scholarly journals Developing a model of placental lesions prediction in varicose veins patients

2021 ◽  
Vol 18 (3) ◽  
pp. 327-339
Author(s):  
L. F. Mozhejko ◽  
Ya. V. Tsikhanovich
Keyword(s):  
Learning Algorithm ◽  
Varicose Veins ◽  
Predictive Biomarkers ◽  
Coagulation Factors ◽  
Placental Insufficiency ◽  
Blood Analysis ◽  
Ultrasound Findings ◽  
Varicose Disease ◽  
Lasso Method ◽  
Endothelial Growth Factor

The objective of the study was to identify predictive biomarkers and generate the model to predict placental lesions in women with varicose veins. We collected serial serum specimens from 128 women with varicose veins between 22 and 24 weeks’ gestation. The investigation includes ultrasound findings, blood analysis of endothelin-1, vascular endothelial growth factor (VEGF), CRP, coagulation factors as well as BMI. We used machine learning algorithm and multivariable logistic regression with Lasso method to predict placental lesions among the pregnant patients with varicose veins.A total of 47 (36.7 %) women with varicose veins subsequently developed placental insufficiency. Mean serum VEGF were higher in women who developed placental insufficiency – 29 (27–31) pg/ml, as compared with women without varicose disease – 24 (22–25) pg/ml, p < 0.001. The performance of the model trained with all the most valuable tests (VEGF, endothelin, CRP, D-dimers, fibrinogen, CEAP class) is admissible (AUC 0.94; CI 0.842–0.956; p < 0.001).We identified novel combination of clinical and laboratory predictive markers that provide pathophysiological insights and could help future improvements of diagnosis and treatment of placental lesions in women with varicose veins.

scholarly journals Intense remodeling of extracellular matrix within the varicose vein: the role of gelatinases and vascular endothelial growth factor

2020 ◽  
Author(s):  
Anna Horecka ◽  
Anna Hordyjewska ◽  
Jadwiga Biernacka ◽  
Wojciech Dąbrowski ◽  
Tomasz Zubilewicz ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
Varicose Veins ◽  
Artery Bypass ◽  
Bypass Graft ◽  
Clinical State ◽  
Vascular Endothelial ◽  
Altered Expression ◽  
Endothelial Growth Factor

Abstract Background Increased blood pressure in the varicose veins (VV) can contribute to the overexpression of matrix metalloproteinases (MMPs), affecting the endothelium, smooth muscle, and extracellular matrix of the vein wall. Gelatinases (MMP-2 and MMP-9), hypoxia, and inflammation occurring in the VV wall contribute to the increased expression of vascular endothelial growth factor (VEGF). Aims Our objective was to analyze the concentration of gelatinases and VEGF in the great saphenous VV wall and plasma of patients. Methods In total, 65 patients (2nd degree according to clinical state classification, etiology, anatomy, and pathophysiology—CEAP classification) aged 22 to 70 were enrolled. Control veins (n = 10) were collected from the patients who underwent coronary artery bypass graft surgery. Control plasma (n = 20) was obtained from healthy individuals. Gelatinases and VEGF levels were measured with the usage of ELISA method. Results A significant increase in MMP-9 (11.2 vs. 9.98 ng/mg of protein) and VEGF (41.06 vs. 26 ng/g of protein) concentration in VV wall compared with control veins was observed. A positive correlation between VEGF versus MMP-2 (p = 0.03, r = 0.27) was found in the VV wall. However, no correlation was found between the concentration of VEGF and MMP-9 (p = 0.4, r = 0.11) in the VV wall. In addition, no statistical differences between MMP-9, MMP-2, and VEGF levels in plasma of VV patients compared with controls were noticed. Conclusions The results of the present study confirm that VV’s patients have altered expression of MMPs and VEGF. Overexpression of MMP-9 and VEGF in the VV wall may contribute to the spreading of inflammatory process and suggests the intense remodeling of extracellular tissue within the VV wall.

Management of Cytomegalovirus Seroconversion during Pregnancy in France

2015 ◽  
Vol 39 (1) ◽  
pp. 4-12 ◽  
Author(s):  
Julie Carrara ◽  
Dieynaba S. N'Diaye ◽  
Elie Azria ◽  
Odile Launay ◽  
Flore Rozenberg ◽  
...  
Keyword(s):  
Health Care ◽  
First Trimester ◽  
Blood Analysis ◽  
Final Decision ◽  
Fetal Blood ◽  
Cmv Infection ◽  
Health Care Practitioners ◽  
Cerebral Mri ◽  
Ultrasound Findings ◽  
First Trimester Of Pregnancy

