scholarly journals Chondrosarcoma pelvis, beyond the boundaries.

2020 ◽  
Vol 27 (09) ◽  
pp. 2014-2022
Author(s):  
Badaruddin Sahito ◽  
Maratib Ali ◽  
Dileep Kumar ◽  
Nauman Hussain ◽  
Noman Parekh ◽  
...  

Objectives: The objective of our study to find the outcome of extensive chondrosarcoma pelvis after surgery. Study Design: Case Series study. Setting: Department of Orthopaedic Surgery Dow University of Health Sciences / Civil Hospital Karachi. Period: From April 2014 to December 2018. Material & Methods: Seven patients with Chondrosarcoma pelvis included in this study. Results: All Seven patients were male. 2 patient age was in 20’s, three in 40’s and two in 60’s with median age of 44. Clinically presentation of patients was variable. One patient present with groin lump, one with pain and swelling lower abdomen, three with hip pain, one patient with severe gluteal pain and lump, one with massive lump extending from the mid abdomen to groin and urine retention and constipation. Five patients have left pelvis involved and two have right side. Two patients have pubic bone and ischium (Level III) involved, two have ilium (Level I) and three have ilium, acetabulum and pubis (Level I, II, III). Two patients with have preoperatively sciatic nerve palsy. Two patients have medical comorbid. One was asthmatic and one had psychiatric illness. No patient had metastasis at presentation. Pubis and ischium with tumor resected in two cases, partial ilium resection in one case, one complete P1 resection with sciatic nerve, one patient have internal hemipelvectomy and one patient had internal hemipelvectomy that bone recycled in liquid nitrogen and pelvis re-implanted and fixed with recon plates and hip joint reconstructed with total hip replacement. One patient had external hemipelvectomy due to pus at tumor site. Total duration of surgery in patient having thirteen hours, and remaining have 3 to 5 hours. Blood loss during these surgeries was in between 1000 to 1200 ml. Three patients have wound infection, one patient had L5 nerve root injury. Patient with external hemipelvectomy develop wound dehiscence and uro-cutaneous fistula. Two patients died, one with recycled bone after 15 months due cardiac problem and 2nd due to disease related complications within 3 months of surgery. Conclusion: Pelvic chondrosarcoma must be operated by the team of surgeons including orthopaedic surgeon, urologist and general surgeon because of the tumor presents with massive lumps due to unrestricted compartment and can involve the important pelvic organ. With team any complication can be prevented and treated immediately.

Vaccines ◽  
2019 ◽  
Vol 7 (3) ◽  
pp. 65
Author(s):  
Chisholm ◽  
Howe ◽  
Best ◽  
Petousis-Harris

Pertussis vaccines have been effective at reducing pertussis-associated morbidity and mortality. However, they have a complex array of limitations, particularly associated with the duration of protection against clinical disease and imperfect immunity (carriage and transmission). Little is known about risk factors for pertussis vaccination failure. Understanding pertussis vaccination failure risk is most important in the paediatric population. This study aims to investigate risk factors for pertussis vaccination failure in (1) infants between birth and six weeks of age born to mothers who received pertussis booster vaccinations during pregnancy and (2) infants after the completion of the primary series (approximately five months old) to four years old. This will be achieved in a two-step process for each study group. Pertussis vaccination failure cases will first be described using a case series study design, relevant case characteristics will be sourced from six national administrative datasets. The case series study results will help select candidate risk factors (hypothesis generating step) to be tested in the retrospective cohort study (hypothesis testing step. Pattern analysis will be used to investigate risk factor patterns in the cohort study. The identification of higher risk groups enables targeting strategies, such as additional doses, to better prevent pertussis disease.


2018 ◽  
Vol 8 (2) ◽  
Author(s):  

