Taking Wuhu City of Anhui Province as an example, this paper constructs two evaluation index systems of tourism industry and regional economic development respectively, and studies the coupling coordination situation and influencing factors of Wuhu City from 2015 to 2019 by using the coupling coordination degree model. The research shows that the comprehensive development level of Wuhu tourism industry and regional economy system has been steadily improved year by year in the past five years. Coupling degree C showed an up-down trend, but was generally at a high level. The comprehensive development level T of the two systems is also in an increasing trend. By 2019, the coupling coordination degree of the tourism-industry system in Wuhu has been upgraded from good coordination to high quality coordination. In the future development process, Wuhu City should continue to promote GDP growth on the basis of the current good development situation, and realize the win-win situation between tourism and regional economic development.