scholarly journals Wound care using metronidazole in a patient with diabetic foot ulcer: a case report

2020 ◽  
Vol 1 ◽  
pp. 172-175
Author(s):  
Agus Santosa ◽  
Okta Fajar Silviana ◽  
Neneng Khasanah
Keyword(s):  
Diabetic Foot ◽  
Public Hospital ◽  
Wound Care ◽  
Foot Ulcer ◽  
Diabetic Foot Ulcer ◽  
Medical Intervention ◽  
Infection Process ◽  
Foot Ulcers ◽  
Diabetic Foot Ulcers ◽  
Wound Area

The control of infection in diabetic foot ulcers is essential to prevent injuries from getting worse. Infection in diabetic foot ulcers is generally caused by bacteria existence in the wound. Antibiotics may not be orally able to exterminate bacteria rapidly in the wound area, so antibiotics are needed directly and topically to the wound to reduce the infection process. This case describes wound care intervention using gauze added by antibiotic metronidazole as a wound compress in a 46-year-old male patient with diabetic foot ulcers treated at Cempaka Ward Banyumas Regional Public Hospital. This case is interesting because the medical intervention given to patients is rarely implemented in clinical practice. The conclusion is that a metronidazole antibiotic used to compress wounds in patients with diabetic foot ulcers can reduce the wound infection process.

NPWT: a gate of hope for patients with diabetic foot ulcers

2019 ◽  
Vol 28 (12) ◽  
pp. S6-S9
Author(s):  
Kazem Hajimohammadi ◽  
Khadijeh Makhdoomi ◽  
Roghayeh Esmaili Zabihi ◽  
Naser Parizad
Keyword(s):  
Type 2 Diabetes ◽  
Diabetic Foot ◽  
Wound Care ◽  
Foot Ulcer ◽  
Diabetic Foot Ulcer ◽  
Foot Ulcers ◽  
Diabetic Foot Ulcers ◽  
Wound Irrigation ◽  
History Of

Non-healing diabetic foot ulcers are a common and costly complication of type 2 diabetes and can result in lower extremity amputation. This case study concerns a 51-year-old man with a 17-year history of uncontrolled type 2 diabetes. He had developed a deep ulcer to the calcaneus of his left foot, which was 12x7 cm in size and infected with multi-drug-resistant Staphylococcus aureus. He was admitted to hospital for the non-healing diabetic foot ulcer and uncontrollable fever and was a candidate for amputation. He was treated with wound irrigation and debridement as well as negative-pressure wound therapy and antibiotic treatment. This strategy was effective and the wound size reduced progressively. The patient recovered well. Medical and wound care teams who deal with non-healing diabetic foot ulcers can benefit from a strategy of combination therapy.

scholarly journals Relationship Between Leukocyte, ESR, and CRP Infection Markers with Changes in Wound Wagner 2 and 3 Diabetic Foot Ulcers

2020 ◽  
Vol 1 (2) ◽  
pp. 26-29
Author(s):  
Patrianef Darwis ◽  
Jimmy Candra Putra ◽  
Dedy Pratama ◽  
Aria Kekalih
Keyword(s):  
Wound Healing ◽  
Significant Relationship ◽  
Diabetic Foot ◽  
Foot Ulcer ◽  
Diabetic Foot Ulcer ◽  
Foot Ulcers ◽  
Diabetic Foot Ulcers ◽  
Research Subjects ◽  
Cross Sectional ◽  
Wound Area

