Age-related aspects of bone tissue condition at chronic pancreatitis

2019 ◽  
Vol 0 (2) ◽  
pp. 70-74
Author(s):  
L. S. Babinets ◽  
N. О. Shevchenko ◽  
I. M. Halabitska
Keyword(s):  
Chronic Pancreatitis ◽  
Bone Tissue ◽  
Age Related

scholarly journals Current Stage of Marine Ceramic Grafts for 3D Bone Tissue Regeneration

Marine Drugs ◽  
2019 ◽  
Vol 17 (8) ◽  
pp. 471 ◽  
Author(s):  
Patricia Diaz-Rodriguez ◽  
Miriam López-Álvarez ◽  
Julia Serra ◽  
Pío González ◽  
Mariana Landín
Keyword(s):  
Bone Tissue ◽  
Tissue Regeneration ◽  
Alveolar Bone ◽  
3D Cell Culture ◽  
Spinal Fractures ◽  
Bone Grafts ◽  
Bone Tissue Regeneration ◽  
Marine Origin ◽  
Age Related ◽  
Current Stage

Bioceramic scaffolds are crucial in tissue engineering for bone regeneration. They usually provide hierarchical porosity, bioactivity, and mechanical support supplying osteoconductive properties and allowing for 3D cell culture. In the case of age-related diseases such as osteoarthritis and osteoporosis, or other bone alterations as alveolar bone resorption or spinal fractures, functional tissue recovery usually requires the use of grafts. These bone grafts or bone void fillers are usually based on porous calcium phosphate grains which, once disposed into the bone defect, act as scaffolds by incorporating, to their own porosity, the intergranular one. Despite their routine use in traumatology and dental applications, specific graft requirements such as osteoinductivity or balanced dissolution rate are still not completely fulfilled. Marine origin bioceramics research opens the possibility to find new sources of bone grafts given the wide diversity of marine materials still largely unexplored. The interest in this field has also been urged by the limitations of synthetic or mammalian-derived grafts already in use and broadly investigated. The present review covers the current stage of major marine origin bioceramic grafts for bone tissue regeneration and their promising properties. Both products already available on the market and those in preclinical phases are included. To understand their clear contribution to the field, the main clinical requirements and the current available biological-derived ceramic grafts with their advantages and limitations have been collected.

Micro CT-Based Large Scale Finite Element Modeling of Compressive and Torsional Properties of Human Cortical Bone

2007 ◽  
Author(s):  
Yener N. Yeni ◽  
Roger R. Zauel
Keyword(s):  
Cortical Bone ◽  
Bone Tissue ◽  
Large Scale ◽  
Present Note ◽  
Fragility Fractures ◽  
The Body ◽  
Micro Ct ◽  
Tissue Quality ◽  
Age Related ◽  
Torsional Properties

Cortical bone tissue quality is imperative in maintaining the mechanical competence of whole bones, particularly at sites of overuse and age-related fragility fractures where a considerable cortical bone component is present. (Note that cortical bone tissue is more than 80% of the bone in the body [1].)

scholarly journals Age-related effect on the concentration of collagen crosslinks in human osteonal and interstitial bone tissue

Bone ◽  
2006 ◽  
Vol 39 (6) ◽  
pp. 1210-1217 ◽  
Author(s):  
Jeffry S. Nyman ◽  
Anuradha Roy ◽  
Rae L. Acuna ◽  
Heather J. Gayle ◽  
Michael J. Reyes ◽  
...  
Keyword(s):  
Bone Tissue ◽  
Related Effect ◽  
Collagen Crosslinks ◽  
Age Related

scholarly journals Osteodensitometric Characteristics of Bone Tissue in Women with Normal Body Weight

2021 ◽  
Vol 10 (3) ◽  
pp. 108-111
Author(s):  
I. G. Pashkova
Keyword(s):  
Body Weight ◽  
Bone Tissue ◽  
Muscle Mass ◽  
Bone Mineralization ◽  
Lumbar Vertebrae ◽  
The Body ◽  
Mineral Density ◽  
Normal Body ◽  
Age Related ◽  
Normal Body Weight

The aim of the study was to investigate age-related changes in bone mineralization indicators in the lumbar vertebrae in women with normal body weight living in the conditions of the Northern region.Material and methods. A complex somatometric examination and quantitative assessment of the bone tissue mineral density in the lumbar vertebrae were performed according to dual-energy X-ray absorptiometry of a group of Slavic women (n=127) with a normal body weight (BMI values from 18.5 to 24.9 kg/m2) aged 20 to 87 years, permanently residing in the Republic of Karelia. Statistical processing of the material was performed using the program "STATISTICA 6.0".Results. The BMI values in women increased significantly every decade of life. Direct correlations of mineral bone density (MBD) with the body length (r=0.46, p<0.001), with the body surface area (r=0.46, p<0.001), with absolute muscle mass (MM) (r=0.39, p<0.001), and with body mass (r=0.29, p<0.001) were revealed. No significant correlation with the adipose mass was found. The incidence of low MBD of the lumbar vertebrae was 48%: osteopenia was in 29%, osteoporosis was in 19% of women. The analysis of the component composition of the body in women with different levels of bone mass showed significant differences in the absolute content of muscle mass.Conclusion. In women with a normal BMI, body weight and muscle mass play an essential role in maintaining lumbar vertebrae bone mineral density.

