scholarly journals Enhanced Sensing of 4-Nitroso-N,N–Dimethyl Aniline using Multi-Walled Carbon Nano Tube Modified Glassy Carbon Electrode

2018 ◽  
Vol 4 (5) ◽  
pp. 567-571
Author(s):  
Aaron Mary Ratna Sylvia ◽  
C. Vedhi ◽  
A. Gomathi
Keyword(s):  
Glassy Carbon Electrode ◽  
Glassy Carbon ◽  
Limit Of Detection ◽  
Stripping Voltammetry ◽  
Differential Pulse ◽  
Carbon Electrode ◽  
Experimental Conditions ◽  
Atomic Force ◽  
Effects Of Ph ◽  
Carbon Nano Tube

The voltammetric behaviour of 4-nitroso-N,N–dimethylaniline (4-NDMA) was investigated on plain glassy carbon electrode (GCE) and multi-walled carbon nanotube modified GCE (MWCNT/GCE) using cyclic voltammetry. Effects of pH, scan rate and concentration were studied. The surface morphology of the modified electrode in the absence and presence of 4-NDMA molecules was characterized by atomic force microscope (AFM). A systematic study on the variation of experimental parameters with differential pulse stripping voltammetry (DPSV) was carried out and the optimized experimental conditions were arrived. MWCNT/GCE performed well compared with the plain GCE system and the limit of detection (LOD) was found to be 7.5 ng/mL 0.1056 ng/mL for 4-NDMA on plain GCE and MWCNT/GCE respectively.

scholarly journals Determination of Uric Acid Using TiO2 Nanoparticles Modified Glassy Carbon Electrode

2021 ◽  
Vol 12 (5) ◽  
pp. 6058-6065
Keyword(s):  
Uric Acid ◽  
Tio2 Nanoparticles ◽  
Glassy Carbon Electrode ◽  
Glassy Carbon ◽  
Electrochemical Behavior ◽  
Limit Of Detection ◽  
Electrical Response ◽  
Differential Pulse ◽  
Carbon Electrode ◽  
Experimental Conditions

In the present study, the electrochemical behavior of uric acid (UA) was evaluated using a titania nanoparticle (TiO2) coated glassy carbon electrode (GCE). TiO2 nanoparticles are synthesized and characterized using Scanning Electron Microscopy (SEM) and Energy Dispersive X-Ray Analysis (EDX) techniques. The electrochemical behavior of uric acid on both bare GCE and Titania coated GCE electrodes were studied through differential pulse voltammetry. Titania-coated GCE showed a higher current at the lower potential for the oxidation of uric acid when compared to bare GCE. The sensor's improved electrocatalytic activity was observed to detect uric acid in a 0.1 M phosphate buffer saline (PBS) solution at pH 7.0. A good linear relationship was observed between electrical response and the concentration of uric acid in the range of 1 to 9 μM. Under optimized experimental conditions, the limit of detection (LOD) was found as 0.764 μM. The sensor has expressed considerable sensitivity towards UA detection without interference and is successfully used to determine UA in human urine samples.

scholarly journals Simultaneous electrochemical sensing of dihydroxy benzene isomers at cost-effective allura red polymeric film modified glassy carbon electrode

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Pattan-Siddappa Ganesh ◽  
Ganesh Shimoga ◽  
Seok-Han Lee ◽  
Sang-Youn Kim ◽  
Eno E. Ebenso
Keyword(s):  
Glassy Carbon Electrode ◽  
Glassy Carbon ◽  
Limit Of Detection ◽  
Tap Water ◽  
Differential Pulse ◽  
Oxidation Potential ◽  
Electrochemical Sensing ◽  
Carbon Electrode ◽  
Buffer Solution ◽  
Allura Red

Abstract Background A simple and simultaneous electrochemical sensing platform was fabricated by electropolymerization of allura red on glassy carbon electrode (GCE) for the interference-free detection of dihydroxy benzene isomers. Methods The modified working electrode was characterized by electrochemical and field emission scanning electron microscopy methods. The modified electrode showed excellent electrocatalytic activity for the electrooxidation of catechol (CC) and hydroquinone (HQ) at physiological pH of 7.4 by cyclic voltammetric (CV) and differential pulse voltammetric (DPV) techniques. Results The effective split in the overlapped oxidation signal of CC and HQ was achieved in a binary mixture with peak to peak separation of 0.102 V and 0.103 V by CV and DPV techniques. The electrode kinetics was found to be adsorption-controlled. The oxidation potential directly depends on the pH of the buffer solution, and it witnessed the transfer of equal number of protons and electrons in the redox phenomenon. Conclusions The limit of detection (LOD) for CC and HQ was calculated to be 0.126 μM and 0.132 μM in the linear range of 0 to 80.0 μM and 0 to 110.0 μM, respectively, by ultra-sensitive DPV technique. The practical applicability of the proposed sensor was evaluated for tap water sample analysis, and good recovery rates were observed. Graphical abstract Electrocatalytic interaction of ALR/GCE with dihydroxy benzene isomers.