Introduction: In 2012, the annual incidence rate of diabetic foot ulcers and gangrene are estimated to be around 2-5% of the general population. About 15% of patients with diabetic foot can have an amputation in the lower limb. Diabetic foot is a health problem that is very difficult to cure. This is further exacerbated by severe conditions of infection and disrupt the process of tissue regeneration, so amputation must be done to prevent the spread of infection. Infection that is not well controlled can inhibit all phases of wound healing. This study aimed to know the relationship between laboratory profile and wound healing in diabetic foot ulcer patients. Method: This was a cross-sectional study with research subjects who were diabetic foot ulcer patients who went to the emergency room and the Cipto Mangunkusumo National Hospital polyclinic during August-December 2019. Statistical analysis was performed to see the correlation between changes in infection marker values and changes in the wound area. Results: During the period August 2019 to December 2019, 30 subjects met the inclusion and exclusion criteria. There were 14 subjects (46.77%) male and 16 subjects (53.3%) female. From the diagnosis, there were 20 subjects (66.3%) with ulcer pedis and ten subjects (33.3%) gangrene pedis. From this study, the average and standard deviation of changes in ABI values were 0.9080 ± 0.100, changes in the number of leukocytes amounted to 4899.87 ± 4512.048, changes in ESR values was 1.8333 ± 1.147, changes in CRP values was 2.6500 ± 1.702, changes in wound area was 10.2727 ± 6.512, and albumin was 2.9487 ± 0.392. From the correlative analysis, it was found between changes in the number of leukocytes with changes in wound area (p=0.058, r=0.350), changes in ESR values with changes in wound area (p=0.034, r=0.388), and changes in CRP values with changes in wound area (p=0.008, r=0.477). Conclusion: There was a significant relationship between changes in ESR values and CRP values with moderate correlation strength changes in the wound area. There was no significant relationship between changes in the number of leukocytes with changes in the wound area. Keywords: wound area, leukocytes, CRP, ESR, diabetic foot ulcer, leukocytes.

scholarly journals Emerging Diabetic Foot Ulcer Microbiome Analysis using Cutting Edge Technologies

2021 ◽  
pp. 193229682199009
Author(s):  
Brian M. Schmidt
Keyword(s):  
Diabetic Foot ◽  
Foot Ulcer ◽  
Diabetic Foot Ulcer ◽  
Standard Of Care ◽  
Molecular Techniques ◽  
Foot Ulcers ◽  
Care Practice ◽  
Antibiotic Administration ◽  
Diabetic Foot Ulcers ◽  
Conventional Culture

One of the most prevalent complications of diabetes mellitus are diabetic foot ulcers (DFU). Diabetic foot ulcers represent a complex condition placing individuals at-risk for major lower extremity amputations and are an independent predictor of patient mortality. DFU heal poorly when standard of care therapy is applied. In fact, wound healing occurs only approximately 30% within 12 weeks and only 45% regardless of time when standard of care is utilized. Similarly, diabetic foot infections occur in half of all DFU and conventional microbiologic cultures can take several days to process before a result is known. DFU represent a significant challenge in this regard because DFU often demonstrate polymicrobial growth, become resistant to preferred antibiotic therapy, and do not inform providers about long-term prognosis. In addition, conventional culture yields may be affected by the timing of antibiotic administration and collection of tissue for analysis. This may lead to suboptimal antibiotic administration or debilitating amputations. The microbiome of DFU is a new frontier to better understand the interactions between host organisms and pathogenic ones. Newer molecular techniques are readily available to assist in analyzing the constituency of the microbiome of DFU. These emerging techniques have already been used to study the microbiome of DFU and have clinical implications that may alter standard of care practice in the near future. Here emerging molecular techniques that can provide clinicians with rapid DFU-related-information and help prognosticate outcomes in this vulnerable patient population are presented.

The Influence of Arterial Calcification on Clinical Outcomes in Patients with Diabetic Foot Ulcer Complicated by Osteomyelitis Treated by Surgery

2021 ◽  
pp. 153473462110225
Author(s):  
Marta Carmena-Pantoja ◽  
Francisco Javier Álvaro-Afonso ◽  
Esther García-Morales ◽  
Yolanda García-Álvarez ◽  
Aroa Tardáguila-García ◽  
...  
Keyword(s):  
Clinical Outcomes ◽  
Diabetic Foot ◽  
Foot Ulcer ◽  
Diabetic Foot Ulcer ◽  
Arterial Calcification ◽  
Foot Ulcers ◽  
Diabetic Foot Ulcers ◽  
Time To Recurrence ◽  
Artery Disease ◽  
Clinical Records

The aim of our study was to analyze the influence of radiographic arterial calcification (RAC) on clinical outcomes and wound healing in patients with diabetic foot ulcers complicated by osteomyelitis treated by surgery. We analyzed retrospectively the clinical records of 102 patients with diabetic foot osteomyelitis who underwent surgery at a specialized diabetic foot unit between January 2014 and December 2016. The clinical data of evolution until its complete epithelialization and a follow-up 1 year were reviewed, and after reviewing the radiological images, patients were classified into 2 groups: those with RAC and those without RAC. We analyzed several clinical features in both groups. The presence of RAC was associated with a greater time of healing (10.68 ± 7.24 vs 8.11 ± 4.50 weeks; P = .029) and shorter time to recurrence and reulceration (13.30 ± 9.25 vs 18.81 ± 11.63 weeks; P = .036). However, this association was not found for patients with mild and moderate peripheral artery disease (PAD), whose time of healing was 8.97 ± 4.51 weeks compared to 9.16 ± 6.39 weeks for patients without PAD; P = .864. The time of healing of diabetic foot ulcers complicated by osteomyelitis treated by surgery can be negatively affected by the presence of RAC even more than by the presence of mild and moderate ischemia. The presence of RAC may offer clinical guidance at the level of primary care though this would need thorough validation in future studies.

