University Research Ethics Commission. Data were analyzed using SPSS where p <0.05 was considered significant. Results. This study showed that there were no differences in IGF-1 levels between CML patients who received imatinib and nilotinib therapy. The mean IGF-1 results were obtained in the imatinib group 107.43±19.70 and nilotinib 107.43±18.09. While the healthy population is 138.60±52.85. Conclusion. No significant differences were found in IGF-1 levels between CML patients receiving imatinib and nilotinib therapy with healthy populations.

High Levels of Circulating Insulin-Like Growth Factor-I Increase Prostate Cancer Risk: A Prospective Study in a Population-Based Nonscreened Cohort

2004 ◽  
Vol 22 (15) ◽  
pp. 3104-3112 ◽  
Author(s):  
Pär Stattin ◽  
Sabina Rinaldi ◽  
Carine Biessy ◽  
Ulf-Håkan Stenman ◽  
Göran Hallmans ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Growth Factor ◽  
Cancer Risk ◽  
Prostate Cancer Risk ◽  
Population Based ◽  
Insulin Like Growth Factor ◽  
Factor I ◽  
Bottom Quartile ◽  
Igf I ◽  
Igfbp 3

PurposeInsulin-like growth factor-I (IGF-I) stimulates proliferation and inhibits apoptosis in prostate cancer cells, and IGF-I has been associated with increased prostate cancer risk in some, but not all, epidemiologic studies.Subjects and MethodsWe extended our previous case-control study nested in the Northern Sweden Health and Disease Cohort, a population-based cohort from a region where little prostate specific antigen (PSA) screening is done. Levels of IGF-I and IGF binding protein-3 (IGFBP-3) were measured in prediagnostic blood samples from a total of 281 men who were subsequently diagnosed with prostate cancer after recruitment (median, 5 years after blood collection) and from 560 matched controls.ResultsLogistic regression analyses showed increases in prostate cancer risk with increasing plasma peptide levels, up to an odds ratio (OR) for top versus bottom quartile of IGF-I of 1.67 (95% CI, 1.02 to 2.71; Ptrend= .05), which was attenuated after adjustment for IGFBP-3 to an OR of 1.47 (95% CI, 0.81 to 2.64; Ptrend= .32). For men younger than 59 years at recruitment, OR for top versus bottom quartile of IGF-I was 4.12 (95% CI, 1.01 to 16.70; Ptrend= .002), which was significantly stronger than for men older than 59 years (Pinteraction= .006). For men with advanced cancer, OR for top versus bottom quartile of IGF-I was 2.87 (95% CI, 1.01 to 8.12; Ptrend= .10).ConclusionOur data add further support for IGF-I as an etiologic factor in prostate cancer and indicate that circulating IGF-I levels measured at a comparatively young age may be most strongly associated with prostate cancer risk.

scholarly journals Correlation Between the Total Small Bowel Length and Anthropometric Measures in Living Humans: Cross-Sectional Study

2019 ◽  
Vol 30 (2) ◽  
pp. 681-686 ◽  
Author(s):  
Mohamed Bekheit ◽  
Mohamed Y. Ibrahim ◽  
Wael Tobar ◽  
Ibrahim Galal ◽  
Athar S. Elward
Keyword(s):  
Small Bowel ◽  
Cross Sectional Study ◽  
Anthropometric Parameters ◽  
Anthropometric Measures ◽  
Cross Sectional ◽  
Small Bowel Length ◽  
Bowel Length ◽  
Important Correlation ◽  
The Mean ◽  
The Individual

Abstract Background Variation in the outcome of bariatric surgery is still an unraveled phenomenon. This variation could be multifactorial. Several reports implicate the total small bowel length (TSBL) in this process. However, the basic information regarding the normal bowel length and its relation to the anthropometric parameters of the living subject is scarce. This study aims at reporting the normal total bowel length in living adult humans and its correlation with the anthropometric parameters. Methods This study included 606 participants (380 females and 226 males). Their mean age was 39.8 ± 11 years, weight = 135.7 ± 29.7 kg, height = 165 ± 9 cm, and BMI = 49.5 ± 7.5 kg/m2. The mean TSBL was 630 ± 175 cm. There was a statistically significant but very weak positive correlation but between the TSBL and both weight and height. Males had significantly higher weight and were significantly taller compared with females. TSBL was significantly longer in males at 661.5 ± 186 cm versus 612 ± 164 cm in females. Conclusion The study reports an average TSBL greater than what is reported in the literature from living humans with a greater range of variation. There is no clinically important correlation between the TSBL and the weight and height of the individual participants in this series.

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