Complications of invasive methods diagnosis of pulmonary dissemination syndrome, their prevention and treatment

2021 ◽  
pp. 22-29
Author(s):  
S.M. Shalagay ◽  
M.S. Opanasenko ◽  
B.M. Konik ◽  
O.V. Tereshkovych ◽  
V.I. Lysenko ◽  
...  
Keyword(s):  
Lung Biopsy ◽  
Transbronchial Lung Biopsy ◽  
Endobronchial Ultrasound ◽  
Open Biopsy ◽  
Group Iii ◽  
Group I ◽  
Prevention And Treatment ◽  
The Right ◽  
Biopsy Complications ◽  
Selection Of

Objective — to study the possible complications that arise when using invasive methods for the diagnosis of pulmonary dissemination syndrome, to develop measures aimed at their prevention and treatment. Materials and methods. Data from 216 patients who used invasive methods to diagnose pulmonary dissemination syndrome were analyzed. Patients were divided into 3 groups, depending on the type of biopsy: Group I — 143 patients who underwent VATS lung biopsy, Group II — 64 patients who underwent endobronchial ultrasound transbronchial biopsy lungs (EBUS TBBL); Group III — 9 patients who underwent open biopsy. Complications in I — 12 (8.4 %), II — 5 (7.8 %), III — 2 (22.2 %), total — 19 (8.8 %). These were lung tear, wound suppuration, disease progression, pneumothorax, hemoptysis, respiratory failure, intrapleural hemorrhage. Results and discussion. Based on the obtained data, we have proposed methods of prevention of complications: radiography of the thoracic cavity in the first day after biopsy; correction of antiplatelet therapy; careful selection of patients for biopsy taking into account age, concomitant pathology, taking drugs, history.Conclusions. Lung biopsy for pulmonary dissemination syndrome is a safe type of diagnosis with a low level of complications — 8.8 %.The least traumatic method is transbronchial lung biopsy under ultrasound control.If it is impossible to perform a transbronchial lung biopsy, or if the obtained material is uninformative, the next step is to use a video­assisted lung biopsy.An open biopsy should be considered last and only under strict indications.It is important to choose the right method of biopsy, taking into account age, history, drugs.

Inhibition of cardiac vagal component of baroreflex by group III and IV afferents

1991 ◽  
Vol 260 (3) ◽  
pp. H730-H734 ◽  
Author(s):  
P. N. McWilliam ◽  
T. Yang
Keyword(s):  
Peroneal Nerve ◽  
Baroreceptor Reflex ◽  
Interval Prolongation ◽  
Group Iii ◽  
Control Value ◽  
Pressure Elevation ◽  
Group I ◽  
Afferent Fibers ◽  
The Difference ◽  
The Right

The action of electrically evoked activity in somatic afferent fibers on the sensitivity of the baroreceptor reflex was examined in decerebrate cats. The sensitivity of the reflex was expressed as the difference between the maximum prolongation of R-R interval in response to carotid sinus pressure elevation and the mean of 10 R-R intervals immediately before pressure elevation. The control value of R-R interval prolongation was 192 +/- 50 ms. Stimulation (10 Hz) of group I and II fibers of the right peroneal nerve (evoked volleys recorded from the sciatic nerve) had no effect on R-R interval prolongation (171 +/- 45 ms). Recruitment of group III fibers (10 Hz) conducting at 23.6 +/- 0.65 m/s reduced the prolongation of R-R interval to 52 +/- 14 ms. Recruitment of group IV fibers (10 Hz) conducting less than 2.5 m/s further reduced the prolongation of R-R interval to 1.0 +/- 8.0 ms. It is concluded that the inhibition of the cardiac vagal component of the baroreceptor reflex produced by electrical stimulation of the peroneal nerve is mediated by afferent fibers of groups III and IV.

