scholarly journals Unplanned 30-Day Readmissions after Hyper-CVAD Chemotherapy in Patients with Acute Lymphoblastic Leukemia

2021 ◽  
Vol 10 (1) ◽  
pp. 21-25
Author(s):  
Mehdi Dehghani ◽  
Shirin Haghighat ◽  
Zahra Radmard ◽  
Nasrin Namdari ◽  
Alireza Rezvani ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Chemotherapy Regimen ◽  
Lymphoblastic Leukemia ◽  
Admission Rate ◽  
Cross Sectional Study ◽  
High Rate ◽  
Cross Sectional ◽  
Mortality And Morbidity ◽  
Common Causes ◽  
The Mean

Introduction: The aim of this study was to investigate the rate and causes of re-hospitalization in the first 30 days after Hyper-CVAD chemotherapy in all patients with acute lymphoblastic leukemia. Methods: This descriptive, analytical and cross-sectional study was performed on 827 admissions in ALL patients aged 18 years and older with unplanned hospitalization after HyperCVAD chemotherapy in less than 30 days’ post chemotherapy from April 2016 to April 2018 in Hematology and medical oncology department. Results: The rate of unplanned re-admission was 9.91% in all patients. Mean follow-up time was 13.77 ± 6.26 months and the mean age of patients was 35.55 ± 14.6 years. Re-admission rate was more frequent in men (65.7%) and most patients were readmitted only once. The mean duration of re-admission was 8.2±4.15 days and most patients were re-admitted after cycles IB, IIIB and IVB of hyper-CVAD chemotherapy. The most common causes of readmission were febrile neutropenia and pancytopenia. Except for significant changes in CBC, no significant changes were observed in other laboratory tests. Urine culture and blood culture were reported positive in 13.6% and 31.57% respectively, and E-coli was the most common organism isolated from cultures. Conclusion: We found increased rate of re-admission following hyper-CVAD chemotherapy in patients with acute lymphoblastic leukemia which was due to side effects of chemotherapy regimen. It seems to be important not only for high rate of mortality and morbidity in patients resulting from this chemotherapy regimen, but also imposing the heavy cost on health system. Therefore, more effective preventive measures are necessary and useful.

scholarly journals Quality of life in adults with acute lymphoblastic leukemia in France: results from a French cross-sectional study

2021 ◽  
pp. 1-11
Author(s):  
Stephane Lepretre ◽  
Chantal Touboul ◽  
Alain Flinois ◽  
Lucie Kutikova ◽  
Christina Giannopoulou ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Acute Lymphoblastic Leukemia ◽  
Lymphoblastic Leukemia ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional

scholarly journals Total body bone measurements: A cross-sectional study in children with acute lymphoblastic leukemia during and following completion of therapy

2009 ◽  
Vol 52 (1) ◽  
pp. 33-38 ◽  
Author(s):  
Kara M. Kelly ◽  
John C. Thornton ◽  
Deborah Hughes ◽  
Ifeyinwa Osunkwo ◽  
Michael Weiner ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Lymphoblastic Leukemia ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Total Body ◽  
Body Bone

scholarly journals ANGKA BANDING APO B/APO A-I PADA GEJALA KORONER AKUT

2016 ◽  
Vol 20 (1) ◽  
pp. 1
Author(s):  
Sienny Linawaty ◽  
JB. Suparyatmo ◽  
Tahono Tahono
Keyword(s):  
High Risk ◽  
Cross Sectional Study ◽  
Risk Category ◽  
Very Low Density Lipoproteins ◽  
Cross Sectional ◽  
Apo B ◽  
Significance Level ◽  
Mortality And Morbidity ◽  
Coronary Syndrome ◽  
The Mean

Coronary Artery Disease has a high prevalence and is frequently occurred and associated with the high mortality and morbidity. Dyslipidemia is one of the risk factors of Coronary Heart Disease (CHD). ApoB contained in very low-density lipoproteins (VLDL), intermediate-density lipoproteins (IDL), LDL and small dense LDL (sd-LDL), with one molecule of apoB in each particle. Apo A-I is the major apolipoprotein in HDL particles. The ratio of apoB/apoA-I is a balance between apoB-containing particles and potentially atherogenic apoA-I that is antiaterogenik. This study is carried to know the determination whether there are differences between apoB/ apoA-I ratio in patients dyslipidemia with ACS and non ACS. The research used a cross-sectional study design with patients dyslipidemia subjects suffering Acute Coronary Syndrome (ACS) and non ACS who enter to the Laboratory of Pathology Clinic at Dr. Moewardi Hospital between July and November 2011. To determine the pattern of data distribution, the researchers used Kolmogorov Smirnov test. For the analysis of differences in mean apoB/apoA-I ratio in the two population groups is used the T test, using a computer program, with the significance level p<0.05, 95% confidence interval. From 74 samples examined the mean age is 56.42 year old. This patients consisted of 33 males (44.6%) and 41 women (55.4%). All subjects are grouped into two groups, dyslipidemia ACS and non dyslipidemia ACS. The results showed apoB/apoA-I ratio significantly different in patients with dyslipidemia with ACS and non ACS. The mean apoB/apoA-I ratio of women and men subjects in both groups, including groups at high risk of myocardial myokard and higher than the cut-off ratio of apoB/ apoA-I (men 0.9 and women 0.8). It can be concluded that the apoB/apoA-I ratio of women and men subjects in both groups, included the high risk category for infarct myokard although lipid abnormalities are still not demonstrated to the risk of infarct myokard.