Introduction: Guidelines for the management of cytomegalovirus (CMV) infection of the fetus are rare. Our main objective was to evaluate how health care practitioners in France manage cases of CMV seroconversion during pregnancy. Material and Methods: A questionnaire was e-mailed to health care practitioners potentially concerned by CMV seroconversion during pregnancy. They were asked if they would recommend amniocentesis, fetal cerebral MRI examination and fetal blood analysis (FBA), depending on the ultrasound results. They then had to indicate whether they would accept termination of pregnancy (TOP), depending on the results of these examinations. Results: A total of 380 health care practitioners responded, mainly obstetricians (73.9%) and midwives (20.2%). Overall, 57% of respondents recommended amniocentesis in the case of CMV seroconversion during the first trimester of pregnancy, ultrasound findings being normal. In cases of positive amniocentesis and a major ultrasound abnormality, 84.5% of respondents would perform cerebral MRI, and 44.4% would perform FBA. In this case, the rate of acceptance of TOP was not significantly different whether the examinations were normal (337/372, 90.6%) or not performed (339/374, 93.3%; p = 0.17). Discussion: Amniocentesis is too infrequently used and should be encouraged. The results of MRI and FBA are often not taken into account in the final decision concerning TOP. Guidelines are needed to clarify the management of CMV seroconversion during pregnancy.

Anatomical Patterns in Varicose Vein Disease: A Duplex Scanning Study

1995 ◽  
Vol 10 (3) ◽  
pp. 94-97 ◽  
Author(s):  
J. J. Guex ◽  
B. Hiltbrand ◽  
J. M. Bayon ◽  
F. Henri ◽  
F. A. Allaert ◽  
...  
Keyword(s):  
Saphenous Vein ◽  
Venous Insufficiency ◽  
Varicose Veins ◽  
Previous Treatment ◽  
Lower Limbs ◽  
Duplex Scanning ◽  
Consecutive Series ◽  
Yield Data ◽  
Varicose Disease ◽  
Vein Disease

Objectives: To determine symptomatology, clinical class, and topographic patterns of varicose veins in a consecutive series of patients with venous complaints. Methods: We performed clinical examination and duplex scanning of 498 lower limbs in 317 patients with obvious varicose veins for whom no previous treatment had been undertaken. Results: Classes of chronic venous insufficiency (CVI) in 498 legs: grade 0: 117 (23.5%); gr 1: 310 (62.2%); gr 2: 47 (9.4%); gr 3: 24 (4.8%). Duplex-detected venous reflux was found in the greater saphenous vein territory (junction or trunk or related perforator or main tributary) in 423 limbs (85.3%) the sapheno-femoral junction was incompetent in only 342 legs (68.7%). Reflux was found in the lesser saphenous vein territory in 100 limbs (20.1%) and in sapheno-popliteal junction in 92 (18.5%). Strictly non saphenous origin of varicosities was found in 31 limbs (6.2%). Deep venous incompetence was found in 48 legs (9.6%). Conclusions: These findings yield data on the distribution and occurence of lower limbs venous lesions in patients with varicose disease.

Association between ultrasound findings and serum levels of vascular endothelial growth factor in ampullary pregnancy

2015 ◽  
Vol 103 (3) ◽  
pp. 734-737 ◽  
Author(s):  
Fábio Roberto Cabar ◽  
Pedro Paulo Pereira ◽  
Regina Schultz ◽  
Rossana Pulcinelli Francisco ◽  
Marcelo Zugaib
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
Serum Levels ◽  
Vascular Endothelial ◽  
Ultrasound Findings ◽  
Endothelial Growth Factor

scholarly journals Are All Anti-Angiogenic Drugs the Same in the Treatment of Second-Line Metastatic Colorectal Cancer? Expert Opinion on Clinical Practice

2021 ◽  
Vol 11 ◽  
Author(s):  
Eleonora Lai ◽  
Stefano Cascinu ◽  
Mario Scartozzi
Keyword(s):  
Colorectal Cancer ◽  
Growth Factor ◽  
Metastatic Colorectal Cancer ◽  
Growth Factor Receptor ◽  
Predictive Biomarkers ◽  
Vascular Endothelial ◽  
The Novel ◽  
Second Line ◽  
Endothelial Growth Factor

Targeting tumor-driven angiogenesis is an effective strategy in the management of metastatic colorectal cancer (mCRC); however, the choice of second-line therapy is complicated by the availability of several drugs, the occurrence of resistance and the lack of validated prognostic and predictive biomarkers. This review examines the use of angiogenesis-targeted therapies for the second-line management of mCRC patients. Mechanisms of resistance and anti-placental growth factor agents are discussed, and the role of aflibercept, a recombinant fusion protein consisting of portions of human vascular endothelial growth factor receptor (VEGFR)-1 and VEGFR-2, is highlighted. The novel mechanism of action of aflibercept makes it a useful second-line agent in mCRC patients progressing after oxaliplatin-based chemotherapy, as well as in those with resistance after bevacizumab.

scholarly journals A GENETIC STUDY OF PATIENTS WITH CHRONIC VENOUS INSUFFICIENCY BASED ON CLINICAL AND GENEALOGICAL METHOD