Tóm tắt Đặt vấn đề: Sỏi đường mật chính thường gặp là ống mật chủ (OMC) là bệnh lý phổ biến ở Việt Nam. Phẫu thuật nội soi (PTSN) để lấy sỏi qua OMC ngày càng được áp dụng rộng rãi trong điều trị bệnh sỏi mật. Kết hợp tán sỏi qua nội soi đường mật trong lúc phẫu thuật nhằm làm sạch sỏi đặc biệt là sỏi trên gan đang được áp dụng ở nhiều cơ sở. Phương pháp nghiên cứu: Nghiên cứu kết quả ứng dụng PTNS và nội soi tán sỏi qua OMC để điều trị sỏi đường mật chính tại bệnh viện VN-TĐ Uông Bí. Phương pháp can thiệp lâm sàng, mô tả tiến cứu. Đối tượng nghiên cứu là những người bệnh có sỏi đường mật chính (sỏi đường mật trong gan và ngoài gan) được PTNS ổ bụng lấy sỏi đường mật qua OMC có kết hợp tán sỏi điện thủy lực được thực hiện tại bệnh viện VN-TĐ Uông Bí từ 9/2014-9/2017. Thông tin của người bệnh được thu thập trước và sau phẫu thuật, xử lý bằng phần mềm thống kê y học SPSS 16.1. Kết quả: Gồm 31 trường hợp (TH) được nghiên cứu, có 9 nam và 22 nữ, tuổi trung bình là 55,45 ± 15,05. Trong đó sỏi OMC đồng thời với sỏi trong gan là 31, sỏi túi mật kết hợp 9 TH. 21 TH lấy hết sỏi đường mật ngay trong phẫu thuật. 10 người bệnh còn sót sỏi trong gan phải lấy sỏi qua đường hầm Kehr sau 1 tháng. 1 người bệnh phải chuyển mổ mở, 2 người bệnh bị rò mật sau mổ. Thời gian phẫu thuật trung bình là 130.65 ± 46.91 phút, thời gian nằm viện trung bình là 8,58 ± 3,59 ngày. Không có tử vong do phẫu thuật. Kết luận: Đây là những kinh nghiệm PTNS mở OMC có kết hợp với nội soi tán sỏi để điều trị sỏi đường mật đầu tiên của chúng tôi. Chúng tôi nhận thấy phẫu thuật có tính khả thi an toàn cũng như hiệu quả tại bệnh viện VN-TĐ Uông Bí. Abstract Introduction: Common bile duct (CBD) stone is endemic in Vietnam. Laparoscopic common bile duct exploration (LCBDE) has gained wide popularity in the treatment of choledocholithiasis. At the same time, electrohydraulic lithotripsy (EHL) via choledochoscopy might help to clear intrahepatic stones. Material and Methods: The aim of this study is to access the results of laparoscopic common bile duct exploration associating with electrohydraulic lithotripsy via choledochoscopy to clear biliary stones Vietnam – Thuy Dien – Uong Bi Hospital. This is a prospective, interventional and descriptive case series study. Patients with both extra-and intra-hepatic stones who underwent laparoscopic common bile duct exploration (LCBDE) from September 2014 to September 2017 were enrolled in our study. The data was prospectively collected and analysed by using SPSS 16.1. Results: There were 9 men and 22 women with age ranging from 12 to 78 years old (average 55,45 ± 3,59). There were 9 patients with gallbladder stones. Complete bile duct clearance was done in 21 patients. 10 patients with residual intrahepatic stones required extracting stones through T tube tunnel by choledochoscopy and EHL. The average duration of surgery was 130.65 ± 46.91 minutes and the average hospital stay was 8,55 ± 3,59 days. There were one conversion to open surgery and two cases of bile leakage. We had non-fatal postoperative complications. Conclusion: This is preliminary experience of LCBDE in my hospital in the management of choledocholithiasis. It should be considered effective and feasible in the treatment of CBD stones in Vietnam – Thuy Dien – Uong Bi Hospital. Keyword: Laparoscopic common bile duct exploration, Electrohydraulic lithotripsy via choledochoscopy