scholarly journals Mechanisms of implementation of osteopenic conditions in patients with combined course of chronic pancreatitis and hypertensive disease

2018 ◽  
Vol 42 (4) ◽  
pp. 36-41
Author(s):  
T. I. Viun
Keyword(s):  
Chronic Pancreatitis ◽  
Acid Phosphatase ◽  
Treatment Group ◽  
Bone Tissue ◽  
Biochemical Markers ◽  
Comparison Group ◽  
Metabolic Disturbances ◽  
Hypertensive Disease ◽  
Total Acid ◽  
Vdr Gene

The comorbidity of chronic pancreatitis (CP) and hypertensive disease (HD), which are often combined with each other, can be considered as predictor states of the complication formation. This is due to the intersection of individual pathogenic links, which are enhanced by their combination. As such a complication, it is possible to consider osteoporotic conditions, leading to metabolic disturbances of bone tissue with quantitative and qualitative changes. The emergence of secondary osteoporosis (SO) is not only phenotypically but also genetically conditioned, which is the basis for studying the gene aberrations of “osteopenically directed genes” and determining the content of SO biochemical markers. Aim of study: to establish the features of the comorbid course of CP and hypertension, to optimize the diagnosis of osteoporotic conditions by studying the content of biochemical markers of OP (total acid phosphatase (TAP) and tartrate-resistant acid phosphatise (TRAP)) and polymorphism of the vitamin D receptor genes (VDR). Materials and methods of research. To solve this problem, 110 patients with CP were examined and further divided into 2 groups: treatment group — 70 persons with CP and hypertensive disease (HD), and the comparison group — 40 patients with isolated CP. These groups were representative by age and sex. The condition of bone tissue was studied in assessing the content of indicators of total acid phosphatase (TAP) and non-prostatic acid phosphatase (TRAP) in blood serum. At the same time, VDR was determined. Results. It was found that the vast majority of patients in the treatment group (84.3%) had an unfavourable B-allele; against the comparison group — 77.5% of events. Changes in the VDR gene polymorphism affected the incidence of the osteoarticular system (CCP, χ2 = 20.81, p <0.01) and had a statistically significant relationship in the distribution of alleles between groups (CCP, χ2 = 30.08, p <0.01). The parameters of TAP and TRAP in patients with combined course of HP and CP were 8.7 ± 2.3 U/L and 5.1 ± 2.3 U/L, respectively, and in the comparison group — 6.9 ± 3.0 U/L and 3.5 ± 2.1 U/L. Thus, the content of TAP and TRAP exceeded the control in the treatment group by 2.5 (TAP) and 1.9 (TRAP) times (p<0.01) and in the comparison group by 2.0 (TAP) and 1.3 TRAP) times (p<0.01), which allowed us to state the development of osteopenic conditions. The distribution of alleles of the VDR gene was characterized by the predominance of the B-allele and was “supported” by changes in the biochemical markers of osteoporosis, which led to the development of osteopenicconditions in such individuals. Thus, the combination of HP and CP is an unfavourable factor in the development of osteoporosis and the basis for early detection of osteoporetic changes. Conclusions. In the combined course of CP and arterial hypertension, there is an increase in the number of persons with the B-allele of the VDR gene (84.3% of cases), the carriers of which have a high risk of osteopenia. With the comorbidity of CP and HD, there are fluctuations in the content of TAP and TRAP, correlating with VDR. Increase in the content of TAP and TRAP in patients with CP and HD often occurs against the background of an unfavourable B-allele of the VDR gene. Combined course of CP and HD is the basis for early diagnosis of osteoporotic complications.

scholarly journals Age-related changes in bone tissue in men

2021 ◽  
Vol 11 (2) ◽  
pp. 62-69
Author(s):  
A.S. Musiienko ◽  
N.V. Zaverukha
Keyword(s):  
Lumbar Spine ◽  
Femoral Neck ◽  
Bone Tissue ◽  
Clinical Signs ◽  
Osteoporotic Fractures ◽  
State Institution ◽  
Mineral Density ◽  
Healthy Men ◽  
Age Related ◽  
Age Related Changes