2018 ◽  
Vol 14 (1-2) ◽  
pp. 59-63
Author(s):  
Kh.O. Korolova ◽  
V.V. Teplyi
Keyword(s):  
Chronic Venous Insufficiency ◽  
Venous Insufficiency ◽  
Autosomal Dominant ◽  
Varicose Veins ◽  
Hereditary Disease ◽  
Dominant Type ◽  
The Family ◽  
Varicose Disease ◽  
Disease Inheritance ◽  
Autosomal Dominant Type

Relevance. Practically 10-15 % of the world's population has varicose veins as a manifestation of chronic venous insufficiency. The clinical and genealogical method is the method allows to identify family cases of disease in patients with chronic venous insufficiency. Objective: to demonstrate the role of heredity in varicose disease, to analyze family cases of varicose disease, to determine the type of disease inheritance and to give a prediction of heredity for descendants, using the clinical and genealogical method. Materials and methods. The study involved 72 patients, mostly women – 46 (63.9 %) persons, with different classes of varicose veins according to the CEAP classification. To determine the type of inheritance we used clinical and genealogical method of pedigrees’ study. The nature of the trait – hereditary or non-hereditary disease; type of the inheritance – autosomal-dominant, autosomal-recessive, sex-linked, were defined. Results. The family nature of the varicose disease was revealed in 17 (23 %) of the 72 examined patients. The autosomal-dominant type of inheritance was determined. There is direct inheritance across generations. Conclusions. We determined the family nature of the disease inheritance, with the autosomal-dominant type of inheritance with a high degree of gene expression. In these families there is a high risk of the birth of the children who will have chronic venous insufficiency.

scholarly journals RAMUCIRUMAB THERAPY IN PATIENTS WITH ADVANCED GASTRIC AND GASTROESOPHAGEAL JUNCTION ADENOCARCINOMA: A SYSTEMATIC REVIEW

2017 ◽  
Vol 22 (3) ◽  
pp. 116-121
Author(s):  
V. A Gorbounova ◽  
N. S Besova ◽  
M. B Bychkov ◽  
S. V Orlov ◽  
L. M Kogoniya ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Gastroesophageal Junction ◽  
Locally Advanced ◽  
Growth Factor Receptor ◽  
Predictive Biomarkers ◽  
Antiangiogenic Agents ◽  
Gastroesophageal Cancer ◽  
Gastroesophageal Junction Adenocarcinoma ◽  
American Society ◽  
Endothelial Growth Factor

Objective. Gastric cancer is the fifth most common malignancy and the third leading cause of the cancer mortality worldwide. It is most often diagnosed at a locally advanced or metastatic stage. Angiogenesis has become an important target in the treatment of solid tumors, and antiangiogenic agents are a promising approach to cancer therapy. In this review, we summarize the current literature on the treatment of gastric and gastroesophageal cancer with ramucirumab, an antiangiogenic agent specifically targeting vascular endothelial growth factor receptor-2 (VEGFR-2). Material and methods. We conducted a systematic search in May 2016 of PubMed and relevant congress proceedings including the American Society of Clinical Oncology, the European Society for Medical Oncology, and the European Cancer Congress. Included studies were aimed to prospectively evaluate the efficacy and safety of ramucirumab in advanced gastric or gastroesophageal cancer. Results. Our search yielded 91 publications including 5 manuscripts and 6 congress abstracts meeting the predefined inclusion criteria. Included studies reported outcomes were related to ramucirumab in gastric cancer, published within the past 5 years. Conclusion. Second-line treatment with ramucirumab, either as monotherapy or in combination with paclitaxel, significantly improves the survival of patients with advanced gastric cancer. Ramucirumab is well tolerated and has an acceptable safety profile. Furthermore, the patient quality of life is maintained with delayed both symptom worsening and deterioration of the functional status. Studies are required to identify potential predictive biomarkers of ramucirumab efficacy.

scholarly journals ENDOVENOUS LAZER COAGULATION: LONG-TERM RESULT - CRITERION OF TRUTH

2018 ◽  
Vol 3 (4) ◽  
pp. 27-30
Author(s):  
A G Shalashov ◽  
A V Kazantsev
Keyword(s):  
Varicose Veins ◽  
Intraoperative Complications ◽  
Lower Limbs ◽  
Long Term Results ◽  
Laser Coagulation ◽  
Term Outcome ◽  
Long Term Outcome ◽  
Long Term Result ◽  
Varicose Disease

Objectives - to study the long-term results of endovenous laser coagulation in patients with varicose veins of the lower extremities. Material and methods. The study included 241 patients with varicose disease of the lower limbs veins, who underwent surgical treatment using the method of endovenous laser coagulation. Results. The technical success of the operation was achieved in all cases, which was confirmed by color duplex scanning. There were no intraoperative complications. Long-term outcome was studied in 174 (72.2%) patients in the period up to 5 years. During the follow-up period the GSV occlusion signs were detected in 168 (96.4%) patients, partial recanalization of the GSV was registered in 6 (3.5%) patients.

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