CROSS SECTIONAL STUDY OF CAUSES AND DETERMINANTS OF STILLBIRTHS AT TERTIARY CARE TEACHING HOSPITAL

2021 ◽  
pp. 41-43
Author(s):  
Chavan L. G ◽  
Bangal V. B. ◽  
Poorna M. N.
Keyword(s):  
Very Low Birth Weight ◽  
Tertiary Care ◽  
Birth Asphyxia ◽  
Cross Sectional Study ◽  
High Rate ◽  
Child Health Services ◽  
Sectional Study ◽  
Cross Sectional ◽  
Risk Pregnancy ◽  
Common Causes

Introduction- Stillbirth rates are unacceptably high in developing countries. It reects the suboptimum quality of maternal and child health services. Material And Methods- Prospective observational cross sectional study, carried out for one year duration at tertiary care referral hospital in central India. Results-There were 9165 deliveries and 9318 babies born in the hospital.There were 318 stillbirths of which 245(77%) were antepartum stillbirths and 73(23%) were intra-partum stillbirths. The stillbirth rate in the present study was 34/1000 births. Ante-partum haemorrhage (36%) and pregnancy induced hypertension (21%) were most common causes of ante-partum stillbirths where as extreme prematurity with very low birth weight (41%), birth asphyxia, meconium aspiration (21%) and intra-partum haemorrhage (15%) were common causes of intra-partum stillbirths. Conclusion- There is high rate of stillbirths in the present study. Health education, improvement of maternal nutrition, regular antenatal check-ups, high risk pregnancy identication and timely referral and institutional deliveries will help in preventing large number of stillbirths.

Toxicity Profile of PEG-Asparaginase in Adult Patients With Acute Lymphoblastic Leukemia in Brazil: A Multicenter Cross-Sectional Study

2020 ◽  
Vol 20 (8) ◽  
pp. e523-e528
Author(s):  
Wellington F. da Silva ◽  
Ires H.B. Massaut ◽  
Rodrigo M. Bendlin ◽  
Lidiane I. Rosa ◽  
Elvira D.R.P. Velloso ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Lymphoblastic Leukemia ◽  
Cross Sectional Study ◽  
Adult Patients ◽  
Toxicity Profile ◽  
Sectional Study ◽  
Cross Sectional

scholarly journals Gingival health in children in the different phases of acute lymphoblastic leukemia

2019 ◽  
Vol 32 (3) ◽  
pp. 134-137 ◽  
Author(s):  
Luidmyla F. Kaskova ◽  
Nataliia V. Yanko ◽  
Irena Y. Vashchenko
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Periodontal Diseases ◽  
Lymphoblastic Leukemia ◽  
Cross Sectional Study ◽  
Healthy Children ◽  
Cross Sectional ◽  
Initiation Phase ◽  
Gingival Health ◽  
Remission Phase ◽  
Permanent Remission

Abstract Acute lymphoblastic leukemia (ALL), the most common type of leukemia in children, has diverse oral cavity complications. While periodontal alterations in such patients are widely known, there were no studies evaluating gingival health from the time of diagnosis to the remission phase. In our study, we, therefore, analysed the frequency of periodontal diseases and the gingival indices in the different phases of ALL in children. Children aged 7-15 years were involved into the cross-sectional study. Therein, 160 children with ALL were divided into three groups: L1 – 50 children examined before the initiation phase, L2 – 50 children examined after 1 month of the chemotherapy, L3 – 60 children examined in permanent hematologic remission. The control (HC) included 150 healthy children. The L1, L2 and L3 groups had significantly worse gingival indices and frequency of gingivitis than the HC group (p < 0.0001). Frequency of gingivitis increased from before the initiation to the remission phase, but significantly only in 7-11 year-old children (p = 0.0004). Gingival indices increased after 1 month of chemotherapy (p < 0.0001), but decreased in the permanent remission phase (p < 0.0001). Our study stresses the need for children with ALL to not only require prevention courses before the initiation and during the chemotherapy phases, but also in the permanent remission phase to minimize the long-term impact of leukemia treatment on gingival health.