scholarly journals Characterization Of Phyto-Synthesized Silver Nanoparticles And Their Antimicrobial Activity Against Diabetic Foot Ulcer Bacterial Isolates

2021 ◽  
Vol 11 (6) ◽  
pp. 88-96
Author(s):  
Chhajed Shweta ◽  
Arora Asha
Keyword(s):  
Antimicrobial Activity ◽  
Silver Nanoparticles ◽  
Diabetic Foot ◽  
Foot Ulcer ◽  
Diabetic Foot Ulcer ◽  
Lower Limbs ◽  
Diffusion Method ◽  
Foot Ulcers ◽  
Diabetic Foot Ulcers ◽  
Bacterial Isolates

Diabetic Foot Ulcer (DFU) is one of the major complications of Diabetes. Patients with Diabetic Foot ulcers have a high susceptibility to microbial infections and are the leading cause of hospitalization and amputation of lower limbs. In the era of increased prevalence of bacterial resistance and outbreak of resistant infectious diseases, it is very essential to develop effective therapeutic strategies towards multi-drug resistant pathogens. The antimicrobial properties of silver nanoparticles have been well studied, therefore their use in biomedicine and pharmacology is a trend. Herein we present the use of Phyto-mediated synthesized AgNPs for the treatment of diabetic foot ulcers by topical administration. The nanoparticles were synthesized by reducing silver nitrate using Terminalia chebula fruit extract. The nanoparticles were analyzed and characterized using UV-Visible Spectrophotometer, FTIR, XRD, SEM with EDAX, TEM, and DLS. The synthesized silver nanoparticles were assayed for antimicrobial activity against five Diabetic Foot Ulcer bacterial isolates i.e. Escherichia coli, Klebsiella Pneumoniae, Pseudomonas aeruginosa, Streptococcus aureus, and Bacillus subtilis. The bactericidal property of synthesized nanoparticles was analyzed by the Agar well diffusion method, which revealed the remarkable antimicrobial effects against all the selective pathogenic bacterial isolates of Diabetic foot ulcers in the present study. These results constituted the basis for further studies on the use of plant-based silver nanoparticles for the treatment of Diabetic Foot ulcers from different origins

scholarly journals Prevention and treatment of diabetic foot ulcers

2017 ◽  
Vol 110 (3) ◽  
pp. 104-109 ◽  
Author(s):  
Jonathan Zhang Ming Lim ◽  
Natasha Su Lynn Ng ◽  
Cecil Thomas
Keyword(s):  
Diabetic Foot ◽  
Healthcare Access ◽  
Foot Ulcer ◽  
Diabetic Foot Ulcer ◽  
Foot Ulcers ◽  
Diabetic Patients ◽  
Diabetic Foot Ulcers ◽  
Foot Care ◽  
Healthcare Provision ◽  
Foot Complications

The rising prevalence of diabetes estimated at 3.6 million people in the UK represents a major public health and socioeconomic burden to our National Health Service. Diabetes and its associated complications are of a growing concern. Diabetes-related foot complications have been identified as the single most common cause of morbidity among diabetic patients. The complicating factor of underlying peripheral vascular disease renders the majority of diabetic foot ulcers asymptomatic until latter evidence of non-healing ulcers become evident. Therefore, preventative strategies including annual diabetic foot screening and diabetic foot care interventions facilitated through a multidisciplinary team have been implemented to enable early identification of diabetic patients at high risk of diabetic foot complications. The National Diabetes Foot Care Audit reported significant variability and deficiencies of care throughout England and Wales, with emphasis on change in the structure of healthcare provision and commissioning, improvement of patient education and availability of healthcare access, and emphasis on preventative strategies to reduce morbidities and mortality of this debilitating disease. This review article aims to summarise major risk factors contributing to the development of diabetic foot ulcers. It also considers the key evidence-based strategies towards preventing diabetic foot ulcer. We discuss tools used in risk stratification and classifications of foot ulcer.

