scholarly journals Evaluation and Correlation of Hepcidin-25 Hormone, Hemoglobin and Packed Cell Volume of Patients With β-Thalassaemia Intermedia Before and After Blood Transfusion for Iraqi Children Patients

2018 ◽  
Vol 31 (3) ◽  
pp. 70
Author(s):  
Mohammed Q. Saadoon ◽  
Bushra H. Ali
Keyword(s):  
Blood Transfusion ◽  
Iron Overload ◽  
Cell Volume ◽  
Packed Cell Volume ◽  
Affected Person ◽  
Before And After ◽  
Thalassaemia Trait ◽  
Thalassaemia Intermedia ◽  
Compound Heterozygotes ◽  
Control Samples

            β-thalassaemia consists of 3 chief forms: thalassaemia primary (other called "cooley's Anaemia" or "Mediterranean durability Anaemia"), thalassaemia intermedia or thalassaemia minor also frequent termed "β-thalassaemia carrier", "β-thalassaemia trait" however, "heterozygous β-thalassaemia". separately from the rare magisterial forms, problem along β-thalassaemia essential are homozygotes or made heterozygotes because B0 and B+ genes, problem including thalassaemia intermedia are typically homozygotes and compound heterozygotes then subjected with thalassaemia minor are broadly heterozygotes. In this study, we take eighty humans the age about them had been mean±SD (9.68±2.08), 40 patients along β-thalassaemia intermedia, then 40 healthy people as much control. extraction gore 5ml from thalassaemia's patients before gore transfusion then afterwards take the blood  by way of three days. The samples we instituted are 120, forty samples before blood transfusion, 40 samples after gore transfusion then 40 control samples. Then we separated every pattern of twin's tubes. Amplify blood attention about β-thalassaemia intermedia patient since blood advancement due according to minimize degree regarding hepcidin-25 further than its instruction was once shown up iron focus meanly affect through hepcidin-25 level, therefore so hepcidin-25 used to be surprisingly significant exchange in β-thalassaemia intermedia affected person afterwards blood advancement yet so much conduct to iron overload. So  we conclude low level of Hemoglobin before and after blood transfusion due to decrease or absent formation of β-globin that because gene disorder, and conclude correlation between hepcidin hormone with Hb and PCV. The aim of this study is to evaluate hepcidin-25 levels, hemoglobin [Hb] and packed cell volume [PCV] before and after blood transfusion, then correlation of hepcidin-25 hormone with [Hb] and [PCV] of children patients with β-thalassaemia intermedia.

scholarly journals Direct-Push Blood Transfusion Practice in the Neonatal Unit of a Tertiary Hospital in South-South, Nigeria

2021 ◽  
pp. 91-96
Author(s):  
E. U. Bassey ◽  
S. B. Adesina
Keyword(s):  
Blood Transfusion ◽  
Cell Volume ◽  
Packed Cell Volume ◽  
Tertiary Hospital ◽  
Transfusion Practice ◽  
Hospital Data ◽  
Direct Push ◽  
Before And After ◽  
Aseptic Conditions ◽  
Blood Bag

Introduction: Transfusion of blood is a life-saving intervention in the care of ill neonates. Donated blood is a scarce national resource and must be used in the most efficient way. Exchange blood transfusion using the blood bag is the commonest mode of blood delivery employed. Other modalities of safe and sustainable blood delivery should also be explored, especially where paucity of funds predominates. This study aims to assess the usefulness of the direct push method where applicable, as an alternative to blood bag delivery in neonatal units of resource poor settings. Methods: A two year retrospective study of newborns admitted in the neonatal wards of the University of Uyo Teaching Hospital. Data obtained were the age, gender, indication for admission, packed cell volume (PCV) before and after transfusion. Blood transfusion was done in aliquots over 24 hours under aseptic conditions, via a peripheral vein. The push and pull method was employed, with no anticoagulant in the syringe. Post-transfusion PCV was done at least 24 hours after the procedure. Results: Of the one thousand and seventy-seven (1077) admitted neonates, two hundred and thirty-nine (22.2%), received blood products. Of these, twenty-one (8.8%), received a direct whole blood transfusion. Age (days) of the neonates transfused ranged from 1 to 26 days, with a mean of 10.4 ± 8.13. The Packed Cell Volume (PCV) pre-transfusion ranged between 20% - 44%, with a mean of 30.05 ± 6.39 while post-transfusion PCV ranged between 31% to 51%, with a mean of 38.17 ± 5.52(Fig. 1). The commonest indication for transfusion was prematurity, 9(42.8%) and neonatal sepsis 5 (23.8%). Conclusion: The direct transfusion of blood occasionally used, seems a relatively safe practice to correct mild/moderate anaemia. It also provides sufficient blood, with the advantage of usage when the umbilical cord access is no longer feasible and where cost of blood would otherwise, hinder quick intervention. This practice may need further evaluation by other centers.