Prognostic Factors in Adolescent and Adult Patients With Acute Lymphoblastic Leukemia With Two Protocols of Chemotherapy: A Cross-Sectional Study

2015 ◽  
Vol 15 (1) ◽  
pp. e7-e14 ◽  
Author(s):  
Edilson Diogenes Pinheiro Junior ◽  
Luis Fernando Pracchia ◽  
Beatriz Beitler de Mauriño ◽  
Gracia Aparecida Martinez ◽  
Pedro Enrique Dorlhiac-Llacer ◽  
...  
Keyword(s):  
Prognostic Factors ◽  
Acute Lymphoblastic Leukemia ◽  
Lymphoblastic Leukemia ◽  
Cross Sectional Study ◽  
Adult Patients ◽  
Sectional Study ◽  
Cross Sectional

scholarly journals ALLERGIC REACTION TO ESCHERICHIA COLI-ASPARAGINASE IN CHILDHOOD ACUTE LYMPHOBLASTIC LEUKEMIA: A STUDY IN A TERTIARY HOSPITAL IN INDONESIA

2020 ◽  
pp. 142-146
Author(s):  
NUR MELANI SARI ◽  
NABILLA PUTRI OSSEVA ◽  
NUR SURYAWAN
Keyword(s):  
Escherichia Coli ◽  
Acute Lymphoblastic Leukemia ◽  
Allergic Reaction ◽  
General Hospital ◽  
Lymphoblastic Leukemia ◽  
Bone Marrow Examination ◽  
Tertiary Hospital ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
E Coli

Objective: The objective of the study was to determine and describe the characteristics of allergic reactions to Escherichia coli-Asparaginase (E. coli-ASP). Methods: This cross-sectional study was performed at Hasan Sadikin Bandung General Hospital on acute lymphoblastic leukemia patients diagnosed from January 1, 2018, to August 31, 2019, confirmed by bone marrow examination. Data were extracted from Bandung Online Pediatric Cancer Registry, medical records, protocol therapy documents, and interview with patient’s guardian. Results: Out of 68 patients, 26 patients (37.6%) were allergic to E. coli-ASP. Twenty-two patients with recorded manifestation’s data evoked 35 symptoms and graded according to common terminology criteria for adverse event v3.0., fever, and urticaria are the most frequent manifestation. While Grade 2 and Grade 3 are the most often developed allergic reaction, patients with age range from 1 to 14 years, male and high risk is mainly allergic. Conclusion: Allergic rate to E. coli-ASP at Hasan Sadikin General Hospital is 37.6%. The most frequent manifestation is fever and urticaria (20%, respectively), Grades 2 and 3 (32%, respectively), and emerged mostly after administration of fourth dose E. coli-ASP (26.9%). Despite the characteristic differences between allergic and non-allergic group, it is not statistically significant.

scholarly journals Blood component therapy, demographic and outcome feature of pediatric acute lymphoblastic leukemia

2021 ◽  
Vol 6 (2) ◽  
pp. e37-e37
Author(s):  
Mehran Noroozi ◽  
Farid Ghazizadeh ◽  
Saba Fani
Keyword(s):  
Bone Marrow ◽  
Acute Lymphoblastic Leukemia ◽  
Lymphoblastic Leukemia ◽  
Fresh Frozen Plasma ◽  
Study Data ◽  
Blood Component ◽  
Cross Sectional ◽  
Blood Component Therapy ◽  
Pediatric All ◽  
The Mean

Introduction: Acute lymphoblastic leukemia (ALL) is the most common childhood malignancy, with an annual incidence rate of three to four cases per 100000 children. Most children with ALL frequently receive blood products including packed cells, platelets, fresh frozen plasma (FFP) and whole blood in the course of chemotherapy and these transfusions may affect ALL outcomes. Objectives: This study aimed to evaluate blood component therapy together with demographic and outcome features of pediatric ALL patients. Patients and Methods: Demographic information of 208 patients with pediatric ALL from February 2011 to August 2019 enrolled in this cross-sectional study. Data is gathered and rechecked from archive files and e-files of Motahari hospital. Results: The mean age of patients at diagnosis was 5.48±3.38 years and Pre-B ALL was the most common phenotype (94.3%). 130 Out of 208 patients were treated with the new protocol and 78 patients were treated with the BFM98 protocol. The majority of relapses were in the bone marrow. The average of received packed cell, platelet and FFP were 4.32±2.93, 5.97±7.09 and 5.29±6.6 units, respectively. The mean overall survival of patients was 3.42±2.58 years in 10 years. Conclusion: According to this study, most of the patients were 5 to 15 years old. Dominant subtype of disease was B-cell type. Most of the deaths were one to 6 years after diagnosis. The relapse rate was about 31% and most of them were in the bone marrow.

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