The purpose of the study was to establish age-related changes of male bone tissue. Materials and methods. The study was conducted by the Department of Clinical Physiology and Pathology of the Musculoskeletal System of the State Institution “D.F. Chebotarev Institute of Gerontology by the National Aca­demy of Medical Sciences of Ukraine”. It involved 342 healthy men aged 20 to 89 years without osteoporosis and osteoporotic fractures or any pathology with a confirmed impact on bone tissue, as well as any somatic pathology in the sub- and decompensation. The following methods of examination were used: questionnaire, anthropometric measurements, clinical and instrumental examination. Bone mineral density (BMD) was measured by the dual-energy X-ray absorptiometry machine “Prodigy, GEНС Lunar” at the level of the entire skeleton, lumbar spine (L1-L4), proximal femur and femoral neck, distal and ultra-distal forearm bones. Results. We have detected a significant 14.8 % decrease of BMD at the level of femoral neck in the group of men aged 60–69 years, by 20 % in the group of men aged 70–79 years, and by 24.1 % in the group of men aged 80–89 years compared to the men aged 20–29 years; at the same time, at the lumbar spine there was re­gistered a decrease of this parameter by 1.6 % in men aged 60–69 years, by 1.9 % in men of 70–79 years and by 0.8 % in men of 80–89 years, respectively. Among the examined practically healthy men, the bone tissue remained at the normal level relative to age in 67.8 %; osteopenia was detected in 27.8 %, and osteoporosis in 4.4 %. Conclusions. An age-associated BMD reduction was registered at various skeletal sites in the practically healthy men wi­thout any clinically significant factors affecting bone tissue metabolism. The most pronounced BMD loss was observed at the level of fe­moral neck. At the same time, 4.4 % of examined had osteoporosis without any clinical signs.

Micromechanics of Osteonal Cortical Bone Fracture

1998 ◽  
Vol 120 (1) ◽  
pp. 112-117 ◽  
Author(s):  
X. E. Guo ◽  
L. C. Liang ◽  
S. A. Goldstein
Keyword(s):  
Stress Intensity Factor ◽  
Stress Intensity ◽  
Fracture Mechanics ◽  
Intensity Factor ◽  
Cortical Bone ◽  
Bone Tissue ◽  
Cement Line ◽  
Linear Elastic ◽  
Age Related ◽  
Microcrack Propagation

Microcracks have been associated with age-related bone tissue fragility and fractures. The objective of this study was to develop a simple osteonal cortical bone model and apply linear elastic fracture mechanics theory to understand the micromechanics of the fracture process in osteonal cortical bone and its dependence on material properties. The linear fracture mechanics of our composite model of conical bone, consisting of an osteon and interstitial bone tissue, was characterized in terms of a stress intensity factor (SIF) near the tip of a microcrack. The interaction between a microcrack and an osteon was studied for different types of osteons and various spacing between the crack and the osteon. The results of the analysis indicate that the fracture mechanics of osteonal cortical bone is dominated by the modulus ratio between the osteon and interstitial bone tissue: A soft osteon promotes microcrack propagation toward the osteon (and cement line) while a stiff one repels the microcrack from the osteon (and cement line). These findings suggest that newly formed, low-stiffness osteons may toughen cortical bone tissue by promoting crack propagation toward osteons. A relatively accurate empirical formula also was obtained to provide an easy estimation of the influence of osteons on the stress intensity factor.

scholarly journals Cathepsin K and matrix metalloproteases activity in bone tissue of OXYS rats with osteoporosis development

2010 ◽  
Vol 56 (2) ◽  
pp. 274-282 ◽  
Author(s):  
A.A. Venediktova ◽  
O.V. Falameeva ◽  
N.G. Kolosova ◽  
M.A. Sadovoj ◽  
T.A. Korolenko
Keyword(s):  
Bone Tissue ◽  
Wistar Rats ◽  
Cathepsin K ◽  
Typical Feature ◽  
Matrix Metalloproteases ◽  
Oxys Rats ◽  
Age Related ◽  
Α2 Macroglobulin ◽  
The Comparative Study ◽  
K Activity

The comparative study of аctivity of cysteine protease cathepsin K and matrix metalloproteases (MMPs) in bone tissue of accelerated senescent OXYS rats with early ageing comparatively to Wistar rats of the same age was performed. Early development osteoporosis is a typical feature of OXYS rats. In bone tissue of 3 month old OXYS rats, before appearance of osteoporosis manifestation cathepsin K activity was higher, whereas MMPs activity was lower than in Wistar rats. In Wistar rats (3 and 14 months old) cathepsin K activity of spine was shown to increase, and MMPs activity to decrease. In OXYS rats age-related change of cathepsin K and MMPs activity in bone tissue had the opposite direction. As a result of this there were no differences between Wistar and OXYS rats 14 months old despite the marked osteoporosis in OXYS rats as revealed our early researches. Serum α2-macroglobulin activity was higher in 14 months old OXYS rats. The role of activation of cathepsin K in bone resorption in the development of osteoporosis in early ageing OXYS rats is discussed.

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