scholarly journals Effect of Halothane and Enflurane Anaesthesia on the Level of Reduced Glutathione in Human Red Blood Cells

1980 ◽  
Vol 8 (3) ◽  
pp. 356-358 ◽  
Author(s):  
N. S. Agar ◽  
G. B. H. Lewis
Keyword(s):  
Cell Volume ◽  
Packed Cell Volume ◽  
Blood Cells ◽  
Reduced Glutathione ◽  
Haemoglobin Concentration ◽  
Red Cell ◽  
Anaesthetic Agents ◽  
Human Red Blood Cells ◽  
Enflurane Anaesthesia ◽  
Before And After

No significant changes were found in packed cell volume, haemoglobin concentration and red cell glutathione levels in patients before and after anaesthesia with halothane or enflurane. These results, though unable to explain the mechanism, support the earlier suggestion that glutathione plays little, if any, role in protecting liver against toxic effects of these anaesthetic agents or their metabolites.

scholarly journals BLOOD PROFILES OF GREEN SEA TURTLE BEFORE AND AFTER THE REHABILITATION

2020 ◽  
Vol 9 (6) ◽  
pp. 930-939
Author(s):  
Ida Bagus Windia Adnyana ◽  
Ida Bagus Nararya Primastana Adnyana ◽  
Siswanto Siswanto
Keyword(s):  
Cell Volume ◽  
Packed Cell Volume ◽  
Haemoglobin Concentration ◽  
Chelonia Mydas ◽  
Sea Turtle ◽  
Corpuscular Haemoglobin ◽  
Turtle Conservation ◽  
Before And After ◽  
Mean Corpuscular Haemoglobin ◽  
Corpuscular Haemoglobin Concentration

Penyu adalah satwa yang terancam punah, sehingga upaya konservasinya perlu ditingkatkan. Kegiatan yang berhubungan dengan konservasi dimaksud adalah rehabilitasi penyu pascamengalami periode out of the water sebelum dilepasliarkan kembali ke alam bebas. Penelitian ini bertujuan untuk mengetahui perbedaan profil dan indeks eritrosit penyu hijau (Chelonia mydas) sebelum dan sesudah mengalami rehabilitasi di Turtle Conservation and Education Center (TCEC) di Pulau Serangan, Denpasar. Penelitian ini menggunakan sampel Sembilan ekor penyu hijau hasil sitaan Polisi Sektor Kuta, Badung, Bali. Sebanyak 2,5 mL darah perifer penyu hijau diambil dari sinus cervicalis dorsalis disimpan di tabung berisikan antikoagulan litium heparin dan dilanjutkan dengan pemeriksaan hematologi. Penentuan nilai total eritrosit dihitung dengan hemositometer. Kadar hemoglobin (Hb) diukur menggunakan Hemoglobinometer Sahli, sedangkan kadar Packed Cell Volume (PCV) ditentukan dengan metode mikrohematokrit. Indeks eritrosit yang meliputi Mean Corpuscular Volume (MCV), Mean Corpuscular Haemoglobin (MCH) dan Mean Corpuscular Haemoglobin Concentration (MCHC) dihitung dengan rumus konvensional yang ditentukan untuk itu. Data hasil penelitian dianalisis secara deskriptif kuantitatif menggunakan uji T berpasangan. Nilai profil darah (Packed Cell Volume, total eritrosit, Hemoglobin) mengalami peningkatan signifikan pasca rehabilitasi dengan nilai rerata hematokrit sebelum rehabilitasi sebesar 28,4±3,09 menjadi 31,7±2,87, nilai total eritrosit sebelum rehabilitasi sebesar 0,44±0,10 menjadi 0,56±0,15, nilai Hemoglobin sebelum rehabilitasi sebesar 6,3±1,28 menjadi 7,53±0,73 serta hasil perhitungan secara statistika dengan uji T-berpasangan menunjukkan profil darah penyu hijau sebelum dan sesudah rehabilitasi memiliki perbedaan yang signifikan yang berarti proses rehabilitas yang dilakukan di Turtle Conservation and Education Center, Serangan berhasil.