1970 ◽  
Vol 3 (2) ◽  
pp. 102-108 ◽  
Author(s):  
R Thapa ◽  
G Paudyal

Introduction: Endophthalmitis following cataract surgery is a rare but devastating ocular complication where delay in treatment not only results in vision loss but also in difficulty to save the eye ball. Objective: To explore the clinical profile and visual outcome following pars plana vitrectomy (PPV) in acute endophthalmitis after cataract surgery. Materials and methods: This is a retrospective interventional case series study conducted at Tilganga Institute of Ophthalmology (TIO), Nepal. All consecutive cases of acute endophthalmitis following cataract surgery treated with PPV from January 2005 to August 2010 were included in the study. Results: There were a total of 34 cases (34 eyes) treated with PPV. The age range was 8 - 93 years with mean age of 56.9 ± 19.5 years. The mean duration of presentation and duration following cataract surgery was 7.7 ± 8.1days and 13 ± 11.6 days respectively. Small incision cataract surgery was done in 75 % of cases followed by phacoemulsification (15.6 %). The mean duration of the last follow -up was 4.3 months. Vision was improved in two-thirds of cases (67.67 %) with a good vision of 6/18 or better in 17.6 %. Among the available vitreous samples of 22 cases, 36.36 % had an abnormality in Gram and Giemsa stains and culture was positive in 13.6 % of cases. Conclusion: Despite the late presentation, the majority of eyes were salvaged with improvement of vision in 67.67 %, with a good vision of 6/18 or better in 17.6 4 % of cases following PPV in acute post operative endophthalmitis. Key words: Endophthalmitis, vitrectomy, cataract surgery, visual outcome DOI: http://dx.doi.org/10.3126/nepjoph.v3i2.5260 Nepal J Ophthalmol 2011; 3(2): 102-108


2017 ◽  
Vol 24 (09) ◽  
pp. 1295-1301
Author(s):  
Sanam Panhwar ◽  
Muhammad Aslam Rind ◽  
Maria Nazir Khyber

Objectives: To predict the frequency of rebleeding by pre-endoscopic clinicalRockall scoring system in patients presenting with upper gastrointestinal hemorrhage. StudyDesign: Descriptive Case series study. Period: six months. Settings: Departments of Medicine,Liaquat University of Medical and Health sciences Jamshoro/Hyderabad. Material & Methods:The source of data was 187 patients who reported with the presenting complaint of hematemesisin ER and were then transferred to Medical Unit for further management. At the time of inclusionthe concerned Physician collected the demographic data, vital and relevant information for thepresence of co morbidities. After admission patients were shifted to endoscopy suite (situatedin Medical Unit) for the endoscopic diagnosis of the underlying condition. Any new episode ofhematemesis was considered as a re-bleed (within 120 hours of time zero). Rockall scoringwas calculated as per operational definition in the specifically designed proforma for the study.Mortality was noticed in the time the patient stayed in the hospital. Rebleeding was the endpoint of this study. Results: A total of 187 patients were selected for this study. Out of these 119were males (63.64%) and 68 (36.36%) were females. The mean age of patients was 59.25 years± 10.3 SD. Mean systolic BP was 107.08 ± 13.3, heart rate was 90.3 ± 11.9 and clinical Rockallscore of 3.5 ± 0.8 SD. A total of 111 (59.4%) patients presented with bleeding esophagealvarices, 36 (19.3%) presented with bleeding gastric varices, together chronic liver diseasewas responsible for 78.4% (147) of patients. Gastric erosions were seen to be the cause ofupper gastrointestinal hemorrhage in 18 (9.6%) of patients, whereas peptic ulcer disease wasthe cause responsible in 20 (10.7%). Lastly gastric carcinoma was seen in only 2 (1.1%) ofpatients. A total of 35 (18.7%) of patients experienced rebleeding episodes during the hospitalstay. Mortality was seen in 31 patients (16.6%). Conclusion: Clinical Rockall score is a goodpredictor of rebleeding and mortality. However, application of this score for the purpose oftriage of patients reporting with bleeding esophageal varices is problematic because this grouphas the presentation of liver failure along with hematemesis so getting low Rockall scores (andpredicting survival without endoscopic intervention) is not possible in this group of patients.


2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Koko Adachi ◽  
Yoshinobu Kameyama ◽  
Kohkichi Andoh

Abstract Background Few studies examined time-to-time changes of cuff pressure of an endotracheal tube during surgery. We retrospectively analyzed the changes of cuff pressure during thyroid surgery and examined its relationships with postoperative airway complications. Case presentation Cuff pressure was initially adjusted at 26 cmH2O and continuously measured in 61 patients. The cuff pressure-time curve dynamically fluctuated, and exceeded 30 cmH2O in all patients, whereas decreased to ≤ 20 cmH20 in 42 (69%) patients. Ratio of the period with such an increase and decrease of cuff pressure to the total duration of surgery were 40% (28–66%) and 9% (0–21%), respectively (median, interquartile range). No patients showed symptoms of airway stenosis requiring treatment except one who developed recurrent laryngeal nerve palsy. No patients had lower respiratory tract infection. Conclusions Cuff pressure dynamically fluctuated during thyroid surgery. Preventing an increase as well as decrease of cuff pressure is required.