Economic analysis of endobronchial ultrasound (EBUS) as a tool in the diagnosis and staging of lung cancer in Singapore

2010 ◽  
Vol 26 (2) ◽  
pp. 170-174 ◽  
Author(s):  
Shin Yuh Ang ◽  
Rachel Woo Yin Tan ◽  
Mariko Siyue Koh ◽  
Jeremy Lim
Keyword(s):  
Lung Cancer ◽  
Lung Biopsy ◽  
Cost Savings ◽  
Needle Aspiration ◽  
The Other ◽  
Transbronchial Lung Biopsy ◽  
Endobronchial Ultrasound ◽  
Economic Evaluations ◽  
Diagnosis Of Lung Cancer ◽  
The Cost

Objectives: Endobronchial ultrasound (EBUS), encompassing endobronchial ultrasound transbronchial needle aspiration (EBUS-TBNA) and Endobronchial ultrasound transbronchial lung biopsy (EBUS-TBLB) has been proven to be a useful modality in the staging and diagnosis of lung cancer. However, there are limited publications on the cost-effectiveness of EBUS and no economic evaluations relevant to the Singapore setting. An economic evaluation using our hospital's data was used to assess the cost implications of EBUS substituting where clinically appropriate: transthoracic needle aspiration; (TTNA), fluoroscopy-guided transbronchial lung biopsy (TBLB), and mediastinoscopy in the diagnosis and staging of lung cancer.Methods: Relationship between the clinical and economic implications of alternative modalities was modeled using data inputs that were relevant to the Singapore setting. Two decision analytic models were constructed to evaluate the cost of EBUS compared with TTNA, TBLB, and staging mediastinoscopy. Only direct costs were imputed.Results: In the base–case analysis, TTNA was the most economical strategy (SGD3,335 = US$2,403) where clinically suitable for the diagnosis of lung cancer as compared to the other options: TBLB (SGD4,499) and EBUS-TBLB (SGD4,857). On the other hand, EBUS-TBNA resulted in expected cost savings of SGD1,214 per positive staging of lung cancer as compared to mediastinoscopy.Conclusions: The use of EBUS-TBNA could result in cost savings of SGD1,214 per positive staging of lung cancer as compared to mediastinoscopy. Whereas TTNA was the most economical intervention for the diagnosis of lung cancer as compared to the other options, its main limitation lies in its suitability only for peripheral lung lesions and high complication rate.

Atrioventricular responses of canine heart following chronic unilateral vagotomy

1987 ◽  
Vol 253 (2) ◽  
pp. H394-H401 ◽  
Author(s):  
D. V. Priola ◽  
C. Anagnostelis ◽  
C. Sanchez-Wilson ◽  
T. M. Blomquist
Keyword(s):  
Frequency Response ◽  
Control Mechanisms ◽  
Canine Heart ◽  
Response Curves ◽  
Group Iii ◽  
Group I ◽  
Group Ii ◽  
The Right ◽  
Inotropic Responses ◽  
Intrinsic Cardiac Nerves

The intrinsic cardiac nerves (ICN) have been shown to develop supersensitivity to nicotine (NIC) following complete extrinsic cardiac denervation. The present experiments were performed to delineate the pattern of ICN distribution in the heart by examining the pattern of NIC supersensitivity after unilateral vagotomy (VGX). Thirty-eight dogs were placed on cardiopulmonary bypass and inotropy evaluated by means of isovolumic pressures from fluid-filled balloons placed in the atria and ventricles. The animals were divided into three groups: group I, sham-operated controls; group II, animals studied 1–2 wk after VGX; and group III, animals studied 8–12 wk after VGX. Chronotropic and inotropic responses were evaluated in terms of NIC and acetylcholine (ACh) dose-response curves as well as frequency-response curves to stimulation of the intact vagus nerve (0.5–30 Hz). No change in NIC sensitivity was observed in group II, and vagal frequency-response curves were identical to group I. In group III dogs, both the right atrium and right ventricle showed significant increases in NIC sensitivity after left vagotomy. All group III animals showed right-shifted frequency-response curves. We conclude that nicotinic supersensitivity of the ICN and inotropic unresponsiveness to vagal stimulation occur but are slow in developing (70–130 days); and preganglionic sprouting does not appear to play a functional role in the adjustment of cardiac control mechanisms to unilateral vagotomy.

scholarly journals BONE INDUCTION BY BMP-2 EXPRESSING ADENOVIRAL VECTOR IN RATS UNDER TREATMENT WITH FK506

2002 ◽  
Vol 06 (01) ◽  
pp. 23-29 ◽  
Author(s):  
Junya Sonobe ◽  
Kazuhisa Bessho ◽  
Shinji Kaihara ◽  
Yasunori Okubo ◽  
Tadahiko Iizuka
Keyword(s):  
Adenoviral Vector ◽  
Host Immunity ◽  
Bone Morphogenetic Protein 2 ◽  
Control Group ◽  
Group Iii ◽  
Group I ◽  
Morphogenetic Protein ◽  
Human Bone Morphogenetic Protein ◽  
The Right