scholarly journals Profil Darah dan Nilai Hematologi Domba Lokal yang Dipelihara di Hutan Pendidikan Gunung Walat Sukabumi

2008 ◽  
Vol 8 (2) ◽  
pp. 1-8
Author(s):  
D.A. Astuti ◽  
D.R. Ekastuti ◽  
Y. Sugiarti ◽  
Marwah Marwah
Keyword(s):  
Cell Volume ◽  
Packed Cell Volume ◽  
Blood Protein ◽  
Feeding Time ◽  
Total Blood ◽  
Eating Time ◽  
Haematological Values ◽  
Hypochromic Anaemia ◽  
Significant Difference ◽  
Before And After

Blood profil and hematological status of local sheep under the gunung walat education forest area SukabumiABSTRACT. Gunung Walat Education Forest (HPGW) is one of special forest which integrated with farm system (Agrosilvopastural). This forest is heterogeneous which dominated with agathis, damar and pinus trees. To support the farming system is needed basic data haematology and blood profil of sheep that lived in HPGW. This research was aimed to evaluate haematological values covering Red Blood Cell, haemoglobin, Packed Cell Volume, MCV, MCH, MCHC and blood nutrient profil of lambs and ewes fed with mixed grass which is grow surrounding HPGW. Evaluation were done on 5 productive ewes and 5 male lambs 5-6 month ages, before and after eating time. The result showed that RBC of the lamb was (7.57 0.40) x 106/mm3 and for ewes was (5.71 0.05) x 106/mm3. Hb of lamb was (7.21 0.27) g/100ml and for ewes was (6.62 0.54) g/100ml, PCV of lamb was (28.10 7.21) % and ewes was (26.80 3.42) %, MCV of lamb was (32.68 1,23) fl and ewes was (50.91 1.53) fl, MCH of lamb was (10.82 0.47) pg and ewes was (12.93 0.29) pg, MCHC of lamb was (27,53 4.70)% and for ewes was (25.54 1.57) %. There were no significant difference on haematological values before and after feeding time except for Packed Cell Volume (P 0.05). The clinical result showed that lambs was suffering normocytic hypochromic anaemia and adults was suffering macrocytic hypochromic anaemia. Glucose level and total blood protein were at normal level while blood triglyseride concentration was lower than normal ewes concentration. 

Preoperative packed cell volume (PCV) and category of surgery as predictors of intra-operative blood transfusion

2017 ◽  
Vol 7 (3) ◽  
pp. 95
Author(s):  
SY Yakubu ◽  
S Awwalu ◽  
LG Dogara ◽  
AD Waziri ◽  
AI Mamman
Keyword(s):  
Blood Transfusion ◽  
Cell Volume ◽  
Packed Cell Volume

scholarly journals An investigation of the effects of intravenous administration of thiomolybdate on copper metabolism in chronic Cu-poisoned sheep

1981 ◽  
Vol 46 (3) ◽  
pp. 469-480 ◽  
Author(s):  
S. R. Gooneratne ◽  
J. McC. Howell ◽  
J. M. Gawthorne
Keyword(s):  
Cell Volume ◽  
Whole Blood ◽  
Packed Cell Volume ◽  
Copper Sulphate ◽  
Trichloroacetic Acid ◽  
Copper Metabolism ◽  
Osmotic Fragility ◽  
Soluble Form ◽  
Before And After ◽  
Copper Poisoning