2021 ◽  
Vol 15 (7) ◽  
pp. 1755-1759
Author(s):  
Muhammad Anwar ◽  
Faisal Waheed ◽  
Khadija Hussain

Objective: The objective of the study was to determine the versatility of reverse sural artery flap in terms of its reliability and efficacy for reconstruction of soft-tissue defects of heel and proximal foot in children. Material and Methods: A total of 30 patients aged 5-13 years with ankle and foot defects admitted to the Plastic Surgery and Burn department at the Sheikh Zayed Hospital, Rahim Yar Khan from January 2018 to July 2020 were studied by designing a retrospective cross-sectional case series study. Results: Out of 30 flaps, 26 (86.7%) healed fully, whereas 4 (13.3%) complicated by partial necrosis requiring a secondary procedure. Nineteen (63.3%) patients had wheel spoke injuries, eight (26.6%) sustained degloving injury after a road traffic accident, and three (0.1%) patients were having a history of electric burn. In 22 patients an interpolated flap was used and in 8 cases an islanded flap. Donor sites were skin grafted in all patients. Two patients developed hypertrophic scarring at donor area. All patients showed good functional results, however flap remained insensate throughout the follow-up period that was minimum for 6 months. Conclusion: The reverse sural artery flap is versatile, reliable and a method of choice in reconstructing soft-tissue defects of the hind foot in children. This flap is easy to dissect, has robust blood supply and does not sacrifice any major blood vessel of the leg. Key Words: Reverse Sural Artery Flap, children, Ankle and Foot, Soft-tissue Defects, Wheel Spook Injury


2016 ◽  
Vol 21 (4) ◽  
pp. 214
Author(s):  
Muhammad Shahid Alam ◽  
Khalid Masood Gondal ◽  
Humayun Siddique ◽  
Yar Muhammad

AbstractIntroduction:A stoma is a surgical procedure in which a part of gut is taken out and connected on the anterior abdominal wall. An anastomosis is the joining together of the two intestinal ends that remain after a diseased section has been removed. The closure of the stoma though thought to be minor surgical procedure, yet it may be associated with appreciable morbidity. When the reversal of stoma is done in less than 8 weeks following primary surgery then it is considered to be early closure. Early closure of the temporary stoma might reduce both stoma related complications and patient ailment. Wound complications are common but there are many associated morbidities due to delay in closure. So the aim of this study is to find the complications associated with early closure of temporary stomaObjective:To evaluate the outcome of early closure of temporary stoma.Material and Methods:This descriptive case series study of 350 patients of both gender aged between13 70 years was conducted in surgical ward of mayo hospital, Lahore in one year duration from 01-01-2014 to 31-12-2014. The non-probability purposive sampling technique was used in this study. Written consent was obtained from the patients. Only the most senior consultants with 5 years experience after post-graduation were the part of the team. Following admission they were advised distal loopogram to rule out any distal obstruction, leakage or any other pathology. Closure was performed and the evaluation of the patient and relevant investigations pertaining to diagnose complications like anastomotic leakage and wound complications was done. This was recorded daily for 5 days post-operatively in ward and then a follow up weekly for 1 month was performed. Analysis of data was done statistically using version 13.0. Mean SD were calculated for age. Frequency and percentages were calculated for gender, anastomotic leakage and wound complications. Post-stratification chi-square test was applied keeping a P-value ? 0.05 as significant.Results:In our study mean age of the patients was 42.73 13.68 years, 60% patients were males whereas 40% patients were females. The study results showed that anastomotic leakage was found in 29 (8.3%) patients and wound complication was found in 20.57% patients. Statistically insignificant difference was found between the wound complication and gender of the patients i.e. p-value = 0.82.Conclusion:According to our study results the outcome of early closure of temporary stoma is a feasible and effective procedure with fewer complications.Keywords:Early Closure, Temporary Stoma, Wound Complication, Anastomotic Leakage.