scholarly journals The effect of tamoxifen on the electrochemical behavior of Bi+3/Bi on the glassy carbon electrode and its determination via differential pulse anodic stripping voltammetry

2019 ◽  
Vol 63 (1) ◽  
Author(s):  
Mehdi Jalali ◽  
Zeinab Deris Falahieh ◽  
Mohammad Alimoradi ◽  
Jalal Albadi ◽  
Ali Niazi
Keyword(s):  
Glassy Carbon Electrode ◽  
Glassy Carbon ◽  
Electrochemical Behavior ◽  
Electrochemical Impedance ◽  
Anodic Stripping Voltammetry ◽  
Stripping Voltammetry ◽  
Differential Pulse ◽  
Peak Height ◽  
Carbon Electrode

The electrochemical behavior of Bi+3 ions on the surface of a glassy carbon electrode, in acidic media and in the presence of tamoxifen, was investigated. Cyclic voltammetry, chronoamperometry, differential pulse voltammetry, electrochemical impedance spectroscopy, and scanning electron microscopy with energy-dispersive X-ray spectroscopy were used to find the probable mechanism contributing to the reduction of the peak height of bismuth oxidation with an increase in the concentration of tamoxifen. The obtained results show a slight interaction between the bismuth species and tamoxifen which co-deposit on the surface of glassy carbon electrode. Therefore, the reduction in the peak height of bismuth oxidation as a function of tamoxifen concentration was used to develop a new differential pulse anodic striping voltammetry method for determination of trace amount of tamoxifen. The effects of experimental parameters on the in situ DPASV of Bi+3 ions in the presence of tamoxifen shown the optimal conditions as: 2 mol L-1 H2SO4 (1% v v-1 MeOH), a deposition potential of -0.5 V, a deposition time of 60 s, and a glassy carbon electrode rotation rate of 300 rpm. The calibration curve was plotted in the range of 0.5 to 6 µg mL-1 and the limits of detection and quantitation were calculated to be 3.1 × 10-5 µg mL-1 and 1.0 × 10-4 µg mL-1, respectively. The mean, RSD, and relative bias for 0.5 µg mL-1 (n=5) were found to be 0.49 µg mL-1, 0.3%, and 2%, respectively. Finally, the proposed method was successfully used for the determination of tamoxifen in serum and pharmaceutical samples.

scholarly journals Preparation and Application of Keggin Silicomolybdic acid Modified Electrode

2020 ◽  
Author(s):  
Miao Liu ◽  
Mingxuan Jia ◽  
Dong Hui Li
Keyword(s):  
Glassy Carbon Electrode ◽  
Modified Electrode ◽  
Glassy Carbon ◽  
Photoelectron Spectroscopy ◽  
Limit Of Detection ◽  
Differential Pulse ◽  
Carbon Electrode ◽  
X Ray ◽  
Linear Relationships

Abstract An innovative method for the determination of isoniazid tablets is studied through electrochemical method for the modification of glassy carbon electrode (GCE). Polyoxomolybdate, with stable structures, has not been widely used for the determination of substance. In this study, the mentioned polyoxomolybdate was characterized by Fourier transform infrared spectroscopy (FT-IR), UV-vis, X-ray diffraction (XRD), Atomic force microscope (AFM) and X-ray photoelectron spectroscopy (XPS), and used to modify the glassy carbon electrode. The electrochemical performance of the polyoxomolybdate@GCE was investigated with cyclic voltammetry (CV) and differential pulse voltammetry (DPV), compared with the unmodified electrode, the proposed polyoxomolybdate modified electrode exhibited strong electro-catalytic activities towards isoniazid (INH). Under the optimized conditions, there was linear relationships between the DPV peak currents and the concentrations in the range of 1 × 10 -7 g/L to 3 × 10 -7 g/L for INH (R 2 = 0.9979), with the limit of detection (LOD) of 0.024 μg/L (based on S/N = 3). The modified electrode has proper reproducibility (RSD < 5%), stability, response time (< 3 min) and lifetime (up to 6 days).

scholarly journals Sensitive Voltammetric Sensor for Tryptophan Detection by Using Polyvinylpyrrolidone Functionalized Graphene/GCE

