scholarly journals Effect of Hydroalcoholic Extract of Ferulago angulata (Schlecht) Boiss on Motor and Memory Disorders in Animal Model of Parkinson Disease

2018 ◽  
Vol 12 (8) ◽  
pp. 36-47
Author(s):  
Razieh Mahmoudi ◽  
Maryam Rafieirad ◽  
Samira Goudarzi ◽  
◽  
◽  
...  
Keyword(s):  
Animal Model ◽  
Parkinson Disease ◽  
Memory Disorders ◽  
Hydroalcoholic Extract

scholarly journals Analysis of the Neuroproteome Associated With Cell Therapy After Intranigral Grafting in a Mouse Model of Parkinson Disease

2021 ◽  
Vol 15 ◽  
Author(s):  
Hassan Dakik ◽  
Sarah Mantash ◽  
Ali Nehme ◽  
Firas Kobeissy ◽  
Masoud Zabet-Moghaddam ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Animal Model ◽  
Systems Biology ◽  
Mouse Model ◽  
Cell Therapy ◽  
Parkinson Disease ◽  
Large Scale ◽  
Brain Regions ◽  
Nigrostriatal Pathway ◽  
Reconstruction Process

Advances in large-scale proteomics analysis have been very useful in understanding pathogenesis of diseases and elaborating therapeutic strategies. Proteomics has been employed to study Parkinson disease (PD); however, sparse studies reported proteome investigation after cell therapy approaches. In this study, we used liquid chromatography–tandem mass spectrometry and systems biology to identify differentially expressed proteins in a translational mouse model of PD after cell therapy. Proteins were extracted from five nigrostriatal-related brain regions of mice previously lesioned with 6-hydroxydopamine in the substantia nigra. Protein expression was compared in non-grafted brain to 1 and 7 days after intranigral grafting of E12.5 embryonic ventral mesencephalon (VM). We found a total of 277 deregulated proteins after transplantation, which are enriched for lipid metabolism, oxidative phosphorylation and PD, thus confirming that our animal model is similar to human PD and that the presence of grafted cells modulates the expression of these proteins. Notably, seven proteins (Acta1, Atp6v1e1, Eci3, Lypla2, Pip4k2a, Sccpdh, and Sh3gl2) were commonly down-regulated after engraftment in all studied brain regions. These proteins are known to be involved in the formation of lipids and recycling of dopamine (DA) vesicle at the synapse. Moreover, intranigral transplantation of VM cells decreased the expression of proteins related to oxidative stress, especially in the nigrostriatal pathway containing the DA grafted neurons. In the same regions, an up-regulation of several proteins including α-synuclein and tyrosine hydroxylase was observed, whereas expression of tetraspanin 7 was shut down. Overall, these results suggest that intranigral transplantation of VM tissue in an animal model of PD may induce a decrease of oxidative stress in the nigrostriatal pathway and a restoration of the machinery of neurotransmitters, particularly DA release to promote DA transmission through a decrease of D2 DA receptors endocytosis. Identification of new mechanistic elements involved in the nigrostriatal reconstruction process, using translational animal models and systems biology, is a promising approach to enhance the repair of this pathway in PD patients undergoing cell therapy.

activation of microglia lead to onset of Parkinson disease-like animal model

2010 ◽  
Vol 68 ◽  
pp. e192
Author(s):  
Atsuko Ishii ◽  
Sachiko Tanaka ◽  
Hirokazu Ohtaki ◽  
Seiji Shioda ◽  
Satoshi Numazawa ◽  
...  
Keyword(s):  
Animal Model ◽  
Parkinson Disease

scholarly journals Wlds-Mediated Protection of Dopaminergic Fibers in an Animal Model of Parkinson Disease

2004 ◽  
Vol 14 (4) ◽  
pp. 326-330 ◽  
Author(s):  
Ali Sajadi ◽  
Bernard L Schneider ◽  
Patrick Aebischer
Keyword(s):  
Animal Model ◽  
Parkinson Disease

scholarly journals Protective Effect of Soy on Movement Disorders Induced by Parkinson Disease in Ovariectomized Animal Model

2013 ◽  
Vol 1 (3) ◽  
pp. 5-10
Author(s):  
Hadi Aligholi ◽  
Maryam Safahani ◽  
Alireza Sarkaki ◽  
Reza Amani ◽  
◽  
...  
Keyword(s):  
Animal Model ◽  
Parkinson Disease ◽  
Protective Effect ◽  
Movement Disorders ◽  
Ovariectomized Animal

scholarly journals Animal Model of Parkinson Disease: Neuroinflammation and Apoptosis in the 6-Hydroxydopamine-Induced Model

2018 ◽  
Author(s):  
Daniel Hernandez-Baltazar ◽  
Rasajna Nadella ◽  
Maria de Jesus Rovirosa-Hernandez ◽  
Laura Mireya Zavala-Flores ◽  
Christian de Jesus Rosas Jarquin
Keyword(s):  
Animal Model ◽  
Parkinson Disease ◽  
6 Hydroxydopamine

scholarly journals The evaluation of the changes in enzymatic antioxidant reserves and lipid peroxidation in chosen parts of the brain in an animal model of Parkinson disease

2017 ◽  
Vol 26 (6) ◽  
pp. 953-959 ◽  
Author(s):  
Ewa Romuk ◽  
Wioletta Szczurek ◽  
Michał Oleś ◽  
Artur Gabrysiak ◽  
Marta Skowron ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Animal Model ◽  
Parkinson Disease ◽  
Enzymatic Antioxidant ◽  
The Brain

scholarly journals “Clinical Study of Memory Disorders in Aging Patients with Associated Cardiovascular, Neurological, Neurobehavioral and Metabolic Diseases”. A Review

2021 ◽  
pp. 1-9
Author(s):  
Castejón OJ ◽  
◽  
Carrero-González Carmen Maria ◽  
Keyword(s):  
Cardiovascular Diseases ◽  
Parkinson Disease ◽  
Sleep Disorders ◽  
Metabolic Diseases ◽  
Cervicogenic Headache ◽  
Memory Disorders ◽  
Gastrointestinal Pathology ◽  
Loss Of Weight ◽  
Hearing Acuity ◽  
Neurobehavioral Disorders

We have observed semantic memory and episodic memory disorders (100%) in patients ranging from 40 to 92 years-old, associated to cardiovascular diseases and blood hypertension (82%), sleep disorders (50%), neurobehavioral disorders (44%), such as depression, anxiety, aggression, and vascular demencia, disorders of language (36%), neurosensory disorders (28%), as diminution of visual and hearing acuity, dizziness (26%), Parkinson disease (34%), Alzheimer disease (21%), gait disturbances (10%), vertigo (10%), cervicalgia and cervicogenic headache (10%) trigeminal neuralgia (2%,), We observed as comorbidities the following non-nervous diseases: metabolic diseases as diabetes (21%) and hypothyroidism (5%), gastrointestinal pathology (21%), such as constipation, loss of sphincter control, and gastritis, arthritis (13%), prostatic hypertrophy (1%) and loss of weight (1%). We consider that according to their high frequency the most risk factors associated to memory disorders are cardiovascular diseases and blood hypertension (82%), sleep disorders (50%), neurobehavioral disorders (44%), such as depression, anxiety, aggression, and vascular demencia, disorders of language (36%), neurosensory disorders (28%), as diminution of visual and hearing acuity, dizziness (26%), and Parkinson disease (34%).

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