POTENSI KOMBINASI EKSTRAK AKAR SIDAGURI (Sida rhombifolia L.) DAN GETAH JARAK (Jatropha curcas L.) SEBAGAI BAHAN DEVITALISASI

Background: Arsenic paste was used to devitalize dental pulp in some problems before surgical, but it has been proven to have many hazardous effects. So, other alternative drugs are needed that are equally effective but safer. Jatropha (Jatropha curcas L.) can cause lysis blood vessels in the pulp, whereas the sidaguri (Sidarhombifolia L.) are effective in relieving inflammation. The purpose of this study was to determine the devitalization effect of jatropha and sidaguri on rabbit animal model.Method: Sidaguri roots were extracted using reflux method while jatropha sap was dried using lyophilization method. For easy application, the extract made into a paste (1; 1) and inserted into the cavity. After 7 days of exposure, the teeth were removed, calcified and followed to histopathological staining and COX-2 expression (IHC).Result: Histopathological examination showed that the paste was able to cause necrosis of pulp nerve. Higher dose of the drug increased the necrosis area, but the paste is not able to reduce COX-2 expression.Conclusion: It can be concluded that the paste has a potential to developed as devitalization agent although it is necessary to study to the reduce the inflammation process.

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Acute Toxicity of Jatropha Curcas L. Latex and Its Histopathological Effects on Dental Pulp and Periapical Tissues

Majalah Obat Tradisional ◽

10.22146/mot.46303 ◽

2020 ◽

Vol 25 (1) ◽

pp. 15

Author(s):

Fazwishni Siregar ◽

Rini Damayanti

Keyword(s):

Body Weight ◽

Acute Toxicity ◽

Jatropha Curcas ◽

Dental Pulp ◽

Direct Contact ◽

Histological Evaluation ◽

Limited Area ◽

Jatropha Curcas L ◽

Significant Difference ◽

Histopathological Effects

Traditional uses of Jatropha curcas L. latex,among others, are to cure toothache. This study aimed to evaluate the acute toxicity of J. curcas latex by oral route and to assess the histopathological effects of J. curcas latex on dental pulp and periapical tissues. For acute toxicity, the latex of 5 g/kg BW was administered intragastrically to the test groups of albino mice and water to the control groups. The assessment was based upon mortality, sign of toxicity, body weight, and histological evaluation of organs. Results showed no mortality in mice up to 5 g/kg body weight, no sign of toxicity, and no tissue alterations macroscopically and histopathologically were observed. There’s no significant difference in body weight between the test and control, both in male and female groups. For testing histopathologic effect on dental pulp, the latex was brought in contact with dental pulp and sealed. The assessment was based on the presence of inflammation and necrosis in dental pulp and periapical tissues, histopathologically. Results showed inflammation and necrosis, which was in direct contact with the latex were observed in a limited area, while underneath was normal pulp. No inflammation or necrosis in periapical tissues was observed in all groups. It caused coagulative necrosis in the pulp which was in direct contact with latex. It can be concluded that J. curcas latex is slightly toxic to mice at a single dose of oral administration. Inflammation and necrosis are observed on dental pulp which is in contact with latex while the tissue underneath is normal. It did not caused inflammation on periapical tissues.

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Pertumbuhan Beberapa Genotipe Jarak Pagar (Jatropha Curcas L.) di Tanah Masam

Buletin Agrohorti ◽

10.29244/agrob.v5i2.16806 ◽

2017 ◽

Vol 5 (2) ◽

pp. 251-263

Author(s):

Indah Retnowati ◽

Memen Surahman

Keyword(s):

Jatropha Curcas ◽

Jatropha Curcas L

Indonesia memiliki banyak tanah masam, tetapi penggunaan masih sangat sedikit karena kandungan nutrisi tanah masam rendah. Sementara itu, jarak pagar merupakan tanaman yang dapat tumbuh di berbagai jenis tanah (termasuk lahan marjinal) dan penggunaannya sebagai bahan baku biodiesel. Oleh karena itu, perlunya penelitian mengenai pertumbuhan jarak pagar pada tanah masam sebagai upaya untuk mengembangkan jarak pagar dan penggunaannya di Indonesia.Untuk memulai upaya, penelitian tentang berbagai genotipe jarak pagar di tanah masam telah dilakukan. Tujuan dari penelitian ini yaitu mempelajari genotipe jarak pagar yang berpotensi untuk tanah masam. Penelitian ini dilakukan di UPTD Pengembangan Teknologi Lahan Kering Singabraja, Kecamatan Tenjo, Bogor, Jawa Barat, dari November 2010-Agustus 201. Penelitian ini menggunakan Rancangan Kelompok Lengkap Teracak (RKLT) dengan satu faktor yaitu genotipe. Hasil penelitian menunjukkan berbagai perbedaan pada pertumbuhan diantara genotipe-genotipe jarak pagar. Secara umum, ada lima genotipe jarak pagar yang terbaik di tanah masam (pH 5.0) yaitu Medan I-5-1, Dompu, IP-2P-3-4-1, Sulawesi, dan Bima M.

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