Nanomaterials ◽  
2020 ◽  
Vol 10 (1) ◽  
pp. 125 ◽  
Author(s):  
Quanguo He ◽  
Jun Liu ◽  
Jinxia Feng ◽  
Yiyong Wu ◽  
Yaling Tian ◽  
...  
Keyword(s):  
Glassy Carbon Electrode ◽  
Glassy Carbon ◽  
Limit Of Detection ◽  
Phosphate Buffer Solution ◽  
Oxidation Mechanism ◽  
Carbon Electrode ◽  
Oxidation Peak ◽  
Experimental Conditions ◽  
Peak Current ◽  
Oxidation Peak Current

In this paper, an electrochemical method for the measurement of tryptophan (Trp) was developed based on a glassy carbon electrode modified with polyvinylpyrrolidonefunctionalized graphene (PVP-GR)/glassy carbon electrode (GCE). In 0.1 M phosphate buffer solution (PBS, pH = 2.2), compared with bare GCE, PVP/GCE, and GR/GCE, the oxidation peak current of Trp increased dramatically at PVP-GR/GCE. The oxidation mechanism of Trp on the PVP-GR/GCE was discussed and the experimental conditions were optimized. Under the best experimental conditions, the oxidation peak current of Trp was proportional to its concentration in the range of 0.06 µM–10.0 µM and 10.0–100.0 µM, and the limit of detection (LOD) was 0.01 µM (S/N = 3). The target modified electrode with excellent repeatability, stability and selectivity, was successfully applied to detectTrp in drugs and biological samples.

scholarly journals Differential pulse adsorptive stripping voltammetric determination of methotrexate using a functionalized carbon nanotubes-modified glassy carbon electrode

2013 ◽  
Vol 11 (11) ◽  
pp. 1837-1843 ◽  
Author(s):  
Geiser Oliveira ◽  
Bruno Janegitz ◽  
Valtencir Zucolotto ◽  
Orlando Fatibello-Filho
Keyword(s):  
Carbon Nanotubes ◽  
Glassy Carbon Electrode ◽  
Glassy Carbon ◽  
High Performance ◽  
Comparative Method ◽  
Differential Pulse ◽  
Carbon Electrode ◽  
Experimental Conditions ◽  
Functionalized Carbon Nanotubes

AbstractA glassy carbon electrode (GC) containing multiwalled functionalized carbon nanotubes (MWCNTs) immobilized within a dihexadecylhydrogenphosphate film (DHP) is proposed as a nanostructured platform for determination of methotrexate (MTX) concentration (a drug used in cancer treatment) using differential pulse adsorptive stripping voltammetry (DPAdSV). The voltammograms for a MTX solution using MWCNTs-DHP/GC electrode presented an oxidation peak potential at 0.98 V vs. Ag/AgCl (3.0 mol L−1 KCl) in a 0.1 mol L−1 sulphuric acid. The apparent heterogeneous electron transfer rate constant of 0.46 s−1 was calculated. The recovery area of 2.62×10−9 mol cm2 was also obtained. Under the optimal experimental conditions, the analytical curve was linear in the MTX concentration range from 5.0×10−8 to 5.0×10−6 mol L−1, with a detection limit of 3.3×10−8 mol L−1. The MWCNTs-DHP/GC electrode can be easily prepared and was applied for the determination of MTX in pharmaceutical formulations, with results similar to those obtained using a high-performance liquid chromatography comparative method.

scholarly journals Electrochemical Oxidation of an Immunosuppressant, Mycophenolate Mofetil, and Its Assay in Pharmaceutical Formulations

2011 ◽  
Vol 2011 ◽  
pp. 1-7 ◽  
Author(s):  
S. N. Prashanth ◽  
K. C. Ramesh ◽  
J. Seetharamappa
Keyword(s):  
Mycophenolate Mofetil ◽  
Electrochemical Oxidation ◽  
Glassy Carbon Electrode ◽  
Glassy Carbon ◽  
Limit Of Detection ◽  
Biological Fluids ◽  
Pharmaceutical Formulations ◽  
Differential Pulse ◽  
Carbon Electrode ◽  
Wide Ph Range

Electrochemical oxidation of mycophenolate mofetil (MMF) has been studied at a glassy carbon electrode in aqueous solution over a wide pH range. MMF was oxidized on glassy carbon electrode (GCE) by an irreversible process that was controlled mainly by diffusion. The irreversibility of the electrode process was verified by different criteria. A probable mechanism for electrochemical oxidation of MMF was proposed. Differential-pulse voltammogram of the drug showed two oxidation peaks at 0.631 V and at 0.921 V (verses SCE) in phosphate buffer of pH 6.0. This process could be used to determine MMF in the concentration range of5.0×10−7to7.5×10−4 M with a limit of detection of1.48×10−7 M. The method was successfully applied for the analysis of MMF in pure and dosage forms and in biological fluids.

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