The purpose of this study was to investigate the effectiveness of human bone morphogenetic protein-2 (BMP-2) expressing adenoviral vector in vivo. The day before vector injection, immunosuppressant FK506 was given subcutaneously to each rat at doses of 12 mg/kg (Group I), 6 mg/kg (Group II) and 3 mg/kg (Group III). FK506 was not administered to the six rats of the control group. Twenty-five liters of AXCAOBMP-2 (3.93 × 109pfu/ml) were injected into the right calf muscle of all rats. On day 21 after vector injection, all groups were investigated radiologically, histologically, and biochemically. Osteoinduction was seen in the AxCAOBMP-2-injected groups with immunosuppression. However, no bone formation was observed in the control group. These findings suggest that AxCAOBMP-2 has the potential of osteoinduction under transient immunosuppression. AxCAOBMP-2 may be useful for future clinical application in bone reconstruction, if host immunity response can be regulated.

scholarly journals Comparison of clinical, biomechanical, and histopathological effects of various suture techniques on repair of tendon rupture by using autograft

2017 ◽  
Vol 61 (2) ◽  
pp. 231-237
Author(s):  
Celal Şahin Ermutlu ◽  
Vedat Baran
Keyword(s):  
Good Alternative ◽  
Suture Technique ◽  
Suture Techniques ◽  
Tissue Loss ◽  
Group Iii ◽  
Interrupted Suture ◽  
Group I ◽  
Tendon Ruptures ◽  
The Right ◽  
And Control

AbstractIntroduction: The purpose of this study was to compare the effectiveness of four different suture techniques in the treatment of experimentally modelled tendon injuries with tissue loss with autograft and grafting applications in rabbits.Material and Methods: The study was performed on 30 male mature (2-year-old) New Zealand rabbits with mean body weight of 3.1 kg, divided into three equal groups. A graft measuring 1 cm in length was collected from the m. tibialis cranialis of each rabbit under general anaesthesia. The graft collected from the right tendon was transplanted into the left tendon, and the graft from the left tendon was transplanted into the right tendon. In all groups, a simple interrupted suture was placed on the left tendon as control, a Bunnell-Mayer suture was placed on the right tendon in group I, a Locking-Loop suture in group II, and a Horizontal U suture in group III. Both hindlimbs were bandaged for four weeks. The tendons were assessed biomechanically and histopathologically.Results: According to the results of the tensile testing, the maximum durability of the techniques ranked as follows: Bunnell-Mayer, Horizontal U, Locking-Loop, and control groups.Conclusion: The use of autografts was a good alternative for the treatment of tendon ruptures with tissue loss. Furthermore, even though there were no clinical or histopathological differences, the suture technique can be chosen based on the results of the tensile test.

scholarly journals Effect of Piglet Birth Weight on Selected Characteristics of Pork

2014 ◽  
Vol 14 (4) ◽  
pp. 967-975 ◽  
Author(s):  
Anna Rekiel ◽  
Justyna Bartosik ◽  
Justyna Więcek ◽  
Martyna Batorska ◽  
Beata Kuczyńska ◽  
...  
Keyword(s):  
Birth Weight ◽  
Shear Force ◽  
Drip Loss ◽  
Large White ◽  
Group Iii ◽  
Group I ◽  
Longissimus Lumborum ◽  
Pig Meat ◽  
The Right ◽  
Age Determinations

Abstract The objective of the study was to determine how different birth weights of piglets influence some chemical and physical characteristics of pig meat. Piglets were grouped according to birth weight: ≤1.30 kg (group I), 1.31-1.70 kg (group II), ≥1.71 kg (group III). Animals were reared and fattened under standardized housing and feeding conditions. Tests were conducted with 60 samples of meat (20 per group) collected from the right side of the carcasses (M. longissimus lumborum) of threebreed crosses of (Polish Landrace × Polish Large White) × Duroc (barrows to gilts, 1:1), which were slaughtered at about 180 days of age. Determinations were made of basic chemical composition, colour of meat, drip loss, shear force value, and fatty acid profile. It was found that the birth weight of the piglets affects meat colour (redness), crude fat content and the proportion of some fatty acids (C16:1, C20:1 n-9, C20:2 n-6, C20:5 n-3).

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