1. Fourteen sheep were dosed repeatedly with a solution of copper sulphate (2 g/l) in order to induce chronic copper poisoning and four similar undosed animals acted as controls.2. Thiomolybdate (TM) was intravenously administered to all control sheep and to all except two of the test sheep. A variety of biochemical factors were studied before and after injections of TM.3. The direct-reacting Cu, whole-blood Cu and plasma Cu concentrations were elevated in animals given TM injections and at the ‘haemolytic crisis’ of untreated chronic Cu-poisoned animals. But most of the increased Cu observed on injecting TM was insoluble in trichloroacetic acid (TCA) and did not enter erythrocytes. The results indicate that uptake of Cu by erythrocytes is essential for haemolysis to occur and that for this to happen the Cu must be in a direct reacting, TCA-soluble form.4. Increased amounts of Cu were excreted in the urine at haemolysis and at the commencement of TM injections. High levels of direct-reacting Cu were found in plasma at these times.5. Marked changes were not found in caeruloplasmin activity, packed cell volume or the osmotic fragility of erythrocytes except at haemolysis. TM injections did not alter these factors in any of the sheep studied.

The Effects of Therapeutic Decrease in Packed Cell Volume on the Responses to Exercise of Patients with Polycythaemia Secondary to Lung Disease

1973 ◽  
Vol 45 (6) ◽  
pp. 833-847 ◽  
Author(s):  
B. D. W. Harrison ◽  
Jane Davis ◽  
R. G. Madgwick ◽  
Marion Evans ◽  
F. J. Prime
Keyword(s):  
Oxygen Consumption ◽  
Cell Volume ◽  
Packed Cell Volume ◽  
Exercise Tolerance ◽  
Lactate Concentration ◽  
Arterial Lactate ◽  
Group Of Seven ◽  
Progressive Exercise ◽  
Before And After ◽  
Pyruvate Ratio

1. Progressive exercise and circulatory studies are reported on a selected group of patients with hypoxaemia and secondary polycythaemia before and after therapeutic decrease of packed cell volume. 2. A significant increase in exercise tolerance was demonstrated in a group of seven patients who claimed subjective benefit from the treatment. 3. No important circulatory changes were detected at rest after treatment. 4. During steady exercise mean pulmonary artery pressure at any given cardiac out-put was lower after treatment suggesting a fall in pulmonary vascular resistance. 5. During steady exercise oxygen consumption was increased in five of six patients subjectively improved by the treatment but no consistent changes in arterial lactate concentration or lactate/pyruvate ratio were observed.

scholarly journals Comparison of Packed Cell Volume Changes after Erythropoietin Administration and Blood Transfusion in Patients with Anemia of Chronic Kidney Disease on Hemodialysis

2021 ◽  
Vol 1 (2) ◽  
pp. 48-51
Author(s):  
Anju Bajracharya ◽  
Jayendra Bajracharya
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Blood Transfusion ◽  
Cell Volume ◽  
Packed Cell Volume ◽  
Therapy Group ◽  
Volume Changes ◽  
Ckd Stage ◽  
The Mean ◽  
Esa Therapy

Introduction: Anemia of chronic kidney disease (CKD) can be managed by regular administration of erythropoiesis stimulating agents (ESAs) and/or blood transfusion. The response to these therapies can be monitored by serial packed cell volume (PCV). Objective: This study was done to compare the temporal changes in PCV after ESA therapy and blood transfusion in patients with recently diagnosed anemia in CKD stage 5 on hemodialysis (CKD 5 HD). Methods: Medical records of patients undergoing hemodialysis at the National Kidney Center, Balaju, Kathmandu from July to September 2013 were examined retrospectively. The data collected were analyzed using Minitab 16. Results: A total of 44 patients were on ESA therapy while 48 patients were on blood transfusion. The mean PCV at the start of blood transfusion was significantly lower than the mean PCV at the start of ESA therapy (p = 0.000) but at four weeks, the mean PCV in blood transfusion group was significantly greater than that in ESA therapy group (p = 0.008). At eight weeks and twelve weeks, the mean PCVs in both groups were not significantly different from each other (p = 0.949 and p = 0.747). Conclusions: Blood transfusion increases PCV immediately and in sustained manner while with ESA therapy, the response takes a longer time to manifest. A large number of non-responders to ESA therapy may have influenced the findings of this study. It is recommended that adequate dosing of ESA and attention to comorbid conditions be followed during ESA therapy. Keywords: Anemia; chronic renal insufficiency; blood transfusion; hematinics.

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