Inter-rater reliability assessment of new diabetic foot ulcers (The Diabetic Foot Ulcer Assessment Scale) based on photograph

2020 ◽  
Vol 30 ◽  
pp. 433-438 ◽  
Author(s):  
Hasniati Haeruddin ◽  
Saldy Yusuf ◽  
Ilhamjaya Patellongi ◽  
Kaharuddin Abdul Rasid ◽  
Harbaeni Harkam ◽  
...  
Keyword(s):  
Diabetic Foot ◽  
Reliability Assessment ◽  
Foot Ulcer ◽  
Diabetic Foot Ulcer ◽  
Assessment Scale ◽  
Foot Ulcers ◽  
Diabetic Foot Ulcers ◽  
Rater Reliability

scholarly journals Stem cell transplantation therapy for diabetic foot ulcer: a narrative review

2021 ◽  
Vol 15 (1) ◽  
pp. 3-18
Author(s):  
Sahar Shafiee ◽  
Maryam Heidarpour ◽  
Sima Sabbagh ◽  
Elham Amini ◽  
Hanieh Saffari ◽  
...  
Keyword(s):  
Stem Cell ◽  
Stem Cell Transplantation ◽  
Diabetic Foot ◽  
Foot Ulcer ◽  
Diabetic Foot Ulcer ◽  
Foot Ulcers ◽  
Diabetic Foot Ulcers ◽  
Cell Based Therapy ◽  
Cell Transplantation Therapy ◽  
Transplantation Therapy

AbstractDiabetes mellitus is a chronic metabolic disease associated with high cardiovascular risk. A vascular complication of diabetes is foot ulcers. Diabetic foot ulcers are prevalent and substantially reduce the quality of life of patients who have them. Currently, diabetic foot ulcer is a major problem for wound care specialists, and its treatment requires considerable health care resources. So far, various therapeutic modalities have been proposed to treat diabetic foot ulcers and one of them is stem cell-based therapy. Stem cell-based therapy has shown great promise for the treatment of diabetic foot ulcers. This strategy has been shown to be safe and effective in both preclinical and clinical trials. In this review, we provide an overview of the stem cell types and possible beneficial effects of stem cell transplantation therapy for diabetic foot ulcers, and an overview of the current status of stem cell research in both preclinical and clinical trial stages of treatment strategies for diabetic foot ulcers.

scholarly journals Combination Therapy Revives Hope for Patients with Diabetic Foot Ulcer: A Case Report

2021 ◽  
Author(s):  
Naser Parizad ◽  
Kazem Hajimohammadi ◽  
Rasoul Goli
Keyword(s):  
Case Report ◽  
Combination Therapy ◽  
Diabetic Foot ◽  
Wound Care ◽  
Stable Condition ◽  
Foot Ulcer ◽  
Wound Management ◽  
Foot Ulcers ◽  
Diabetic Foot Ulcers ◽  
Present Case Report

Abstract BackgroundDiabetic foot ulcers, as one of the most debilitating complications of diabetes, can lead to amputation. Treatment and management of diabetic foot ulcers are among the most critical challenges for the patients and their families. Case presentationThe present case report is of a 63-year-old man with a 5-year history of uncontrolled type 2 diabetes who has had diabetic foot ulcers for the past three years on three sites of the left external ankle in the form of two deep circular ulcers with sizes of 6×4 cm and 6×8 cm, the sole as a superficial ulcer with a size of 6×3 cm, and the left heel as a deep skin groove. Moreover, the left hallux was completely gangrenous. The patient's ulcers were infected with Staphylococcus aureus and multidrug-resistant Pseudomonas aeruginosa. Despite antibiotic therapy and routine dressing changes, the patient showed no improvement during the hospital stay. Accordingly, the patient was transferred to our service after consulting with the wound management team. Diabetic foot ulcers were treated and managed using a combination of maggot therapy, the Negative Pressure Wound Therapy (NPWT), and silver foam dressing. After three months and ten days, the patient's ulcers completely healed, and he was discharged from our service with the excellent and stable condition. ConclusionsBased on the present case report study's clinical results, wound-care teams can use the combination therapy applied in this study to treat refractory diabetic foot ulcers.

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