2017 ◽  
Vol 34 (09) ◽  
pp. 851-855
Author(s):  
Tran Le ◽  
Michael Adler ◽  
Holly Ouillette ◽  
Pamela Berens ◽  
Judith Smith

Objective The objective of this study was to observe the efficacy of antiemetic therapy (no emesis/retching episodes and no rescue medication use) when granisetron is administered via a transdermal patch system (TDS) in women who are 6 to 14 weeks pregnant when compared with oral ondansetron by evaluating the frequency of the use of rescue medications for control of nausea/vomiting of pregnancy (NVP). Methods This was an observational case series study to observe the potential benefits of granisetron TDS compared with oral ondansetron for management of NVP in pregnant patients during the first trimester. Dates of data collection were September 1, 2014, through December 31, 2015. There was no direct contact with patient. The oral ondansetron and granisetron TDS patients were matched by age, 4:1. The proportion of patients who received rescue antiemetics was calculated from those patients who continued to experience NVP. Risk factors for NVP were identified and compared between groups. Descriptive statistics were used to describe study results. Results Patients were prescribed rescue antiemetics in 0/3 patients in the granisetron TDS group compared with 2/12 patients in the oral ondansetron group. Conclusion Prospective efficacy studies on the use of granisetron TDS for management of NVP are needed to confirm this clinical observation.


2008 ◽  
Vol 1 ◽  
pp. CMTIM.S1024
Author(s):  
Garth H. Utter ◽  
Gregory P. Victorino ◽  
David H. Wisner

Background Trauma patients in rural areas are frequently transferred to regional trauma centers for expeditious evaluation and management of potentially life-threatening injuries. We sought to characterize how long the process takes, once it has begun, for acutely injured patients to be transferred from emergency departments (EDs) of referring hospitals to trauma centers and how the time is spent. Methods We conducted a retrospective multi-institutional case series study. We reviewed records of acutely injured trauma patients transferred from the EDs of 114 outlying hospitals to the EDs of three Level I or II regional trauma centers over a 12–24 month period. We calculated the duration of the transfer process and its component time intervals (reported as the mean ± standard deviation). Results Among 1099 patients transferred from 114 referring hospitals, the mean Injury Severity Score was 11.6. Mortality was 5.9%. Half of all transfers were by ground ambulance, 36% by helicopter, and 13% by airplane. The mean time from patient presentation at the ED of the referring hospital until transfer request was 126 ± 94 min, and the mean time from transfer acceptance until arrival at the trauma center was an additional 119 ± 60 min. The mean time from transfer acceptance to departure of the patient from the ED of the referring hospital was 68 ± 48 min. Transportation time accounted for 48 ± 29 min, or 40% of the total time between transfer acceptance and arrival at the accepting hospital. Conclusions Interhospital transfer of acutely injured trauma patients takes a substantial amount of time even after acceptance of the patient, and actual time spent in transportation accounts for only 40% of the time from transfer acceptance to arrival of the patient at the receiving hospital, on average. Efforts to speed transfers should focus on shortening the time from transfer acceptance to departure from the referring hospital.


2021 ◽  
Vol 15 (6) ◽  
pp. 1394-1396
Author(s):  
M. W. Saleem ◽  
S. Ali, L. Wajid

Aim: To analyze the post mastoidectomy complications in patients presenting at tertiary care hospital. Methods: This case series study was conducted at Department of ENT, DG Khan Hospital, DG Khan from March 2020 to September 2020 over the period of 6 months. Total 65 patients came for open cavity mastoidectomy either male or female having age between 20-60 years were selected for this study. Results: In present study 65 patients had undergone open cavity mastoidectomy. Mean age of the patients was 39.95 ± 12.57 years. Out of 65 patients, cavity complications was found in 20 (31%) patients. Among the 20 patients who had cavity problems, the most common problem was prolonged discharge found in 19 (95%) patients followed by accumulation of wax in the cavity was found in 5 (25%) patients, Vertigo persisting beyond the immediate postoperative period was found in 3 (15%) patients, perichondritis of pinna was seen in 1 (5%) patients, development of facial palsy was found in 5 (50%) patients, recurrent cholesteatoma was found in 3 (15%) patients and wound infection was found in 2 (10%) patients. Conclusion: Results of present study showed higher rate of post operative complications after mastoidectomy. Sclerotic mastoid was most common. Higher rate of complications was seen after 40th decade of life. Most of the patients were male as compared to female. Prolonged discharge was the most common problem. Keywords: Mastoidectomy, Cavity, Meatoplasty, Pneumatisation, Cholesteatoma


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